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IL2RB (interleukin 2 receptor subunit beta)

Identity

Other namesCD122
IL15RB
P70-75
HGNC (Hugo) IL2RB
LocusID (NCBI) 3560
Atlas_Id 40958
Location 22q12.3  [Link to chromosome band 22q12]
Location_base_pair Starts at 37521880 and ends at 37545962 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TRB () / IL2RB (22q12.3)WIPF2 (17q21.1) / IL2RB (22q12.3)WIPF2 17q21.1 / IL2RB 22q12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IL2RB   6009
Cards
Entrez_Gene (NCBI)IL2RB  3560  interleukin 2 receptor subunit beta
AliasesCD122; IL15RB; P70-75
GeneCards (Weizmann)IL2RB
Ensembl hg19 (Hinxton)ENSG00000100385 [Gene_View]  chr22:37521880-37545962 [Contig_View]  IL2RB [Vega]
Ensembl hg38 (Hinxton)ENSG00000100385 [Gene_View]  chr22:37521880-37545962 [Contig_View]  IL2RB [Vega]
ICGC DataPortalENSG00000100385
TCGA cBioPortalIL2RB
AceView (NCBI)IL2RB
Genatlas (Paris)IL2RB
WikiGenes3560
SOURCE (Princeton)IL2RB
Genomic and cartography
GoldenPath hg19 (UCSC)IL2RB  -     chr22:37521880-37545962 -  22q12.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IL2RB  -     22q12.3   [Description]    (hg38-Dec_2013)
EnsemblIL2RB - 22q12.3 [CytoView hg19]  IL2RB - 22q12.3 [CytoView hg38]
Mapping of homologs : NCBIIL2RB [Mapview hg19]  IL2RB [Mapview hg38]
OMIM146710   
Gene and transcription
Genbank (Entrez)AA834613 AK312860 AW193701 BC025691 CR456506
RefSeq transcript (Entrez)NM_000878
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)IL2RB
Cluster EST : UnigeneHs.474787 [ NCBI ]
CGAP (NCI)Hs.474787
Alternative Splicing GalleryENSG00000100385
Gene ExpressionIL2RB [ NCBI-GEO ]   IL2RB [ EBI - ARRAY_EXPRESS ]   IL2RB [ SEEK ]   IL2RB [ MEM ]
Gene Expression Viewer (FireBrowse)IL2RB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3560
GTEX Portal (Tissue expression)IL2RB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14784 (Uniprot)
NextProtP14784  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14784
Splice isoforms : SwissVarP14784 (Swissvar)
PhosPhoSitePlusP14784
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_S_F1 (PS01355)   
Domains : Interpro (EBI)FN3_dom    Hempt_rcpt_S_F1_CS    Ig-like_fold   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM Disease mutations3560
Blocks (Seattle)IL2RB
PDB (SRS)1ILM    1ILN    2B5I    2ERJ    3QAZ    4GS7   
PDB (PDBSum)1ILM    1ILN    2B5I    2ERJ    3QAZ    4GS7   
PDB (IMB)1ILM    1ILN    2B5I    2ERJ    3QAZ    4GS7   
PDB (RSDB)1ILM    1ILN    2B5I    2ERJ    3QAZ    4GS7   
Structural Biology KnowledgeBase1ILM    1ILN    2B5I    2ERJ    3QAZ    4GS7   
SCOP (Structural Classification of Proteins)1ILM    1ILN    2B5I    2ERJ    3QAZ    4GS7   
CATH (Classification of proteins structures)1ILM    1ILN    2B5I    2ERJ    3QAZ    4GS7   
SuperfamilyP14784
Human Protein AtlasENSG00000100385
Peptide AtlasP14784
HPRD00896
IPIIPI00878728   IPI00878405   IPI00878276   IPI00878426   IPI00878872   IPI00916279   
Protein Interaction databases
DIP (DOE-UCLA)P14784
IntAct (EBI)P14784
FunCoupENSG00000100385
BioGRIDIL2RB
STRING (EMBL)IL2RB
ZODIACIL2RB
Ontologies - Pathways
QuickGOP14784
Ontology : AmiGOMAPK cascade  interleukin-2 receptor activity  interleukin-2 receptor activity  Ras guanyl-nucleotide exchange factor activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  protein complex assembly  signal transduction  external side of plasma membrane  membrane  viral process  cytokine-mediated signaling pathway  interleukin-2 binding  natural killer cell activation  interleukin-2-mediated signaling pathway  negative regulation of apoptotic process  positive regulation of GTPase activity  
Ontology : EGO-EBIMAPK cascade  interleukin-2 receptor activity  interleukin-2 receptor activity  Ras guanyl-nucleotide exchange factor activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  protein complex assembly  signal transduction  external side of plasma membrane  membrane  viral process  cytokine-mediated signaling pathway  interleukin-2 binding  natural killer cell activation  interleukin-2-mediated signaling pathway  negative regulation of apoptotic process  positive regulation of GTPase activity  
Pathways : BIOCARTAIL 2 signaling pathway [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Endocytosis    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Measles    HTLV-I infection    Transcriptional misregulation in cancer   
NDEx NetworkIL2RB
Atlas of Cancer Signalling NetworkIL2RB
Wikipedia pathwaysIL2RB
Orthology - Evolution
OrthoDB3560
GeneTree (enSembl)ENSG00000100385
Phylogenetic Trees/Animal Genes : TreeFamIL2RB
Homologs : HomoloGeneIL2RB
Homology/Alignments : Family Browser (UCSC)IL2RB
Gene fusions - Rearrangements
Fusion: TCGAWIPF2 17q21.1 IL2RB 22q12.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerIL2RB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL2RB
dbVarIL2RB
ClinVarIL2RB
1000_GenomesIL2RB 
Exome Variant ServerIL2RB
ExAC (Exome Aggregation Consortium)IL2RB (select the gene name)
Genetic variants : HAPMAP3560
Genomic Variants (DGV)IL2RB [DGVbeta]
Mutations
ICGC Data PortalIL2RB 
TCGA Data PortalIL2RB 
Broad Tumor PortalIL2RB
OASIS PortalIL2RB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL2RB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL2RB
DgiDB (Drug Gene Interaction Database)IL2RB
DoCM (Curated mutations)IL2RB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL2RB (select a term)
intoGenIL2RB
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:37521880-37545962  ENSG00000100385
CONAN: Copy Number AnalysisIL2RB 
Mutations and Diseases : HGMDIL2RB
OMIM146710   
MedgenIL2RB
Genetic Testing Registry IL2RB
NextProtP14784 [Medical]
TSGene3560
GENETestsIL2RB
Huge Navigator IL2RB [HugePedia]
snp3D : Map Gene to Disease3560
BioCentury BCIQIL2RB
ClinGenIL2RB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3560
Chemical/Pharm GKB GenePA29829
Clinical trialIL2RB
Miscellaneous
canSAR (ICR)IL2RB (select the gene name)
Probes
Litterature
PubMed141 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL2RB
EVEXIL2RB
GoPubMedIL2RB
iHOPIL2RB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 18:54:51 CEST 2016

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