IL32 (interleukin 32)

2008-05-01  

Identity

HGNC
IL32
LOCATION
16p13.3
LOCUSID
9235
ALIAS
IL-32alpha,IL-32beta,IL-32delta,IL-32gamma,NK4,TAIF,TAIFa,TAIFb,TAIFc,TAIFd
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9235
MIM: 606001
HGNC: 16830
Ensembl: ENSG00000008517

Variants:

dbSNP: 9235
ClinVar: 9235
TCGA: ENSG00000008517
COSMIC: IL32

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008517ENST00000008180P24001
ENSG00000008517ENST00000325568P24001
ENSG00000008517ENST00000382213P24001
ENSG00000008517ENST00000396887P24001
ENSG00000008517ENST00000396890P24001
ENSG00000008517ENST00000440815P24001
ENSG00000008517ENST00000444393P24001
ENSG00000008517ENST00000525228E9PK07
ENSG00000008517ENST00000525377E9PIV2
ENSG00000008517ENST00000525643P24001
ENSG00000008517ENST00000526464P24001
ENSG00000008517ENST00000528163P24001
ENSG00000008517ENST00000529550P24001
ENSG00000008517ENST00000529699C6GKH1
ENSG00000008517ENST00000530538P24001
ENSG00000008517ENST00000530890P24001
ENSG00000008517ENST00000531965P24001
ENSG00000008517ENST00000533097P24001
ENSG00000008517ENST00000534507P24001
ENSG00000008517ENST00000548246P24001
ENSG00000008517ENST00000548476P24001
ENSG00000008517ENST00000548652P24001
ENSG00000008517ENST00000548807F8VSD2
ENSG00000008517ENST00000549213P24001
ENSG00000008517ENST00000551122P24001
ENSG00000008517ENST00000551513F8VVN4
ENSG00000008517ENST00000552356P24001
ENSG00000008517ENST00000552664P24001
ENSG00000008517ENST00000552936F8W1V1
ENSG00000008517ENST00000613483C6GKH1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
164927352006IL-32, a proinflammatory cytokine in rheumatoid arthritis.116
169037742006Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism.76
265516702015Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes.64
164103142006Involvement of IL-32 in activation-induced cell death in T cells.57
182966362008Interleukin-32 induces the differentiation of monocytes into macrophage-like cells.54
182870212008Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.45
184146682008Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection.44
208895502010IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection.44
251433642014IL-32 is a molecular marker of a host defense network in human tuberculosis.42
235676182013Components of the interleukin-33/ST2 system are differentially expressed and regulated in human cardiac cells and in cells of the cardiac vasculature.41

Citation

Dessen P

IL32 (interleukin 32)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50130/il32