IL34 (interleukin 34)

2015-08-01 Affiliation

Identity

HGNC

IL34

LOCATION

16q22.1

LOCUSID

146433

ALIAS

C16orf77,IL-34

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 146433
MIM: 612081
HGNC: 28529
Ensembl: ENSG00000157368

Variants:

dbSNP: 146433
ClinVar: 146433
TCGA: ENSG00000157368
COSMIC: IL34

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000157368	ENST00000288098	Q6ZMJ4
ENSG00000157368	ENST00000288098	A0A024QZ87
ENSG00000157368	ENST00000429149	Q6ZMJ4
ENSG00000157368	ENST00000429149	A0A024QZ87
ENSG00000157368	ENST00000563721	H3BPB7
ENSG00000157368	ENST00000566361	J3QQT3

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147

References

Pubmed ID	Year	Title	Citations
18467591	2008	Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.	203
23177320	2012	Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia.	182
20504948	2010	Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells.	127
26754294	2016	miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis.	50
23744080	2013	Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34.	44
25471534	2015	Interleukin-34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment.	41
22039170	2012	Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients.	35
22264405	2012	Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis.	35
25066464	2014	IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells.	30
27550451	2016	Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells.	28

Citation

Dessen P

IL34 (interleukin 34)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55352/il34