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IL34 (interleukin 34)

Identity

Alias_namesC16orf77
chromosome 16 open reading frame 77
Alias_symbol (synonym)MGC34647
IL-34
Other alias
HGNC (Hugo) IL34
LocusID (NCBI) 146433
Atlas_Id 55352
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 70579895 and ends at 70660682 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IL34 (16q22.1) / ARG2 (14q24.1)IL34 (16q22.1) / CNGB1 (16q21)IL34 (16q22.1) / FLJ00418 ()
IL34 (16q22.1) / ST3GAL2 (16q22.1)SNTB2 (16q22.1) / IL34 (16q22.1)IL34 16q22.1 / ARG2 14q24.1
IL34 16q22.1 / CNGB1 16q21IL34 16q22.1 / ST3GAL2 16q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IL34   28529
Cards
Entrez_Gene (NCBI)IL34  146433  interleukin 34
AliasesC16orf77; IL-34
GeneCards (Weizmann)IL34
Ensembl hg19 (Hinxton)ENSG00000157368 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157368 [Gene_View]  chr16:70579895-70660682 [Contig_View]  IL34 [Vega]
ICGC DataPortalENSG00000157368
TCGA cBioPortalIL34
AceView (NCBI)IL34
Genatlas (Paris)IL34
WikiGenes146433
SOURCE (Princeton)IL34
Genetics Home Reference (NIH)IL34
Genomic and cartography
GoldenPath hg38 (UCSC)IL34  -     chr16:70579895-70660682 +  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL34  -     16q22.1   [Description]    (hg19-Feb_2009)
EnsemblIL34 - 16q22.1 [CytoView hg19]  IL34 - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBIIL34 [Mapview hg19]  IL34 [Mapview hg38]
OMIM612081   
Gene and transcription
Genbank (Entrez)AK172744 AK307727 AK308799 AK314913 AW292500
RefSeq transcript (Entrez)NM_001172771 NM_001172772 NM_152456
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL34
Cluster EST : UnigeneHs.461214 [ NCBI ]
CGAP (NCI)Hs.461214
Alternative Splicing GalleryENSG00000157368
Gene ExpressionIL34 [ NCBI-GEO ]   IL34 [ EBI - ARRAY_EXPRESS ]   IL34 [ SEEK ]   IL34 [ MEM ]
Gene Expression Viewer (FireBrowse)IL34 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)146433
GTEX Portal (Tissue expression)IL34
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZMJ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZMJ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZMJ4
Splice isoforms : SwissVarQ6ZMJ4
PhosPhoSitePlusQ6ZMJ4
Domains : Interpro (EBI)IL-34   
Domain families : Pfam (Sanger)IL34 (PF15036)   
Domain families : Pfam (NCBI)pfam15036   
Conserved Domain (NCBI)IL34
DMDM Disease mutations146433
Blocks (Seattle)IL34
PDB (SRS)4DKC    4DKD    4DKE    4DKF   
PDB (PDBSum)4DKC    4DKD    4DKE    4DKF   
PDB (IMB)4DKC    4DKD    4DKE    4DKF   
PDB (RSDB)4DKC    4DKD    4DKE    4DKF   
Structural Biology KnowledgeBase4DKC    4DKD    4DKE    4DKF   
SCOP (Structural Classification of Proteins)4DKC    4DKD    4DKE    4DKF   
CATH (Classification of proteins structures)4DKC    4DKD    4DKE    4DKF   
SuperfamilyQ6ZMJ4
Human Protein AtlasENSG00000157368
Peptide AtlasQ6ZMJ4
HPRD14582
IPIIPI00167031   IPI00903195   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZMJ4
IntAct (EBI)Q6ZMJ4
FunCoupENSG00000157368
BioGRIDIL34
STRING (EMBL)IL34
ZODIACIL34
Ontologies - Pathways
QuickGOQ6ZMJ4
Ontology : AmiGOpositive regulation of protein phosphorylation  cytokine activity  macrophage colony-stimulating factor receptor binding  extracellular region  extracellular space  inflammatory response  growth factor activity  positive regulation of cell proliferation  innate immune response  positive regulation of macrophage differentiation  positive regulation of monocyte differentiation  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  cytokine activity  macrophage colony-stimulating factor receptor binding  extracellular region  extracellular space  inflammatory response  growth factor activity  positive regulation of cell proliferation  innate immune response  positive regulation of macrophage differentiation  positive regulation of monocyte differentiation  
NDEx NetworkIL34
Atlas of Cancer Signalling NetworkIL34
Wikipedia pathwaysIL34
Orthology - Evolution
OrthoDB146433
GeneTree (enSembl)ENSG00000157368
Phylogenetic Trees/Animal Genes : TreeFamIL34
HOVERGENQ6ZMJ4
HOGENOMQ6ZMJ4
Homologs : HomoloGeneIL34
Homology/Alignments : Family Browser (UCSC)IL34
Gene fusions - Rearrangements
Fusion : MitelmanIL34/ARG2 [16q22.1/14q24.1]  
Fusion : MitelmanIL34/CNGB1 [16q22.1/16q21]  [t(16;16)(q21;q22)]  
Fusion : MitelmanIL34/ST3GAL2 [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Fusion: TCGAIL34 16q22.1 ARG2 14q24.1 KIRC
Fusion: TCGAIL34 16q22.1 CNGB1 16q21 LUAD
Fusion: TCGAIL34 16q22.1 ST3GAL2 16q22.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL34 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL34
dbVarIL34
ClinVarIL34
1000_GenomesIL34 
Exome Variant ServerIL34
ExAC (Exome Aggregation Consortium)IL34 (select the gene name)
Genetic variants : HAPMAP146433
Genomic Variants (DGV)IL34 [DGVbeta]
DECIPHERIL34 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL34 
Mutations
ICGC Data PortalIL34 
TCGA Data PortalIL34 
Broad Tumor PortalIL34
OASIS PortalIL34 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL34  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL34
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL34
DgiDB (Drug Gene Interaction Database)IL34
DoCM (Curated mutations)IL34 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL34 (select a term)
intoGenIL34
Cancer3DIL34(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612081   
Orphanet
MedgenIL34
Genetic Testing Registry IL34
NextProtQ6ZMJ4 [Medical]
TSGene146433
GENETestsIL34
Target ValidationIL34
Huge Navigator IL34 [HugePedia]
snp3D : Map Gene to Disease146433
BioCentury BCIQIL34
ClinGenIL34
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD146433
Chemical/Pharm GKB GenePA162392024
Clinical trialIL34
Miscellaneous
canSAR (ICR)IL34 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL34
EVEXIL34
GoPubMedIL34
iHOPIL34
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:13:14 CEST 2017

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