IL36A (interleukin 36 alpha)

2014-01-01  

Identity

HGNC
LOCATION
2q14.1
LOCUSID
ALIAS
FIL1,FIL1(EPSILON),FIL1E,IL-1F6,IL1(EPSILON),IL1F6

Other Information

Locus ID:

NCBI: 27179
MIM: 605509
HGNC: 15562
Ensembl: ENSG00000136694

Variants:

dbSNP: 27179
ClinVar: 27179
TCGA: ENSG00000136694
COSMIC: IL36A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136694ENST00000259211Q9UHA7

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

References

Pubmed IDYearTitleCitations
147345512004Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.121
179089362007Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation.114
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
212425152011IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression.83
219656792011Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity.82
248294172014IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.70
114663632001Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.65
232683682013The novel cytokine interleukin-36α is expressed in psoriatic and rheumatoid arthritis synovium.40
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
259027392015Interleukin-36α axis is modulated in patients with primary Sjögren's syndrome.21

Citation

Dessen P

IL36A (interleukin 36 alpha)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53685/il36a