IL36B (interleukin 36 beta)

2014-11-01  

Identity

HGNC
LOCATION
2q14.1
LOCUSID
ALIAS
FIL1,FIL1-(ETA),FIL1H,FILI-(ETA),IL-1F8,IL-1H2,IL1-ETA,IL1F8,IL1H2

Other Information

Locus ID:

NCBI: 27177
MIM: 605508
HGNC: 15564
Ensembl: ENSG00000136696

Variants:

dbSNP: 27177
ClinVar: 27177
TCGA: ENSG00000136696
COSMIC: IL36B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136696ENST00000259213Q9NZH7
ENSG00000136696ENST00000327407Q9NZH7

Expression (GTEx)

0
1
2
3
4
5
6
7

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
147345512004Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.121
212425152011IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression.83
219656792011Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity.82
248294172014IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.70
166469782006The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes.33
223183822012The double-stranded RNA analogue polyinosinic-polycytidylic acid induces keratinocyte pyroptosis and release of IL-36γ.33
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
201414842010The interleukin-1 family gene polymorphisms in Korean patients with rheumatoid arthritis.8
288113832017Interleukin-36 cytokines may overcome microbial immune evasion strategies that inhibit interleukin-1 family signaling.8
184846912008Interleukin 1 polymorphisms in patients with ankylosing spondylitis in Korea.3

Citation

Dessen P

IL36B (interleukin 36 beta)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64601/il36b