Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IL4 (interleukin 4)

Identity

Alias (NCBI)BCGF-1
BCGF1
BSF-1
BSF1
IL-4
HGNC (Hugo) IL4
HGNC Alias symbBSF1
IL-4
BCGF1
BCGF-1
MGC79402
HGNC Alias nameB_cell stimulatory factor 1
 lymphocyte stimulatory factor 1
 B cell growth factor 1
LocusID (NCBI) 3565
Atlas_Id 40960
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 132673989 and ends at 132682678 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Primary DLBCL of the central nervous system (CNS)
t(14;16)(q32;q23) IGH::MAF


External links

 

Nomenclature
HGNC (Hugo)IL4   6014
Cards
Entrez_Gene (NCBI)IL4    interleukin 4
AliasesBCGF-1; BCGF1; BSF-1; BSF1; 
IL-4
GeneCards (Weizmann)IL4
Ensembl hg19 (Hinxton)ENSG00000113520 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113520 [Gene_View]  ENSG00000113520 [Sequence]  chr5:132673989-132682678 [Contig_View]  IL4 [Vega]
ICGC DataPortalENSG00000113520
TCGA cBioPortalIL4
AceView (NCBI)IL4
Genatlas (Paris)IL4
SOURCE (Princeton)IL4
Genetics Home Reference (NIH)IL4
Genomic and cartography
GoldenPath hg38 (UCSC)IL4  -     chr5:132673989-132682678 +  5q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL4  -     5q31.1   [Description]    (hg19-Feb_2009)
GoldenPathIL4 - 5q31.1 [CytoView hg19]  IL4 - 5q31.1 [CytoView hg38]
ImmunoBaseENSG00000113520
Genome Data Viewer NCBIIL4 [Mapview hg19]  
OMIM147780   
Gene and transcription
Genbank (Entrez)AB102862 AF043336 AM937235 BC066277 BC066278
RefSeq transcript (Entrez)NM_000589 NM_001354990 NM_172348
Consensus coding sequences : CCDS (NCBI)IL4
Gene ExpressionIL4 [ NCBI-GEO ]   IL4 [ EBI - ARRAY_EXPRESS ]   IL4 [ SEEK ]   IL4 [ MEM ]
Gene Expression Viewer (FireBrowse)IL4 [ Firebrowse - Broad ]
GenevisibleExpression of IL4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3565
GTEX Portal (Tissue expression)IL4
Human Protein AtlasENSG00000113520-IL4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05112   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05112  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05112
PhosPhoSitePlusP05112
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_4_13 (PS00838)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    IL-4    IL-4/IL-13    IL-4/IL-13_CS   
Domain families : Pfam (Sanger)IL4 (PF00727)   
Domain families : Pfam (NCBI)pfam00727   
Domain families : Smart (EMBL)IL4_13 (SM00190)  
Conserved Domain (NCBI)IL4
PDB (RSDB)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX    6OEL   
PDB Europe1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX    6OEL   
PDB (PDBSum)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX    6OEL   
PDB (IMB)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX    6OEL   
Structural Biology KnowledgeBase1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX    6OEL   
SCOP (Structural Classification of Proteins)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX    6OEL   
CATH (Classification of proteins structures)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX    6OEL   
SuperfamilyP05112
AlphaFold pdb e-kbP05112   
Human Protein Atlas [tissue]ENSG00000113520-IL4 [tissue]
HPRD00989
Protein Interaction databases
DIP (DOE-UCLA)P05112
IntAct (EBI)P05112
BioGRIDIL4
STRING (EMBL)IL4
ZODIACIL4
Ontologies - Pathways
QuickGOP05112
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  microglial cell activation  innate immune response in mucosa  positive regulation of defense response to virus by host  negative regulation of acute inflammatory response  negative regulation of chronic inflammatory response  cytokine activity  interleukin-4 receptor binding  protein binding  extracellular region  extracellular space  extracellular space  immune response  growth factor activity  cholesterol metabolic process  positive regulation of cell population proliferation  positive regulation of cell population proliferation  positive regulation of gene expression  positive regulation of gene expression  negative regulation of epithelial cell migration  negative regulation of epithelial cell migration  positive regulation of macroautophagy  positive regulation of macroautophagy  B cell differentiation  positive regulation of cell migration  positive regulation of B cell proliferation  B cell costimulation  negative regulation of tumor necrosis factor production  positive regulation of interleukin-10 production  positive regulation of interleukin-10 production  positive regulation of interleukin-13 production  positive regulation of interleukin-13 production  type 2 immune response  positive regulation of T cell proliferation  T cell activation  macrophage activation  regulation of phosphorylation  positive regulation of tyrosine phosphorylation of STAT protein  positive regulation of tyrosine phosphorylation of STAT protein  activation of Janus kinase activity  activation of Janus kinase activity  myeloid dendritic cell differentiation  myeloid dendritic cell differentiation  negative regulation of macrophage activation  negative regulation of apoptotic process  positive regulation of mast cell degranulation  T-helper 2 cell differentiation  regulation of isotype switching  positive regulation of MHC class II biosynthetic process  positive regulation of MHC class II biosynthetic process  positive regulation of T cell differentiation  positive regulation of T cell differentiation  negative regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of receptor-mediated endocytosis  positive regulation of receptor-mediated endocytosis  positive regulation of isotype switching to IgE isotypes  positive regulation of isotype switching to IgE isotypes  positive regulation of isotype switching to IgG isotypes  positive regulation of isotype switching to IgG isotypes  negative regulation of inflammatory response  regulation of immune response  positive regulation of mononuclear cell migration  dendritic cell differentiation  extrinsic apoptotic signaling pathway in absence of ligand  positive regulation of cold-induced thermogenesis  neuroinflammatory response  negative regulation of neuroinflammatory response  positive regulation of amyloid-beta clearance  positive regulation of amyloid-beta clearance  positive regulation of myoblast fusion  positive regulation of cellular respiration  negative regulation of complement-dependent cytotoxicity  negative regulation of complement-dependent cytotoxicity  negative regulation of cellular response to transforming growth factor beta stimulus  negative regulation of T-helper 17 cell differentiation  negative regulation of endothelial cell apoptotic process  negative regulation of endothelial cell apoptotic process  positive regulation of eosinophil chemotaxis  positive regulation of T-helper 2 cell cytokine production  positive regulation of ATP biosynthetic process  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  microglial cell activation  innate immune response in mucosa  positive regulation of defense response to virus by host  negative regulation of acute inflammatory response  negative regulation of chronic inflammatory response  cytokine activity  interleukin-4 receptor binding  protein binding  extracellular region  extracellular space  extracellular space  immune response  growth factor activity  cholesterol metabolic process  positive regulation of cell population proliferation  positive regulation of cell population proliferation  positive regulation of gene expression  positive regulation of gene expression  negative regulation of epithelial cell migration  negative regulation of epithelial cell migration  positive regulation of macroautophagy  positive regulation of macroautophagy  B cell differentiation  positive regulation of cell migration  positive regulation of B cell proliferation  B cell costimulation  negative regulation of tumor necrosis factor production  positive regulation of interleukin-10 production  positive regulation of interleukin-10 production  positive regulation of interleukin-13 production  positive regulation of interleukin-13 production  type 2 immune response  positive regulation of T cell proliferation  T cell activation  macrophage activation  regulation of phosphorylation  positive regulation of tyrosine phosphorylation of STAT protein  positive regulation of tyrosine phosphorylation of STAT protein  activation of Janus kinase activity  activation of Janus kinase activity  myeloid dendritic cell differentiation  myeloid dendritic cell differentiation  negative regulation of macrophage activation  negative regulation of apoptotic process  positive regulation of mast cell degranulation  T-helper 2 cell differentiation  regulation of isotype switching  positive regulation of MHC class II biosynthetic process  positive regulation of MHC class II biosynthetic process  positive regulation of T cell differentiation  positive regulation of T cell differentiation  negative regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of receptor-mediated endocytosis  positive regulation of receptor-mediated endocytosis  positive regulation of isotype switching to IgE isotypes  positive regulation of isotype switching to IgE isotypes  positive regulation of isotype switching to IgG isotypes  positive regulation of isotype switching to IgG isotypes  negative regulation of inflammatory response  regulation of immune response  positive regulation of mononuclear cell migration  dendritic cell differentiation  extrinsic apoptotic signaling pathway in absence of ligand  positive regulation of cold-induced thermogenesis  neuroinflammatory response  negative regulation of neuroinflammatory response  positive regulation of amyloid-beta clearance  positive regulation of amyloid-beta clearance  positive regulation of myoblast fusion  positive regulation of cellular respiration  negative regulation of complement-dependent cytotoxicity  negative regulation of complement-dependent cytotoxicity  negative regulation of cellular response to transforming growth factor beta stimulus  negative regulation of T-helper 17 cell differentiation  negative regulation of endothelial cell apoptotic process  negative regulation of endothelial cell apoptotic process  positive regulation of eosinophil chemotaxis  positive regulation of T-helper 2 cell cytokine production  positive regulation of ATP biosynthetic process  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTABIOCARTA_ASBCELLPATHWAY    BIOCARTA_CYTOKINEPATHWAY    BIOCARTA_INFLAMPATHWAY    BIOCARTA_DCPATHWAY    BIOCARTA_GATA3PATHWAY    BIOCARTA_IL4PATHWAY    BIOCARTA_IL5PATHWAY    BIOCARTA_STEMPATHWAY    BIOCARTA_TOB1PATHWAY    BIOCARTA_NKTPATHWAY    BIOCARTA_TH1TH2PATHWAY    BIOCARTA_41BBPATHWAY   
Pathways : KEGGKEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION    KEGG_JAK_STAT_SIGNALING    KEGG_HEMATOPOIETIC_CELL_LINEAGE    KEGG_T_CELL_RECEPTOR_SIGNALING    KEGG_FC_EPSILON_RI_SIGNALING    KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION    KEGG_LEISHMANIA_INFECTION    KEGG_ASTHMA    KEGG_AUTOIMMUNE_THYROID_DISEASE    KEGG_ALLOGRAFT_REJECTION   
NDEx NetworkIL4
Atlas of Cancer Signalling NetworkIL4
Wikipedia pathwaysIL4
Orthology - Evolution
OrthoDB3565
GeneTree (enSembl)ENSG00000113520
Phylogenetic Trees/Animal Genes : TreeFamIL4
Homologs : HomoloGeneIL4
Homology/Alignments : Family Browser (UCSC)IL4
Gene fusions - Rearrangements
Fusion : QuiverIL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL4
dbVarIL4
ClinVarIL4
MonarchIL4
1000_GenomesIL4 
Exome Variant ServerIL4
GNOMAD BrowserENSG00000113520
Varsome BrowserIL4
ACMGIL4 variants
VarityP05112
Genomic Variants (DGV)IL4 [DGVbeta]
DECIPHERIL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL4 
Mutations
ICGC Data PortalIL4 
TCGA Data PortalIL4 
Broad Tumor PortalIL4
OASIS PortalIL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL4
Mutations and Diseases : HGMDIL4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIL4
DgiDB (Drug Gene Interaction Database)IL4
DoCM (Curated mutations)IL4
CIViC (Clinical Interpretations of Variants in Cancer)IL4
Cancer3DIL4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147780   
Orphanet
DisGeNETIL4
MedgenIL4
Genetic Testing Registry IL4
NextProtP05112 [Medical]
GENETestsIL4
Target ValidationIL4
Huge Navigator IL4 [HugePedia]
ClinGenIL4
Clinical trials, drugs, therapy
MyCancerGenomeIL4
Protein Interactions : CTDIL4
Pharm GKB GenePA197
PharosP05112
Clinical trialIL4
Miscellaneous
canSAR (ICR)IL4
HarmonizomeIL4
ARCHS4IL4
DataMed IndexIL4
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:38:34 CET 2022

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