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IL4 (interleukin 4)

Identity

Other namesBCGF-1
BCGF1
BSF-1
BSF1
IL-4
HGNC (Hugo) IL4
LocusID (NCBI) 3565
Location 5q31.1
Location_base_pair Starts at 132009678 and ends at 132018370 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL4   6014
Cards
Entrez_Gene (NCBI)IL4  3565  interleukin 4
GeneCards (Weizmann)IL4
Ensembl (Hinxton)ENSG00000113520 [Gene_View]  chr5:132009678-132018370 [Contig_View]  IL4 [Vega]
ICGC DataPortalENSG00000113520
cBioPortalIL4
AceView (NCBI)IL4
Genatlas (Paris)IL4
WikiGenes3565
SOURCE (Princeton)NM_000589 NM_172348
Genomic and cartography
GoldenPath (UCSC)IL4  -  5q31.1   chr5:132009678-132018370 +  5q31.1   [Description]    (hg19-Feb_2009)
EnsemblIL4 - 5q31.1 [CytoView]
Mapping of homologs : NCBIIL4 [Mapview]
OMIM147780   
Gene and transcription
Genbank (Entrez)AB102862 AF043336 AM937235 BC066277 BC066278
RefSeq transcript (Entrez)NM_000589 NM_172348
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_023252 NT_034772 NW_001838952 NW_004929323
Consensus coding sequences : CCDS (NCBI)IL4
Cluster EST : UnigeneHs.73917 [ NCBI ]
CGAP (NCI)Hs.73917
Alternative Splicing : Fast-db (Paris)GSHG0024230
Alternative Splicing GalleryENSG00000113520
Gene ExpressionIL4 [ NCBI-GEO ]     IL4 [ SEEK ]   IL4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05112 (Uniprot)
NextProtP05112  [Medical]
With graphics : InterProP05112
Splice isoforms : SwissVarP05112 (Swissvar)
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_4_13 (PS00838)   
Domains : Interpro (EBI)4_helix_cytokine-like_core [organisation]   4_helix_cytokine_core [organisation]   IL-4 [organisation]   IL-4/IL-13 [organisation]   IL-4/IL-13_CS [organisation]  
Related proteins : CluSTrP05112
Domain families : Pfam (Sanger)IL4 (PF00727)   
Domain families : Pfam (NCBI)pfam00727   
Domain families : Smart (EMBL)IL4_13 (SM00190)  
DMDM Disease mutations3565
Blocks (Seattle)P05112
PDB (SRS)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7   
PDB (PDBSum)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7   
PDB (IMB)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7   
PDB (RSDB)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7   
Human Protein AtlasENSG00000113520 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP05112
HPRD00989
IPIIPI00007081   IPI00217945   
Protein Interaction databases
DIP (DOE-UCLA)P05112
IntAct (EBI)P05112
FunCoupENSG00000113520
BioGRIDIL4
InParanoidP05112
Interologous Interaction database P05112
IntegromeDBIL4
STRING (EMBL)IL4
Ontologies - Pathways
Ontology : AmiGOinnate immune response in mucosa  T-helper 1 cell lineage commitment  negative regulation of acute inflammatory response  negative regulation of chronic inflammatory response  cytokine activity  interleukin-4 receptor binding  protein binding  extracellular space  chemotaxis  immune response  cellular defense response  female pregnancy  response to nutrient  growth factor activity  cholesterol metabolic process  external side of plasma membrane  regulation of proton transport  response to organic cyclic compound  B cell differentiation  positive regulation of B cell proliferation  B cell costimulation  positive regulation of interleukin-10 production  positive regulation of interleukin-13 production  response to cytokine  T-helper 2 cell cytokine production  type 2 immune response  positive regulation of T cell proliferation  positive regulation of activated T cell proliferation  regulation of phosphorylation  response to drug  positive regulation of tyrosine phosphorylation of Stat5 protein  defense response to protozoan  negative regulation of macrophage activation  negative regulation of apoptotic process  negative regulation of nitric oxide biosynthetic process  T-helper 2 cell differentiation  positive regulation of chemokine biosynthetic process  connective tissue growth factor biosynthetic process  regulation of isotype switching  positive regulation of MHC class II biosynthetic process  response to ethanol  positive regulation of T cell differentiation  negative regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of isotype switching to IgE isotypes  positive regulation of isotype switching to IgG isotypes  regulation of immune response  positive regulation of sequence-specific DNA binding transcription factor activity  cellular response to mercury ion  dendritic cell differentiation  extrinsic apoptotic signaling pathway in absence of ligand  negative regulation of T-helper 17 cell differentiation  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIinnate immune response in mucosa  T-helper 1 cell lineage commitment  negative regulation of acute inflammatory response  negative regulation of chronic inflammatory response  cytokine activity  interleukin-4 receptor binding  protein binding  extracellular space  chemotaxis  immune response  cellular defense response  female pregnancy  response to nutrient  growth factor activity  cholesterol metabolic process  external side of plasma membrane  regulation of proton transport  response to organic cyclic compound  B cell differentiation  positive regulation of B cell proliferation  B cell costimulation  positive regulation of interleukin-10 production  positive regulation of interleukin-13 production  response to cytokine  T-helper 2 cell cytokine production  type 2 immune response  positive regulation of T cell proliferation  positive regulation of activated T cell proliferation  regulation of phosphorylation  response to drug  positive regulation of tyrosine phosphorylation of Stat5 protein  defense response to protozoan  negative regulation of macrophage activation  negative regulation of apoptotic process  negative regulation of nitric oxide biosynthetic process  T-helper 2 cell differentiation  positive regulation of chemokine biosynthetic process  connective tissue growth factor biosynthetic process  regulation of isotype switching  positive regulation of MHC class II biosynthetic process  response to ethanol  positive regulation of T cell differentiation  negative regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of isotype switching to IgE isotypes  positive regulation of isotype switching to IgG isotypes  regulation of immune response  positive regulation of sequence-specific DNA binding transcription factor activity  cellular response to mercury ion  dendritic cell differentiation  extrinsic apoptotic signaling pathway in absence of ligand  negative regulation of T-helper 17 cell differentiation  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTACytokine Network [Genes]    Dendritic cells in regulating TH1 and TH2 Development [Genes]    Cytokines and Inflammatory Response [Genes]    Regulation of hematopoiesis by cytokines [Genes]    The 4-1BB-dependent immune response [Genes]    GATA3 participate in activating the Th2 cytokine genes expression [Genes]    IL 4 signaling pathway [Genes]    IL 5 Signaling Pathway [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]    Th1/Th2 Differentiation [Genes]    Role of Tob in T-cell activation [Genes]    Antigen Dependent B Cell Activation [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Hematopoietic cell lineage    T cell receptor signaling pathway    Fc epsilon RI signaling pathway    Intestinal immune network for IgA production    Leishmaniasis    Measles    Asthma    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Allograft rejection   
Protein Interaction DatabaseIL4
Wikipedia pathwaysIL4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IL4
snp3D : Map Gene to Disease3565
SNP (GeneSNP Utah)IL4
SNP : HGBaseIL4
Genetic variants : HAPMAPIL4
Exome VariantIL4
1000_GenomesIL4 
ICGC programENSG00000113520 
Somatic Mutations in Cancer : COSMICIL4 
CONAN: Copy Number AnalysisIL4 
Mutations and Diseases : HGMDIL4
Genomic VariantsIL4  IL4 [DGVbeta]
dbVarIL4
ClinVarIL4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM147780   
MedgenIL4
GENETestsIL4
Disease Genetic AssociationIL4
Huge Navigator IL4 [HugePedia]  IL4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneIL4
Homology/Alignments : Family Browser (UCSC)IL4
Phylogenetic Trees/Animal Genes : TreeFamIL4
Chemical/Protein Interactions : CTD3565
Chemical/Pharm GKB GenePA197
Clinical trialIL4
Cancer Resource (Charite)ENSG00000113520
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineIL4
iHOPIL4
OncoSearchIL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:59:38 CEST 2014

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