| Nomenclature |
|---|
| HGNC (Hugo) | IL4 6014 |
| Cards |
|---|
| Entrez_Gene (NCBI) | IL4 interleukin 4 |
| Aliases | BCGF-1; BCGF1; BSF-1; BSF1; |
| IL-4 |
| GeneCards (Weizmann) | IL4 |
| Ensembl hg19 (Hinxton) | ENSG00000113520 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000113520 [Gene_View] ENSG00000113520 [Sequence] chr5:132673989-132682678 [Contig_View] IL4 [Vega] |
| ICGC DataPortal | ENSG00000113520 |
| TCGA cBioPortal | IL4 |
| AceView (NCBI) | IL4 |
| Genatlas (Paris) | IL4 |
| SOURCE (Princeton) | IL4 |
| Genetics Home Reference (NIH) | IL4 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | IL4 - chr5:132673989-132682678 + 5q31.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | IL4 - 5q31.1 [Description] (hg19-Feb_2009) |
| GoldenPath | IL4 - 5q31.1 [CytoView hg19] IL4 - 5q31.1 [CytoView hg38] |
| ImmunoBase | ENSG00000113520 |
| genome Data Viewer NCBI | IL4 [Mapview hg19] |
| OMIM | 147780 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB102862 AF043336 AM937235 BC066277 BC066278 |
| RefSeq transcript (Entrez) | NM_000589 NM_001354990 NM_172348 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | IL4 |
| Alternative Splicing Gallery | ENSG00000113520 |
| Gene Expression | IL4 [ NCBI-GEO ] IL4 [ EBI - ARRAY_EXPRESS ]
IL4 [ SEEK ] IL4 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | IL4 [ Firebrowse - Broad ] |
| Genevisible | Expression of IL4 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 3565 |
| GTEX Portal (Tissue expression) | IL4 |
| Human Protein Atlas | ENSG00000113520-IL4 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P05112 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P05112 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P05112 |
| Splice isoforms : SwissVar | P05112 |
| PhosPhoSitePlus | P05112 |
| Domaine pattern : Prosite (Expaxy) | INTERLEUKIN_4_13 (PS00838) |
| Domains : Interpro (EBI) | 4_helix_cytokine-like_core IL-4 IL-4/IL-13 IL-4/IL-13_CS |
| Domain families : Pfam (Sanger) | IL4 (PF00727) |
| Domain families : Pfam (NCBI) | pfam00727 |
| Domain families : Smart (EMBL) | IL4_13 (SM00190) |
| Conserved Domain (NCBI) | IL4 |
| Blocks (Seattle) | IL4 |
| PDB (RSDB) | 1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL |
| PDB Europe | 1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL |
| PDB (PDBSum) | 1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL |
| PDB (IMB) | 1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL |
| Structural Biology KnowledgeBase | 1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL |
| SCOP (Structural Classification of Proteins) | 1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL |
| CATH (Classification of proteins structures) | 1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL |
| Superfamily | P05112 |
| Human Protein Atlas [tissue] | ENSG00000113520-IL4 [tissue] |
| Peptide Atlas | P05112 |
| HPRD | 00989 |
| IPI | IPI00007081 IPI00217945 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P05112 |
| IntAct (EBI) | P05112 |
| BioGRID | IL4 |
| STRING (EMBL) | IL4 |
| ZODIAC | IL4 |
| Ontologies - Pathways |
|---|
| QuickGO | P05112 |
| Ontology : AmiGO | microglial cell activation innate immune response in mucosa positive regulation of defense response to virus by host negative regulation of acute inflammatory response negative regulation of chronic inflammatory response cytokine activity interleukin-4 receptor binding protein binding extracellular region extracellular space extracellular space immune response growth factor activity cholesterol metabolic process positive regulation of cell proliferation positive regulation of cell proliferation positive regulation of gene expression positive regulation of gene expression negative regulation of epithelial cell migration negative regulation of epithelial cell migration positive regulation of macroautophagy positive regulation of macroautophagy cytokine-mediated signaling pathway B cell differentiation positive regulation of cell migration positive regulation of B cell proliferation B cell costimulation positive regulation of interleukin-10 production positive regulation of interleukin-13 production positive regulation of interleukin-13 production T-helper 2 cell cytokine production T-helper 2 cell cytokine production type 2 immune response positive regulation of T cell proliferation T cell activation macrophage activation regulation of phosphorylation positive regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein negative regulation of tumor necrosis factor biosynthetic process negative regulation of tumor necrosis factor biosynthetic process activation of Janus kinase activity activation of Janus kinase activity myeloid dendritic cell differentiation myeloid dendritic cell differentiation negative regulation of macrophage activation negative regulation of apoptotic process positive regulation of mast cell degranulation T-helper 2 cell differentiation positive regulation of chemokine biosynthetic process regulation of isotype switching positive regulation of MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of T cell differentiation positive regulation of T cell differentiation negative regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of receptor-mediated endocytosis positive regulation of receptor-mediated endocytosis positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgG isotypes positive regulation of isotype switching to IgG isotypes negative regulation of inflammatory response regulation of immune response positive regulation of mononuclear cell migration dendritic cell differentiation extrinsic apoptotic signaling pathway in absence of ligand positive regulation of cold-induced thermogenesis neuroinflammatory response negative regulation of neuroinflammatory response positive regulation of amyloid-beta clearance positive regulation of amyloid-beta clearance positive regulation of myoblast fusion positive regulation of cellular respiration negative regulation of complement-dependent cytotoxicity negative regulation of complement-dependent cytotoxicity negative regulation of T-helper 17 cell differentiation negative regulation of endothelial cell apoptotic process negative regulation of endothelial cell apoptotic process positive regulation of eosinophil chemotaxis positive regulation of ATP biosynthetic process positive regulation of interleukin-10 secretion negative regulation of extrinsic apoptotic signaling pathway |
| Ontology : EGO-EBI | microglial cell activation innate immune response in mucosa positive regulation of defense response to virus by host negative regulation of acute inflammatory response negative regulation of chronic inflammatory response cytokine activity interleukin-4 receptor binding protein binding extracellular region extracellular space extracellular space immune response growth factor activity cholesterol metabolic process positive regulation of cell proliferation positive regulation of cell proliferation positive regulation of gene expression positive regulation of gene expression negative regulation of epithelial cell migration negative regulation of epithelial cell migration positive regulation of macroautophagy positive regulation of macroautophagy cytokine-mediated signaling pathway B cell differentiation positive regulation of cell migration positive regulation of B cell proliferation B cell costimulation positive regulation of interleukin-10 production positive regulation of interleukin-13 production positive regulation of interleukin-13 production T-helper 2 cell cytokine production T-helper 2 cell cytokine production type 2 immune response positive regulation of T cell proliferation T cell activation macrophage activation regulation of phosphorylation positive regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein negative regulation of tumor necrosis factor biosynthetic process negative regulation of tumor necrosis factor biosynthetic process activation of Janus kinase activity activation of Janus kinase activity myeloid dendritic cell differentiation myeloid dendritic cell differentiation negative regulation of macrophage activation negative regulation of apoptotic process positive regulation of mast cell degranulation T-helper 2 cell differentiation positive regulation of chemokine biosynthetic process regulation of isotype switching positive regulation of MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of T cell differentiation positive regulation of T cell differentiation negative regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of receptor-mediated endocytosis positive regulation of receptor-mediated endocytosis positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgG isotypes positive regulation of isotype switching to IgG isotypes negative regulation of inflammatory response regulation of immune response positive regulation of mononuclear cell migration dendritic cell differentiation extrinsic apoptotic signaling pathway in absence of ligand positive regulation of cold-induced thermogenesis neuroinflammatory response negative regulation of neuroinflammatory response positive regulation of amyloid-beta clearance positive regulation of amyloid-beta clearance positive regulation of myoblast fusion positive regulation of cellular respiration negative regulation of complement-dependent cytotoxicity negative regulation of complement-dependent cytotoxicity negative regulation of T-helper 17 cell differentiation negative regulation of endothelial cell apoptotic process negative regulation of endothelial cell apoptotic process positive regulation of eosinophil chemotaxis positive regulation of ATP biosynthetic process positive regulation of interleukin-10 secretion negative regulation of extrinsic apoptotic signaling pathway |
| Pathways : KEGG | Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Jak-STAT signaling pathway Hematopoietic cell lineage T cell receptor signaling pathway Fc epsilon RI signaling pathway Intestinal immune network for IgA production Leishmaniasis Measles Asthma Autoimmune thyroid disease Inflammatory bowel disease (IBD) Allograft rejection |
| NDEx Network | IL4 |
| Atlas of Cancer Signalling Network | IL4 |
| Wikipedia pathways | IL4 |
| Orthology - Evolution |
|---|
| OrthoDB | 3565 |
| GeneTree (enSembl) | ENSG00000113520 |
| Phylogenetic Trees/Animal Genes : TreeFam | IL4 |
| HOGENOM | P05112 |
| Homologs : HomoloGene | IL4 |
| Homology/Alignments : Family Browser (UCSC) | IL4 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | IL4 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | IL4 [hg38] |
| dbVar | IL4 |
| ClinVar | IL4 |
| Monarch | IL4 |
| 1000_Genomes | IL4 |
| Exome Variant Server | IL4 |
| GNOMAD Browser | ENSG00000113520 |
| Varsome Browser | IL4 |
| Genomic Variants (DGV) | IL4 [DGVbeta] |
| DECIPHER | IL4 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | IL4 |
| Mutations |
|---|
| ICGC Data Portal | IL4 |
| TCGA Data Portal | IL4 |
| Broad Tumor Portal | IL4 |
| OASIS Portal | IL4 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | IL4 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | IL4 |
| Mutations and Diseases : HGMD | IL4 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | TBsLVD Tuberculosis susceptibility Locus Variation Database |
| BioMuta | search IL4 |
| DgiDB (Drug Gene Interaction Database) | IL4 |
| DoCM (Curated mutations) | IL4 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | IL4 (select a term) |
| intoGen | IL4 |
| Cancer3D | IL4(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 147780 |
| Orphanet | |
| DisGeNET | IL4 |
| Medgen | IL4 |
| Genetic Testing Registry | IL4
|
| NextProt | P05112 [Medical] |
| GENETests | IL4 |
| Target Validation | IL4 |
| Huge Navigator |
IL4 [HugePedia] |
| ClinGen | IL4 |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | IL4 |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA197 |
| Pharos | P05112 |
| Clinical trial | IL4 |
| Miscellaneous |
|---|
| canSAR (ICR) | IL4 (select the gene name) |
| Harmonizome | IL4 |
| DataMed Index | IL4 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | IL4 |
