IL4 (interleukin 4)

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

IL4 (interleukin 4)

Identity

Other names	BCGF-1
	BCGF1
	BSF-1
	BSF1
	IL-4
HGNC (Hugo)	IL4
LocusID (NCBI)	3565
Location	5q31.1
Location_base_pair	Starts at 132009678 and ends at 132018370 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	IL4 6014
	Cards
Entrez_Gene (NCBI)	IL4 3565 interleukin 4
GeneCards (Weizmann)	IL4
Ensembl hg19 (Hinxton)	ENSG00000113520 [Gene_View] chr5:132009678-132018370 [Contig_View] IL4 [Vega]
Ensembl hg38 (Hinxton)	ENSG00000113520 [Gene_View] chr5:132009678-132018370 [Contig_View] IL4 [Vega]
ICGC DataPortal	ENSG00000113520
cBioPortal	IL4
AceView (NCBI)	IL4
Genatlas (Paris)	IL4
WikiGenes	3565
SOURCE (Princeton)	IL4
	Genomic and cartography
GoldenPath hg19 (UCSC)	IL4 - chr5:132009678-132018370 + 5q31.1 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	IL4 - 5q31.1 [Description] (hg38-Dec_2013)
Ensembl	IL4 - 5q31.1 [CytoView hg19] IL4 - 5q31.1 [CytoView hg38]
Mapping of homologs : NCBI	IL4 [Mapview hg19] IL4 [Mapview hg38]
OMIM	147780
	Gene and transcription
Genbank (Entrez)	AB102862 AF043336 AM937235 BC066277 BC066278
RefSeq transcript (Entrez)	NM_000589 NM_172348
RefSeq genomic (Entrez)	AC_000137 NC_000005 NC_018916 NG_023252 NT_034772 NW_001838952 NW_004929323
Consensus coding sequences : CCDS (NCBI)	IL4
Cluster EST : Unigene	Hs.73917 [ NCBI ]
CGAP (NCI)	Hs.73917
Alternative Splicing : Fast-db (Paris)	GSHG0024230
Alternative Splicing Gallery	ENSG00000113520
Gene Expression	IL4 [ NCBI-GEO ] IL4 [ SEEK ] IL4 [ MEM ]
SOURCE (Princeton)	Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P05112 (Uniprot)
NextProt	P05112 [Medical]
With graphics : InterPro	P05112
Splice isoforms : SwissVar	P05112 (Swissvar)
Domaine pattern : Prosite (Expaxy)	INTERLEUKIN_4_13 (PS00838)
Domains : Interpro (EBI)	4_helix_cytokine-like_core 4_helix_cytokine_core IL-4 IL-4/IL-13 IL-4/IL-13_CS
Related proteins : CluSTr	P05112
Domain families : Pfam (Sanger)	IL4 (PF00727)
Domain families : Pfam (NCBI)	pfam00727
Domain families : Smart (EMBL)	IL4_13 (SM00190)
DMDM Disease mutations	3565
Blocks (Seattle)	P05112
PDB (SRS)	1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7
PDB (PDBSum)	1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7
PDB (IMB)	1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7
PDB (RSDB)	1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7
Human Protein Atlas	ENSG00000113520
Peptide Atlas	P05112
HPRD	00989
IPI	IPI00007081 IPI00217945
	Protein Interaction databases
DIP (DOE-UCLA)	P05112
IntAct (EBI)	P05112
FunCoup	ENSG00000113520
BioGRID	IL4
IntegromeDB	IL4
STRING (EMBL)	IL4
	Ontologies - Pathways
QuickGO	P05112
Ontology : AmiGO	innate immune response in mucosa T-helper 1 cell lineage commitment negative regulation of acute inflammatory response negative regulation of chronic inflammatory response cytokine activity interleukin-4 receptor binding protein binding extracellular space chemotaxis immune response cellular defense response female pregnancy response to nutrient growth factor activity cholesterol metabolic process external side of plasma membrane regulation of proton transport response to organic cyclic compound B cell differentiation positive regulation of B cell proliferation B cell costimulation positive regulation of interleukin-10 production positive regulation of interleukin-13 production response to cytokine T-helper 2 cell cytokine production type 2 immune response positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of phosphorylation response to drug positive regulation of tyrosine phosphorylation of Stat5 protein defense response to protozoan negative regulation of macrophage activation negative regulation of apoptotic process negative regulation of nitric oxide biosynthetic process T-helper 2 cell differentiation positive regulation of chemokine biosynthetic process connective tissue growth factor biosynthetic process regulation of isotype switching positive regulation of MHC class II biosynthetic process response to ethanol positive regulation of T cell differentiation negative regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgG isotypes regulation of immune response positive regulation of sequence-specific DNA binding transcription factor activity cellular response to mercury ion dendritic cell differentiation extrinsic apoptotic signaling pathway in absence of ligand negative regulation of T-helper 17 cell differentiation negative regulation of extrinsic apoptotic signaling pathway
Ontology : EGO-EBI	innate immune response in mucosa T-helper 1 cell lineage commitment negative regulation of acute inflammatory response negative regulation of chronic inflammatory response cytokine activity interleukin-4 receptor binding protein binding extracellular space chemotaxis immune response cellular defense response female pregnancy response to nutrient growth factor activity cholesterol metabolic process external side of plasma membrane regulation of proton transport response to organic cyclic compound B cell differentiation positive regulation of B cell proliferation B cell costimulation positive regulation of interleukin-10 production positive regulation of interleukin-13 production response to cytokine T-helper 2 cell cytokine production type 2 immune response positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of phosphorylation response to drug positive regulation of tyrosine phosphorylation of Stat5 protein defense response to protozoan negative regulation of macrophage activation negative regulation of apoptotic process negative regulation of nitric oxide biosynthetic process T-helper 2 cell differentiation positive regulation of chemokine biosynthetic process connective tissue growth factor biosynthetic process regulation of isotype switching positive regulation of MHC class II biosynthetic process response to ethanol positive regulation of T cell differentiation negative regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgG isotypes regulation of immune response positive regulation of sequence-specific DNA binding transcription factor activity cellular response to mercury ion dendritic cell differentiation extrinsic apoptotic signaling pathway in absence of ligand negative regulation of T-helper 17 cell differentiation negative regulation of extrinsic apoptotic signaling pathway
Pathways : BIOCARTA	Cytokine Network [Genes] Dendritic cells in regulating TH1 and TH2 Development [Genes] Cytokines and Inflammatory Response [Genes] Regulation of hematopoiesis by cytokines [Genes] The 4-1BB-dependent immune response [Genes] GATA3 participate in activating the Th2 cytokine genes expression [Genes] IL 4 signaling pathway [Genes] IL 5 Signaling Pathway [Genes] Selective expression of chemokine receptors during T-cell polarization [Genes] Th1/Th2 Differentiation [Genes] Role of Tob in T-cell activation [Genes] Antigen Dependent B Cell Activation [Genes]
Pathways : KEGG	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Jak-STAT signaling pathway Hematopoietic cell lineage T cell receptor signaling pathway Fc epsilon RI signaling pathway Intestinal immune network for IgA production Leishmaniasis Measles Asthma Autoimmune thyroid disease Inflammatory bowel disease (IBD) Allograft rejection
Protein Interaction Database	IL4
DoCM (Curated mutations)	IL4
Wikipedia pathways	IL4
	Gene fusion - rearrangements
	Polymorphisms : SNP, variants
NCBI Variation Viewer	IL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	IL4
dbVar	IL4
ClinVar	IL4
1000_Genomes	IL4
Exome Variant Server	IL4
SNP (GeneSNP Utah)	IL4
SNP : HGBase	IL4
Genetic variants : HAPMAP	IL4
Genomic Variants (DGV)	IL4 [DGVbeta]
	Mutations
ICGC Data Portal	ENSG00000113520
Somatic Mutations in Cancer : COSMIC	IL4
CONAN: Copy Number Analysis	IL4
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)	TBsLVD Tuberculosis susceptibility Locus Variation Database
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	5:132009678-132018370
Mutations and Diseases : HGMD	IL4
OMIM	147780
Medgen	IL4
NextProt	P05112 [Medical]
GENETests	IL4
Disease Genetic Association	IL4
Huge Navigator	IL4 [HugePedia] IL4 [HugeCancerGEM]
snp3D : Map Gene to Disease	3565
DGIdb (Drug Gene Interaction db)	IL4
	General knowledge
Homologs : HomoloGene	IL4
Homology/Alignments : Family Browser (UCSC)	IL4
Phylogenetic Trees/Animal Genes : TreeFam	IL4
Chemical/Protein Interactions : CTD	3565
Chemical/Pharm GKB Gene	PA197
Clinical trial	IL4
Cancer Resource (Charite)	ENSG00000113520
	Other databases
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
CoreMine	IL4
GoPubMed	IL4
iHOP	IL4

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2014	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 14 16:19:55 CET 2015

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