IL4I1 (interleukin 4 induced 1)

2007-02-01  

Identity

HGNC
IL4I1
LOCATION
19q13.33
LOCUSID
259307
ALIAS
FIG1,LAAO,LAO,hIL4I1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 259307
MIM: 609742
HGNC: 19094
Ensembl: ENSG00000104951

Variants:

dbSNP: 259307
ClinVar: 259307
TCGA: ENSG00000104951
COSMIC: IL4I1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104951ENST00000341114Q96RQ9
ENSG00000104951ENST00000391826Q96RQ9
ENSG00000104951ENST00000593956M0QYW8
ENSG00000104951ENST00000595948Q96RQ9
ENSG00000104951ENST00000596011M0R2S9
ENSG00000104951ENST00000596022M0R1L1
ENSG00000104951ENST00000597295M0QYH9
ENSG00000104951ENST00000601717M0QXY7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Valine, leucine and isoleucine degradationKEGGko00280
Tyrosine metabolismKEGGko00350
Phenylalanine metabolismKEGGko00360
Tryptophan metabolismKEGGko00380
Phenylalanine, tyrosine and tryptophan biosynthesisKEGGko00400
Valine, leucine and isoleucine degradationKEGGhsa00280
Tyrosine metabolismKEGGhsa00350
Phenylalanine metabolismKEGGhsa00360
Tryptophan metabolismKEGGhsa00380
Phenylalanine, tyrosine and tryptophan biosynthesisKEGGhsa00400
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Tyrosine degradation, tyrosine => homogentisateKEGGM00044
Tyrosine degradation, tyrosine => homogentisateKEGGhsa_M00044
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Phenylalanine and tyrosine catabolismREACTOMER-HSA-71182
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
254469722015Differential expression of the immunosuppressive enzyme IL4I1 in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells.5
120314862002Characterization of the human homolog of the IL-4 induced gene-1 (Fig1).0
124464502003Interleukin 4-induced gene 1 is activated in primary mediastinal large B-cell lymphoma.0
173561322007Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation.0
194363102009The novel immunosuppressive enzyme IL4I1 is expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages.0
206839002010Dichotomy between factors inducing the immunosuppressive enzyme IL-4-induced gene 1 (IL4I1) in B lymphocytes and mononuclear phagocytes.0
233558812013Antibacterial properties of the mammalian L-amino acid oxidase IL4I1.0
243072432014IL-4-induced gene 1 maintains high Tob1 expression that contributes to TCR unresponsiveness in human T helper 17 cells.0
266739642016Alterations of the immunosuppressive IL4I1 enzyme activity induced by naturally occurring SNP/mutations.0
288910652018IL4-induced gene 1 is secreted at the immune synapse and modulates TCR activation independently of its enzymatic activity.0

Citation

Dessen P

IL4I1 (interleukin 4 induced 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43872/il4i1