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IL5 (interleukin 5)

Identity

Alias_namesinterleukin 5 (colony-stimulating factor, eosinophil)
Alias_symbol (synonym)IL-5
EDF
TRF
Other alias
HGNC (Hugo) IL5
LocusID (NCBI) 3567
Atlas_Id 40961
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 132541444 and ends at 132543522 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RAD50 (5q31.1) / IL5 (5q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL5   6016
Cards
Entrez_Gene (NCBI)IL5  3567  interleukin 5
AliasesEDF; IL-5; TRF
GeneCards (Weizmann)IL5
Ensembl hg19 (Hinxton)ENSG00000113525 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113525 [Gene_View]  ENSG00000113525 [Sequence]  chr5:132541444-132543522 [Contig_View]  IL5 [Vega]
ICGC DataPortalENSG00000113525
TCGA cBioPortalIL5
AceView (NCBI)IL5
Genatlas (Paris)IL5
WikiGenes3567
SOURCE (Princeton)IL5
Genetics Home Reference (NIH)IL5
Genomic and cartography
GoldenPath hg38 (UCSC)IL5  -     chr5:132541444-132543522 -  5q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL5  -     5q31.1   [Description]    (hg19-Feb_2009)
GoldenPathIL5 - 5q31.1 [CytoView hg19]  IL5 - 5q31.1 [CytoView hg38]
ImmunoBaseENSG00000113525
Mapping of homologs : NCBIIL5 [Mapview hg19]  IL5 [Mapview hg38]
OMIM147850   
Gene and transcription
Genbank (Entrez)BC066279 BC066280 BC066281 BC066282 BC069137
RefSeq transcript (Entrez)NM_000879
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL5
Cluster EST : UnigeneHs.2247 [ NCBI ]
CGAP (NCI)Hs.2247
Alternative Splicing GalleryENSG00000113525
Gene ExpressionIL5 [ NCBI-GEO ]   IL5 [ EBI - ARRAY_EXPRESS ]   IL5 [ SEEK ]   IL5 [ MEM ]
Gene Expression Viewer (FireBrowse)IL5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3567
GTEX Portal (Tissue expression)IL5
Human Protein AtlasENSG00000113525-IL5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05113   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05113  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05113
Splice isoforms : SwissVarP05113
PhosPhoSitePlusP05113
Domains : Interpro (EBI)4_helix_cytokine-like_core    IL-5   
Domain families : Pfam (Sanger)IL5 (PF02025)   
Domain families : Pfam (NCBI)pfam02025   
Domain structure : Prodom (Prabi Lyon)Interleukin_5 (PD006721)   
Conserved Domain (NCBI)IL5
DMDM Disease mutations3567
Blocks (Seattle)IL5
PDB (RSDB)1HUL    3QT2    3VA2   
PDB Europe1HUL    3QT2    3VA2   
PDB (PDBSum)1HUL    3QT2    3VA2   
PDB (IMB)1HUL    3QT2    3VA2   
Structural Biology KnowledgeBase1HUL    3QT2    3VA2   
SCOP (Structural Classification of Proteins)1HUL    3QT2    3VA2   
CATH (Classification of proteins structures)1HUL    3QT2    3VA2   
SuperfamilyP05113
Human Protein Atlas [tissue]ENSG00000113525-IL5 [tissue]
Peptide AtlasP05113
HPRD00997
IPIIPI00007082   IPI00796601   
Protein Interaction databases
DIP (DOE-UCLA)P05113
IntAct (EBI)P05113
FunCoupENSG00000113525
BioGRIDIL5
STRING (EMBL)IL5
ZODIACIL5
Ontologies - Pathways
QuickGOP05113
Ontology : AmiGOMAPK cascade  cytokine activity  interleukin-5 receptor binding  protein binding  extracellular region  extracellular region  extracellular space  inflammatory response  immune response  growth factor activity  cytokine-mediated signaling pathway  positive regulation of B cell proliferation  positive regulation of eosinophil differentiation  positive regulation of transcription, DNA-templated  positive regulation of JAK-STAT cascade  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of immunoglobulin secretion  positive regulation of DNA-binding transcription factor activity  positive regulation of podosome assembly  
Ontology : EGO-EBIMAPK cascade  cytokine activity  interleukin-5 receptor binding  protein binding  extracellular region  extracellular region  extracellular space  inflammatory response  immune response  growth factor activity  cytokine-mediated signaling pathway  positive regulation of B cell proliferation  positive regulation of eosinophil differentiation  positive regulation of transcription, DNA-templated  positive regulation of JAK-STAT cascade  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of immunoglobulin secretion  positive regulation of DNA-binding transcription factor activity  positive regulation of podosome assembly  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Hematopoietic cell lineage    T cell receptor signaling pathway    Fc epsilon RI signaling pathway    Intestinal immune network for IgA production    Asthma    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Allograft rejection   
NDEx NetworkIL5
Atlas of Cancer Signalling NetworkIL5
Wikipedia pathwaysIL5
Orthology - Evolution
OrthoDB3567
GeneTree (enSembl)ENSG00000113525
Phylogenetic Trees/Animal Genes : TreeFamIL5
HOGENOMP05113
Homologs : HomoloGeneIL5
Homology/Alignments : Family Browser (UCSC)IL5
Gene fusions - Rearrangements
Fusion : QuiverIL5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL5
dbVarIL5
ClinVarIL5
1000_GenomesIL5 
Exome Variant ServerIL5
ExAC (Exome Aggregation Consortium)ENSG00000113525
GNOMAD BrowserENSG00000113525
Varsome BrowserIL5
Genetic variants : HAPMAP3567
Genomic Variants (DGV)IL5 [DGVbeta]
DECIPHERIL5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL5 
Mutations
ICGC Data PortalIL5 
TCGA Data PortalIL5 
Broad Tumor PortalIL5
OASIS PortalIL5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL5
Mutations and Diseases : HGMDIL5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL5
DgiDB (Drug Gene Interaction Database)IL5
DoCM (Curated mutations)IL5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL5 (select a term)
intoGenIL5
Cancer3DIL5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147850   
Orphanet
DisGeNETIL5
MedgenIL5
Genetic Testing Registry IL5
NextProtP05113 [Medical]
TSGene3567
GENETestsIL5
Target ValidationIL5
Huge Navigator IL5 [HugePedia]
snp3D : Map Gene to Disease3567
BioCentury BCIQIL5
ClinGenIL5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3567
Chemical/Pharm GKB GenePA29833
Clinical trialIL5
Miscellaneous
canSAR (ICR)IL5 (select the gene name)
DataMed IndexIL5
Probes
Litterature
PubMed219 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL5
EVEXIL5
GoPubMedIL5
iHOPIL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Nov 13 17:48:23 CET 2019
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