Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IL5RA (interleukin 5 receptor subunit alpha)

Identity

Alias_namesIL5R
interleukin 5 receptor
Alias_symbol (synonym)CDw125
CD125
Other aliasHSIL5R3
HGNC (Hugo) IL5RA
LocusID (NCBI) 3568
Atlas_Id 40962
Location 3p26.2  [Link to chromosome band 3p26]
Location_base_pair Starts at 3066324 and ends at 3110374 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BPTF (17q24.2) / IL5RA (3p26.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IL5RA   6017
Cards
Entrez_Gene (NCBI)IL5RA  3568  interleukin 5 receptor subunit alpha
AliasesCD125; CDw125; HSIL5R3; IL5R
GeneCards (Weizmann)IL5RA
Ensembl hg19 (Hinxton)ENSG00000091181 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000091181 [Gene_View]  chr3:3066324-3110374 [Contig_View]  IL5RA [Vega]
ICGC DataPortalENSG00000091181
TCGA cBioPortalIL5RA
AceView (NCBI)IL5RA
Genatlas (Paris)IL5RA
WikiGenes3568
SOURCE (Princeton)IL5RA
Genetics Home Reference (NIH)IL5RA
Genomic and cartography
GoldenPath hg38 (UCSC)IL5RA  -     chr3:3066324-3110374 -  3p26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL5RA  -     3p26.2   [Description]    (hg19-Feb_2009)
EnsemblIL5RA - 3p26.2 [CytoView hg19]  IL5RA - 3p26.2 [CytoView hg38]
Mapping of homologs : NCBIIL5RA [Mapview hg19]  IL5RA [Mapview hg38]
OMIM147851   
Gene and transcription
Genbank (Entrez)AB288089 AB288090 AK304256 BC027599 BI520196
RefSeq transcript (Entrez)NM_000564 NM_001243099 NM_175724 NM_175725 NM_175726 NM_175727 NM_175728
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL5RA
Cluster EST : UnigeneHs.68876 [ NCBI ]
CGAP (NCI)Hs.68876
Alternative Splicing GalleryENSG00000091181
Gene ExpressionIL5RA [ NCBI-GEO ]   IL5RA [ EBI - ARRAY_EXPRESS ]   IL5RA [ SEEK ]   IL5RA [ MEM ]
Gene Expression Viewer (FireBrowse)IL5RA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3568
GTEX Portal (Tissue expression)IL5RA
Human Protein AtlasENSG00000091181-IL5RA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01344   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01344  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01344
Splice isoforms : SwissVarQ01344
PhosPhoSitePlusQ01344
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_S_F2 (PS01356)   
Domains : Interpro (EBI)FN3_dom    Ig-like_fold    Short_hematopoietin_rcpt_2_CS    TypeI_recpt_CBD   
Domain families : Pfam (Sanger)IL6Ra-bind (PF09240)   
Domain families : Pfam (NCBI)pfam09240   
Conserved Domain (NCBI)IL5RA
DMDM Disease mutations3568
Blocks (Seattle)IL5RA
PDB (SRS)1OBX    1OBZ    3QT2    3VA2   
PDB (PDBSum)1OBX    1OBZ    3QT2    3VA2   
PDB (IMB)1OBX    1OBZ    3QT2    3VA2   
PDB (RSDB)1OBX    1OBZ    3QT2    3VA2   
Structural Biology KnowledgeBase1OBX    1OBZ    3QT2    3VA2   
SCOP (Structural Classification of Proteins)1OBX    1OBZ    3QT2    3VA2   
CATH (Classification of proteins structures)1OBX    1OBZ    3QT2    3VA2   
SuperfamilyQ01344
Human Protein Atlas [tissue]ENSG00000091181-IL5RA [tissue]
Peptide AtlasQ01344
HPRD00998
IPIIPI00306687   IPI00395487   IPI00221146   IPI00792045   IPI00915764   IPI00021163   IPI00924865   
Protein Interaction databases
DIP (DOE-UCLA)Q01344
IntAct (EBI)Q01344
FunCoupENSG00000091181
BioGRIDIL5RA
STRING (EMBL)IL5RA
ZODIACIL5RA
Ontologies - Pathways
QuickGOQ01344
Ontology : AmiGOMAPK cascade  inflammatory response to antigenic stimulus  protein tyrosine kinase activity  interleukin-5 receptor activity  Ras guanyl-nucleotide exchange factor activity  protein binding  extracellular space  intracellular  plasma membrane  signal transduction  cell proliferation  integral component of membrane  peptidyl-tyrosine phosphorylation  regulation of interleukin-5 production  interleukin-5-mediated signaling pathway  positive regulation of GTPase activity  
Ontology : EGO-EBIMAPK cascade  inflammatory response to antigenic stimulus  protein tyrosine kinase activity  interleukin-5 receptor activity  Ras guanyl-nucleotide exchange factor activity  protein binding  extracellular space  intracellular  plasma membrane  signal transduction  cell proliferation  integral component of membrane  peptidyl-tyrosine phosphorylation  regulation of interleukin-5 production  interleukin-5-mediated signaling pathway  positive regulation of GTPase activity  
Pathways : BIOCARTAIL 5 Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Hematopoietic cell lineage   
NDEx NetworkIL5RA
Atlas of Cancer Signalling NetworkIL5RA
Wikipedia pathwaysIL5RA
Orthology - Evolution
OrthoDB3568
GeneTree (enSembl)ENSG00000091181
Phylogenetic Trees/Animal Genes : TreeFamIL5RA
HOVERGENQ01344
HOGENOMQ01344
Homologs : HomoloGeneIL5RA
Homology/Alignments : Family Browser (UCSC)IL5RA
Gene fusions - Rearrangements
Tumor Fusion PortalIL5RA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL5RA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL5RA
dbVarIL5RA
ClinVarIL5RA
1000_GenomesIL5RA 
Exome Variant ServerIL5RA
ExAC (Exome Aggregation Consortium)ENSG00000091181
GNOMAD BrowserENSG00000091181
Genetic variants : HAPMAP3568
Genomic Variants (DGV)IL5RA [DGVbeta]
DECIPHERIL5RA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL5RA 
Mutations
ICGC Data PortalIL5RA 
TCGA Data PortalIL5RA 
Broad Tumor PortalIL5RA
OASIS PortalIL5RA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL5RA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL5RA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL5RA
DgiDB (Drug Gene Interaction Database)IL5RA
DoCM (Curated mutations)IL5RA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL5RA (select a term)
intoGenIL5RA
Cancer3DIL5RA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147851   
Orphanet
DisGeNETIL5RA
MedgenIL5RA
Genetic Testing Registry IL5RA
NextProtQ01344 [Medical]
TSGene3568
GENETestsIL5RA
Target ValidationIL5RA
Huge Navigator IL5RA [HugePedia]
snp3D : Map Gene to Disease3568
BioCentury BCIQIL5RA
ClinGenIL5RA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3568
Chemical/Pharm GKB GenePA29834
Clinical trialIL5RA
Miscellaneous
canSAR (ICR)IL5RA (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL5RA
EVEXIL5RA
GoPubMedIL5RA
iHOPIL5RA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:17:46 CET 2017

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