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IL6R (interleukin 6 receptor)

Identity

Other namesCD126
IL-6R-1
IL-6RA
IL6Q
IL6RA
IL6RQ
gp80
HGNC (Hugo) IL6R
LocusID (NCBI) 3570
Location 1q21.3
Location_base_pair Starts at 154377669 and ends at 154441926 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL6R   6019
Cards
Entrez_Gene (NCBI)IL6R  3570  interleukin 6 receptor
GeneCards (Weizmann)IL6R
Ensembl (Hinxton)ENSG00000160712 [Gene_View]  chr1:154377669-154441926 [Contig_View]  IL6R [Vega]
ICGC DataPortalENSG00000160712
cBioPortalIL6R
AceView (NCBI)IL6R
Genatlas (Paris)IL6R
WikiGenes3570
SOURCE (Princeton)NM_000565 NM_001206866 NM_181359
Genomic and cartography
GoldenPath (UCSC)IL6R  -  1q21.3   chr1:154377669-154441926 +  1q21.3   [Description]    (hg19-Feb_2009)
EnsemblIL6R - 1q21.3 [CytoView]
Mapping of homologs : NCBIIL6R [Mapview]
OMIM147880   614689   614752   
Gene and transcription
Genbank (Entrez)AA035377 AK223582 AK293013 AK312730 BC035327
RefSeq transcript (Entrez)NM_000565 NM_001206866 NM_181359
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_012087 NT_004487 NW_001838529 NW_004929293
Consensus coding sequences : CCDS (NCBI)IL6R
Cluster EST : UnigeneHs.135087 [ NCBI ]
CGAP (NCI)Hs.135087
Alternative Splicing : Fast-db (Paris)GSHG0001007
Alternative Splicing GalleryENSG00000160712
Gene ExpressionIL6R [ NCBI-GEO ]     IL6R [ SEEK ]   IL6R [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08887 (Uniprot)
NextProtP08887  [Medical]
With graphics : InterProP08887
Splice isoforms : SwissVarP08887 (Swissvar)
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F3 (PS01354)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)Fibronectin_type3 [organisation]   Hematopoietin_rcpt_L_F3_CS [organisation]   Ig-like_dom [organisation]   Ig-like_fold [organisation]   Ig_sub2 [organisation]   IL-6_rcpt_alpha-bd [organisation]  
Related proteins : CluSTrP08887
Domain families : Pfam (Sanger)IL6Ra-bind (PF09240)   
Domain families : Pfam (NCBI)pfam09240   
Domain families : Smart (EMBL)FN3 (SM00060)  IGc2 (SM00408)  
DMDM Disease mutations3570
Blocks (Seattle)P08887
PDB (SRS)1N26    1N2Q    1P9M    2ARW   
PDB (PDBSum)1N26    1N2Q    1P9M    2ARW   
PDB (IMB)1N26    1N2Q    1P9M    2ARW   
PDB (RSDB)1N26    1N2Q    1P9M    2ARW   
Human Protein AtlasENSG00000160712 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP08887
HPRD01000
IPIIPI00031171   IPI00413309   IPI01017930   IPI00964694   IPI00964398   IPI00966256   
Protein Interaction databases
DIP (DOE-UCLA)P08887
IntAct (EBI)P08887
FunCoupENSG00000160712
BioGRIDIL6R
InParanoidP08887
Interologous Interaction database P08887
IntegromeDBIL6R
STRING (EMBL)IL6R
Ontologies - Pathways
Ontology : AmiGOhepatic immune response  neutrophil mediated immunity  monocyte chemotaxis  positive regulation of leukocyte chemotaxis  positive regulation of leukocyte chemotaxis  ciliary neurotrophic factor receptor activity  interleukin-6 receptor activity  interleukin-6 receptor binding  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  interleukin-6 receptor complex  acute-phase response  positive regulation of cell proliferation  positive regulation of cell proliferation  cell surface  positive regulation of activation of Janus kinase activity  basolateral plasma membrane  apical plasma membrane  cytokine-mediated signaling pathway  enzyme binding  interleukin-6 binding  endocrine pancreas development  endocrine pancreas development  negative regulation of interleukin-8 production  positive regulation of chemokine production  positive regulation of interleukin-6 production  negative regulation of collagen biosynthetic process  response to cytokine  positive regulation of tyrosine phosphorylation of Stat3 protein  protein homodimerization activity  positive regulation of MAPK cascade  positive regulation of osteoblast differentiation  positive regulation of smooth muscle cell proliferation  positive regulation of peptidyl-tyrosine phosphorylation  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  interleukin-6-mediated signaling pathway  ciliary neurotrophic factor binding  ciliary neurotrophic factor-mediated signaling pathway  extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIhepatic immune response  neutrophil mediated immunity  monocyte chemotaxis  positive regulation of leukocyte chemotaxis  positive regulation of leukocyte chemotaxis  ciliary neurotrophic factor receptor activity  interleukin-6 receptor activity  interleukin-6 receptor binding  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  interleukin-6 receptor complex  acute-phase response  positive regulation of cell proliferation  positive regulation of cell proliferation  cell surface  positive regulation of activation of Janus kinase activity  basolateral plasma membrane  apical plasma membrane  cytokine-mediated signaling pathway  enzyme binding  interleukin-6 binding  endocrine pancreas development  endocrine pancreas development  negative regulation of interleukin-8 production  positive regulation of chemokine production  positive regulation of interleukin-6 production  negative regulation of collagen biosynthetic process  response to cytokine  positive regulation of tyrosine phosphorylation of Stat3 protein  protein homodimerization activity  positive regulation of MAPK cascade  positive regulation of osteoblast differentiation  positive regulation of smooth muscle cell proliferation  positive regulation of peptidyl-tyrosine phosphorylation  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  interleukin-6-mediated signaling pathway  ciliary neurotrophic factor binding  ciliary neurotrophic factor-mediated signaling pathway  extrinsic apoptotic signaling pathway  
Pathways : BIOCARTAIL 6 signaling pathway [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    HIF-1 signaling pathway    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Hematopoietic cell lineage    Non-alcoholic fatty liver disease (NAFLD)   
Protein Interaction DatabaseIL6R
Wikipedia pathwaysIL6R
Gene fusion - rearrangments
Rearrangement : COSMICIL6R [1q21.3]  -  ATP8B2 [1q21.3]  
  [COSF705] [COSF706] 
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IL6R
snp3D : Map Gene to Disease3570
SNP (GeneSNP Utah)IL6R
SNP : HGBaseIL6R
Genetic variants : HAPMAPIL6R
Exome VariantIL6R
1000_GenomesIL6R 
ICGC programENSG00000160712 
Somatic Mutations in Cancer : COSMICIL6R 
CONAN: Copy Number AnalysisIL6R 
Mutations and Diseases : HGMDIL6R
Genomic VariantsIL6R  IL6R [DGVbeta]
dbVarIL6R
ClinVarIL6R
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM147880    614689    614752   
MedgenIL6R
GENETestsIL6R
Disease Genetic AssociationIL6R
Huge Navigator IL6R [HugePedia]  IL6R [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneIL6R
Homology/Alignments : Family Browser (UCSC)IL6R
Phylogenetic Trees/Animal Genes : TreeFamIL6R
Chemical/Protein Interactions : CTD3570
Chemical/Pharm GKB GenePA29835
Clinical trialIL6R
Cancer Resource (Charite)ENSG00000160712
Other databases
Probes
Litterature
PubMed258 Pubmed reference(s) in Entrez
CoreMineIL6R
iHOPIL6R
OncoSearchIL6R
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:59:39 CEST 2014

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