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IL6R (interleukin 6 receptor)

Identity

Other namesCD126
IL-6R-1
IL-6RA
IL6Q
IL6RA
IL6RQ
gp80
HGNC (Hugo) IL6R
LocusID (NCBI) 3570
Atlas_Id 40963
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 154377669 and ends at 154441926 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IL6R (1q21.3) / ATP8B2 (1q21.3)IL6R (1q21.3) / CADPS2 (7q31.32)IL6R 1q21.3 / ATP8B2 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IL6R   6019
Cards
Entrez_Gene (NCBI)IL6R  3570  interleukin 6 receptor
AliasesCD126; IL-6R-1; IL-6RA; IL6Q; 
IL6RA; IL6RQ; gp80
GeneCards (Weizmann)IL6R
Ensembl hg19 (Hinxton)ENSG00000160712 [Gene_View]  chr1:154377669-154441926 [Contig_View]  IL6R [Vega]
Ensembl hg38 (Hinxton)ENSG00000160712 [Gene_View]  chr1:154377669-154441926 [Contig_View]  IL6R [Vega]
ICGC DataPortalENSG00000160712
TCGA cBioPortalIL6R
AceView (NCBI)IL6R
Genatlas (Paris)IL6R
WikiGenes3570
SOURCE (Princeton)IL6R
Genomic and cartography
GoldenPath hg19 (UCSC)IL6R  -     chr1:154377669-154441926 +  1q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IL6R  -     1q21.3   [Description]    (hg38-Dec_2013)
EnsemblIL6R - 1q21.3 [CytoView hg19]  IL6R - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIIL6R [Mapview hg19]  IL6R [Mapview hg38]
OMIM147880   614689   614752   
Gene and transcription
Genbank (Entrez)AA035377 AK223582 AK293013 AK312730 BC035327
RefSeq transcript (Entrez)NM_000565 NM_001206866 NM_181359
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_012087 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)IL6R
Cluster EST : UnigeneHs.135087 [ NCBI ]
CGAP (NCI)Hs.135087
Alternative Splicing GalleryENSG00000160712
Gene ExpressionIL6R [ NCBI-GEO ]   IL6R [ EBI - ARRAY_EXPRESS ]   IL6R [ SEEK ]   IL6R [ MEM ]
Gene Expression Viewer (FireBrowse)IL6R [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3570
GTEX Portal (Tissue expression)IL6R
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08887 (Uniprot)
NextProtP08887  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08887
Splice isoforms : SwissVarP08887 (Swissvar)
PhosPhoSitePlusP08887
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F3 (PS01354)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)FN3_dom    Hematopoietin_rcpt_L_F3_CS    Ig-like_dom    Ig-like_fold    Ig_sub2    Immunoglobulin    TypeI_recpt_CBD   
Domain families : Pfam (Sanger)ig (PF00047)    IL6Ra-bind (PF09240)   
Domain families : Pfam (NCBI)pfam00047    pfam09240   
Domain families : Smart (EMBL)FN3 (SM00060)  IGc2 (SM00408)  
DMDM Disease mutations3570
Blocks (Seattle)IL6R
PDB (SRS)1N26    1N2Q    1P9M    2ARW   
PDB (PDBSum)1N26    1N2Q    1P9M    2ARW   
PDB (IMB)1N26    1N2Q    1P9M    2ARW   
PDB (RSDB)1N26    1N2Q    1P9M    2ARW   
Structural Biology KnowledgeBase1N26    1N2Q    1P9M    2ARW   
SCOP (Structural Classification of Proteins)1N26    1N2Q    1P9M    2ARW   
CATH (Classification of proteins structures)1N26    1N2Q    1P9M    2ARW   
SuperfamilyP08887
Human Protein AtlasENSG00000160712
Peptide AtlasP08887
HPRD01000
IPIIPI00031171   IPI00413309   IPI01017930   IPI00964694   IPI00964398   IPI00966256   
Protein Interaction databases
DIP (DOE-UCLA)P08887
IntAct (EBI)P08887
FunCoupENSG00000160712
BioGRIDIL6R
STRING (EMBL)IL6R
ZODIACIL6R
Ontologies - Pathways
QuickGOP08887
Ontology : AmiGOhepatic immune response  neutrophil mediated immunity  monocyte chemotaxis  positive regulation of leukocyte chemotaxis  ciliary neurotrophic factor receptor activity  interleukin-6 receptor activity  interleukin-6 receptor binding  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  interleukin-6 receptor complex  acute-phase response  positive regulation of cell proliferation  positive regulation of cell proliferation  cell surface  positive regulation of activation of Janus kinase activity  basolateral plasma membrane  apical plasma membrane  cytokine-mediated signaling pathway  enzyme binding  interleukin-6 binding  endocrine pancreas development  endocrine pancreas development  negative regulation of interleukin-8 production  positive regulation of chemokine production  positive regulation of interleukin-6 production  negative regulation of collagen biosynthetic process  response to cytokine  positive regulation of tyrosine phosphorylation of Stat3 protein  protein homodimerization activity  positive regulation of MAPK cascade  positive regulation of osteoblast differentiation  positive regulation of smooth muscle cell proliferation  positive regulation of peptidyl-tyrosine phosphorylation  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  interleukin-6-mediated signaling pathway  ciliary neurotrophic factor receptor complex  ciliary neurotrophic factor binding  ciliary neurotrophic factor-mediated signaling pathway  extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIhepatic immune response  neutrophil mediated immunity  monocyte chemotaxis  positive regulation of leukocyte chemotaxis  ciliary neurotrophic factor receptor activity  interleukin-6 receptor activity  interleukin-6 receptor binding  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  interleukin-6 receptor complex  acute-phase response  positive regulation of cell proliferation  positive regulation of cell proliferation  cell surface  positive regulation of activation of Janus kinase activity  basolateral plasma membrane  apical plasma membrane  cytokine-mediated signaling pathway  enzyme binding  interleukin-6 binding  endocrine pancreas development  endocrine pancreas development  negative regulation of interleukin-8 production  positive regulation of chemokine production  positive regulation of interleukin-6 production  negative regulation of collagen biosynthetic process  response to cytokine  positive regulation of tyrosine phosphorylation of Stat3 protein  protein homodimerization activity  positive regulation of MAPK cascade  positive regulation of osteoblast differentiation  positive regulation of smooth muscle cell proliferation  positive regulation of peptidyl-tyrosine phosphorylation  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  interleukin-6-mediated signaling pathway  ciliary neurotrophic factor receptor complex  ciliary neurotrophic factor binding  ciliary neurotrophic factor-mediated signaling pathway  extrinsic apoptotic signaling pathway  
Pathways : BIOCARTAIL 6 signaling pathway [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    HIF-1 signaling pathway    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Hematopoietic cell lineage    Non-alcoholic fatty liver disease (NAFLD)   
NDEx NetworkIL6R
Atlas of Cancer Signalling NetworkIL6R
Wikipedia pathwaysIL6R
Orthology - Evolution
OrthoDB3570
GeneTree (enSembl)ENSG00000160712
Phylogenetic Trees/Animal Genes : TreeFamIL6R
Homologs : HomoloGeneIL6R
Homology/Alignments : Family Browser (UCSC)IL6R
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIL6R [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL6R
dbVarIL6R
ClinVarIL6R
1000_GenomesIL6R 
Exome Variant ServerIL6R
ExAC (Exome Aggregation Consortium)IL6R (select the gene name)
Genetic variants : HAPMAP3570
Genomic Variants (DGV)IL6R [DGVbeta]
Mutations
ICGC Data PortalIL6R 
TCGA Data PortalIL6R 
Broad Tumor PortalIL6R
OASIS PortalIL6R [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL6R 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL6R
DgiDB (Drug Gene Interaction Database)IL6R
DoCM (Curated mutations)IL6R (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL6R (select a term)
intoGenIL6R
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:154377669-154441926  ENSG00000160712
CONAN: Copy Number AnalysisIL6R 
Mutations and Diseases : HGMDIL6R
OMIM147880    614689    614752   
MedgenIL6R
Genetic Testing Registry IL6R
NextProtP08887 [Medical]
TSGene3570
GENETestsIL6R
Huge Navigator IL6R [HugePedia]
snp3D : Map Gene to Disease3570
BioCentury BCIQIL6R
ClinGenIL6R
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3570
Chemical/Pharm GKB GenePA29835
Clinical trialIL6R
Miscellaneous
canSAR (ICR)IL6R (select the gene name)
Probes
Litterature
PubMed306 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL6R
EVEXIL6R
GoPubMedIL6R
iHOPIL6R
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 18:54:55 CEST 2016

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