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IL6ST (interleukin 6 cytokine family signal transducer)

Identity

Alias (NCBI)CD130
CDW130
GP130
HIES4
IL-6RB
sGP130
HGNC (Hugo) IL6ST
HGNC Alias symbGP130
CD130
sGP130
IL-6RB
HGNC Alias namegp130, oncostatin M receptor
 Interleukin-6 receptor subunit beta
 membrane glycoprotein 130
HGNC Previous nameinterleukin 6 signal transducer (gp130, oncostatin M receptor)
 interleukin 6 signal transducer
LocusID (NCBI) 3572
Atlas_Id 40964
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 55935097 and ends at 55994963 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IL6ST (5q11.2) / ANKRD55 (5q11.2)IL6ST (5q11.2) / BTG2 (1q32.1)IL6ST (5q11.2) / IL6ST (5q11.2)
IL6ST (5q11.2) / KDM1B (6p22.3)RFC2 (7q11.23) / IL6ST (5q11.2)IL6ST 5q11.2 / ANKRD55 5q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IL6ST   6021
Cards
Entrez_Gene (NCBI)IL6ST    interleukin 6 cytokine family signal transducer
AliasesCD130; CDW130; GP130; HIES4; 
IL-6RB; sGP130
GeneCards (Weizmann)IL6ST
Ensembl hg19 (Hinxton)ENSG00000134352 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134352 [Gene_View]  ENSG00000134352 [Sequence]  chr5:55935097-55994963 [Contig_View]  IL6ST [Vega]
ICGC DataPortalENSG00000134352
TCGA cBioPortalIL6ST
AceView (NCBI)IL6ST
Genatlas (Paris)IL6ST
SOURCE (Princeton)IL6ST
Genetics Home Reference (NIH)IL6ST
Genomic and cartography
GoldenPath hg38 (UCSC)IL6ST  -     chr5:55935097-55994963 -  5q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL6ST  -     5q11.2   [Description]    (hg19-Feb_2009)
GoldenPathIL6ST - 5q11.2 [CytoView hg19]  IL6ST - 5q11.2 [CytoView hg38]
ImmunoBaseENSG00000134352
Genome Data Viewer NCBIIL6ST [Mapview hg19]  
OMIM600694   618523   
Gene and transcription
Genbank (Entrez)AB015706 AB074172 AB102799 AB102800 AB102801
RefSeq transcript (Entrez)NM_001190981 NM_001364275 NM_001364276 NM_001364277 NM_001364278 NM_001364279 NM_002184 NM_175767
Consensus coding sequences : CCDS (NCBI)IL6ST
Gene ExpressionIL6ST [ NCBI-GEO ]   IL6ST [ EBI - ARRAY_EXPRESS ]   IL6ST [ SEEK ]   IL6ST [ MEM ]
Gene Expression Viewer (FireBrowse)IL6ST [ Firebrowse - Broad ]
GenevisibleExpression of IL6ST in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3572
GTEX Portal (Tissue expression)IL6ST
Human Protein AtlasENSG00000134352-IL6ST [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40189   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40189  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40189
PhosPhoSitePlusP40189
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F2 (PS01353)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Hematopoietin_rcpt_Gp130_CS    Ig-like_fold    IgC2-like_lig-bd    TypeI_recpt_CBD   
Domain families : Pfam (Sanger)fn3 (PF00041)    IL6Ra-bind (PF09240)    Lep_receptor_Ig (PF06328)   
Domain families : Pfam (NCBI)pfam00041    pfam09240    pfam06328   
Domain families : Smart (EMBL)FN3 (SM00060)  
Conserved Domain (NCBI)IL6ST
PDB (RSDB)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
PDB Europe1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
PDB (PDBSum)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
PDB (IMB)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
Structural Biology KnowledgeBase1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
SCOP (Structural Classification of Proteins)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
CATH (Classification of proteins structures)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
SuperfamilyP40189
AlphaFold pdb e-kbP40189   
Human Protein Atlas [tissue]ENSG00000134352-IL6ST [tissue]
HPRD02824
Protein Interaction databases
DIP (DOE-UCLA)P40189
IntAct (EBI)P40189
BioGRIDIL6ST
STRING (EMBL)IL6ST
ZODIACIL6ST
Ontologies - Pathways
QuickGOP40189
Ontology : AmiGOpositive regulation of acute inflammatory response  positive regulation of adaptive immune response  cytokine receptor activity  ciliary neurotrophic factor receptor activity  interleukin-6 receptor activity  interleukin-6 receptor activity  interleukin-11 receptor activity  leukemia inhibitory factor receptor activity  oncostatin-M receptor activity  ciliary neurotrophic factor receptor binding  interleukin-6 receptor binding  protein binding  extracellular region  plasma membrane  interleukin-6 receptor complex  oncostatin-M receptor complex  glycogen metabolic process  positive regulation of cell population proliferation  positive regulation of cell population proliferation  external side of plasma membrane  positive regulation of vascular endothelial growth factor production  positive regulation of cardiac muscle hypertrophy  membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  growth factor binding  growth factor binding  cytokine binding  interleukin-11 binding  interleukin-6 binding  interleukin-6 binding  dendrite  response to cytokine  interleukin-11-mediated signaling pathway  oncostatin-M-mediated signaling pathway  positive regulation of T cell proliferation  positive regulation of tyrosine phosphorylation of STAT protein  identical protein binding  neuronal cell body  negative regulation of apoptotic process  receptor complex  interleukin-27 receptor activity  positive regulation of osteoblast differentiation  positive regulation of Notch signaling pathway  positive regulation of astrocyte differentiation  leukemia inhibitory factor signaling pathway  intestinal epithelial cell development  extracellular exosome  interleukin-6-mediated signaling pathway  interleukin-6-mediated signaling pathway  interleukin-6-mediated signaling pathway  interleukin-27-mediated signaling pathway  interleukin-27-mediated signaling pathway  ciliary neurotrophic factor receptor complex  ciliary neurotrophic factor-mediated signaling pathway  interleukin-35-mediated signaling pathway  
Ontology : EGO-EBIpositive regulation of acute inflammatory response  positive regulation of adaptive immune response  cytokine receptor activity  ciliary neurotrophic factor receptor activity  interleukin-6 receptor activity  interleukin-6 receptor activity  interleukin-11 receptor activity  leukemia inhibitory factor receptor activity  oncostatin-M receptor activity  ciliary neurotrophic factor receptor binding  interleukin-6 receptor binding  protein binding  extracellular region  plasma membrane  interleukin-6 receptor complex  oncostatin-M receptor complex  glycogen metabolic process  positive regulation of cell population proliferation  positive regulation of cell population proliferation  external side of plasma membrane  positive regulation of vascular endothelial growth factor production  positive regulation of cardiac muscle hypertrophy  membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  growth factor binding  growth factor binding  cytokine binding  interleukin-11 binding  interleukin-6 binding  interleukin-6 binding  dendrite  response to cytokine  interleukin-11-mediated signaling pathway  oncostatin-M-mediated signaling pathway  positive regulation of T cell proliferation  positive regulation of tyrosine phosphorylation of STAT protein  identical protein binding  neuronal cell body  negative regulation of apoptotic process  receptor complex  interleukin-27 receptor activity  positive regulation of osteoblast differentiation  positive regulation of Notch signaling pathway  positive regulation of astrocyte differentiation  leukemia inhibitory factor signaling pathway  intestinal epithelial cell development  extracellular exosome  interleukin-6-mediated signaling pathway  interleukin-6-mediated signaling pathway  interleukin-6-mediated signaling pathway  interleukin-27-mediated signaling pathway  interleukin-27-mediated signaling pathway  ciliary neurotrophic factor receptor complex  ciliary neurotrophic factor-mediated signaling pathway  interleukin-35-mediated signaling pathway  
Pathways : BIOCARTAIL 6 signaling pathway [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Viral carcinogenesis   
NDEx NetworkIL6ST
Atlas of Cancer Signalling NetworkIL6ST
Wikipedia pathwaysIL6ST
Orthology - Evolution
OrthoDB3572
GeneTree (enSembl)ENSG00000134352
Phylogenetic Trees/Animal Genes : TreeFamIL6ST
Homologs : HomoloGeneIL6ST
Homology/Alignments : Family Browser (UCSC)IL6ST
Gene fusions - Rearrangements
Fusion : MitelmanIL6ST/ANKRD55 [5q11.2/5q11.2]  
Fusion : MitelmanIL6ST/KDM1B [5q11.2/6p22.3]  
Fusion : QuiverIL6ST
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL6ST [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL6ST
dbVarIL6ST
ClinVarIL6ST
MonarchIL6ST
1000_GenomesIL6ST 
Exome Variant ServerIL6ST
GNOMAD BrowserENSG00000134352
Varsome BrowserIL6ST
ACMGIL6ST variants
VarityP40189
Genomic Variants (DGV)IL6ST [DGVbeta]
DECIPHERIL6ST [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL6ST 
Mutations
ICGC Data PortalIL6ST 
TCGA Data PortalIL6ST 
Broad Tumor PortalIL6ST
OASIS PortalIL6ST [ Somatic mutations - Copy number]
Cancer Gene: CensusIL6ST 
Somatic Mutations in Cancer : COSMICIL6ST  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL6ST
Mutations and Diseases : HGMDIL6ST
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIL6ST
DgiDB (Drug Gene Interaction Database)IL6ST
DoCM (Curated mutations)IL6ST
CIViC (Clinical Interpretations of Variants in Cancer)IL6ST
Cancer3DIL6ST
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600694    618523   
Orphanet
DisGeNETIL6ST
MedgenIL6ST
Genetic Testing Registry IL6ST
NextProtP40189 [Medical]
GENETestsIL6ST
Target ValidationIL6ST
Huge Navigator IL6ST [HugePedia]
ClinGenIL6ST
Clinical trials, drugs, therapy
MyCancerGenomeIL6ST
Protein Interactions : CTDIL6ST
Pharm GKB GenePA29837
PharosP40189
Clinical trialIL6ST
Miscellaneous
canSAR (ICR)IL6ST
HarmonizomeIL6ST
DataMed IndexIL6ST
Probes
Litterature
PubMed276 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIL6ST
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:13:53 CEST 2021

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