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IL6ST (interleukin 6 signal transducer)

Identity

Other namesCD130
CDW130
GP130
IL-6RB
HGNC (Hugo) IL6ST
LocusID (NCBI) 3572
Location 5q11.2
Location_base_pair Starts at 55230925 and ends at 55290821 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL6ST   6021
Cards
Entrez_Gene (NCBI)IL6ST  3572  interleukin 6 signal transducer
GeneCards (Weizmann)IL6ST
Ensembl (Hinxton)ENSG00000134352 [Gene_View]  chr5:55230925-55290821 [Contig_View]  IL6ST [Vega]
ICGC DataPortalENSG00000134352
AceView (NCBI)IL6ST
Genatlas (Paris)IL6ST
WikiGenes3572
SOURCE (Princeton)NM_001190981 NM_002184 NM_175767
Genomic and cartography
GoldenPath (UCSC)IL6ST  -  5q11.2   chr5:55230925-55290821 -  5q11.2   [Description]    (hg19-Feb_2009)
EnsemblIL6ST - 5q11.2 [CytoView]
Mapping of homologs : NCBIIL6ST [Mapview]
OMIM600694   
Gene and transcription
Genbank (Entrez)AB015706 AB074172 AB102799 AB102800 AB102801
RefSeq transcript (Entrez)NM_001190981 NM_002184 NM_175767
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NT_034772 NW_001838934 NW_004929322
Consensus coding sequences : CCDS (NCBI)IL6ST
Cluster EST : UnigeneHs.706627 [ NCBI ]
CGAP (NCI)Hs.706627
Alternative Splicing : Fast-db (Paris)GSHG0024798
Alternative Splicing GalleryENSG00000134352
Gene ExpressionIL6ST [ NCBI-GEO ]     IL6ST [ SEEK ]   IL6ST [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40189 (Uniprot)
NextProtP40189  [Medical]
With graphics : InterProP40189
Splice isoforms : SwissVarP40189 (Swissvar)
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F2 (PS01353)   
Domains : Interpro (EBI)Fibronectin_type3    Hematopoietin_rcpt_Gp130_CS    Ig-like_fold    IgC2-like_lig-bd    IL-6_rcpt_alpha-bd   
Related proteins : CluSTrP40189
Domain families : Pfam (Sanger)fn3 (PF00041)    IL6Ra-bind (PF09240)    Lep_receptor_Ig (PF06328)   
Domain families : Pfam (NCBI)pfam00041    pfam09240    pfam06328   
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM Disease mutations3572
Blocks (Seattle)P40189
PDB (SRS)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
PDB (PDBSum)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
PDB (IMB)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
PDB (RSDB)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
Human Protein AtlasENSG00000134352
Peptide AtlasP40189
HPRD02824
IPIIPI00297124   IPI00939624   IPI00816609   IPI00554478   IPI00554499   IPI00554577   IPI00554518   IPI00554522   IPI00967182   IPI00554459   
Protein Interaction databases
DIP (DOE-UCLA)P40189
IntAct (EBI)P40189
FunCoupENSG00000134352
BioGRIDIL6ST
InParanoidP40189
Interologous Interaction database P40189
IntegromeDBIL6ST
STRING (EMBL)IL6ST
Ontologies - Pathways
Ontology : AmiGOpositive regulation of acute inflammatory response  positive regulation of adaptive immune response  ciliary neurotrophic factor receptor activity  interleukin-6 receptor activity  interleukin-6 receptor activity  interleukin-11 receptor activity  leukemia inhibitory factor receptor activity  oncostatin-M receptor activity  ciliary neurotrophic factor receptor binding  interleukin-6 receptor binding  protein binding  extracellular region  extracellular space  plasma membrane  interleukin-6 receptor complex  oncostatin-M receptor complex  glycogen metabolic process  positive regulation of cell proliferation  positive regulation of cell proliferation  regulation of Notch signaling pathway  external side of plasma membrane  positive regulation vascular endothelial growth factor production  positive regulation of cardiac muscle hypertrophy  membrane  viral process  cytokine-mediated signaling pathway  growth factor binding  growth factor binding  interleukin-11 binding  interleukin-6 binding  dendrite  response to cytokine  interleukin-11-mediated signaling pathway  oncostatin-M-mediated signaling pathway  positive regulation of T cell proliferation  positive regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of tyrosine phosphorylation of Stat3 protein  protein homodimerization activity  neuronal cell body  negative regulation of apoptotic process  interleukin-27 receptor activity  positive regulation of osteoblast differentiation  positive regulation of astrocyte differentiation  leukemia inhibitory factor signaling pathway  extracellular vesicular exosome  interleukin-6-mediated signaling pathway  negative regulation of interleukin-6-mediated signaling pathway  interleukin-27-mediated signaling pathway  ciliary neurotrophic factor receptor complex  ciliary neurotrophic factor-mediated signaling pathway  
Ontology : EGO-EBIpositive regulation of acute inflammatory response  positive regulation of adaptive immune response  ciliary neurotrophic factor receptor activity  interleukin-6 receptor activity  interleukin-6 receptor activity  interleukin-11 receptor activity  leukemia inhibitory factor receptor activity  oncostatin-M receptor activity  ciliary neurotrophic factor receptor binding  interleukin-6 receptor binding  protein binding  extracellular region  extracellular space  plasma membrane  interleukin-6 receptor complex  oncostatin-M receptor complex  glycogen metabolic process  positive regulation of cell proliferation  positive regulation of cell proliferation  regulation of Notch signaling pathway  external side of plasma membrane  positive regulation vascular endothelial growth factor production  positive regulation of cardiac muscle hypertrophy  membrane  viral process  cytokine-mediated signaling pathway  growth factor binding  growth factor binding  interleukin-11 binding  interleukin-6 binding  dendrite  response to cytokine  interleukin-11-mediated signaling pathway  oncostatin-M-mediated signaling pathway  positive regulation of T cell proliferation  positive regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of tyrosine phosphorylation of Stat3 protein  protein homodimerization activity  neuronal cell body  negative regulation of apoptotic process  interleukin-27 receptor activity  positive regulation of osteoblast differentiation  positive regulation of astrocyte differentiation  leukemia inhibitory factor signaling pathway  extracellular vesicular exosome  interleukin-6-mediated signaling pathway  negative regulation of interleukin-6-mediated signaling pathway  interleukin-27-mediated signaling pathway  ciliary neurotrophic factor receptor complex  ciliary neurotrophic factor-mediated signaling pathway  
Pathways : BIOCARTAIL 6 signaling pathway [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Viral carcinogenesis   
Protein Interaction DatabaseIL6ST
Wikipedia pathwaysIL6ST
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IL6ST
SNP (GeneSNP Utah)IL6ST
SNP : HGBaseIL6ST
Genetic variants : HAPMAPIL6ST
1000_GenomesIL6ST 
ICGC programENSG00000134352 
Cancer Gene: CensusIL6ST 
CONAN: Copy Number AnalysisIL6ST 
Somatic Mutations in Cancer : COSMICIL6ST 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDIL6ST
OMIM600694   
MedgenIL6ST
GENETestsIL6ST
Disease Genetic AssociationIL6ST
Huge Navigator IL6ST [HugePedia]  IL6ST [HugeCancerGEM]
Genomic VariantsIL6ST  IL6ST [DGVbeta]
Exome VariantIL6ST
dbVarIL6ST
ClinVarIL6ST
snp3D : Map Gene to Disease3572
General knowledge
Homologs : HomoloGeneIL6ST
Homology/Alignments : Family Browser (UCSC)IL6ST
Phylogenetic Trees/Animal Genes : TreeFamIL6ST
Chemical/Protein Interactions : CTD3572
Chemical/Pharm GKB GenePA29837
Clinical trialIL6ST
Cancer Resource (Charite)ENSG00000134352
Other databases
Probes
Litterature
PubMed191 Pubmed reference(s) in Entrez
CoreMineIL6ST
iHOPIL6ST
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:52:56 CEST 2014

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