IL6ST (interleukin 6 cytokine family signal transducer)

2003-08-01  

Identity

HGNC
LOCATION
5q11.2
LOCUSID
ALIAS
CD130,CDW130,GP130,HIES4,IL-6RB,sGP130
FUSION GENES

Other Information

Locus ID:

NCBI: 3572
MIM: 600694
HGNC: 6021
Ensembl: ENSG00000134352

Variants:

dbSNP: 3572
ClinVar: 3572
TCGA: ENSG00000134352
COSMIC: IL6ST

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134352ENST00000336909P40189
ENSG00000134352ENST00000381286Q5FC02
ENSG00000134352ENST00000381287P40189
ENSG00000134352ENST00000381293Q5FC05
ENSG00000134352ENST00000381294P40189
ENSG00000134352ENST00000381294A0A0A0N0L2
ENSG00000134352ENST00000381298P40189
ENSG00000134352ENST00000396816Q5FC07
ENSG00000134352ENST00000502326P40189
ENSG00000134352ENST00000503773D6RH03
ENSG00000134352ENST00000522633P40189
ENSG00000134352ENST00000651614A0A494BZU0

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 signalingREACTOMER-HSA-1059683
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
RAF-independent MAPK1/3 activationREACTOMER-HSA-112409
MAPK3 (ERK1) activationREACTOMER-HSA-110056
MAPK1 (ERK2) activationREACTOMER-HSA-112411
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
204538422010Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.480
180600322007Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas.259
147646902004WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.213
269697352016Repurposing the CRISPR-Cas9 system for targeted DNA methylation.178
128297852003Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.169
190205032009Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours.123
127826022003Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.107
249864242014Interleukin-6 and its receptors: a highly regulated and dynamic system.102
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75

Citation

Dessen P

IL6ST (interleukin 6 cytokine family signal transducer)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40964/il6st