Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IL6ST (interleukin 6 signal transducer)

Identity

Other namesCD130
CDW130
GP130
IL-6RB
HGNC (Hugo) IL6ST
LocusID (NCBI) 3572
Atlas_Id 40964
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 55230925 and ends at 55290821 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IL6ST (5q11.2) / ANKRD55 (5q11.2)IL6ST (5q11.2) / BTG2 (1q32.1)IL6ST (5q11.2) / IL6ST (5q11.2)
IL6ST (5q11.2) / KDM1B (6p22.3)RFC2 (7q11.23) / IL6ST (5q11.2)IL6ST 5q11.2 / ANKRD55 5q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Lung: Translocations in Adenocarcinoma

External links

Nomenclature
HGNC (Hugo)IL6ST   6021
Cards
Entrez_Gene (NCBI)IL6ST  3572  interleukin 6 signal transducer
AliasesCD130; CDW130; GP130; IL-6RB
GeneCards (Weizmann)IL6ST
Ensembl hg19 (Hinxton)ENSG00000134352 [Gene_View]  chr5:55230925-55290821 [Contig_View]  IL6ST [Vega]
Ensembl hg38 (Hinxton)ENSG00000134352 [Gene_View]  chr5:55230925-55290821 [Contig_View]  IL6ST [Vega]
ICGC DataPortalENSG00000134352
TCGA cBioPortalIL6ST
AceView (NCBI)IL6ST
Genatlas (Paris)IL6ST
WikiGenes3572
SOURCE (Princeton)IL6ST
Genomic and cartography
GoldenPath hg19 (UCSC)IL6ST  -     chr5:55230925-55290821 -  5q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IL6ST  -     5q11.2   [Description]    (hg38-Dec_2013)
EnsemblIL6ST - 5q11.2 [CytoView hg19]  IL6ST - 5q11.2 [CytoView hg38]
Mapping of homologs : NCBIIL6ST [Mapview hg19]  IL6ST [Mapview hg38]
OMIM600694   
Gene and transcription
Genbank (Entrez)AB015706 AB074172 AB102799 AB102800 AB102801
RefSeq transcript (Entrez)NM_001190981 NM_002184 NM_175767
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_034772 NW_004929322
Consensus coding sequences : CCDS (NCBI)IL6ST
Cluster EST : UnigeneHs.706627 [ NCBI ]
CGAP (NCI)Hs.706627
Alternative Splicing GalleryENSG00000134352
Gene ExpressionIL6ST [ NCBI-GEO ]   IL6ST [ EBI - ARRAY_EXPRESS ]   IL6ST [ SEEK ]   IL6ST [ MEM ]
Gene Expression Viewer (FireBrowse)IL6ST [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3572
GTEX Portal (Tissue expression)IL6ST
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40189 (Uniprot)
NextProtP40189  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40189
Splice isoforms : SwissVarP40189 (Swissvar)
PhosPhoSitePlusP40189
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F2 (PS01353)   
Domains : Interpro (EBI)FN3_dom    Hematopoietin_rcpt_Gp130_CS    Ig-like_fold    IgC2-like_lig-bd    TypeI_recpt_CBD   
Domain families : Pfam (Sanger)fn3 (PF00041)    IL6Ra-bind (PF09240)    Lep_receptor_Ig (PF06328)   
Domain families : Pfam (NCBI)pfam00041    pfam09240    pfam06328   
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM Disease mutations3572
Blocks (Seattle)IL6ST
PDB (SRS)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
PDB (PDBSum)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
PDB (IMB)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
PDB (RSDB)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
Structural Biology KnowledgeBase1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
SCOP (Structural Classification of Proteins)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
CATH (Classification of proteins structures)1BJ8    1BQU    1I1R    1N2Q    1P9M    1PVH    3L5H    3L5I    3L5J   
SuperfamilyP40189
Human Protein AtlasENSG00000134352
Peptide AtlasP40189
HPRD02824
IPIIPI00297124   IPI00939624   IPI00816609   IPI00554478   IPI00554499   IPI00554577   IPI00554518   IPI00554522   IPI00967182   IPI00554459   
Protein Interaction databases
DIP (DOE-UCLA)P40189
IntAct (EBI)P40189
FunCoupENSG00000134352
BioGRIDIL6ST
STRING (EMBL)IL6ST
ZODIACIL6ST
Ontologies - Pathways
QuickGOP40189
Ontology : AmiGOpositive regulation of acute inflammatory response  positive regulation of adaptive immune response  ciliary neurotrophic factor receptor activity  interleukin-6 receptor activity  interleukin-11 receptor activity  leukemia inhibitory factor receptor activity  oncostatin-M receptor activity  ciliary neurotrophic factor receptor binding  interleukin-6 receptor binding  protein binding  extracellular region  extracellular space  plasma membrane  interleukin-6 receptor complex  oncostatin-M receptor complex  glycogen metabolic process  positive regulation of cell proliferation  positive regulation of cell proliferation  regulation of Notch signaling pathway  external side of plasma membrane  positive regulation of vascular endothelial growth factor production  positive regulation of cardiac muscle hypertrophy  membrane  viral process  cytokine-mediated signaling pathway  growth factor binding  growth factor binding  interleukin-11 binding  interleukin-6 binding  dendrite  response to cytokine  interleukin-11-mediated signaling pathway  oncostatin-M-mediated signaling pathway  positive regulation of T cell proliferation  positive regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of tyrosine phosphorylation of Stat3 protein  protein homodimerization activity  neuronal cell body  negative regulation of apoptotic process  interleukin-27 receptor activity  positive regulation of osteoblast differentiation  positive regulation of astrocyte differentiation  leukemia inhibitory factor signaling pathway  extracellular exosome  interleukin-6-mediated signaling pathway  negative regulation of interleukin-6-mediated signaling pathway  interleukin-27-mediated signaling pathway  ciliary neurotrophic factor receptor complex  ciliary neurotrophic factor-mediated signaling pathway  
Ontology : EGO-EBIpositive regulation of acute inflammatory response  positive regulation of adaptive immune response  ciliary neurotrophic factor receptor activity  interleukin-6 receptor activity  interleukin-11 receptor activity  leukemia inhibitory factor receptor activity  oncostatin-M receptor activity  ciliary neurotrophic factor receptor binding  interleukin-6 receptor binding  protein binding  extracellular region  extracellular space  plasma membrane  interleukin-6 receptor complex  oncostatin-M receptor complex  glycogen metabolic process  positive regulation of cell proliferation  positive regulation of cell proliferation  regulation of Notch signaling pathway  external side of plasma membrane  positive regulation of vascular endothelial growth factor production  positive regulation of cardiac muscle hypertrophy  membrane  viral process  cytokine-mediated signaling pathway  growth factor binding  growth factor binding  interleukin-11 binding  interleukin-6 binding  dendrite  response to cytokine  interleukin-11-mediated signaling pathway  oncostatin-M-mediated signaling pathway  positive regulation of T cell proliferation  positive regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of tyrosine phosphorylation of Stat3 protein  protein homodimerization activity  neuronal cell body  negative regulation of apoptotic process  interleukin-27 receptor activity  positive regulation of osteoblast differentiation  positive regulation of astrocyte differentiation  leukemia inhibitory factor signaling pathway  extracellular exosome  interleukin-6-mediated signaling pathway  negative regulation of interleukin-6-mediated signaling pathway  interleukin-27-mediated signaling pathway  ciliary neurotrophic factor receptor complex  ciliary neurotrophic factor-mediated signaling pathway  
Pathways : BIOCARTAIL 6 signaling pathway [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Viral carcinogenesis   
NDEx Network
Atlas of Cancer Signalling NetworkIL6ST
Wikipedia pathwaysIL6ST
Orthology - Evolution
OrthoDB3572
GeneTree (enSembl)ENSG00000134352
Phylogenetic Trees/Animal Genes : TreeFamIL6ST
Homologs : HomoloGeneIL6ST
Homology/Alignments : Family Browser (UCSC)IL6ST
Gene fusions - Rearrangements
Fusion: TCGAIL6ST 5q11.2 ANKRD55 5q11.2 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerIL6ST [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL6ST
dbVarIL6ST
ClinVarIL6ST
1000_GenomesIL6ST 
Exome Variant ServerIL6ST
ExAC (Exome Aggregation Consortium)IL6ST (select the gene name)
Genetic variants : HAPMAP3572
Genomic Variants (DGV)IL6ST [DGVbeta]
Mutations
ICGC Data PortalIL6ST 
TCGA Data PortalIL6ST 
Broad Tumor PortalIL6ST
OASIS PortalIL6ST [ Somatic mutations - Copy number]
Cancer Gene: CensusIL6ST 
Somatic Mutations in Cancer : COSMICIL6ST 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL6ST
DgiDB (Drug Gene Interaction Database)IL6ST
DoCM (Curated mutations)IL6ST (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL6ST (select a term)
intoGenIL6ST
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)5:55230925-55290821  ENSG00000134352
CONAN: Copy Number AnalysisIL6ST 
Mutations and Diseases : HGMDIL6ST
OMIM600694   
MedgenIL6ST
Genetic Testing Registry IL6ST
NextProtP40189 [Medical]
TSGene3572
GENETestsIL6ST
Huge Navigator IL6ST [HugePedia]
snp3D : Map Gene to Disease3572
BioCentury BCIQIL6ST
ClinGenIL6ST
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3572
Chemical/Pharm GKB GenePA29837
Clinical trialIL6ST
Miscellaneous
canSAR (ICR)IL6ST (select the gene name)
Probes
Litterature
PubMed218 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL6ST
EVEXIL6ST
GoPubMedIL6ST
iHOPIL6ST
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:04:25 CEST 2016

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