Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IL7 (interleukin 7)

Identity

Alias_symbol (synonym)IL-7
Other alias
HGNC (Hugo) IL7
LocusID (NCBI) 3574
Atlas_Id 43614
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 78732772 and ends at 78805523 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
JAZF1 (7p15.2) / IL7 (8q21.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL7   6023
Cards
Entrez_Gene (NCBI)IL7  3574  interleukin 7
AliasesIL-7
GeneCards (Weizmann)IL7
Ensembl hg19 (Hinxton)ENSG00000104432 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104432 [Gene_View]  ENSG00000104432 [Sequence]  chr8:78732772-78805523 [Contig_View]  IL7 [Vega]
ICGC DataPortalENSG00000104432
TCGA cBioPortalIL7
AceView (NCBI)IL7
Genatlas (Paris)IL7
WikiGenes3574
SOURCE (Princeton)IL7
Genetics Home Reference (NIH)IL7
Genomic and cartography
GoldenPath hg38 (UCSC)IL7  -     chr8:78732772-78805523 -  5q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL7  -     5q11.2   [Description]    (hg19-Feb_2009)
EnsemblIL7 - 5q11.2 [CytoView hg19]  IL7 - 5q11.2 [CytoView hg38]
Mapping of homologs : NCBIIL7 [Mapview hg19]  IL7 [Mapview hg38]
OMIM146660   
Gene and transcription
Genbank (Entrez)AB102879 AB102880 AB102882 AB102883 AB102885
RefSeq transcript (Entrez)NM_000880 NM_001199886 NM_001199887 NM_001199888
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL7
Cluster EST : UnigeneHs.591873 [ NCBI ]
CGAP (NCI)Hs.591873
Alternative Splicing GalleryENSG00000104432
Gene ExpressionIL7 [ NCBI-GEO ]   IL7 [ EBI - ARRAY_EXPRESS ]   IL7 [ SEEK ]   IL7 [ MEM ]
Gene Expression Viewer (FireBrowse)IL7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3574
GTEX Portal (Tissue expression)IL7
Human Protein AtlasENSG00000104432-IL7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13232   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13232  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13232
Splice isoforms : SwissVarP13232
PhosPhoSitePlusP13232
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_7_9 (PS00255)   
Domains : Interpro (EBI)IL-7    IL-7/IL-9_CS    IL-7/IL-9_fam    IL7_sf   
Domain families : Pfam (Sanger)IL7 (PF01415)   
Domain families : Pfam (NCBI)pfam01415   
Domain families : Smart (EMBL)IL7 (SM00127)  
Conserved Domain (NCBI)IL7
DMDM Disease mutations3574
Blocks (Seattle)IL7
PDB (SRS)1IL7    3DI2    3DI3   
PDB (PDBSum)1IL7    3DI2    3DI3   
PDB (IMB)1IL7    3DI2    3DI3   
PDB (RSDB)1IL7    3DI2    3DI3   
Structural Biology KnowledgeBase1IL7    3DI2    3DI3   
SCOP (Structural Classification of Proteins)1IL7    3DI2    3DI3   
CATH (Classification of proteins structures)1IL7    3DI2    3DI3   
SuperfamilyP13232
Human Protein Atlas [tissue]ENSG00000104432-IL7 [tissue]
Peptide AtlasP13232
HPRD00892
IPIIPI00007748   IPI00982118   IPI00983308   IPI00554803   IPI00744116   
Protein Interaction databases
DIP (DOE-UCLA)P13232
IntAct (EBI)P13232
FunCoupENSG00000104432
BioGRIDIL7
STRING (EMBL)IL7
ZODIACIL7
Ontologies - Pathways
QuickGOP13232
Ontology : AmiGOpositive regulation of cytokine-mediated signaling pathway  T cell lineage commitment  cytokine activity  interleukin-7 receptor binding  protein binding  extracellular region  extracellular region  extracellular space  humoral immune response  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  animal organ morphogenesis  regulation of gene expression  regulation of signaling receptor activity  cytokine-mediated signaling pathway  positive regulation of B cell proliferation  positive regulation of chemokine production  interleukin-7-mediated signaling pathway  negative regulation of apoptotic process  negative regulation of catalytic activity  bone resorption  positive regulation of T cell differentiation  positive regulation of organ growth  homeostasis of number of cells within a tissue  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIpositive regulation of cytokine-mediated signaling pathway  T cell lineage commitment  cytokine activity  interleukin-7 receptor binding  protein binding  extracellular region  extracellular region  extracellular space  humoral immune response  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  animal organ morphogenesis  regulation of gene expression  regulation of signaling receptor activity  cytokine-mediated signaling pathway  positive regulation of B cell proliferation  positive regulation of chemokine production  interleukin-7-mediated signaling pathway  negative regulation of apoptotic process  negative regulation of catalytic activity  bone resorption  positive regulation of T cell differentiation  positive regulation of organ growth  homeostasis of number of cells within a tissue  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Hematopoietic cell lineage   
NDEx NetworkIL7
Atlas of Cancer Signalling NetworkIL7
Wikipedia pathwaysIL7
Orthology - Evolution
OrthoDB3574
GeneTree (enSembl)ENSG00000104432
Phylogenetic Trees/Animal Genes : TreeFamIL7
HOVERGENP13232
HOGENOMP13232
Homologs : HomoloGeneIL7
Homology/Alignments : Family Browser (UCSC)IL7
Gene fusions - Rearrangements
Fusion : QuiverIL7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL7
dbVarIL7
ClinVarIL7
1000_GenomesIL7 
Exome Variant ServerIL7
ExAC (Exome Aggregation Consortium)ENSG00000104432
GNOMAD BrowserENSG00000104432
Varsome BrowserIL7
Genetic variants : HAPMAP3574
Genomic Variants (DGV)IL7 [DGVbeta]
DECIPHERIL7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL7 
Mutations
ICGC Data PortalIL7 
TCGA Data PortalIL7 
Broad Tumor PortalIL7
OASIS PortalIL7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL7
DgiDB (Drug Gene Interaction Database)IL7
DoCM (Curated mutations)IL7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL7 (select a term)
intoGenIL7
Cancer3DIL7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146660   
Orphanet
DisGeNETIL7
MedgenIL7
Genetic Testing Registry IL7
NextProtP13232 [Medical]
TSGene3574
GENETestsIL7
Target ValidationIL7
Huge Navigator IL7 [HugePedia]
snp3D : Map Gene to Disease3574
BioCentury BCIQIL7
ClinGenIL7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3574
Chemical/Pharm GKB GenePA29839
Clinical trialIL7
Miscellaneous
canSAR (ICR)IL7 (select the gene name)
Probes
Litterature
PubMed239 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL7
EVEXIL7
GoPubMedIL7
iHOPIL7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 11:08:17 CEST 2018
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