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IL8 (interleukin 8)

Identity

Other namesCXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
HGNC (Hugo) IL8
LocusID (NCBI) 3576
Location 4q13.3
Location_base_pair Starts at 74606223 and ends at 74609433 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL8   6025
Cards
Entrez_Gene (NCBI)IL8  3576  interleukin 8
GeneCards (Weizmann)IL8
Ensembl (Hinxton)ENSG00000169429 [Gene_View]  chr4:74606223-74609433 [Contig_View]  IL8 [Vega]
AceView (NCBI)IL8
Genatlas (Paris)IL8
WikiGenes3576
SOURCE (Princeton)NM_000584
Genomic and cartography
GoldenPath (UCSC)IL8  -  4q13.3   chr4:74606223-74609433 +  4q13.3   [Description]    (hg19-Feb_2009)
EnsemblIL8 - 4q13.3 [CytoView]
Mapping of homologs : NCBIIL8 [Mapview]
OMIM146930   
Gene and transcription
Genbank (Entrez)AJ227913 AK131067 AK311874 BC013615 BG497712
RefSeq transcript (Entrez)NM_000584
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NG_029889 NT_022778 NW_001838914 NW_004929320
Consensus coding sequences : CCDS (NCBI)IL8
Cluster EST : UnigeneHs.624 [ NCBI ]
CGAP (NCI)Hs.624
Alternative Splicing : Fast-db (Paris)GSHG0022655
Alternative Splicing GalleryENSG00000169429
Gene ExpressionIL8 [ NCBI-GEO ]     IL8 [ SEEK ]   IL8 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10145 (Uniprot)
NextProtP10145  [Medical]
With graphics : InterProP10145
Splice isoforms : SwissVarP10145 (Swissvar)
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CXC (PS00471)   
Domains : Interpro (EBI)Chemokine_CXC    Chemokine_CXC_CS    Chemokine_IL8-like_dom   
Related proteins : CluSTrP10145
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
DMDM Disease mutations3576
Blocks (Seattle)P10145
PDB (SRS)1ICW    1IKL    1IKM    1IL8    1ILP    1ILQ    1QE6    1ROD    2IL8    3IL8   
PDB (PDBSum)1ICW    1IKL    1IKM    1IL8    1ILP    1ILQ    1QE6    1ROD    2IL8    3IL8   
PDB (IMB)1ICW    1IKL    1IKM    1IL8    1ILP    1ILQ    1QE6    1ROD    2IL8    3IL8   
PDB (RSDB)1ICW    1IKL    1IKM    1IL8    1ILP    1ILQ    1QE6    1ROD    2IL8    3IL8   
Human Protein AtlasENSG00000169429
Peptide AtlasP10145
HPRD00909
IPIIPI00288914   IPI00215621   IPI00894389   
Protein Interaction databases
DIP (DOE-UCLA)P10145
IntAct (EBI)P10145
FunCoupENSG00000169429
BioGRIDIL8
InParanoidP10145
Interologous Interaction database P10145
IntegromeDBIL8
STRING (EMBL)IL8
Ontologies - Pathways
Ontology : AmiGOangiogenesis  response to molecule of bacterial origin  interleukin-8 receptor binding  protein binding  extracellular region  extracellular space  cellular component movement  inflammatory response  immune response  activation of signaling protein activity involved in unfolded protein response  cell cycle arrest  signal transduction  G-protein coupled receptor signaling pathway  chemokine activity  negative regulation of cell proliferation  calcium-mediated signaling  regulation of cell adhesion  neutrophil chemotaxis  endoplasmic reticulum unfolded protein response  receptor internalization  response to endoplasmic reticulum stress  intracellular signal transduction  neutrophil activation  cellular protein metabolic process  cellular response to fibroblast growth factor stimulus  regulation of single stranded viral RNA replication via double stranded DNA intermediate  negative regulation of G-protein coupled receptor protein signaling pathway  embryonic digestive tract development  induction of positive chemotaxis  cellular response to lipopolysaccharide  cellular response to interleukin-1  cellular response to tumor necrosis factor  positive regulation of neutrophil chemotaxis  
Ontology : EGO-EBIangiogenesis  response to molecule of bacterial origin  interleukin-8 receptor binding  protein binding  extracellular region  extracellular space  cellular component movement  inflammatory response  immune response  activation of signaling protein activity involved in unfolded protein response  cell cycle arrest  signal transduction  G-protein coupled receptor signaling pathway  chemokine activity  negative regulation of cell proliferation  calcium-mediated signaling  regulation of cell adhesion  neutrophil chemotaxis  endoplasmic reticulum unfolded protein response  receptor internalization  response to endoplasmic reticulum stress  intracellular signal transduction  neutrophil activation  cellular protein metabolic process  cellular response to fibroblast growth factor stimulus  regulation of single stranded viral RNA replication via double stranded DNA intermediate  negative regulation of G-protein coupled receptor protein signaling pathway  embryonic digestive tract development  induction of positive chemotaxis  cellular response to lipopolysaccharide  cellular response to interleukin-1  cellular response to tumor necrosis factor  positive regulation of neutrophil chemotaxis  
Pathways : BIOCARTAFree Radical Induced Apoptosis [Genes]    Proepithelin Conversion to Epithelin and Wound Repair Control [Genes]    Cytokine Network [Genes]    IL 17 Signaling Pathway [Genes]    Cytokines and Inflammatory Response [Genes]    Adhesion and Diapedesis of Granulocytes [Genes]    Regulation of hematopoiesis by cytokines [Genes]    Cells and Molecules involved in local acute inflammatory response [Genes]    Adhesion and Diapedesis of Lymphocytes [Genes]    NFkB activation by Nontypeable Hemophilus influenzae [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    NF-kappa B signaling pathway    Toll-like receptor signaling pathway    NOD-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Epithelial cell signaling in Helicobacter pylori infection    Shigellosis    Salmonella infection    Pertussis    Legionellosis    Chagas disease (American trypanosomiasis)    Malaria    Amoebiasis    Hepatitis C    Hepatitis B    Influenza A    Pathways in cancer    Transcriptional misregulation in cancer    Bladder cancer    Rheumatoid arthritis   
REACTOMEIL8
Protein Interaction DatabaseIL8
Wikipedia pathwaysIL8
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IL8
SNP (GeneSNP Utah)IL8
SNP : HGBaseIL8
Genetic variants : HAPMAPIL8
1000_GenomesIL8 
ICGC programENSG00000169429 
Somatic Mutations in Cancer : COSMICIL8 
CONAN: Copy Number AnalysisIL8 
Mutations and Diseases : HGMDIL8
OMIM146930   
GENETestsIL8
Disease Genetic AssociationIL8
Huge Navigator IL8 [HugePedia]  IL8 [HugeCancerGEM]
Genomic VariantsIL8  IL8 [DGVbeta]
Exome VariantIL8
dbVarIL8
ClinVarIL8
snp3D : Map Gene to Disease3576
General knowledge
Homologs : HomoloGeneIL8
Homology/Alignments : Family Browser (UCSC)IL8
Phylogenetic Trees/Animal Genes : TreeFamIL8
Chemical/Protein Interactions : CTD3576
Chemical/Pharm GKB GenePA29841
Clinical trialIL8
Cancer Resource (Charite)ENSG00000169429
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineIL8
iHOPIL8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:55:35 CEST 2014

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