ILK (integrin-linked kinase)

Identity

Other names	DKFZp686F1765
	P59
HGNC	ILK
Location	11p15.4
Location_base_pair	Starts at 6581540 and ends at 6588675 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ILK   6040
Entrez_Gene	ILK  3611  integrin-linked kinase
	Cards
GeneCards	ILK
Ensembl	ILK [Search_View]   ENSG00000166333 [Gene_View]
Genatlas	ILK
GeneLynx	ILK
eGenome	ILK
euGene	3611
	Genomic and cartography
GoldenPath	ILK  -  11p15.4   chr11:6581540-6588675 +  11p15.4   [Description]    (hg18-March_2006)
Ensembl	ILK - 11p15.4 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ILK
	Gene and transcription
Genbank	AB209416 [ ENTREZ ]
Genbank	AK314843 [ ENTREZ ]
Genbank	BC001554 [ ENTREZ ]
Genbank	CB113885 [ ENTREZ ]
Genbank	CR407673 [ ENTREZ ]
RefSeq	NM_001014794 [ SRS ]    NM_001014794 [ ENTREZ ]
RefSeq	NM_001014795 [ SRS ]    NM_001014795 [ ENTREZ ]
RefSeq	NM_004517 [ SRS ]    NM_004517 [ ENTREZ ]
RefSeq	AC_000054 [ SRS ]    AC_000054 [ ENTREZ ]
RefSeq	AC_000143 [ SRS ]    AC_000143 [ ENTREZ ]
RefSeq	NC_000011 [ SRS ]    NC_000011 [ ENTREZ ]
RefSeq	NT_009237 [ SRS ]    NT_009237 [ ENTREZ ]
RefSeq	NW_001838021 [ SRS ]    NW_001838021 [ ENTREZ ]
RefSeq	NW_925006 [ SRS ]    NW_925006 [ ENTREZ ]
AceView	ILK AceView - NCBI
Unigene	Hs.713573 [ SRS ]    Hs.713573 [ NCBI ]     HS713573 [ spliceNest ]
Fast-db	2113 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q13418 [ SRS]    Q13418 [ EXPASY ]     Q13418 [ INTERPRO ]     Q13418 [ UNIPROT ]
Prosite	PS50297 ANK_REP_REGION [ SRS ]    PS50297 ANK_REP_REGION [ Expasy ]
Prosite	PS50088 ANK_REPEAT [ SRS ]    PS50088 ANK_REPEAT [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR002110 ANK [ SRS ]    IPR002110 ANK [ EBI ]
Interpro	IPR016253 Integrin-linked_kinase [ SRS ]    IPR016253 Integrin-linked_kinase [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
CluSTr	Q13418
Pfam	PF00023 Ank [ SRS ]    PF00023 Ank [ Sanger ]    pfam00023 [ NCBI-CDD ]
Pfam	PF07714 Pkinase_Tyr [ SRS ]    PF07714 Pkinase_Tyr [ Sanger ]    pfam07714 [ NCBI-CDD ]
Smart	SM00248 ANK [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	Q13418 ILK_HUMAN [ Domain structure ]   Q13418 ILK_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q13418
HPRD	03842
	Protein Interaction databases
DIP	Q13418
IntAct	Q13418
	Polymorphism : SNP, mutations, diseases
OMIM	602366    [ map ]
GENECLINICS	602366
SNP	ILK [dbSNP-NCBI]
SNP	NM_001014794 [SNP-NCI]
SNP	NM_001014795 [SNP-NCI]
SNP	NM_004517 [SNP-NCI]
SNP	ILK [GeneSNPs - Utah]  ILK] [HGBASE - SRS]
HAPMAP	ILK [HAPMAP]
COSMIC	ILK [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ILK
	General knowledge
Family Browser	ILK [UCSC Family Browser]
SOURCE	NM_001014794
SOURCE	NM_001014795
SOURCE	NM_004517
SMD	Hs.713573
SAGE	Hs.713573
Enzyme	2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   2.7.11.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	ureteric bud branching [Amigo]  ureteric bud branching
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	protein tyrosine kinase activity [Amigo]  protein tyrosine kinase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	cytoplasm [Amigo]  cytoplasm
GO	plasma membrane [Amigo]  plasma membrane
GO	focal adhesion [Amigo]  focal adhesion
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	cell-matrix adhesion [Amigo]  cell-matrix adhesion
GO	integrin-mediated signaling pathway [Amigo]  integrin-mediated signaling pathway
GO	integrin-mediated signaling pathway [Amigo]  integrin-mediated signaling pathway
GO	positive regulation of cell proliferation [Amigo]  positive regulation of cell proliferation
GO	kinase activity [Amigo]  kinase activity
GO	transferase activity [Amigo]  transferase activity
GO	cell junction [Amigo]  cell junction
GO	establishment and/or maintenance of epithelial cell apical/basal polarity [Amigo]  establishment and/or maintenance of epithelial cell apical/basal polarity
BIOCARTA	PTEN dependent cell cycle arrest and apoptosis    [Genes]
KEGG	PPAR signaling pathway
KEGG	Focal adhesion
PubGene	ILK
TreeFam	ILK
CTD	3611 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ILK Related clones (RZPD - Berlin)
	PubMed
PubMed	97 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:46:34 2008