ILKAP (ILK associated serine/threonine phosphatase)

2015-06-01  

Identity

HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
ILKAP2,ILKAP3,PP2C-DELTA,PP2CD,PPM1O
FUSION GENES

Other Information

Locus ID:

NCBI: 80895
MIM: 618909
HGNC: 15566
Ensembl: ENSG00000132323

Variants:

dbSNP: 80895
ClinVar: 80895
TCGA: ENSG00000132323
COSMIC: ILKAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132323ENST00000254654Q9H0C8
ENSG00000132323ENST00000450411H7C2I8
ENSG00000132323ENST00000457149E9PC05
ENSG00000132323ENST00000612675F8SNU6
ENSG00000132323ENST00000622223F8SNU7

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447288Essential hypertensionDiseaseClinicalAnnotationassociatedPD
PA449899hydrochlorothiazideChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
264606182015ILKAP, ILK and PINCH1 control cell survival of p53-wildtype glioblastoma cells after irradiation.6
233298452013Characterization of nuclear localization signal in the N terminus of integrin-linked kinase-associated phosphatase (ILKAP) and its essential role in the down-regulation of RSK2 protein signaling.3
217827892011Palladin is a novel binding partner of ILKAP in eukaryotic cells.2
247431862014Involvement of ANXA5 and ILKAP in susceptibility to malignant melanoma.2
258724522015Endometrial ILKAP expression among patients with endometriosis and its association with clinical characteristics.0
297424942018ILKAP Binding to and Dephosphorylating HIF-1α is Essential for Apoptosis Induced by Severe Hypoxia.0

Citation

Dessen P

ILKAP (ILK associated serine/threonine phosphatase)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/55279/ilkap