IMPA1 (inositol monophosphatase 1)

2003-05-01 Affiliation

Identity

HGNC

IMPA1

LOCATION

8q21.13

LOCUSID

3612

ALIAS

IMP,IMPA,MRT59

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3612
MIM: 602064
HGNC: 6050
Ensembl: ENSG00000133731

Variants:

dbSNP: 3612
ClinVar: 3612
TCGA: ENSG00000133731
COSMIC: IMPA1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000133731	ENST00000256108	P29218
ENSG00000133731	ENST00000256108	A0A024R830
ENSG00000133731	ENST00000311489	P29218
ENSG00000133731	ENST00000449740	P29218
ENSG00000133731	ENST00000449740	A0A140VJL8
ENSG00000133731	ENST00000518188	E5RG94
ENSG00000133731	ENST00000518202	E5RI82
ENSG00000133731	ENST00000519816	E5RHE9
ENSG00000133731	ENST00000519964	E5RIP7
ENSG00000133731	ENST00000521360	E5RG13
ENSG00000133731	ENST00000521979	E5RIF4
ENSG00000133731	ENST00000522997	E5RGY4
ENSG00000133731	ENST00000523942	H0YBL1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Inositol phosphate metabolism	KEGG	ko00562
Phosphatidylinositol signaling system	KEGG	ko04070
Inositol phosphate metabolism	KEGG	hsa00562
Phosphatidylinositol signaling system	KEGG	hsa04070
Metabolic pathways	KEGG	hsa01100
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol	KEGG	hsa_M00131
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol	KEGG	M00131
Metabolism	REACTOME	R-HSA-1430728
Inositol phosphate metabolism	REACTOME	R-HSA-1483249
Synthesis of IP2, IP, and Ins in the cytosol	REACTOME	R-HSA-1855183

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17068342	2007	Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.	20
14699425	2004	Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder.	19
20153384	2010	Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2.	6
23027737	2012	Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.	5
26416544	2016	A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability.	3
27440438	2016	Multibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme.	3
30289407	2018	Co-crystallization of human inositol monophosphatase with the lithium mimetic L-690,330.	0
30616629	2019	Loss-of-function mutation in inositol monophosphatase 1 (IMPA1) results in abnormal synchrony in resting-state EEG.	0

Citation

Dessen P

IMPA1 (inositol monophosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40971/impa1