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IMPA2 (inositol monophosphatase 2)

Identity

Alias_namesinositol(myo)-1(or 4)-monophosphatase 2
Other alias-
HGNC (Hugo) IMPA2
LocusID (NCBI) 3613
Atlas_Id 46987
Location 18p11.21  [Link to chromosome band 18p11]
Location_base_pair Starts at 11981427 and ends at 12030885 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LDLRAD4 (18p11.21) / IMPA2 (18p11.21)LILRB4 (19q13.42) / IMPA2 (18p11.21)NUCB2 (11p15.1) / IMPA2 (18p11.21)
C18orf1 IMPA2 18p11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IMPA2   6051
Cards
Entrez_Gene (NCBI)IMPA2  3613  inositol monophosphatase 2
Aliases
GeneCards (Weizmann)IMPA2
Ensembl hg19 (Hinxton)ENSG00000141401 [Gene_View]  chr18:11981427-12030885 [Contig_View]  IMPA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000141401 [Gene_View]  chr18:11981427-12030885 [Contig_View]  IMPA2 [Vega]
ICGC DataPortalENSG00000141401
TCGA cBioPortalIMPA2
AceView (NCBI)IMPA2
Genatlas (Paris)IMPA2
WikiGenes3613
SOURCE (Princeton)IMPA2
Genetics Home Reference (NIH)IMPA2
Genomic and cartography
GoldenPath hg19 (UCSC)IMPA2  -     chr18:11981427-12030885 +  18p11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IMPA2  -     18p11.21   [Description]    (hg38-Dec_2013)
EnsemblIMPA2 - 18p11.21 [CytoView hg19]  IMPA2 - 18p11.21 [CytoView hg38]
Mapping of homologs : NCBIIMPA2 [Mapview hg19]  IMPA2 [Mapview hg38]
OMIM605922   
Gene and transcription
Genbank (Entrez)AF014398 AF200432 BC017176 BC031560 BE219864
RefSeq transcript (Entrez)NM_014214
RefSeq genomic (Entrez)NC_000018 NC_018929 NG_028104 NT_010859 NW_004929409
Consensus coding sequences : CCDS (NCBI)IMPA2
Cluster EST : UnigeneHs.743311 [ NCBI ]
CGAP (NCI)Hs.743311
Alternative Splicing GalleryENSG00000141401
Gene ExpressionIMPA2 [ NCBI-GEO ]   IMPA2 [ EBI - ARRAY_EXPRESS ]   IMPA2 [ SEEK ]   IMPA2 [ MEM ]
Gene Expression Viewer (FireBrowse)IMPA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3613
GTEX Portal (Tissue expression)IMPA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14732   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14732  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14732
Splice isoforms : SwissVarO14732
Catalytic activity : Enzyme3.1.3.25 [ Enzyme-Expasy ]   3.1.3.253.1.3.25 [ IntEnz-EBI ]   3.1.3.25 [ BRENDA ]   3.1.3.25 [ KEGG ]   
PhosPhoSitePlusO14732
Domaine pattern : Prosite (Expaxy)IMP_1 (PS00629)    IMP_2 (PS00630)   
Domains : Interpro (EBI)Inositol_monoP_metal-BS    Inositol_monoPase_Li-sen    Inositol_monophosphatase    Inositol_monophosphatase_CS   
Domain families : Pfam (Sanger)Inositol_P (PF00459)   
Domain families : Pfam (NCBI)pfam00459   
Conserved Domain (NCBI)IMPA2
DMDM Disease mutations3613
Blocks (Seattle)IMPA2
PDB (SRS)2CZH    2CZI    2CZK    2DDK    2FVZ   
PDB (PDBSum)2CZH    2CZI    2CZK    2DDK    2FVZ   
PDB (IMB)2CZH    2CZI    2CZK    2DDK    2FVZ   
PDB (RSDB)2CZH    2CZI    2CZK    2DDK    2FVZ   
Structural Biology KnowledgeBase2CZH    2CZI    2CZK    2DDK    2FVZ   
SCOP (Structural Classification of Proteins)2CZH    2CZI    2CZK    2DDK    2FVZ   
CATH (Classification of proteins structures)2CZH    2CZI    2CZK    2DDK    2FVZ   
SuperfamilyO14732
Human Protein AtlasENSG00000141401
Peptide AtlasO14732
HPRD09329
IPIIPI00023635   IPI00555726   IPI00448781   
Protein Interaction databases
DIP (DOE-UCLA)O14732
IntAct (EBI)O14732
FunCoupENSG00000141401
BioGRIDIMPA2
STRING (EMBL)IMPA2
ZODIACIMPA2
Ontologies - Pathways
QuickGOO14732
Ontology : AmiGOmagnesium ion binding  protein binding  cytoplasm  cytosol  inositol metabolic process  inositol biosynthetic process  phosphate-containing compound metabolic process  signal transduction  inositol monophosphate 1-phosphatase activity  inositol monophosphate 1-phosphatase activity  protein homodimerization activity  inositol phosphate metabolic process  phosphatidylinositol phosphorylation  inositol phosphate dephosphorylation  inositol monophosphate 3-phosphatase activity  inositol monophosphate 4-phosphatase activity  
Ontology : EGO-EBImagnesium ion binding  protein binding  cytoplasm  cytosol  inositol metabolic process  inositol biosynthetic process  phosphate-containing compound metabolic process  signal transduction  inositol monophosphate 1-phosphatase activity  inositol monophosphate 1-phosphatase activity  protein homodimerization activity  inositol phosphate metabolic process  phosphatidylinositol phosphorylation  inositol phosphate dephosphorylation  inositol monophosphate 3-phosphatase activity  inositol monophosphate 4-phosphatase activity  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx NetworkIMPA2
Atlas of Cancer Signalling NetworkIMPA2
Wikipedia pathwaysIMPA2
Orthology - Evolution
OrthoDB3613
GeneTree (enSembl)ENSG00000141401
Phylogenetic Trees/Animal Genes : TreeFamIMPA2
HOVERGENO14732
HOGENOMO14732
Homologs : HomoloGeneIMPA2
Homology/Alignments : Family Browser (UCSC)IMPA2
Gene fusions - Rearrangements
Fusion : MitelmanLDLRAD4/IMPA2 [18p11.21/18p11.21]  [t(18;18)(p11;p11)]  
Fusion: TCGAC18orf1 IMPA2 18p11.21 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIMPA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IMPA2
dbVarIMPA2
ClinVarIMPA2
1000_GenomesIMPA2 
Exome Variant ServerIMPA2
ExAC (Exome Aggregation Consortium)IMPA2 (select the gene name)
Genetic variants : HAPMAP3613
Genomic Variants (DGV)IMPA2 [DGVbeta]
DECIPHER (Syndromes)18:11981427-12030885  ENSG00000141401
CONAN: Copy Number AnalysisIMPA2 
Mutations
ICGC Data PortalIMPA2 
TCGA Data PortalIMPA2 
Broad Tumor PortalIMPA2
OASIS PortalIMPA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIMPA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIMPA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IMPA2
DgiDB (Drug Gene Interaction Database)IMPA2
DoCM (Curated mutations)IMPA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IMPA2 (select a term)
intoGenIMPA2
Cancer3DIMPA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605922   
Orphanet
MedgenIMPA2
Genetic Testing Registry IMPA2
NextProtO14732 [Medical]
TSGene3613
GENETestsIMPA2
Huge Navigator IMPA2 [HugePedia]
snp3D : Map Gene to Disease3613
BioCentury BCIQIMPA2
ClinGenIMPA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3613
Chemical/Pharm GKB GenePA29861
Clinical trialIMPA2
Miscellaneous
canSAR (ICR)IMPA2 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIMPA2
EVEXIMPA2
GoPubMedIMPA2
iHOPIMPA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:05:13 CEST 2017

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