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IMPACT (impact RWD domain protein)

Identity

Alias_namesImpact homolog (mouse)
Alias_symbol (synonym)RWDD5
Other alias
HGNC (Hugo) IMPACT
LocusID (NCBI) 55364
Atlas_Id 64610
Location 18q11.2  [Link to chromosome band 18q11]
Location_base_pair Starts at 24426645 and ends at 24453530 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IMPACT (18q11.2) / DPY19L4 (8q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IMPACT   20387
Cards
Entrez_Gene (NCBI)IMPACT  55364  impact RWD domain protein
AliasesRWDD5
GeneCards (Weizmann)IMPACT
Ensembl hg19 (Hinxton)ENSG00000154059 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154059 [Gene_View]  chr18:24426645-24453530 [Contig_View]  IMPACT [Vega]
ICGC DataPortalENSG00000154059
TCGA cBioPortalIMPACT
AceView (NCBI)IMPACT
Genatlas (Paris)IMPACT
WikiGenes55364
SOURCE (Princeton)IMPACT
Genetics Home Reference (NIH)IMPACT
Genomic and cartography
GoldenPath hg38 (UCSC)IMPACT  -     chr18:24426645-24453530 +  18q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IMPACT  -     18q11.2   [Description]    (hg19-Feb_2009)
EnsemblIMPACT - 18q11.2 [CytoView hg19]  IMPACT - 18q11.2 [CytoView hg38]
Mapping of homologs : NCBIIMPACT [Mapview hg19]  IMPACT [Mapview hg38]
OMIM615319   
Gene and transcription
Genbank (Entrez)AB026264 AF208694 AK292533 AK312727 BC034016
RefSeq transcript (Entrez)NM_018439
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IMPACT
Cluster EST : UnigeneHs.515317 [ NCBI ]
CGAP (NCI)Hs.515317
Alternative Splicing GalleryENSG00000154059
Gene ExpressionIMPACT [ NCBI-GEO ]   IMPACT [ EBI - ARRAY_EXPRESS ]   IMPACT [ SEEK ]   IMPACT [ MEM ]
Gene Expression Viewer (FireBrowse)IMPACT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55364
GTEX Portal (Tissue expression)IMPACT
Human Protein AtlasENSG00000154059-IMPACT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2X3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2X3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2X3
Splice isoforms : SwissVarQ9P2X3
PhosPhoSitePlusQ9P2X3
Domaine pattern : Prosite (Expaxy)RWD (PS50908)    UPF0029 (PS00910)   
Domains : Interpro (EBI)Impact    Impact_N    Ribosomal_S5_D2-typ_fold    RWD-domain    UBQ-conjugating_enzyme/RWD    UPF0029_Impact_CS   
Domain families : Pfam (Sanger)RWD (PF05773)    UPF0029 (PF01205)   
Domain families : Pfam (NCBI)pfam05773    pfam01205   
Domain families : Smart (EMBL)RWD (SM00591)  
Conserved Domain (NCBI)IMPACT
DMDM Disease mutations55364
Blocks (Seattle)IMPACT
SuperfamilyQ9P2X3
Human Protein Atlas [tissue]ENSG00000154059-IMPACT [tissue]
Peptide AtlasQ9P2X3
HPRD13739
IPIIPI00020451   IPI00890808   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2X3
IntAct (EBI)Q9P2X3
FunCoupENSG00000154059
BioGRIDIMPACT
STRING (EMBL)IMPACT
ZODIACIMPACT
Ontologies - Pathways
QuickGOQ9P2X3
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  negative regulation of protein phosphorylation  molecular_function  actin binding  cellular_component  cytoplasm  polysome  biological_process  negative regulation of protein complex assembly  negative regulation of protein autophosphorylation  cellular response to amino acid starvation  cellular response to glucose starvation  ribosome binding  positive regulation of neuron differentiation  negative regulation of cell death  regulation of eIF2 alpha phosphorylation by amino acid starvation  cellular response to hydrogen peroxide  positive regulation of translational initiation in response to starvation  cellular response to acidic pH  cellular response to UV-C  cellular response to benomyl  negative regulation of transcription from RNA polymerase II promoter in response to stress  neuron projection extension  cellular response to leucine starvation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  negative regulation of protein phosphorylation  molecular_function  actin binding  cellular_component  cytoplasm  polysome  biological_process  negative regulation of protein complex assembly  negative regulation of protein autophosphorylation  cellular response to amino acid starvation  cellular response to glucose starvation  ribosome binding  positive regulation of neuron differentiation  negative regulation of cell death  regulation of eIF2 alpha phosphorylation by amino acid starvation  cellular response to hydrogen peroxide  positive regulation of translational initiation in response to starvation  cellular response to acidic pH  cellular response to UV-C  cellular response to benomyl  negative regulation of transcription from RNA polymerase II promoter in response to stress  neuron projection extension  cellular response to leucine starvation  
NDEx NetworkIMPACT
Atlas of Cancer Signalling NetworkIMPACT
Wikipedia pathwaysIMPACT
Orthology - Evolution
OrthoDB55364
GeneTree (enSembl)ENSG00000154059
Phylogenetic Trees/Animal Genes : TreeFamIMPACT
HOVERGENQ9P2X3
HOGENOMQ9P2X3
Homologs : HomoloGeneIMPACT
Homology/Alignments : Family Browser (UCSC)IMPACT
Gene fusions - Rearrangements
Tumor Fusion PortalIMPACT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIMPACT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IMPACT
dbVarIMPACT
ClinVarIMPACT
1000_GenomesIMPACT 
Exome Variant ServerIMPACT
ExAC (Exome Aggregation Consortium)ENSG00000154059
GNOMAD BrowserENSG00000154059
Genetic variants : HAPMAP55364
Genomic Variants (DGV)IMPACT [DGVbeta]
DECIPHERIMPACT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIMPACT 
Mutations
ICGC Data PortalIMPACT 
TCGA Data PortalIMPACT 
Broad Tumor PortalIMPACT
OASIS PortalIMPACT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIMPACT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIMPACT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IMPACT
DgiDB (Drug Gene Interaction Database)IMPACT
DoCM (Curated mutations)IMPACT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IMPACT (select a term)
intoGenIMPACT
Cancer3DIMPACT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615319   
Orphanet
DisGeNETIMPACT
MedgenIMPACT
Genetic Testing Registry IMPACT
NextProtQ9P2X3 [Medical]
TSGene55364
GENETestsIMPACT
Target ValidationIMPACT
Huge Navigator IMPACT [HugePedia]
snp3D : Map Gene to Disease55364
BioCentury BCIQIMPACT
ClinGenIMPACT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55364
Chemical/Pharm GKB GenePA143485502
Clinical trialIMPACT
Miscellaneous
canSAR (ICR)IMPACT (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIMPACT
EVEXIMPACT
GoPubMedIMPACT
iHOPIMPACT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:37:30 CET 2017

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