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INHA (inhibin alpha subunit)

Identity

Alias_namesinhibin
Other alias-
HGNC (Hugo) INHA
LocusID (NCBI) 3623
Atlas_Id 506
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 219572232 and ends at 219575713 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;10)(p11;p12) DDX3X/MLLT10


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Ovary: Sex cord-stromal tumors


External links

Nomenclature
HGNC (Hugo)INHA   6065
Cards
Entrez_Gene (NCBI)INHA  3623  inhibin alpha subunit
Aliases
GeneCards (Weizmann)INHA
Ensembl hg19 (Hinxton)ENSG00000123999 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123999 [Gene_View]  chr2:219572232-219575713 [Contig_View]  INHA [Vega]
ICGC DataPortalENSG00000123999
TCGA cBioPortalINHA
AceView (NCBI)INHA
Genatlas (Paris)INHA
WikiGenes3623
SOURCE (Princeton)INHA
Genetics Home Reference (NIH)INHA
Genomic and cartography
GoldenPath hg38 (UCSC)INHA  -     chr2:219572232-219575713 +  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INHA  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblINHA - 2q35 [CytoView hg19]  INHA - 2q35 [CytoView hg38]
Mapping of homologs : NCBIINHA [Mapview hg19]  INHA [Mapview hg38]
OMIM147380   
Gene and transcription
Genbank (Entrez)AW025787 BC006391 BC039076 BT006954 DQ890602
RefSeq transcript (Entrez)NM_002191
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)INHA
Cluster EST : UnigeneHs.407506 [ NCBI ]
CGAP (NCI)Hs.407506
Alternative Splicing GalleryENSG00000123999
Gene ExpressionINHA [ NCBI-GEO ]   INHA [ EBI - ARRAY_EXPRESS ]   INHA [ SEEK ]   INHA [ MEM ]
Gene Expression Viewer (FireBrowse)INHA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3623
GTEX Portal (Tissue expression)INHA
Human Protein AtlasENSG00000123999-INHA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05111   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05111  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05111
Splice isoforms : SwissVarP05111
PhosPhoSitePlusP05111
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    Inhibin_asu    TGF-b_C    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)   
Domain families : Pfam (NCBI)pfam00019   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)INHA
DMDM Disease mutations3623
Blocks (Seattle)INHA
SuperfamilyP05111
Human Protein Atlas [tissue]ENSG00000123999-INHA [tissue]
Peptide AtlasP05111
HPRD00933
IPIIPI00007080   IPI00930302   
Protein Interaction databases
DIP (DOE-UCLA)P05111
IntAct (EBI)P05111
FunCoupENSG00000123999
BioGRIDINHA
STRING (EMBL)INHA
ZODIACINHA
Ontologies - Pathways
QuickGOP05111
Ontology : AmiGOskeletal system development  ovarian follicle development  photoreceptor outer segment  photoreceptor inner segment  receptor binding  cytokine activity  transforming growth factor beta receptor binding  hormone activity  protein binding  protein binding  extracellular region  cytoplasm  cell cycle arrest  signal transduction  cell surface receptor signaling pathway  cell-cell signaling  nervous system development  growth factor activity  male gonad development  response to external stimulus  positive regulation of pathway-restricted SMAD protein phosphorylation  cell differentiation  erythrocyte differentiation  BMP signaling pathway  inhibin-betaglycan-ActRII complex  inhibin binding  regulation of cell proliferation  negative regulation of phosphorylation  hemoglobin biosynthetic process  regulation of apoptotic process  neuronal cell body  regulation of MAPK cascade  inhibin A complex  inhibin B complex  negative regulation of interferon-gamma biosynthetic process  negative regulation of B cell differentiation  negative regulation of macrophage differentiation  negative regulation of cell cycle  positive regulation of follicle-stimulating hormone secretion  negative regulation of follicle-stimulating hormone secretion  protein heterodimerization activity  cell development  regulation of cell cycle  SMAD protein signal transduction  
Ontology : EGO-EBIskeletal system development  ovarian follicle development  photoreceptor outer segment  photoreceptor inner segment  receptor binding  cytokine activity  transforming growth factor beta receptor binding  hormone activity  protein binding  protein binding  extracellular region  cytoplasm  cell cycle arrest  signal transduction  cell surface receptor signaling pathway  cell-cell signaling  nervous system development  growth factor activity  male gonad development  response to external stimulus  positive regulation of pathway-restricted SMAD protein phosphorylation  cell differentiation  erythrocyte differentiation  BMP signaling pathway  inhibin-betaglycan-ActRII complex  inhibin binding  regulation of cell proliferation  negative regulation of phosphorylation  hemoglobin biosynthetic process  regulation of apoptotic process  neuronal cell body  regulation of MAPK cascade  inhibin A complex  inhibin B complex  negative regulation of interferon-gamma biosynthetic process  negative regulation of B cell differentiation  negative regulation of macrophage differentiation  negative regulation of cell cycle  positive regulation of follicle-stimulating hormone secretion  negative regulation of follicle-stimulating hormone secretion  protein heterodimerization activity  cell development  regulation of cell cycle  SMAD protein signal transduction  
NDEx NetworkINHA
Atlas of Cancer Signalling NetworkINHA
Wikipedia pathwaysINHA
Orthology - Evolution
OrthoDB3623
GeneTree (enSembl)ENSG00000123999
Phylogenetic Trees/Animal Genes : TreeFamINHA
HOVERGENP05111
HOGENOMP05111
Homologs : HomoloGeneINHA
Homology/Alignments : Family Browser (UCSC)INHA
Gene fusions - Rearrangements
Tumor Fusion PortalINHA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINHA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INHA
dbVarINHA
ClinVarINHA
1000_GenomesINHA 
Exome Variant ServerINHA
ExAC (Exome Aggregation Consortium)ENSG00000123999
GNOMAD BrowserENSG00000123999
Genetic variants : HAPMAP3623
Genomic Variants (DGV)INHA [DGVbeta]
DECIPHERINHA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINHA 
Mutations
ICGC Data PortalINHA 
TCGA Data PortalINHA 
Broad Tumor PortalINHA
OASIS PortalINHA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINHA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINHA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INHA
DgiDB (Drug Gene Interaction Database)INHA
DoCM (Curated mutations)INHA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INHA (select a term)
intoGenINHA
Cancer3DINHA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147380   
Orphanet
DisGeNETINHA
MedgenINHA
Genetic Testing Registry INHA
NextProtP05111 [Medical]
TSGene3623
GENETestsINHA
Target ValidationINHA
Huge Navigator INHA [HugePedia]
snp3D : Map Gene to Disease3623
BioCentury BCIQINHA
ClinGenINHA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3623
Chemical/Pharm GKB GenePA29876
Clinical trialINHA
Miscellaneous
canSAR (ICR)INHA (select the gene name)
Probes
Litterature
PubMed149 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINHA
EVEXINHA
GoPubMedINHA
iHOPINHA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Nov 20 20:41:21 CET 2017

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