Atlas of Genetics and Cytogenetics in Oncology and Haematology


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INHBA (inhibin beta A subunit)

Identity

Alias_namesinhibin, beta A (activin A, activin AB alpha polypeptide)
inhibin, beta A
inhibin beta A
Other aliasEDF
FRP
HGNC (Hugo) INHBA
LocusID (NCBI) 3624
Atlas_Id 40980
Location 7p14.1  [Link to chromosome band 7p14]
Location_base_pair Starts at 41685114 and ends at 41703108 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)INHBA   6066
Cards
Entrez_Gene (NCBI)INHBA  3624  inhibin beta A subunit
AliasesEDF; FRP
GeneCards (Weizmann)INHBA
Ensembl hg19 (Hinxton)ENSG00000122641 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122641 [Gene_View]  chr7:41685114-41703108 [Contig_View]  INHBA [Vega]
ICGC DataPortalENSG00000122641
TCGA cBioPortalINHBA
AceView (NCBI)INHBA
Genatlas (Paris)INHBA
WikiGenes3624
SOURCE (Princeton)INHBA
Genetics Home Reference (NIH)INHBA
Genomic and cartography
GoldenPath hg38 (UCSC)INHBA  -     chr7:41685114-41703108 -  7p14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INHBA  -     7p14.1   [Description]    (hg19-Feb_2009)
EnsemblINHBA - 7p14.1 [CytoView hg19]  INHBA - 7p14.1 [CytoView hg38]
Mapping of homologs : NCBIINHBA [Mapview hg19]  INHBA [Mapview hg38]
OMIM147290   
Gene and transcription
Genbank (Entrez)AA491465 AF218018 AK001903 AK222742 AK290584
RefSeq transcript (Entrez)NM_002192
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)INHBA
Cluster EST : UnigeneHs.583348 [ NCBI ]
CGAP (NCI)Hs.583348
Alternative Splicing GalleryENSG00000122641
Gene ExpressionINHBA [ NCBI-GEO ]   INHBA [ EBI - ARRAY_EXPRESS ]   INHBA [ SEEK ]   INHBA [ MEM ]
Gene Expression Viewer (FireBrowse)INHBA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3624
GTEX Portal (Tissue expression)INHBA
Human Protein AtlasENSG00000122641-INHBA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08476   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08476  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08476
Splice isoforms : SwissVarP08476
PhosPhoSitePlusP08476
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    Inhibin_betaA    TGF-b_C    TGF-b_propeptide    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)INHBA
DMDM Disease mutations3624
Blocks (Seattle)INHBA
PDB (SRS)1NYS    1NYU    1S4Y    2ARP    2ARV    2B0U    2P6A    3B4V    4MID    5HLY    5HLZ   
PDB (PDBSum)1NYS    1NYU    1S4Y    2ARP    2ARV    2B0U    2P6A    3B4V    4MID    5HLY    5HLZ   
PDB (IMB)1NYS    1NYU    1S4Y    2ARP    2ARV    2B0U    2P6A    3B4V    4MID    5HLY    5HLZ   
PDB (RSDB)1NYS    1NYU    1S4Y    2ARP    2ARV    2B0U    2P6A    3B4V    4MID    5HLY    5HLZ   
Structural Biology KnowledgeBase1NYS    1NYU    1S4Y    2ARP    2ARV    2B0U    2P6A    3B4V    4MID    5HLY    5HLZ   
SCOP (Structural Classification of Proteins)1NYS    1NYU    1S4Y    2ARP    2ARV    2B0U    2P6A    3B4V    4MID    5HLY    5HLZ   
CATH (Classification of proteins structures)1NYS    1NYU    1S4Y    2ARP    2ARV    2B0U    2P6A    3B4V    4MID    5HLY    5HLZ   
SuperfamilyP08476
Human Protein Atlas [tissue]ENSG00000122641-INHBA [tissue]
Peptide AtlasP08476
HPRD00929
IPIIPI00028670   
Protein Interaction databases
DIP (DOE-UCLA)P08476
IntAct (EBI)P08476
FunCoupENSG00000122641
BioGRIDINHBA
STRING (EMBL)INHBA
ZODIACINHBA
Ontologies - Pathways
QuickGOP08476
Ontology : AmiGOG1/S transition of mitotic cell cycle  ovarian follicle development  ovarian follicle development  hair follicle development  hematopoietic progenitor cell differentiation  cytokine activity  transforming growth factor beta receptor binding  hormone activity  protein binding  extracellular region  extracellular region  regulation of transcription from RNA polymerase II promoter  defense response  cell cycle arrest  cell surface receptor signaling pathway  cell-cell signaling  nervous system development  growth factor activity  negative regulation of cell proliferation  male gonad development  positive regulation of gene expression  positive regulation of pathway-restricted SMAD protein phosphorylation  peptide hormone binding  striatal medium spiny neuron differentiation  cell differentiation  erythrocyte differentiation  negative regulation of cell growth  positive regulation of cellular protein metabolic process  activin receptor signaling pathway  inhibin binding  endodermal cell differentiation  negative regulation of phosphorylation  odontogenesis  response to drug  hemoglobin biosynthetic process  progesterone secretion  identical protein binding  regulation of MAPK cascade  activin A complex  inhibin A complex  negative regulation of interferon-gamma biosynthetic process  negative regulation of B cell differentiation  positive regulation of erythrocyte differentiation  negative regulation of macrophage differentiation  negative regulation of cell cycle  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  regulation of follicle-stimulating hormone secretion  positive regulation of follicle-stimulating hormone secretion  negative regulation of follicle-stimulating hormone secretion  protein heterodimerization activity  mesodermal cell differentiation  cell development  perinuclear region of cytoplasm  palate development  positive regulation of ovulation  SMAD protein signal transduction  eyelid development in camera-type eye  type II activin receptor binding  cellular response to follicle-stimulating hormone stimulus  cellular response to cholesterol  GABAergic neuron differentiation  extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  ovarian follicle development  ovarian follicle development  hair follicle development  hematopoietic progenitor cell differentiation  cytokine activity  transforming growth factor beta receptor binding  hormone activity  protein binding  extracellular region  extracellular region  regulation of transcription from RNA polymerase II promoter  defense response  cell cycle arrest  cell surface receptor signaling pathway  cell-cell signaling  nervous system development  growth factor activity  negative regulation of cell proliferation  male gonad development  positive regulation of gene expression  positive regulation of pathway-restricted SMAD protein phosphorylation  peptide hormone binding  striatal medium spiny neuron differentiation  cell differentiation  erythrocyte differentiation  negative regulation of cell growth  positive regulation of cellular protein metabolic process  activin receptor signaling pathway  inhibin binding  endodermal cell differentiation  negative regulation of phosphorylation  odontogenesis  response to drug  hemoglobin biosynthetic process  progesterone secretion  identical protein binding  regulation of MAPK cascade  activin A complex  inhibin A complex  negative regulation of interferon-gamma biosynthetic process  negative regulation of B cell differentiation  positive regulation of erythrocyte differentiation  negative regulation of macrophage differentiation  negative regulation of cell cycle  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  regulation of follicle-stimulating hormone secretion  positive regulation of follicle-stimulating hormone secretion  negative regulation of follicle-stimulating hormone secretion  protein heterodimerization activity  mesodermal cell differentiation  cell development  perinuclear region of cytoplasm  palate development  positive regulation of ovulation  SMAD protein signal transduction  eyelid development in camera-type eye  type II activin receptor binding  cellular response to follicle-stimulating hormone stimulus  cellular response to cholesterol  GABAergic neuron differentiation  extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGCytokine-cytokine receptor interaction    TGF-beta signaling pathway   
NDEx NetworkINHBA
Atlas of Cancer Signalling NetworkINHBA
Wikipedia pathwaysINHBA
Orthology - Evolution
OrthoDB3624
GeneTree (enSembl)ENSG00000122641
Phylogenetic Trees/Animal Genes : TreeFamINHBA
HOVERGENP08476
HOGENOMP08476
Homologs : HomoloGeneINHBA
Homology/Alignments : Family Browser (UCSC)INHBA
Gene fusions - Rearrangements
Tumor Fusion PortalINHBA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINHBA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INHBA
dbVarINHBA
ClinVarINHBA
1000_GenomesINHBA 
Exome Variant ServerINHBA
ExAC (Exome Aggregation Consortium)ENSG00000122641
GNOMAD BrowserENSG00000122641
Genetic variants : HAPMAP3624
Genomic Variants (DGV)INHBA [DGVbeta]
DECIPHERINHBA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINHBA 
Mutations
ICGC Data PortalINHBA 
TCGA Data PortalINHBA 
Broad Tumor PortalINHBA
OASIS PortalINHBA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINHBA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINHBA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INHBA
DgiDB (Drug Gene Interaction Database)INHBA
DoCM (Curated mutations)INHBA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INHBA (select a term)
intoGenINHBA
Cancer3DINHBA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147290   
Orphanet18742   
DisGeNETINHBA
MedgenINHBA
Genetic Testing Registry INHBA
NextProtP08476 [Medical]
TSGene3624
GENETestsINHBA
Target ValidationINHBA
Huge Navigator INHBA [HugePedia]
snp3D : Map Gene to Disease3624
BioCentury BCIQINHBA
ClinGenINHBA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3624
Chemical/Pharm GKB GenePA29877
Clinical trialINHBA
Miscellaneous
canSAR (ICR)INHBA (select the gene name)
Probes
Litterature
PubMed237 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINHBA
EVEXINHBA
GoPubMedINHBA
iHOPINHBA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:17:51 CET 2017

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