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INHBE (inhibin subunit beta E)

Identity

Alias_namesinhibin
Alias_symbol (synonym)activin
MGC4638
Other alias-
HGNC (Hugo) INHBE
LocusID (NCBI) 83729
Atlas_Id 51532
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 57455291 and ends at 57458013 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TSFM (12q14.1) / INHBE (12q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(q13;q14) TSFM/INHBE


External links

Nomenclature
HGNC (Hugo)INHBE   24029
Cards
Entrez_Gene (NCBI)INHBE  83729  inhibin subunit beta E
Aliases
GeneCards (Weizmann)INHBE
Ensembl hg19 (Hinxton)ENSG00000139269 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139269 [Gene_View]  ENSG00000139269 [Sequence]  chr12:57455291-57458013 [Contig_View]  INHBE [Vega]
ICGC DataPortalENSG00000139269
TCGA cBioPortalINHBE
AceView (NCBI)INHBE
Genatlas (Paris)INHBE
WikiGenes83729
SOURCE (Princeton)INHBE
Genetics Home Reference (NIH)INHBE
Genomic and cartography
GoldenPath hg38 (UCSC)INHBE  -     chr12:57455291-57458013 +  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INHBE  -     12q13.3   [Description]    (hg19-Feb_2009)
EnsemblINHBE - 12q13.3 [CytoView hg19]  INHBE - 12q13.3 [CytoView hg38]
Mapping of homologs : NCBIINHBE [Mapview hg19]  INHBE [Mapview hg38]
OMIM612031   
Gene and transcription
Genbank (Entrez)AF412024 AK075285 AK308647 BC005161 BF305618
RefSeq transcript (Entrez)NM_031479
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)INHBE
Cluster EST : UnigeneHs.632713 [ NCBI ]
CGAP (NCI)Hs.632713
Alternative Splicing GalleryENSG00000139269
Gene ExpressionINHBE [ NCBI-GEO ]   INHBE [ EBI - ARRAY_EXPRESS ]   INHBE [ SEEK ]   INHBE [ MEM ]
Gene Expression Viewer (FireBrowse)INHBE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83729
GTEX Portal (Tissue expression)INHBE
Human Protein AtlasENSG00000139269-INHBE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58166   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP58166  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP58166
Splice isoforms : SwissVarP58166
PhosPhoSitePlusP58166
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    Inhibin_betaC    TGF-b_C    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)   
Domain families : Pfam (NCBI)pfam00019   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)INHBE
DMDM Disease mutations83729
Blocks (Seattle)INHBE
SuperfamilyP58166
Human Protein Atlas [tissue]ENSG00000139269-INHBE [tissue]
Peptide AtlasP58166
HPRD11047
IPIIPI00011036   IPI01021541   
Protein Interaction databases
DIP (DOE-UCLA)P58166
IntAct (EBI)P58166
FunCoupENSG00000139269
BioGRIDINHBE
STRING (EMBL)INHBE
ZODIACINHBE
Ontologies - Pathways
QuickGOP58166
Ontology : AmiGOcytokine activity  transforming growth factor beta receptor binding  hormone activity  extracellular space  growth factor activity  regulation of signaling receptor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  regulation of apoptotic process  regulation of MAPK cascade  cell development  SMAD protein signal transduction  
Ontology : EGO-EBIcytokine activity  transforming growth factor beta receptor binding  hormone activity  extracellular space  growth factor activity  regulation of signaling receptor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  regulation of apoptotic process  regulation of MAPK cascade  cell development  SMAD protein signal transduction  
Pathways : KEGGCytokine-cytokine receptor interaction    TGF-beta signaling pathway   
NDEx NetworkINHBE
Atlas of Cancer Signalling NetworkINHBE
Wikipedia pathwaysINHBE
Orthology - Evolution
OrthoDB83729
GeneTree (enSembl)ENSG00000139269
Phylogenetic Trees/Animal Genes : TreeFamINHBE
HOVERGENP58166
HOGENOMP58166
Homologs : HomoloGeneINHBE
Homology/Alignments : Family Browser (UCSC)INHBE
Gene fusions - Rearrangements
Fusion : MitelmanTSFM/INHBE [12q14.1/12q13.3]  [t(12;12)(q13;q14)]  
Fusion : QuiverINHBE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINHBE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INHBE
dbVarINHBE
ClinVarINHBE
1000_GenomesINHBE 
Exome Variant ServerINHBE
ExAC (Exome Aggregation Consortium)ENSG00000139269
GNOMAD BrowserENSG00000139269
Varsome BrowserINHBE
Genetic variants : HAPMAP83729
Genomic Variants (DGV)INHBE [DGVbeta]
DECIPHERINHBE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINHBE 
Mutations
ICGC Data PortalINHBE 
TCGA Data PortalINHBE 
Broad Tumor PortalINHBE
OASIS PortalINHBE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINHBE  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINHBE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INHBE
DgiDB (Drug Gene Interaction Database)INHBE
DoCM (Curated mutations)INHBE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INHBE (select a term)
intoGenINHBE
Cancer3DINHBE(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612031   
Orphanet
DisGeNETINHBE
MedgenINHBE
Genetic Testing Registry INHBE
NextProtP58166 [Medical]
TSGene83729
GENETestsINHBE
Target ValidationINHBE
Huge Navigator INHBE [HugePedia]
snp3D : Map Gene to Disease83729
BioCentury BCIQINHBE
ClinGenINHBE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83729
Chemical/Pharm GKB GenePA134898991
Clinical trialINHBE
Miscellaneous
canSAR (ICR)INHBE (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINHBE
EVEXINHBE
GoPubMedINHBE
iHOPINHBE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:13:32 CET 2018

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