INMT (indolethylamine N-methyltransferase)

2014-11-01  

Identity

HGNC
LOCATION
7p14.3
LOCUSID
ALIAS
TEMT

Other Information

Locus ID:

NCBI: 11185
MIM: 604854
HGNC: 6069
Ensembl: ENSG00000241644

Variants:

dbSNP: 11185
ClinVar: 11185
TCGA: ENSG00000241644
COSMIC: INMT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241644ENST00000013222O95050
ENSG00000241644ENST00000409539O95050

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Tryptophan metabolismKEGGko00380
Selenocompound metabolismKEGGko00450
Tryptophan metabolismKEGGhsa00380
Selenocompound metabolismKEGGhsa00450
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Methylation of MeSeH for excretionREACTOMER-HSA-2408552

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
265379462015Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene.9
261830642015Potential Association of INMT Nonsynonymous Variant (His46Pro) with Hirschsprung's Disease.2
313106422019Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants.1

Citation

Dessen P

INMT (indolethylamine N-methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64619/inmt