INPP1 (inositol polyphosphate-1-phosphatase)

2006-10-01  

Identity

HGNC
LOCATION
2q32.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 3628
MIM: 147263
HGNC: 6071
Ensembl: ENSG00000151689

Variants:

dbSNP: 3628
ClinVar: 3628
TCGA: ENSG00000151689
COSMIC: INPP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151689ENST00000322522P49441
ENSG00000151689ENST00000322522Q6IBG4
ENSG00000151689ENST00000392329P49441
ENSG00000151689ENST00000392329Q6IBG4
ENSG00000151689ENST00000409027B8ZZF6
ENSG00000151689ENST00000413239C9J2Z6
ENSG00000151689ENST00000423767E7EUX4
ENSG00000151689ENST00000430311A0A1D5RMQ4
ENSG00000151689ENST00000431594E7ENF2
ENSG00000151689ENST00000444194E7ET59
ENSG00000151689ENST00000451089C9J2N5
ENSG00000151689ENST00000458193C9J128
ENSG00000151689ENST00000458647C9J173

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositolKEGGhsa_M00131
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositolKEGGM00131
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IP2, IP, and Ins in the cytosolREACTOMER-HSA-1855183

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
146711922003Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance.19
167877062006Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder.19
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
175707382007The pharmacogenetics of lithium response depends upon clinical co-morbidity.17
247389462014Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness.10
234536402013Genetic variability at IMPA2, INPP1 and GSK3β increases the risk of suicidal behavior in bipolar patients.9
145744552003Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms.8
119013562002Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes.2
293816552018Integrated analysis of the genetic basis of suicidal behavior: what has been shown by structural genetic studies so far.2

Citation

Dessen P

INPP1 (inositol polyphosphate-1-phosphatase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43318/inpp1