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INPP4A (inositol polyphosphate-4-phosphatase type I A)

Identity

Alias_namesINPP4
inositol polyphosphate-4-phosphatase, type I, 107kD
inositol polyphosphate-4-phosphatase, type I, 107kDa
Other aliasTVAS1
HGNC (Hugo) INPP4A
LocusID (NCBI) 3631
Atlas_Id 43319
Location 2q11.2  [Link to chromosome band 2q11]
Location_base_pair Starts at 98444858 and ends at 98591033 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HJURP (2q37.1) / INPP4A (2q11.2)INPP4A (2q11.2) / HJURP (2q37.1)INPP4A (2q11.2) / MGAT4A (2q11.2)
INPP4A 2q11.2 / MGAT4A 2q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)INPP4A   6074
Cards
Entrez_Gene (NCBI)INPP4A  3631  inositol polyphosphate-4-phosphatase type I A
AliasesINPP4; TVAS1
GeneCards (Weizmann)INPP4A
Ensembl hg19 (Hinxton)ENSG00000040933 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000040933 [Gene_View]  chr2:98444858-98591033 [Contig_View]  INPP4A [Vega]
ICGC DataPortalENSG00000040933
TCGA cBioPortalINPP4A
AceView (NCBI)INPP4A
Genatlas (Paris)INPP4A
WikiGenes3631
SOURCE (Princeton)INPP4A
Genetics Home Reference (NIH)INPP4A
Genomic and cartography
GoldenPath hg38 (UCSC)INPP4A  -     chr2:98444858-98591033 +  2q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INPP4A  -     2q11.2   [Description]    (hg19-Feb_2009)
EnsemblINPP4A - 2q11.2 [CytoView hg19]  INPP4A - 2q11.2 [CytoView hg38]
Mapping of homologs : NCBIINPP4A [Mapview hg19]  INPP4A [Mapview hg38]
OMIM600916   
Gene and transcription
Genbank (Entrez)AB462500 AF368319 AK057550 AK091533 AK307823
RefSeq transcript (Entrez)NM_001134224 NM_001134225 NM_001566 NM_004027
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)INPP4A
Cluster EST : UnigeneHs.469386 [ NCBI ]
CGAP (NCI)Hs.469386
Alternative Splicing GalleryENSG00000040933
Gene ExpressionINPP4A [ NCBI-GEO ]   INPP4A [ EBI - ARRAY_EXPRESS ]   INPP4A [ SEEK ]   INPP4A [ MEM ]
Gene Expression Viewer (FireBrowse)INPP4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3631
GTEX Portal (Tissue expression)INPP4A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PE3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PE3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PE3
Splice isoforms : SwissVarQ96PE3
Catalytic activity : Enzyme3.1.3.66 [ Enzyme-Expasy ]   3.1.3.663.1.3.66 [ IntEnz-EBI ]   3.1.3.66 [ BRENDA ]   3.1.3.66 [ KEGG ]   
PhosPhoSitePlusQ96PE3
Domains : Interpro (EBI)C2_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)INPP4A
DMDM Disease mutations3631
Blocks (Seattle)INPP4A
SuperfamilyQ96PE3
Human Protein AtlasENSG00000040933
Peptide AtlasQ96PE3
HPRD02949
IPIIPI00645392   IPI00916254   IPI00044388   IPI00215830   IPI01009678   IPI00917526   
Protein Interaction databases
DIP (DOE-UCLA)Q96PE3
IntAct (EBI)Q96PE3
FunCoupENSG00000040933
BioGRIDINPP4A
STRING (EMBL)INPP4A
ZODIACINPP4A
Ontologies - Pathways
QuickGOQ96PE3
Ontology : AmiGOprotein binding  cytoplasm  cytosol  phosphatidylinositol biosynthetic process  signal transduction  dephosphorylation  phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity  phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity  inositol-1,3,4-trisphosphate 4-phosphatase activity  phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity  phosphatidylinositol-3-phosphate biosynthetic process  inositol phosphate metabolic process  inositol-3,4-bisphosphate 4-phosphatase activity  
Ontology : EGO-EBIprotein binding  cytoplasm  cytosol  phosphatidylinositol biosynthetic process  signal transduction  dephosphorylation  phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity  phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity  inositol-1,3,4-trisphosphate 4-phosphatase activity  phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity  phosphatidylinositol-3-phosphate biosynthetic process  inositol phosphate metabolic process  inositol-3,4-bisphosphate 4-phosphatase activity  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx NetworkINPP4A
Atlas of Cancer Signalling NetworkINPP4A
Wikipedia pathwaysINPP4A
Orthology - Evolution
OrthoDB3631
GeneTree (enSembl)ENSG00000040933
Phylogenetic Trees/Animal Genes : TreeFamINPP4A
HOVERGENQ96PE3
HOGENOMQ96PE3
Homologs : HomoloGeneINPP4A
Homology/Alignments : Family Browser (UCSC)INPP4A
Gene fusions - Rearrangements
Fusion : MitelmanINPP4A/HJURP [2q11.2/2q37.1]  
Fusion : MitelmanINPP4A/MGAT4A [2q11.2/2q11.2]  [t(2;2)(q11;q11)]  
Fusion: TCGAINPP4A 2q11.2 MGAT4A 2q11.2 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINPP4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INPP4A
dbVarINPP4A
ClinVarINPP4A
1000_GenomesINPP4A 
Exome Variant ServerINPP4A
ExAC (Exome Aggregation Consortium)INPP4A (select the gene name)
Genetic variants : HAPMAP3631
Genomic Variants (DGV)INPP4A [DGVbeta]
DECIPHERINPP4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINPP4A 
Mutations
ICGC Data PortalINPP4A 
TCGA Data PortalINPP4A 
Broad Tumor PortalINPP4A
OASIS PortalINPP4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINPP4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINPP4A
intOGen PortalINPP4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INPP4A
DgiDB (Drug Gene Interaction Database)INPP4A
DoCM (Curated mutations)INPP4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INPP4A (select a term)
intoGenINPP4A
Cancer3DINPP4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600916   
Orphanet
MedgenINPP4A
Genetic Testing Registry INPP4A
NextProtQ96PE3 [Medical]
TSGene3631
GENETestsINPP4A
Target ValidationINPP4A
Huge Navigator INPP4A [HugePedia]
snp3D : Map Gene to Disease3631
BioCentury BCIQINPP4A
ClinGenINPP4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3631
Chemical/Pharm GKB GenePA29882
Clinical trialINPP4A
Miscellaneous
canSAR (ICR)INPP4A (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINPP4A
EVEXINPP4A
GoPubMedINPP4A
iHOPINPP4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:56:25 CEST 2017

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