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INPP4A (inositol polyphosphate-4-phosphatase type I A)

Identity

Alias (NCBI)INPP4
TVAS1
HGNC (Hugo) INPP4A
HGNC Alias nameType I inositol 3,4-bisphosphate 4-phosphatase
HGNC Previous nameINPP4
HGNC Previous nameinositol polyphosphate-4-phosphatase, type I, 107kD
 inositol polyphosphate-4-phosphatase, type I, 107kDa
LocusID (NCBI) 3631
Atlas_Id 43319
Location 2q11.2  [Link to chromosome band 2q11]
Location_base_pair Starts at 98444858 and ends at 98594392 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HJURP (2q37.1) / INPP4A (2q11.2)INPP4A (2q11.2) / HJURP (2q37.1)INPP4A (2q11.2) / MGAT4A (2q11.2)
INPP4A 2q11.2 / MGAT4A 2q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)INPP4A   6074
Cards
Entrez_Gene (NCBI)INPP4A    inositol polyphosphate-4-phosphatase type I A
AliasesINPP4; TVAS1
GeneCards (Weizmann)INPP4A
Ensembl hg19 (Hinxton)ENSG00000040933 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000040933 [Gene_View]  ENSG00000040933 [Sequence]  chr2:98444858-98594392 [Contig_View]  INPP4A [Vega]
ICGC DataPortalENSG00000040933
TCGA cBioPortalINPP4A
AceView (NCBI)INPP4A
Genatlas (Paris)INPP4A
SOURCE (Princeton)INPP4A
Genetics Home Reference (NIH)INPP4A
Genomic and cartography
GoldenPath hg38 (UCSC)INPP4A  -     chr2:98444858-98594392 +  2q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INPP4A  -     2q11.2   [Description]    (hg19-Feb_2009)
GoldenPathINPP4A - 2q11.2 [CytoView hg19]  INPP4A - 2q11.2 [CytoView hg38]
ImmunoBaseENSG00000040933
Genome Data Viewer NCBIINPP4A [Mapview hg19]  
OMIM600916   
Gene and transcription
Genbank (Entrez)AB462500 AF368319 AK057550 AK091533 AK307823
RefSeq transcript (Entrez)NM_001134224 NM_001134225 NM_001351424 NM_001351425 NM_001351426 NM_001351427 NM_001351428 NM_001351429 NM_001566 NM_004027
Consensus coding sequences : CCDS (NCBI)INPP4A
Gene ExpressionINPP4A [ NCBI-GEO ]   INPP4A [ EBI - ARRAY_EXPRESS ]   INPP4A [ SEEK ]   INPP4A [ MEM ]
Gene Expression Viewer (FireBrowse)INPP4A [ Firebrowse - Broad ]
GenevisibleExpression of INPP4A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3631
GTEX Portal (Tissue expression)INPP4A
Human Protein AtlasENSG00000040933-INPP4A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PE3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PE3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PE3
PhosPhoSitePlusQ96PE3
Domaine pattern : Prosite (Expaxy)C2 (PS50004)   
Domains : Interpro (EBI)C2_domain_sf    INPP4   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)INPP4A
SuperfamilyQ96PE3
AlphaFold pdb e-kbQ96PE3   
Human Protein Atlas [tissue]ENSG00000040933-INPP4A [tissue]
HPRD02949
Protein Interaction databases
DIP (DOE-UCLA)Q96PE3
IntAct (EBI)Q96PE3
BioGRIDINPP4A
STRING (EMBL)INPP4A
ZODIACINPP4A
Ontologies - Pathways
QuickGOQ96PE3
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  phosphatidylinositol biosynthetic process  signal transduction  postsynaptic density  dephosphorylation  phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity  inositol-1,3,4-trisphosphate 4-phosphatase activity  early endosome membrane  nuclear membrane  phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity  phosphatidylinositol-3-phosphate biosynthetic process  inositol phosphate metabolic process  inositol-3,4-bisphosphate 4-phosphatase activity  recycling endosome membrane  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  phosphatidylinositol biosynthetic process  signal transduction  postsynaptic density  dephosphorylation  phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity  inositol-1,3,4-trisphosphate 4-phosphatase activity  early endosome membrane  nuclear membrane  phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity  phosphatidylinositol-3-phosphate biosynthetic process  inositol phosphate metabolic process  inositol-3,4-bisphosphate 4-phosphatase activity  recycling endosome membrane  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx NetworkINPP4A
Atlas of Cancer Signalling NetworkINPP4A
Wikipedia pathwaysINPP4A
Orthology - Evolution
OrthoDB3631
GeneTree (enSembl)ENSG00000040933
Phylogenetic Trees/Animal Genes : TreeFamINPP4A
Homologs : HomoloGeneINPP4A
Homology/Alignments : Family Browser (UCSC)INPP4A
Gene fusions - Rearrangements
Fusion : MitelmanINPP4A/HJURP [2q11.2/2q37.1]  
Fusion : MitelmanINPP4A/MGAT4A [2q11.2/2q11.2]  
Fusion : QuiverINPP4A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINPP4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INPP4A
dbVarINPP4A
ClinVarINPP4A
MonarchINPP4A
1000_GenomesINPP4A 
Exome Variant ServerINPP4A
GNOMAD BrowserENSG00000040933
Varsome BrowserINPP4A
ACMGINPP4A variants
VarityQ96PE3
Genomic Variants (DGV)INPP4A [DGVbeta]
DECIPHERINPP4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINPP4A 
Mutations
ICGC Data PortalINPP4A 
TCGA Data PortalINPP4A 
Broad Tumor PortalINPP4A
OASIS PortalINPP4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINPP4A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DINPP4A
Mutations and Diseases : HGMDINPP4A
intOGen PortalINPP4A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaINPP4A
DgiDB (Drug Gene Interaction Database)INPP4A
DoCM (Curated mutations)INPP4A
CIViC (Clinical Interpretations of Variants in Cancer)INPP4A
Cancer3DINPP4A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600916   
Orphanet
DisGeNETINPP4A
MedgenINPP4A
Genetic Testing Registry INPP4A
NextProtQ96PE3 [Medical]
GENETestsINPP4A
Target ValidationINPP4A
Huge Navigator INPP4A [HugePedia]
ClinGenINPP4A
Clinical trials, drugs, therapy
MyCancerGenomeINPP4A
Protein Interactions : CTDINPP4A
Pharm GKB GenePA29882
PharosQ96PE3
Clinical trialINPP4A
Miscellaneous
canSAR (ICR)INPP4A
HarmonizomeINPP4A
DataMed IndexINPP4A
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXINPP4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:01 CEST 2021

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