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INPP4B (inositol polyphosphate-4-phosphatase type II B)

Identity

Alias_namesinositol polyphosphate-4-phosphatase, type II, 105kD
inositol polyphosphate-4-phosphatase, type II, 105kDa
Other alias-
HGNC (Hugo) INPP4B
LocusID (NCBI) 8821
Atlas_Id 43320
Location 4q31.21  [Link to chromosome band 4q31]
Location_base_pair Starts at 142949182 and ends at 143767604 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EGFLAM (5p13.2) / INPP4B (4q31.21)FBXW7 (4q31.3) / INPP4B (4q31.21)INPP4B (4q31.21) / ELL3 (15q15.3)
INPP4B (4q31.21) / GPX3 (5q33.1)INPP4B (4q31.21) / IST1 (16q22.2)INPP4B (4q31.21) / WBSCR17 (7q11.22)
KIAA0232 (4p16.1) / INPP4B (4q31.21)MAPK10 (4q21.3) / INPP4B (4q31.21)SKAP2 (7p15.2) / INPP4B (4q31.21)
FBXW7 4q31.3 / INPP4B 4q31.21KIAA0232 4p16.1 / INPP4B 4q31.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)INPP4B   6075
Cards
Entrez_Gene (NCBI)INPP4B  8821  inositol polyphosphate-4-phosphatase type II B
Aliases
GeneCards (Weizmann)INPP4B
Ensembl hg19 (Hinxton)ENSG00000109452 [Gene_View]  chr4:142949182-143767604 [Contig_View]  INPP4B [Vega]
Ensembl hg38 (Hinxton)ENSG00000109452 [Gene_View]  chr4:142949182-143767604 [Contig_View]  INPP4B [Vega]
ICGC DataPortalENSG00000109452
TCGA cBioPortalINPP4B
AceView (NCBI)INPP4B
Genatlas (Paris)INPP4B
WikiGenes8821
SOURCE (Princeton)INPP4B
Genetics Home Reference (NIH)INPP4B
Genomic and cartography
GoldenPath hg19 (UCSC)INPP4B  -     chr4:142949182-143767604 -  4q31.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)INPP4B  -     4q31.21   [Description]    (hg38-Dec_2013)
EnsemblINPP4B - 4q31.21 [CytoView hg19]  INPP4B - 4q31.21 [CytoView hg38]
Mapping of homologs : NCBIINPP4B [Mapview hg19]  INPP4B [Mapview hg38]
OMIM607494   
Gene and transcription
Genbank (Entrez)AK298118 AK300891 AK302936 AY753912 BC005273
RefSeq transcript (Entrez)NM_001101669 NM_003866
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)INPP4B
Cluster EST : UnigeneHs.531403 [ NCBI ]
CGAP (NCI)Hs.531403
Alternative Splicing GalleryENSG00000109452
Gene ExpressionINPP4B [ NCBI-GEO ]   INPP4B [ EBI - ARRAY_EXPRESS ]   INPP4B [ SEEK ]   INPP4B [ MEM ]
Gene Expression Viewer (FireBrowse)INPP4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8821
GTEX Portal (Tissue expression)INPP4B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15327   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15327  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15327
Splice isoforms : SwissVarO15327
Catalytic activity : Enzyme3.1.3.66 [ Enzyme-Expasy ]   3.1.3.663.1.3.66 [ IntEnz-EBI ]   3.1.3.66 [ BRENDA ]   3.1.3.66 [ KEGG ]   
PhosPhoSitePlusO15327
Domains : Interpro (EBI)C2_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)INPP4B
DMDM Disease mutations8821
Blocks (Seattle)INPP4B
SuperfamilyO15327
Human Protein AtlasENSG00000109452
Peptide AtlasO15327
HPRD06322
IPIIPI00022020   IPI00963837   IPI00922726   IPI00965101   IPI00964458   IPI00968221   IPI00029309   IPI00963881   IPI00966726   IPI00967550   IPI00968243   IPI00965363   IPI00965796   
Protein Interaction databases
DIP (DOE-UCLA)O15327
IntAct (EBI)O15327
FunCoupENSG00000109452
BioGRIDINPP4B
STRING (EMBL)INPP4B
ZODIACINPP4B
Ontologies - Pathways
QuickGOO15327
Ontology : AmiGOprotein binding  cytoplasm  cytosol  phosphatidylinositol biosynthetic process  signal transduction  dephosphorylation  dephosphorylation  phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity  inositol-1,3,4-trisphosphate 4-phosphatase activity  phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity  phosphatidylinositol-3-phosphate biosynthetic process  inositol phosphate metabolic process  inositol-3,4-bisphosphate 4-phosphatase activity  
Ontology : EGO-EBIprotein binding  cytoplasm  cytosol  phosphatidylinositol biosynthetic process  signal transduction  dephosphorylation  dephosphorylation  phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity  inositol-1,3,4-trisphosphate 4-phosphatase activity  phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity  phosphatidylinositol-3-phosphate biosynthetic process  inositol phosphate metabolic process  inositol-3,4-bisphosphate 4-phosphatase activity  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx NetworkINPP4B
Atlas of Cancer Signalling NetworkINPP4B
Wikipedia pathwaysINPP4B
Orthology - Evolution
OrthoDB8821
GeneTree (enSembl)ENSG00000109452
Phylogenetic Trees/Animal Genes : TreeFamINPP4B
HOVERGENO15327
HOGENOMO15327
Homologs : HomoloGeneINPP4B
Homology/Alignments : Family Browser (UCSC)INPP4B
Gene fusions - Rearrangements
Fusion : MitelmanFBXW7/INPP4B [4q31.3/4q31.21]  [t(4;4)(q31;q31)]  
Fusion : MitelmanKIAA0232/INPP4B [4p16.1/4q31.21]  [t(4;4)(p16;q31)]  
Fusion: TCGAFBXW7 4q31.3 INPP4B 4q31.21 LUSC
Fusion: TCGAKIAA0232 4p16.1 INPP4B 4q31.21 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINPP4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INPP4B
dbVarINPP4B
ClinVarINPP4B
1000_GenomesINPP4B 
Exome Variant ServerINPP4B
ExAC (Exome Aggregation Consortium)INPP4B (select the gene name)
Genetic variants : HAPMAP8821
Genomic Variants (DGV)INPP4B [DGVbeta]
DECIPHER (Syndromes)4:142949182-143767604  ENSG00000109452
CONAN: Copy Number AnalysisINPP4B 
Mutations
ICGC Data PortalINPP4B 
TCGA Data PortalINPP4B 
Broad Tumor PortalINPP4B
OASIS PortalINPP4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINPP4B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINPP4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INPP4B
DgiDB (Drug Gene Interaction Database)INPP4B
DoCM (Curated mutations)INPP4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INPP4B (select a term)
intoGenINPP4B
Cancer3DINPP4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607494   
Orphanet
MedgenINPP4B
Genetic Testing Registry INPP4B
NextProtO15327 [Medical]
TSGene8821
GENETestsINPP4B
Huge Navigator INPP4B [HugePedia]
snp3D : Map Gene to Disease8821
BioCentury BCIQINPP4B
ClinGenINPP4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8821
Chemical/Pharm GKB GenePA29883
Clinical trialINPP4B
Miscellaneous
canSAR (ICR)INPP4B (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINPP4B
EVEXINPP4B
GoPubMedINPP4B
iHOPINPP4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:05:18 CEST 2017

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