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INPP5A (inositol polyphosphate-5-phosphatase A)

Identity

Alias (NCBI)5PTASE
HGNC (Hugo) INPP5A
HGNC Alias symb5PTASE
HGNC Alias nameCTCL tumor antigen HD-CL-02
 43 kDa inositol polyphosphate 5-phophatase
 inositol polyphosphate 5-phophatase, 40kDa
 InsP3 5-phosphatase
 type I inositol-1,4,5-trisphosphate 5-phosphatase
HGNC Previous nameinositol polyphosphate-5-phosphatase, 40kD
 inositol polyphosphate-5-phosphatase, 40kDa
LocusID (NCBI) 3632
Atlas_Id 43321
Location 10q26.3  [Link to chromosome band 10q26]
Location_base_pair Starts at 132537787 and ends at 132783480 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
INPP5A (10q26.3) / AFAP1L2 (10q25.3)INPP5A (10q26.3) / C10orf91 (10q26.3)INPP5A (10q26.3) / CFAP46 (10q26.3)
INPP5A (10q26.3) / CSTA (3q21.1)INPP5A (10q26.3) / DLG2 (11q14.1)INPP5A (10q26.3) / FAM149B1 (10q22.2)
INPP5A (10q26.3) / FRMD4A (10p13)INPP5A (10q26.3) / JAKMIP3 (10q26.3)INPP5A (10q26.3) / KIF20B (10q23.31)
JAKMIP3 (10q26.3) / INPP5A (10q26.3)PAPPA (9q33.1) / INPP5A (10q26.3)INPP5A 10q26.3 / AFAP1L2 10q25.3
INPP5A 10q26.3 / C10orf91 10q26.3INPP5A 10q26.3 C10orf93INPP5A 10q26.3 / CSTA 3q21.1
INPP5A 10q26.3 / DLG2 11q14.1INPP5A 10q26.3 / FAM149B1 10q22.2INPP5A 10q26.3 / FRMD4A 10p13
INPP5A 10q26.3 / JAKMIP3 10q26.3INPP5A 10q26.3 / KIF20B 10q23.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)INPP5A   6076
Cards
Entrez_Gene (NCBI)INPP5A    inositol polyphosphate-5-phosphatase A
Aliases5PTASE
GeneCards (Weizmann)INPP5A
Ensembl hg19 (Hinxton)ENSG00000068383 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000068383 [Gene_View]  ENSG00000068383 [Sequence]  chr10:132537787-132783480 [Contig_View]  INPP5A [Vega]
ICGC DataPortalENSG00000068383
TCGA cBioPortalINPP5A
AceView (NCBI)INPP5A
Genatlas (Paris)INPP5A
SOURCE (Princeton)INPP5A
Genetics Home Reference (NIH)INPP5A
Genomic and cartography
GoldenPath hg38 (UCSC)INPP5A  -     chr10:132537787-132783480 +  10q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INPP5A  -     10q26.3   [Description]    (hg19-Feb_2009)
GoldenPathINPP5A - 10q26.3 [CytoView hg19]  INPP5A - 10q26.3 [CytoView hg38]
ImmunoBaseENSG00000068383
Genome Data Viewer NCBIINPP5A [Mapview hg19]  
OMIM600106   
Gene and transcription
Genbank (Entrez)AF273055 BC052265 BC062300 BC096280 BC096281
RefSeq transcript (Entrez)NM_001321042 NM_005539
Consensus coding sequences : CCDS (NCBI)INPP5A
Gene ExpressionINPP5A [ NCBI-GEO ]   INPP5A [ EBI - ARRAY_EXPRESS ]   INPP5A [ SEEK ]   INPP5A [ MEM ]
Gene Expression Viewer (FireBrowse)INPP5A [ Firebrowse - Broad ]
GenevisibleExpression of INPP5A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3632
GTEX Portal (Tissue expression)INPP5A
Human Protein AtlasENSG00000068383-INPP5A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14642   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14642  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14642
PhosPhoSitePlusQ14642
Domains : Interpro (EBI)Endo/exonu/phosph_ase_sf    Endo/exonuclease/phosphatase    INPP5A    IPPc   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)   
Domain families : Pfam (NCBI)pfam03372   
Domain families : Smart (EMBL)IPPc (SM00128)  
Conserved Domain (NCBI)INPP5A
SuperfamilyQ14642
AlphaFold pdb e-kbQ14642   
Human Protein Atlas [tissue]ENSG00000068383-INPP5A [tissue]
HPRD02521
Protein Interaction databases
DIP (DOE-UCLA)Q14642
IntAct (EBI)Q14642
BioGRIDINPP5A
STRING (EMBL)INPP5A
ZODIACINPP5A
Ontologies - Pathways
QuickGOQ14642
Ontology : AmiGOinositol-polyphosphate 5-phosphatase activity  inositol-polyphosphate 5-phosphatase activity  inositol-polyphosphate 5-phosphatase activity  protein binding  plasma membrane  plasma membrane  membrane  membrane  dendrite  PH domain binding  inositol phosphate metabolic process  inositol phosphate dephosphorylation  inositol phosphate dephosphorylation  phosphatidylinositol dephosphorylation  inositol phosphate-mediated signaling  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity  negative regulation of neuron death  
Ontology : EGO-EBIinositol-polyphosphate 5-phosphatase activity  inositol-polyphosphate 5-phosphatase activity  inositol-polyphosphate 5-phosphatase activity  protein binding  plasma membrane  plasma membrane  membrane  membrane  dendrite  PH domain binding  inositol phosphate metabolic process  inositol phosphate dephosphorylation  inositol phosphate dephosphorylation  phosphatidylinositol dephosphorylation  inositol phosphate-mediated signaling  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity  negative regulation of neuron death  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx NetworkINPP5A
Atlas of Cancer Signalling NetworkINPP5A
Wikipedia pathwaysINPP5A
Orthology - Evolution
OrthoDB3632
GeneTree (enSembl)ENSG00000068383
Phylogenetic Trees/Animal Genes : TreeFamINPP5A
Homologs : HomoloGeneINPP5A
Homology/Alignments : Family Browser (UCSC)INPP5A
Gene fusions - Rearrangements
Fusion : MitelmanINPP5A/AFAP1L2 [10q26.3/10q25.3]  
Fusion : MitelmanINPP5A/C10orf91 [10q26.3/10q26.3]  
Fusion : MitelmanINPP5A/CFAP46 [10q26.3/10q26.3]  
Fusion : MitelmanINPP5A/CSTA [10q26.3/3q21.1]  
Fusion : MitelmanINPP5A/DLG2 [10q26.3/11q14.1]  
Fusion : MitelmanINPP5A/FAM149B1 [10q26.3/10q22.2]  
Fusion : MitelmanINPP5A/FRMD4A [10q26.3/10p13]  
Fusion : MitelmanINPP5A/JAKMIP3 [10q26.3/10q26.3]  
Fusion : MitelmanINPP5A/KIF20B [10q26.3/10q23.31]  
Fusion : QuiverINPP5A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINPP5A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INPP5A
dbVarINPP5A
ClinVarINPP5A
MonarchINPP5A
1000_GenomesINPP5A 
Exome Variant ServerINPP5A
GNOMAD BrowserENSG00000068383
Varsome BrowserINPP5A
ACMGINPP5A variants
VarityQ14642
Genomic Variants (DGV)INPP5A [DGVbeta]
DECIPHERINPP5A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINPP5A 
Mutations
ICGC Data PortalINPP5A 
TCGA Data PortalINPP5A 
Broad Tumor PortalINPP5A
OASIS PortalINPP5A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINPP5A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DINPP5A
Mutations and Diseases : HGMDINPP5A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaINPP5A
DgiDB (Drug Gene Interaction Database)INPP5A
DoCM (Curated mutations)INPP5A
CIViC (Clinical Interpretations of Variants in Cancer)INPP5A
Cancer3DINPP5A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600106   
Orphanet
DisGeNETINPP5A
MedgenINPP5A
Genetic Testing Registry INPP5A
NextProtQ14642 [Medical]
GENETestsINPP5A
Target ValidationINPP5A
Huge Navigator INPP5A [HugePedia]
ClinGenINPP5A
Clinical trials, drugs, therapy
MyCancerGenomeINPP5A
Protein Interactions : CTDINPP5A
Pharm GKB GenePA29884
PharosQ14642
Clinical trialINPP5A
Miscellaneous
canSAR (ICR)INPP5A
HarmonizomeINPP5A
DataMed IndexINPP5A
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXINPP5A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:14:01 CEST 2021

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