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INPP5A (inositol polyphosphate-5-phosphatase A)

Identity

Other names5PTASE
HGNC (Hugo) INPP5A
LocusID (NCBI) 3632
Atlas_Id 43321
Location 10q26.3  [Link to chromosome band 10q26]
Location_base_pair Starts at 134351353 and ends at 134596984 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
INPP5A (10q26.3) / AFAP1L2 (10q25.3)INPP5A (10q26.3) / C10orf91 (10q26.3)INPP5A (10q26.3) / CFAP46 (10q26.3)
INPP5A (10q26.3) / CSTA (3q21.1)INPP5A (10q26.3) / DLG2 (11q14.1)INPP5A (10q26.3) / FAM149B1 (10q22.2)
INPP5A (10q26.3) / FRMD4A (10p13)INPP5A (10q26.3) / JAKMIP3 (10q26.3)INPP5A (10q26.3) / KIF20B (10q23.31)
JAKMIP3 (10q26.3) / INPP5A (10q26.3)PAPPA (9q33.1) / INPP5A (10q26.3)INPP5A 10q26.3 / AFAP1L2 10q25.3
INPP5A 10q26.3 / C10orf91 10q26.3INPP5A 10q26.3 C10orf93INPP5A 10q26.3 / CSTA 3q21.1
INPP5A 10q26.3 / DLG2 11q14.1INPP5A 10q26.3 / FAM149B1 10q22.2INPP5A 10q26.3 / FRMD4A 10p13
INPP5A 10q26.3 / JAKMIP3 10q26.3INPP5A 10q26.3 / KIF20B 10q23.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)INPP5A   6076
Cards
Entrez_Gene (NCBI)INPP5A  3632  inositol polyphosphate-5-phosphatase A
Aliases5PTASE
GeneCards (Weizmann)INPP5A
Ensembl hg19 (Hinxton)ENSG00000068383 [Gene_View]  chr10:134351353-134596984 [Contig_View]  INPP5A [Vega]
Ensembl hg38 (Hinxton)ENSG00000068383 [Gene_View]  chr10:134351353-134596984 [Contig_View]  INPP5A [Vega]
ICGC DataPortalENSG00000068383
TCGA cBioPortalINPP5A
AceView (NCBI)INPP5A
Genatlas (Paris)INPP5A
WikiGenes3632
SOURCE (Princeton)INPP5A
Genomic and cartography
GoldenPath hg19 (UCSC)INPP5A  -     chr10:134351353-134596984 +  10q26.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)INPP5A  -     10q26.3   [Description]    (hg38-Dec_2013)
EnsemblINPP5A - 10q26.3 [CytoView hg19]  INPP5A - 10q26.3 [CytoView hg38]
Mapping of homologs : NCBIINPP5A [Mapview hg19]  INPP5A [Mapview hg38]
OMIM600106   
Gene and transcription
Genbank (Entrez)AF273055 BC052265 BC062300 BC096280 BC096281
RefSeq transcript (Entrez)NM_001321042 NM_005539
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_030059 NW_004929377
Consensus coding sequences : CCDS (NCBI)INPP5A
Cluster EST : UnigeneHs.715308 [ NCBI ]
CGAP (NCI)Hs.715308
Alternative Splicing GalleryENSG00000068383
Gene ExpressionINPP5A [ NCBI-GEO ]   INPP5A [ EBI - ARRAY_EXPRESS ]   INPP5A [ SEEK ]   INPP5A [ MEM ]
Gene Expression Viewer (FireBrowse)INPP5A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3632
GTEX Portal (Tissue expression)INPP5A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14642 (Uniprot)
NextProtQ14642  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14642
Splice isoforms : SwissVarQ14642 (Swissvar)
Catalytic activity : Enzyme3.1.3.56 [ Enzyme-Expasy ]   3.1.3.563.1.3.56 [ IntEnz-EBI ]   3.1.3.56 [ BRENDA ]   3.1.3.56 [ KEGG ]   
PhosPhoSitePlusQ14642
Domains : Interpro (EBI)Endo/exonuclease/phosphatase    IPPc   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)   
Domain families : Pfam (NCBI)pfam03372   
Domain families : Smart (EMBL)IPPc (SM00128)  
DMDM Disease mutations3632
Blocks (Seattle)INPP5A
SuperfamilyQ14642
Human Protein AtlasENSG00000068383
Peptide AtlasQ14642
HPRD02521
IPIIPI00032262   IPI00514660   IPI00384273   IPI00514460   IPI01010770   IPI00413212   IPI00552455   
Protein Interaction databases
DIP (DOE-UCLA)Q14642
IntAct (EBI)Q14642
FunCoupENSG00000068383
BioGRIDINPP5A
STRING (EMBL)INPP5A
ZODIACINPP5A
Ontologies - Pathways
QuickGOQ14642
Ontology : AmiGOinositol-polyphosphate 5-phosphatase activity  protein binding  plasma membrane  membrane  PH domain binding  inositol phosphate metabolic process  phosphatidylinositol dephosphorylation  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity  extracellular exosome  
Ontology : EGO-EBIinositol-polyphosphate 5-phosphatase activity  protein binding  plasma membrane  membrane  PH domain binding  inositol phosphate metabolic process  phosphatidylinositol dephosphorylation  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity  extracellular exosome  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx Network
Atlas of Cancer Signalling NetworkINPP5A
Wikipedia pathwaysINPP5A
Orthology - Evolution
OrthoDB3632
GeneTree (enSembl)ENSG00000068383
Phylogenetic Trees/Animal Genes : TreeFamINPP5A
Homologs : HomoloGeneINPP5A
Homology/Alignments : Family Browser (UCSC)INPP5A
Gene fusions - Rearrangements
Fusion: TCGAINPP5A 10q26.3 AFAP1L2 10q25.3 LGG
Fusion: TCGAINPP5A 10q26.3 C10orf91 10q26.3 OV
Fusion: TCGAINPP5A 10q26.3 C10orf93 BLCA
Fusion: TCGAINPP5A 10q26.3 CSTA 3q21.1 KIRC
Fusion: TCGAINPP5A 10q26.3 DLG2 11q14.1 BRCA
Fusion: TCGAINPP5A 10q26.3 FAM149B1 10q22.2 BRCA
Fusion: TCGAINPP5A 10q26.3 FRMD4A 10p13 OV
Fusion: TCGAINPP5A 10q26.3 JAKMIP3 10q26.3 LUAD
Fusion: TCGAINPP5A 10q26.3 KIF20B 10q23.31 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerINPP5A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INPP5A
dbVarINPP5A
ClinVarINPP5A
1000_GenomesINPP5A 
Exome Variant ServerINPP5A
ExAC (Exome Aggregation Consortium)INPP5A (select the gene name)
Genetic variants : HAPMAP3632
Genomic Variants (DGV)INPP5A [DGVbeta]
Mutations
ICGC Data PortalINPP5A 
TCGA Data PortalINPP5A 
Broad Tumor PortalINPP5A
OASIS PortalINPP5A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINPP5A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INPP5A
DgiDB (Drug Gene Interaction Database)INPP5A
DoCM (Curated mutations)INPP5A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INPP5A (select a term)
intoGenINPP5A
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)10:134351353-134596984  ENSG00000068383
CONAN: Copy Number AnalysisINPP5A 
Mutations and Diseases : HGMDINPP5A
OMIM600106   
MedgenINPP5A
Genetic Testing Registry INPP5A
NextProtQ14642 [Medical]
TSGene3632
GENETestsINPP5A
Huge Navigator INPP5A [HugePedia]
snp3D : Map Gene to Disease3632
BioCentury BCIQINPP5A
ClinGenINPP5A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3632
Chemical/Pharm GKB GenePA29884
Clinical trialINPP5A
Miscellaneous
canSAR (ICR)INPP5A (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINPP5A
EVEXINPP5A
GoPubMedINPP5A
iHOPINPP5A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:04:32 CEST 2016

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