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INPP5B (inositol polyphosphate-5-phosphatase B)

Identity

Alias (NCBI)5PTase
HGNC (Hugo) INPP5B
HGNC Alias nametype II inositol 1,4,5-trisphosphate 5-phosphatase
HGNC Previous nameinositol polyphosphate-5-phosphatase, 75kD
 inositol polyphosphate-5-phosphatase, 75kDa
LocusID (NCBI) 3633
Atlas_Id 43322
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 37860697 and ends at 37947053 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
INPP5B (1p34.3) / INPP5B (1p34.3)INPP5B (1p34.3) / PDCL (9q33.2)INPP5B (1p34.3) / SF3A3 (1p34.3)
RANBP2 (2q12.3) / INPP5B (1p34.3)SNX22 (15q22.31) / INPP5B (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)INPP5B   6077
Cards
Entrez_Gene (NCBI)INPP5B    inositol polyphosphate-5-phosphatase B
Aliases5PTase
GeneCards (Weizmann)INPP5B
Ensembl hg19 (Hinxton)ENSG00000204084 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204084 [Gene_View]  ENSG00000204084 [Sequence]  chr1:37860697-37947053 [Contig_View]  INPP5B [Vega]
ICGC DataPortalENSG00000204084
TCGA cBioPortalINPP5B
AceView (NCBI)INPP5B
Genatlas (Paris)INPP5B
SOURCE (Princeton)INPP5B
Genetics Home Reference (NIH)INPP5B
Genomic and cartography
GoldenPath hg38 (UCSC)INPP5B  -     chr1:37860697-37947053 -  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INPP5B  -     1p34.3   [Description]    (hg19-Feb_2009)
GoldenPathINPP5B - 1p34.3 [CytoView hg19]  INPP5B - 1p34.3 [CytoView hg38]
ImmunoBaseENSG00000204084
Genome Data Viewer NCBIINPP5B [Mapview hg19]  
OMIM147264   
Gene and transcription
Genbank (Entrez)AK022846 AK093261 AK295062 AK310824 AL833055
RefSeq transcript (Entrez)NM_001297434 NM_001350227 NM_001350228 NM_001365820 NM_001365821 NM_001365822 NM_001365823 NM_001365824 NM_001365825 NM_005540
Consensus coding sequences : CCDS (NCBI)INPP5B
Gene ExpressionINPP5B [ NCBI-GEO ]   INPP5B [ EBI - ARRAY_EXPRESS ]   INPP5B [ SEEK ]   INPP5B [ MEM ]
Gene Expression Viewer (FireBrowse)INPP5B [ Firebrowse - Broad ]
GenevisibleExpression of INPP5B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3633
GTEX Portal (Tissue expression)INPP5B
Human Protein AtlasENSG00000204084-INPP5B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32019   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32019  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32019
Catalytic activity : Enzyme3.1.3.36 [ Enzyme-Expasy ]   3.1.3.363.1.3.36 [ IntEnz-EBI ]   3.1.3.36 [ BRENDA ]   3.1.3.36 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP32019
Domaine pattern : Prosite (Expaxy)RHOGAP (PS50238)   
Domains : Interpro (EBI)Endo/exonu/phosph_ase_sf    Endo/exonuclease/phosphatase    Ig-like_fold    INPP5B_PH_dom    IPPc    OCRL1/INPP5B_INPP5c    Rho_GTPase_activation_prot    RhoGAP_dom   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)    INPP5B_PH (PF16776)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam03372    pfam16776    pfam00620   
Domain families : Smart (EMBL)IPPc (SM00128)  RhoGAP (SM00324)  
Conserved Domain (NCBI)INPP5B
PDB (RSDB)3MTC    3N9V    4CML    5A7I    5A7J   
PDB Europe3MTC    3N9V    4CML    5A7I    5A7J   
PDB (PDBSum)3MTC    3N9V    4CML    5A7I    5A7J   
PDB (IMB)3MTC    3N9V    4CML    5A7I    5A7J   
Structural Biology KnowledgeBase3MTC    3N9V    4CML    5A7I    5A7J   
SCOP (Structural Classification of Proteins)3MTC    3N9V    4CML    5A7I    5A7J   
CATH (Classification of proteins structures)3MTC    3N9V    4CML    5A7I    5A7J   
SuperfamilyP32019
AlphaFold pdb e-kbP32019   
Human Protein Atlas [tissue]ENSG00000204084-INPP5B [tissue]
HPRD00924
Protein Interaction databases
DIP (DOE-UCLA)P32019
IntAct (EBI)P32019
BioGRIDINPP5B
STRING (EMBL)INPP5B
ZODIACINPP5B
Ontologies - Pathways
QuickGOP32019
Ontology : AmiGOin utero embryonic development  phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity  phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity  protein binding  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  cytosol  cytosol  cytosol  plasma membrane  signal transduction  spermatogenesis  membrane  membrane  integral component of membrane  flagellated sperm motility  phagocytic vesicle membrane  early endosome membrane  inositol phosphate metabolic process  inositol phosphate dephosphorylation  phosphatidylinositol dephosphorylation  phosphatidylinositol dephosphorylation  metal ion binding  regulation of small GTPase mediated signal transduction  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,4,5-trisphosphate 5-phosphatase activity  regulation of protein processing  
Ontology : EGO-EBIin utero embryonic development  phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity  phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity  protein binding  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  cytosol  cytosol  cytosol  plasma membrane  signal transduction  spermatogenesis  membrane  membrane  integral component of membrane  flagellated sperm motility  phagocytic vesicle membrane  early endosome membrane  inositol phosphate metabolic process  inositol phosphate dephosphorylation  phosphatidylinositol dephosphorylation  phosphatidylinositol dephosphorylation  metal ion binding  regulation of small GTPase mediated signal transduction  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,4,5-trisphosphate 5-phosphatase activity  regulation of protein processing  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx NetworkINPP5B
Atlas of Cancer Signalling NetworkINPP5B
Wikipedia pathwaysINPP5B
Orthology - Evolution
OrthoDB3633
GeneTree (enSembl)ENSG00000204084
Phylogenetic Trees/Animal Genes : TreeFamINPP5B
Homologs : HomoloGeneINPP5B
Homology/Alignments : Family Browser (UCSC)INPP5B
Gene fusions - Rearrangements
Fusion : MitelmanINPP5B/SF3A3 [1p34.3/1p34.3]  
Fusion : QuiverINPP5B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINPP5B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INPP5B
dbVarINPP5B
ClinVarINPP5B
MonarchINPP5B
1000_GenomesINPP5B 
Exome Variant ServerINPP5B
GNOMAD BrowserENSG00000204084
Varsome BrowserINPP5B
ACMGINPP5B variants
VarityP32019
Genomic Variants (DGV)INPP5B [DGVbeta]
DECIPHERINPP5B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINPP5B 
Mutations
ICGC Data PortalINPP5B 
TCGA Data PortalINPP5B 
Broad Tumor PortalINPP5B
OASIS PortalINPP5B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINPP5B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DINPP5B
Mutations and Diseases : HGMDINPP5B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaINPP5B
DgiDB (Drug Gene Interaction Database)INPP5B
DoCM (Curated mutations)INPP5B
CIViC (Clinical Interpretations of Variants in Cancer)INPP5B
Cancer3DINPP5B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147264   
Orphanet
DisGeNETINPP5B
MedgenINPP5B
Genetic Testing Registry INPP5B
NextProtP32019 [Medical]
GENETestsINPP5B
Target ValidationINPP5B
Huge Navigator INPP5B [HugePedia]
ClinGenINPP5B
Clinical trials, drugs, therapy
MyCancerGenomeINPP5B
Protein Interactions : CTDINPP5B
Pharm GKB GenePA29885
PharosP32019
Clinical trialINPP5B
Miscellaneous
canSAR (ICR)INPP5B
HarmonizomeINPP5B
DataMed IndexINPP5B
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXINPP5B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:01 CEST 2021

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