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INPP5B (inositol polyphosphate-5-phosphatase B)

Identity

Alias_names4
5-trisphosphate 5-phosphatase
Other alias5PTase
HGNC (Hugo) INPP5B
LocusID (NCBI) 3633
Atlas_Id 43322
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 37860697 and ends at 37931791 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
INPP5B (1p34.3) / INPP5B (1p34.3)INPP5B (1p34.3) / PDCL (9q33.2)INPP5B (1p34.3) / SF3A3 (1p34.3)
RANBP2 (2q12.3) / INPP5B (1p34.3)SNX22 (15q22.31) / INPP5B (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)INPP5B   6077
Cards
Entrez_Gene (NCBI)INPP5B  3633  inositol polyphosphate-5-phosphatase B
Aliases5PTase
GeneCards (Weizmann)INPP5B
Ensembl hg19 (Hinxton)ENSG00000204084 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204084 [Gene_View]  chr1:37860697-37931791 [Contig_View]  INPP5B [Vega]
ICGC DataPortalENSG00000204084
TCGA cBioPortalINPP5B
AceView (NCBI)INPP5B
Genatlas (Paris)INPP5B
WikiGenes3633
SOURCE (Princeton)INPP5B
Genetics Home Reference (NIH)INPP5B
Genomic and cartography
GoldenPath hg38 (UCSC)INPP5B  -     chr1:37860697-37931791 -  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INPP5B  -     1p34.3   [Description]    (hg19-Feb_2009)
EnsemblINPP5B - 1p34.3 [CytoView hg19]  INPP5B - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBIINPP5B [Mapview hg19]  INPP5B [Mapview hg38]
OMIM147264   
Gene and transcription
Genbank (Entrez)AK022846 AK093261 AK295062 AK310824 AL833055
RefSeq transcript (Entrez)NM_001297434 NM_001350227 NM_001350228 NM_005540
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)INPP5B
Cluster EST : UnigeneHs.449942 [ NCBI ]
CGAP (NCI)Hs.449942
Alternative Splicing GalleryENSG00000204084
Gene ExpressionINPP5B [ NCBI-GEO ]   INPP5B [ EBI - ARRAY_EXPRESS ]   INPP5B [ SEEK ]   INPP5B [ MEM ]
Gene Expression Viewer (FireBrowse)INPP5B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3633
GTEX Portal (Tissue expression)INPP5B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32019   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32019  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32019
Splice isoforms : SwissVarP32019
Catalytic activity : Enzyme3.1.3.36 [ Enzyme-Expasy ]   3.1.3.363.1.3.36 [ IntEnz-EBI ]   3.1.3.36 [ BRENDA ]   3.1.3.36 [ KEGG ]   
PhosPhoSitePlusP32019
Domaine pattern : Prosite (Expaxy)RHOGAP (PS50238)   
Domains : Interpro (EBI)Endo/exonuclease/phosphatase    INPP5B_PH_dom    IPPc    Rho_GTPase_activation_prot    RhoGAP_dom   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)    INPP5B_PH (PF16776)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam03372    pfam16776    pfam00620   
Domain families : Smart (EMBL)IPPc (SM00128)  RhoGAP (SM00324)  
Conserved Domain (NCBI)INPP5B
DMDM Disease mutations3633
Blocks (Seattle)INPP5B
PDB (SRS)3MTC    3N9V    4CML    5A7I    5A7J   
PDB (PDBSum)3MTC    3N9V    4CML    5A7I    5A7J   
PDB (IMB)3MTC    3N9V    4CML    5A7I    5A7J   
PDB (RSDB)3MTC    3N9V    4CML    5A7I    5A7J   
Structural Biology KnowledgeBase3MTC    3N9V    4CML    5A7I    5A7J   
SCOP (Structural Classification of Proteins)3MTC    3N9V    4CML    5A7I    5A7J   
CATH (Classification of proteins structures)3MTC    3N9V    4CML    5A7I    5A7J   
SuperfamilyP32019
Human Protein AtlasENSG00000204084
Peptide AtlasP32019
HPRD00924
IPIIPI00478376   IPI00553072   IPI00244111   IPI00604769   IPI00910501   IPI00478901   
Protein Interaction databases
DIP (DOE-UCLA)P32019
IntAct (EBI)P32019
FunCoupENSG00000204084
BioGRIDINPP5B
STRING (EMBL)INPP5B
ZODIACINPP5B
Ontologies - Pathways
QuickGOP32019
Ontology : AmiGOin utero embryonic development  phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity  GTPase activator activity  protein binding  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  cytosol  cytosol  plasma membrane  signal transduction  spermatogenesis  membrane  integral component of membrane  flagellated sperm motility  phagocytic vesicle membrane  early endosome membrane  positive regulation of GTPase activity  inositol phosphate metabolic process  phosphatidylinositol dephosphorylation  metal ion binding  regulation of small GTPase mediated signal transduction  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity  regulation of protein processing  
Ontology : EGO-EBIin utero embryonic development  phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity  GTPase activator activity  protein binding  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  cytosol  cytosol  plasma membrane  signal transduction  spermatogenesis  membrane  integral component of membrane  flagellated sperm motility  phagocytic vesicle membrane  early endosome membrane  positive regulation of GTPase activity  inositol phosphate metabolic process  phosphatidylinositol dephosphorylation  metal ion binding  regulation of small GTPase mediated signal transduction  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity  regulation of protein processing  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx NetworkINPP5B
Atlas of Cancer Signalling NetworkINPP5B
Wikipedia pathwaysINPP5B
Orthology - Evolution
OrthoDB3633
GeneTree (enSembl)ENSG00000204084
Phylogenetic Trees/Animal Genes : TreeFamINPP5B
HOVERGENP32019
HOGENOMP32019
Homologs : HomoloGeneINPP5B
Homology/Alignments : Family Browser (UCSC)INPP5B
Gene fusions - Rearrangements
Fusion : MitelmanINPP5B/SF3A3 [1p34.3/1p34.3]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINPP5B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INPP5B
dbVarINPP5B
ClinVarINPP5B
1000_GenomesINPP5B 
Exome Variant ServerINPP5B
ExAC (Exome Aggregation Consortium)INPP5B (select the gene name)
Genetic variants : HAPMAP3633
Genomic Variants (DGV)INPP5B [DGVbeta]
DECIPHERINPP5B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINPP5B 
Mutations
ICGC Data PortalINPP5B 
TCGA Data PortalINPP5B 
Broad Tumor PortalINPP5B
OASIS PortalINPP5B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINPP5B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINPP5B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INPP5B
DgiDB (Drug Gene Interaction Database)INPP5B
DoCM (Curated mutations)INPP5B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INPP5B (select a term)
intoGenINPP5B
Cancer3DINPP5B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147264   
Orphanet
MedgenINPP5B
Genetic Testing Registry INPP5B
NextProtP32019 [Medical]
TSGene3633
GENETestsINPP5B
Target ValidationINPP5B
Huge Navigator INPP5B [HugePedia]
snp3D : Map Gene to Disease3633
BioCentury BCIQINPP5B
ClinGenINPP5B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3633
Chemical/Pharm GKB GenePA29885
Clinical trialINPP5B
Miscellaneous
canSAR (ICR)INPP5B (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINPP5B
EVEXINPP5B
GoPubMedINPP5B
iHOPINPP5B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:13:25 CEST 2017

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