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INPP5D (inositol polyphosphate-5-phosphatase D)

Identity

Other namesSHIP
SHIP-1
SHIP1
SIP-145
hp51CN
p150Ship
HGNC (Hugo) INPP5D
LocusID (NCBI) 3635
Atlas_Id 40983
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 233924677 and ends at 234116549 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARHGAP15 (2q22.2) / INPP5D (2q37.1)ATG16L1 (2q37.1) / INPP5D (2q37.1)INPP5D (2q37.1) / ABL1 (9q34.12)
INPP5D (2q37.1) / C7orf73 (7q33)PIK3R5 (17p13.1) / INPP5D (2q37.1)TUBD1 (17q23.1) / INPP5D (2q37.1)
TUBD1 17q23.1 / INPP5D 2q37.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;9)(q37;q34) INPP5D-ABL1

External links

Nomenclature
HGNC (Hugo)INPP5D   6079
Cards
Entrez_Gene (NCBI)INPP5D  3635  inositol polyphosphate-5-phosphatase D
AliasesSHIP; SHIP-1; SHIP1; SIP-145; 
hp51CN; p150Ship
GeneCards (Weizmann)INPP5D
Ensembl hg19 (Hinxton)ENSG00000168918 [Gene_View]  chr2:233924677-234116549 [Contig_View]  INPP5D [Vega]
Ensembl hg38 (Hinxton)ENSG00000168918 [Gene_View]  chr2:233924677-234116549 [Contig_View]  INPP5D [Vega]
ICGC DataPortalENSG00000168918
TCGA cBioPortalINPP5D
AceView (NCBI)INPP5D
Genatlas (Paris)INPP5D
WikiGenes3635
SOURCE (Princeton)INPP5D
Genomic and cartography
GoldenPath hg19 (UCSC)INPP5D  -     chr2:233924677-234116549 +  2q37.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)INPP5D  -     2q37.1   [Description]    (hg38-Dec_2013)
EnsemblINPP5D - 2q37.1 [CytoView hg19]  INPP5D - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBIINPP5D [Mapview hg19]  INPP5D [Mapview hg38]
OMIM601582   
Gene and transcription
Genbank (Entrez)AK298651 AK309644 AW503130 BC027960 BC062985
RefSeq transcript (Entrez)NM_001017915 NM_005541
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_033988 NT_005403 NW_004929305 NW_004929306 NW_011332690
Consensus coding sequences : CCDS (NCBI)INPP5D
Cluster EST : UnigeneHs.601911 [ NCBI ]
CGAP (NCI)Hs.601911
Alternative Splicing GalleryENSG00000168918
Gene ExpressionINPP5D [ NCBI-GEO ]   INPP5D [ EBI - ARRAY_EXPRESS ]   INPP5D [ SEEK ]   INPP5D [ MEM ]
Gene Expression Viewer (FireBrowse)INPP5D [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3635
GTEX Portal (Tissue expression)INPP5D
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92835 (Uniprot)
NextProtQ92835  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92835
Splice isoforms : SwissVarQ92835 (Swissvar)
Catalytic activity : Enzyme3.1.3.86 [ Enzyme-Expasy ]   3.1.3.863.1.3.86 [ IntEnz-EBI ]   3.1.3.86 [ BRENDA ]   3.1.3.86 [ KEGG ]   
PhosPhoSitePlusQ92835
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)Endo/exonuclease/phosphatase    IPPc    SH2   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam03372    pfam00017   
Domain families : Smart (EMBL)IPPc (SM00128)  SH2 (SM00252)  
DMDM Disease mutations3635
Blocks (Seattle)INPP5D
PDB (SRS)2YSX   
PDB (PDBSum)2YSX   
PDB (IMB)2YSX   
PDB (RSDB)2YSX   
Structural Biology KnowledgeBase2YSX   
SCOP (Structural Classification of Proteins)2YSX   
CATH (Classification of proteins structures)2YSX   
SuperfamilyQ92835
Human Protein AtlasENSG00000168918
Peptide AtlasQ92835
HPRD09033
Protein Interaction databases
DIP (DOE-UCLA)Q92835
IntAct (EBI)Q92835
FunCoupENSG00000168918
BioGRIDINPP5D
STRING (EMBL)INPP5D
ZODIACINPP5D
Ontologies - Pathways
QuickGOQ92835
Ontology : AmiGOinositol-polyphosphate 5-phosphatase activity  protein binding  cytosol  cytoskeleton  plasma membrane  phosphatidylinositol biosynthetic process  phosphate-containing compound metabolic process  apoptotic process  signal transduction  determination of adult lifespan  negative regulation of signal transduction  immunoglobulin mediated immune response  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  SH3 domain binding  negative regulation of B cell proliferation  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity  intracellular signal transduction  positive regulation of apoptotic process  inositol phosphate metabolic process  membrane raft  negative regulation of interleukin-6 biosynthetic process  positive regulation of B cell differentiation  positive regulation of erythrocyte differentiation  negative regulation of monocyte differentiation  negative regulation of neutrophil differentiation  negative regulation of osteoclast differentiation  negative regulation of bone resorption  phosphatidylinositol dephosphorylation  negative regulation of immune response  T cell receptor signaling pathway  leukocyte migration  PTB domain binding  inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity  
Ontology : EGO-EBIinositol-polyphosphate 5-phosphatase activity  protein binding  cytosol  cytoskeleton  plasma membrane  phosphatidylinositol biosynthetic process  phosphate-containing compound metabolic process  apoptotic process  signal transduction  determination of adult lifespan  negative regulation of signal transduction  immunoglobulin mediated immune response  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  SH3 domain binding  negative regulation of B cell proliferation  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity  intracellular signal transduction  positive regulation of apoptotic process  inositol phosphate metabolic process  membrane raft  negative regulation of interleukin-6 biosynthetic process  positive regulation of B cell differentiation  positive regulation of erythrocyte differentiation  negative regulation of monocyte differentiation  negative regulation of neutrophil differentiation  negative regulation of osteoclast differentiation  negative regulation of bone resorption  phosphatidylinositol dephosphorylation  negative regulation of immune response  T cell receptor signaling pathway  leukocyte migration  PTB domain binding  inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis   
NDEx NetworkINPP5D
Atlas of Cancer Signalling NetworkINPP5D
Wikipedia pathwaysINPP5D
Orthology - Evolution
OrthoDB3635
GeneTree (enSembl)ENSG00000168918
Phylogenetic Trees/Animal Genes : TreeFamINPP5D
Homologs : HomoloGeneINPP5D
Homology/Alignments : Family Browser (UCSC)INPP5D
Gene fusions - Rearrangements
Fusion: TCGATUBD1 17q23.1 INPP5D 2q37.1 HNSC
Polymorphisms : SNP, variants
NCBI Variation ViewerINPP5D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INPP5D
dbVarINPP5D
ClinVarINPP5D
1000_GenomesINPP5D 
Exome Variant ServerINPP5D
ExAC (Exome Aggregation Consortium)INPP5D (select the gene name)
Genetic variants : HAPMAP3635
Genomic Variants (DGV)INPP5D [DGVbeta]
Mutations
ICGC Data PortalINPP5D 
TCGA Data PortalINPP5D 
Broad Tumor PortalINPP5D
OASIS PortalINPP5D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINPP5D 
BioMutasearch INPP5D
DgiDB (Drug Gene Interaction Database)INPP5D
DoCM (Curated mutations)INPP5D (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INPP5D (select a term)
intoGenINPP5D
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:233924677-234116549  ENSG00000168918
CONAN: Copy Number AnalysisINPP5D 
Mutations and Diseases : HGMDINPP5D
OMIM601582   
MedgenINPP5D
Genetic Testing Registry INPP5D
NextProtQ92835 [Medical]
TSGene3635
GENETestsINPP5D
Huge Navigator INPP5D [HugePedia]
snp3D : Map Gene to Disease3635
BioCentury BCIQINPP5D
ClinGenINPP5D
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3635
Chemical/Pharm GKB GenePA29887
Clinical trialINPP5D
Miscellaneous
canSAR (ICR)INPP5D (select the gene name)
Probes
Litterature
PubMed117 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINPP5D
EVEXINPP5D
GoPubMedINPP5D
iHOPINPP5D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 18:55:08 CEST 2016

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