INPP5D (inositol polyphosphate-5-phosphatase D)

2003-11-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
SHIP,SHIP-1,SHIP1,SIP-145,hp51CN,p150Ship
FUSION GENES

Other Information

Locus ID:

NCBI: 3635
MIM: 601582
HGNC: 6079
Ensembl: ENSG00000168918

Variants:

dbSNP: 3635
ClinVar: 3635
TCGA: ENSG00000168918
COSMIC: INPP5D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168918ENST00000359570Q92835
ENSG00000168918ENST00000415617H0Y5Q9
ENSG00000168918ENST00000417661H7C403
ENSG00000168918ENST00000445964Q92835
ENSG00000168918ENST00000491070R4GMN8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
B cell receptor signaling pathwayKEGGko04662
Fc epsilon RI signaling pathwayKEGGko04664
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
B cell receptor signaling pathwayKEGGhsa04662
Fc epsilon RI signaling pathwayKEGGhsa04664
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Downstream TCR signalingREACTOMER-HSA-202424
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927
Interleukin receptor SHC signalingREACTOMER-HSA-912526
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
PECAM1 interactionsREACTOMER-HSA-210990
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IP3 and IP4 in the cytosolREACTOMER-HSA-1855204
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
196411832009Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia.80
200411452009MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response.70
198904742009Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
242068422013Tks5 and SHIP2 regulate invadopodium maturation, but not initiation, in breast carcinoma cells.57
249141342014MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia.51
231543882013Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells.48
156042182005Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation.42
211558372011Inhibitor and activator: dual functions for SHIP in immunity and cancer.42

Citation

Dessen P

INPP5D (inositol polyphosphate-5-phosphatase D)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40983/inpp5d