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INPP5D (inositol polyphosphate-5-phosphatase, 145kDa)

Identity

Other namesSHIP
SHIP-1
SHIP1
SIP-145
hp51CN
HGNC (Hugo) INPP5D
LocusID (NCBI) 3635
Location 2q37.1
Location_base_pair Starts at 233925036 and ends at 234116549 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)INPP5D   6079
Entrez_Gene (NCBI)INPP5D  3635  inositol polyphosphate-5-phosphatase, 145kDa
Cards
GeneCards (Weizmann)INPP5D
Ensembl (Hinxton)ENSG00000168918 [Gene_View]  chr2:233925036-234116549 [Contig_View]  INPP5D [Vega]
AceView (NCBI)INPP5D
Genatlas (Paris)INPP5D
SOURCE (Stanford)NM_001017915 NM_005541
Genomic and cartography
GoldenPath (UCSC)INPP5D  -  2q37.1   chr2:233925036-234116549 +  2q37.1   [Description]    (hg19-Feb_2009)
EnsemblINPP5D - 2q37.1 [CytoView]
Mapping of homologs : NCBIINPP5D [Mapview]
OMIM601582   
Gene and transcription
Genbank (Entrez)AK298651 AK309644 BC027960 BC062985 BC099920
RefSeq transcript (SRS)NM_001017915 NM_005541
RefSeq transcript (Entrez)NM_001017915 NM_005541
RefSeq genomic (SRS)AC_000134 NC_000002 NC_018913 NT_005120 NT_005403 NW_001838867 NW_001838868 NW_004078008 NW_004078009
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NT_005120 NT_005403 NW_001838867 NW_001838868 NW_004078008 NW_004078009
Consensus coding sequences : CCDS (NCBI)INPP5D
Cluster EST : UnigeneHs.601911 [ SRS ] Hs.601911 [ NCBI ]
CGAP (NCI)Hs.601911
Alternative Splicing : Fast-db (Paris)GSHG0017288
Alternative Splicing GalleryENSG00000168918
Gene ExpressionINPP5D [ NCBI-GEO ]   INPP5D [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92835 (SRS) Q92835 (Uniprot)
NextProtQ92835
With graphics : InterProQ92835
Splice isoforms : SwissVarQ92835(Swissvar)
Domaine pattern : Prosite (SRS)SH2 (PS50001)   
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (SRS)Endo/exonuclease/phosphatase    IPPc    SH2   
Domains : Interpro (EBI)Endo/exonuclease/phosphatase    IPPc    SH2   
Related proteins : CluSTrQ92835
Domain families : Pfam (SRS)Exo_endo_phos (PF03372)    SH2 (PF00017)   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam03372    pfam00017   
Domain families : Smart (EMBL)IPPc (SM00128)  SH2 (SM00252)  
DMDM3635
Blocks (Seattle)Q92835
PDB (SRS)2YSX   
PDB (PDBSum)2YSX   
PDB (IMB)2YSX   
PDB (RSDB)2YSX   
Human Protein AtlasENSG00000168918
HPRD09033
Protein Interaction databases
DIP (DOE-UCLA)Q92835
IntAct (EBI)Q92835
FunCoupENSG00000168918
REACTOMEINPP5D
Protein Interaction Database3635
BioGRIDINPP5D
InParanoidQ92835
Interologous Interaction database Q92835
IntegromeDBINPP5D
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)INPP5D
SNP (GeneSNP Utah)INPP5D
SNP : HGBaseINPP5D
Genetic variants : HAPMAPINPP5D
Somatic Mutations in Cancer : COSMICINPP5D 
CONAN: Copy Number AnalysisINPP5D 
Translocation Breakpoints in Cancer : TICdbINPP5D 
Mutations and Diseases : HGMDINPP5D
OMIM601582   
GENETests601582   
Disease Genetic AssociationINPP5D
Huge Navigator INPP5D [HugePedia]  INPP5D [HugeCancerGEM]
Genomic VariantsINPP5D  INPP5D [DGVbeta]
snp3D : Map Gene to Disease3635
General knowledge
Homologs : HomoloGeneINPP5D
Homology/Alignments : Family Browser (UCSC)INPP5D
Phylogenetic Trees/Animal Genes : TreeFamINPP5D
Catalytic activity : Enzyme3.1.3.86 [ Enzyme-Expasy ]   3.1.3.86 [ Enzyme-SRS ]   3.1.3.86 [ IntEnz-EBI ]   3.1.3.86 [ BRENDA ]   3.1.3.86 [ KEGG ]   
Chemical/Protein Interactions : CTD3635
Chemical/Pharm GKB GenePA29887
Clinical trialINPP5D
Cancer Resource (Charite)ENSG00000168918
Ontology : AmiGOinositol-polyphosphate 5-phosphatase activity  protein binding  cytosol  actin filament  plasma membrane  phospholipid metabolic process  phosphatidylinositol biosynthetic process  phosphate-containing compound metabolic process  apoptotic process  signal transduction  blood coagulation  determination of adult lifespan  negative regulation of signal transduction  immunoglobulin mediated immune response  SH3 domain binding  inositol-4,5-bisphosphate 5-phosphatase activity  cortical cytoskeleton  negative regulation of B cell proliferation  phosphatidylinositol trisphosphate phosphatase activity  intracellular signal transduction  positive regulation of apoptotic process  small molecule metabolic process  negative regulation of interleukin-6 biosynthetic process  positive regulation of B cell differentiation  positive regulation of erythrocyte differentiation  negative regulation of monocyte differentiation  negative regulation of neutrophil differentiation  negative regulation of osteoclast differentiation  negative regulation of bone resorption  phosphatidylinositol phosphorylation  negative regulation of immune response  T cell receptor signaling pathway  leukocyte migration  PTB domain binding  
Ontology : EGO-EBIinositol-polyphosphate 5-phosphatase activity  protein binding  cytosol  actin filament  plasma membrane  phospholipid metabolic process  phosphatidylinositol biosynthetic process  phosphate-containing compound metabolic process  apoptotic process  signal transduction  blood coagulation  determination of adult lifespan  negative regulation of signal transduction  immunoglobulin mediated immune response  SH3 domain binding  inositol-4,5-bisphosphate 5-phosphatase activity  cortical cytoskeleton  negative regulation of B cell proliferation  phosphatidylinositol trisphosphate phosphatase activity  intracellular signal transduction  positive regulation of apoptotic process  small molecule metabolic process  negative regulation of interleukin-6 biosynthetic process  positive regulation of B cell differentiation  positive regulation of erythrocyte differentiation  negative regulation of monocyte differentiation  negative regulation of neutrophil differentiation  negative regulation of osteoclast differentiation  negative regulation of bone resorption  phosphatidylinositol phosphorylation  negative regulation of immune response  T cell receptor signaling pathway  leukocyte migration  PTB domain binding  
Pathways : KEGGFc epsilon RI signaling pathwayPhosphatidylinositol signaling systemInsulin signaling pathwayB cell receptor signaling pathway
Other databases
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
PubGeneINPP5D
iHOPINPP5D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:48:22 CEST 2013
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