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INPP5D (inositol polyphosphate-5-phosphatase, 145kDa)

Identity

Other namesSHIP
SHIP-1
SHIP1
SIP-145
hp51CN
p150Ship
HGNC (Hugo) INPP5D
LocusID (NCBI) 3635
Atlas_Id 40983
Location 2q37.1
Location_base_pair Starts at 233924677 and ends at 234116549 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)INPP5D   6079
Cards
Entrez_Gene (NCBI)INPP5D  3635  inositol polyphosphate-5-phosphatase, 145kDa
GeneCards (Weizmann)INPP5D
Ensembl hg19 (Hinxton)ENSG00000168918 [Gene_View]  chr2:233924677-234116549 [Contig_View]  INPP5D [Vega]
Ensembl hg38 (Hinxton)ENSG00000168918 [Gene_View]  chr2:233924677-234116549 [Contig_View]  INPP5D [Vega]
ICGC DataPortalENSG00000168918
TCGA cBioPortalINPP5D
AceView (NCBI)INPP5D
Genatlas (Paris)INPP5D
WikiGenes3635
SOURCE (Princeton)INPP5D
Genomic and cartography
GoldenPath hg19 (UCSC)INPP5D  -     chr2:233924677-234116549 +  2q37.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)INPP5D  -     2q37.1   [Description]    (hg38-Dec_2013)
EnsemblINPP5D - 2q37.1 [CytoView hg19]  INPP5D - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBIINPP5D [Mapview hg19]  INPP5D [Mapview hg38]
OMIM601582   
Gene and transcription
Genbank (Entrez)AK298651 AK309644 AW503130 BC027960 BC062985
RefSeq transcript (Entrez)NM_001017915 NM_005541
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_033988 NT_005403 NW_004929305 NW_004929306 NW_011332690
Consensus coding sequences : CCDS (NCBI)INPP5D
Cluster EST : UnigeneHs.601911 [ NCBI ]
CGAP (NCI)Hs.601911
Alternative Splicing : Fast-db (Paris)GSHG0017288
Alternative Splicing GalleryENSG00000168918
Gene ExpressionINPP5D [ NCBI-GEO ]     INPP5D [ SEEK ]   INPP5D [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92835 (Uniprot)
NextProtQ92835  [Medical]
With graphics : InterProQ92835
Splice isoforms : SwissVarQ92835 (Swissvar)
Catalytic activity : Enzyme3.1.3.86 [ Enzyme-Expasy ]   3.1.3.863.1.3.86 [ IntEnz-EBI ]   3.1.3.86 [ BRENDA ]   3.1.3.86 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)Endo/exonuclease/phosphatase    IPPc    SH2   
Related proteins : CluSTrQ92835
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam03372    pfam00017   
Domain families : Smart (EMBL)IPPc (SM00128)  SH2 (SM00252)  
DMDM Disease mutations3635
Blocks (Seattle)Q92835
PDB (SRS)2YSX   
PDB (PDBSum)2YSX   
PDB (IMB)2YSX   
PDB (RSDB)2YSX   
Human Protein AtlasENSG00000168918
Peptide AtlasQ92835
HPRD09033
Protein Interaction databases
DIP (DOE-UCLA)Q92835
IntAct (EBI)Q92835
FunCoupENSG00000168918
BioGRIDINPP5D
IntegromeDBINPP5D
STRING (EMBL)INPP5D
Ontologies - Pathways
QuickGOQ92835
Ontology : AmiGOinositol-polyphosphate 5-phosphatase activity  protein binding  cytosol  phospholipid metabolic process  phosphatidylinositol biosynthetic process  phosphate-containing compound metabolic process  apoptotic process  signal transduction  blood coagulation  membrane  SH3 domain binding  inositol phosphate metabolic process  small molecule metabolic process  phosphatidylinositol dephosphorylation  T cell receptor signaling pathway  leukocyte migration  
Ontology : EGO-EBIinositol-polyphosphate 5-phosphatase activity  protein binding  cytosol  phospholipid metabolic process  phosphatidylinositol biosynthetic process  phosphate-containing compound metabolic process  apoptotic process  signal transduction  blood coagulation  membrane  SH3 domain binding  inositol phosphate metabolic process  small molecule metabolic process  phosphatidylinositol dephosphorylation  T cell receptor signaling pathway  leukocyte migration  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis   
Protein Interaction DatabaseINPP5D
DoCM (Curated mutations)INPP5D
Wikipedia pathwaysINPP5D
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerINPP5D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INPP5D
dbVarINPP5D
ClinVarINPP5D
1000_GenomesINPP5D 
Exome Variant ServerINPP5D
SNP (GeneSNP Utah)INPP5D
SNP : HGBaseINPP5D
Genetic variants : HAPMAPINPP5D
Genomic Variants (DGV)INPP5D [DGVbeta]
Mutations
ICGC Data PortalINPP5D 
TCGA Data PortalINPP5D 
Tumor PortalINPP5D
Somatic Mutations in Cancer : COSMICINPP5D 
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:233924677-234116549
CONAN: Copy Number AnalysisINPP5D 
Mutations and Diseases : HGMDINPP5D
OMIM601582   
MedgenINPP5D
NextProtQ92835 [Medical]
GENETestsINPP5D
Disease Genetic AssociationINPP5D
Huge Navigator INPP5D [HugePedia]  INPP5D [HugeCancerGEM]
snp3D : Map Gene to Disease3635
DGIdb (Drug Gene Interaction db)INPP5D
General knowledge
Homologs : HomoloGeneINPP5D
Homology/Alignments : Family Browser (UCSC)INPP5D
Phylogenetic Trees/Animal Genes : TreeFamINPP5D
Chemical/Protein Interactions : CTD3635
Chemical/Pharm GKB GenePA29887
Clinical trialINPP5D
Cancer Resource (Charite)ENSG00000168918
Other databases
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
CoreMineINPP5D
GoPubMedINPP5D
iHOPINPP5D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 20 19:27:52 CEST 2015

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