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INPP5D (inositol polyphosphate-5-phosphatase, 145kDa)

Identity

Other namesSHIP
SHIP-1
SHIP1
SIP-145
hp51CN
p150Ship
HGNC (Hugo) INPP5D
LocusID (NCBI) 3635
Location 2q37.1
Location_base_pair Starts at 233924677 and ends at 234116549 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)INPP5D   6079
Cards
Entrez_Gene (NCBI)INPP5D  3635  inositol polyphosphate-5-phosphatase, 145kDa
GeneCards (Weizmann)INPP5D
Ensembl (Hinxton)ENSG00000168918 [Gene_View]  chr2:233924677-234116549 [Contig_View]  INPP5D [Vega]
ICGC DataPortalENSG00000168918
cBioPortalINPP5D
AceView (NCBI)INPP5D
Genatlas (Paris)INPP5D
WikiGenes3635
SOURCE (Princeton)NM_001017915 NM_005541
Genomic and cartography
GoldenPath (UCSC)INPP5D  -  2q37.1   chr2:233924677-234116549 +  2q37.1   [Description]    (hg19-Feb_2009)
EnsemblINPP5D - 2q37.1 [CytoView]
Mapping of homologs : NCBIINPP5D [Mapview]
OMIM601582   
Gene and transcription
Genbank (Entrez)AK298651 AK309644 AW503130 BC027960 BC062985
RefSeq transcript (Entrez)NM_001017915 NM_005541
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_033988 NT_005403 NW_001838867 NW_001838868 NW_004929305 NW_004929306
Consensus coding sequences : CCDS (NCBI)INPP5D
Cluster EST : UnigeneHs.601911 [ NCBI ]
CGAP (NCI)Hs.601911
Alternative Splicing : Fast-db (Paris)GSHG0017288
Alternative Splicing GalleryENSG00000168918
Gene ExpressionINPP5D [ NCBI-GEO ]     INPP5D [ SEEK ]   INPP5D [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92835 (Uniprot)
NextProtQ92835  [Medical]
With graphics : InterProQ92835
Splice isoforms : SwissVarQ92835 (Swissvar)
Catalytic activity : Enzyme3.1.3.86 [ Enzyme-Expasy ]   3.1.3.863.1.3.86 [ IntEnz-EBI ]   3.1.3.86 [ BRENDA ]   3.1.3.86 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)Endo/exonuclease/phosphatase [organisation]   IPPc [organisation]   SH2 [organisation]  
Related proteins : CluSTrQ92835
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam03372    pfam00017   
Domain families : Smart (EMBL)IPPc (SM00128)  SH2 (SM00252)  
DMDM Disease mutations3635
Blocks (Seattle)Q92835
PDB (SRS)2YSX   
PDB (PDBSum)2YSX   
PDB (IMB)2YSX   
PDB (RSDB)2YSX   
Human Protein AtlasENSG00000168918 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ92835
HPRD09033
Protein Interaction databases
DIP (DOE-UCLA)Q92835
IntAct (EBI)Q92835
FunCoupENSG00000168918
BioGRIDINPP5D
InParanoidQ92835
Interologous Interaction database Q92835
IntegromeDBINPP5D
STRING (EMBL)INPP5D
Ontologies - Pathways
Ontology : AmiGOinositol-polyphosphate 5-phosphatase activity  protein binding  cytosol  phospholipid metabolic process  phosphatidylinositol biosynthetic process  phosphate-containing compound metabolic process  apoptotic process  signal transduction  blood coagulation  determination of adult lifespan  negative regulation of signal transduction  membrane  immunoglobulin mediated immune response  SH3 domain binding  negative regulation of B cell proliferation  phosphatidylinositol trisphosphate phosphatase activity  intracellular signal transduction  positive regulation of apoptotic process  inositol phosphate metabolic process  small molecule metabolic process  negative regulation of interleukin-6 biosynthetic process  positive regulation of B cell differentiation  positive regulation of erythrocyte differentiation  negative regulation of monocyte differentiation  negative regulation of neutrophil differentiation  negative regulation of osteoclast differentiation  negative regulation of bone resorption  phosphatidylinositol dephosphorylation  negative regulation of immune response  T cell receptor signaling pathway  leukocyte migration  PTB domain binding  
Ontology : EGO-EBIinositol-polyphosphate 5-phosphatase activity  protein binding  cytosol  phospholipid metabolic process  phosphatidylinositol biosynthetic process  phosphate-containing compound metabolic process  apoptotic process  signal transduction  blood coagulation  determination of adult lifespan  negative regulation of signal transduction  membrane  immunoglobulin mediated immune response  SH3 domain binding  negative regulation of B cell proliferation  phosphatidylinositol trisphosphate phosphatase activity  intracellular signal transduction  positive regulation of apoptotic process  inositol phosphate metabolic process  small molecule metabolic process  negative regulation of interleukin-6 biosynthetic process  positive regulation of B cell differentiation  positive regulation of erythrocyte differentiation  negative regulation of monocyte differentiation  negative regulation of neutrophil differentiation  negative regulation of osteoclast differentiation  negative regulation of bone resorption  phosphatidylinositol dephosphorylation  negative regulation of immune response  T cell receptor signaling pathway  leukocyte migration  PTB domain binding  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis   
Protein Interaction DatabaseINPP5D
Wikipedia pathwaysINPP5D
Gene fusion - rearrangments
Rearrangement : TICdbINPP5D [2q37.1]  -  ABL1 [6p21.32]
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)INPP5D
snp3D : Map Gene to Disease3635
SNP (GeneSNP Utah)INPP5D
SNP : HGBaseINPP5D
Genetic variants : HAPMAPINPP5D
Exome VariantINPP5D
1000_GenomesINPP5D 
ICGC programENSG00000168918 
Somatic Mutations in Cancer : COSMICINPP5D 
CONAN: Copy Number AnalysisINPP5D 
Mutations and Diseases : HGMDINPP5D
Mutations and Diseases : intOGenINPP5D
Genomic VariantsINPP5D  INPP5D [DGVbeta]
dbVarINPP5D
ClinVarINPP5D
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM601582   
MedgenINPP5D
GENETestsINPP5D
Disease Genetic AssociationINPP5D
Huge Navigator INPP5D [HugePedia]  INPP5D [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneINPP5D
Homology/Alignments : Family Browser (UCSC)INPP5D
Phylogenetic Trees/Animal Genes : TreeFamINPP5D
Chemical/Protein Interactions : CTD3635
Chemical/Pharm GKB GenePA29887
Clinical trialINPP5D
Cancer Resource (Charite)ENSG00000168918
Other databases
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
CoreMineINPP5D
iHOPINPP5D
OncoSearchINPP5D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 18:57:01 CEST 2014

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