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INPP5D (inositol polyphosphate-5-phosphatase D)

Identity

Alias (NCBI)SHIP
SHIP-1
SHIP1
SIP-145
hp51CN
p150Ship
HGNC (Hugo) INPP5D
HGNC Alias symbSHIP
hp51CN
SHIP1
HGNC Alias nameSH2 domain-containing inositol 5'-phosphatase 1
HGNC Previous nameinositol polyphosphate-5-phosphatase, 145kD
 inositol polyphosphate-5-phosphatase, 145kDa
LocusID (NCBI) 3635
Atlas_Id 40983
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 233060342 and ends at 233207903 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP15 (2q22.2) / INPP5D (2q37.1)ATG16L1 (2q37.1) / INPP5D (2q37.1)INPP5D (2q37.1) / ABL1 (9q34.12)
INPP5D (2q37.1) / C7orf73 (7q33)PIK3R5 (17p13.1) / INPP5D (2q37.1)TUBD1 (17q23.1) / INPP5D (2q37.1)
TUBD1 17q23.1 / INPP5D 2q37.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Aggressive natural killer leukemia (ANKL)
t(2;9)(q37;q34) INPP5D/ABL1


External links

Nomenclature
HGNC (Hugo)INPP5D   6079
Cards
Entrez_Gene (NCBI)INPP5D    inositol polyphosphate-5-phosphatase D
AliasesSHIP; SHIP-1; SHIP1; SIP-145; 
hp51CN; p150Ship
GeneCards (Weizmann)INPP5D
Ensembl hg19 (Hinxton)ENSG00000168918 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168918 [Gene_View]  ENSG00000168918 [Sequence]  chr2:233060342-233207903 [Contig_View]  INPP5D [Vega]
ICGC DataPortalENSG00000168918
TCGA cBioPortalINPP5D
AceView (NCBI)INPP5D
Genatlas (Paris)INPP5D
SOURCE (Princeton)INPP5D
Genetics Home Reference (NIH)INPP5D
Genomic and cartography
GoldenPath hg38 (UCSC)INPP5D  -     chr2:233060342-233207903 +  2q37.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INPP5D  -     2q37.1   [Description]    (hg19-Feb_2009)
GoldenPathINPP5D - 2q37.1 [CytoView hg19]  INPP5D - 2q37.1 [CytoView hg38]
ImmunoBaseENSG00000168918
genome Data Viewer NCBIINPP5D [Mapview hg19]  
OMIM601582   
Gene and transcription
Genbank (Entrez)AK298651 AK309644 AW503130 BC027960 BC062985
RefSeq transcript (Entrez)NM_001017915 NM_005541
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)INPP5D
Alternative Splicing GalleryENSG00000168918
Gene ExpressionINPP5D [ NCBI-GEO ]   INPP5D [ EBI - ARRAY_EXPRESS ]   INPP5D [ SEEK ]   INPP5D [ MEM ]
Gene Expression Viewer (FireBrowse)INPP5D [ Firebrowse - Broad ]
GenevisibleExpression of INPP5D in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3635
GTEX Portal (Tissue expression)INPP5D
Human Protein AtlasENSG00000168918-INPP5D [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92835   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92835  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92835
Splice isoforms : SwissVarQ92835
PhosPhoSitePlusQ92835
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)Endo/exonu/phosph_ase_sf    Endo/exonuclease/phosphatase    IPPc    SH2    SH2_dom_sf   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam03372    pfam00017   
Domain families : Smart (EMBL)IPPc (SM00128)  SH2 (SM00252)  
Conserved Domain (NCBI)INPP5D
Blocks (Seattle)INPP5D
PDB (RSDB)2YSX    6IBD    6XY7   
PDB Europe2YSX    6IBD    6XY7   
PDB (PDBSum)2YSX    6IBD    6XY7   
PDB (IMB)2YSX    6IBD    6XY7   
Structural Biology KnowledgeBase2YSX    6IBD    6XY7   
SCOP (Structural Classification of Proteins)2YSX    6IBD    6XY7   
CATH (Classification of proteins structures)2YSX    6IBD    6XY7   
SuperfamilyQ92835
Human Protein Atlas [tissue]ENSG00000168918-INPP5D [tissue]
Peptide AtlasQ92835
HPRD09033
Protein Interaction databases
DIP (DOE-UCLA)Q92835
IntAct (EBI)Q92835
BioGRIDINPP5D
STRING (EMBL)INPP5D
ZODIACINPP5D
Ontologies - Pathways
QuickGOQ92835
Ontology : AmiGOphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity  inositol-polyphosphate 5-phosphatase activity  protein binding  cytosol  cytosol  cytoskeleton  plasma membrane  phosphatidylinositol biosynthetic process  phosphate-containing compound metabolic process  apoptotic process  signal transduction  determination of adult lifespan  negative regulation of signal transduction  immunoglobulin mediated immune response  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  SH3 domain binding  cytokine-mediated signaling pathway  negative regulation of B cell proliferation  negative regulation of interleukin-6 production  intracellular signal transduction  positive regulation of apoptotic process  inositol phosphate metabolic process  membrane raft  positive regulation of B cell differentiation  positive regulation of erythrocyte differentiation  negative regulation of monocyte differentiation  negative regulation of neutrophil differentiation  negative regulation of osteoclast differentiation  negative regulation of bone resorption  phosphatidylinositol dephosphorylation  negative regulation of immune response  T cell receptor signaling pathway  leukocyte migration  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity  
Ontology : EGO-EBIphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity  inositol-polyphosphate 5-phosphatase activity  protein binding  cytosol  cytosol  cytoskeleton  plasma membrane  phosphatidylinositol biosynthetic process  phosphate-containing compound metabolic process  apoptotic process  signal transduction  determination of adult lifespan  negative regulation of signal transduction  immunoglobulin mediated immune response  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  SH3 domain binding  cytokine-mediated signaling pathway  negative regulation of B cell proliferation  negative regulation of interleukin-6 production  intracellular signal transduction  positive regulation of apoptotic process  inositol phosphate metabolic process  membrane raft  positive regulation of B cell differentiation  positive regulation of erythrocyte differentiation  negative regulation of monocyte differentiation  negative regulation of neutrophil differentiation  negative regulation of osteoclast differentiation  negative regulation of bone resorption  phosphatidylinositol dephosphorylation  negative regulation of immune response  T cell receptor signaling pathway  leukocyte migration  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis   
NDEx NetworkINPP5D
Atlas of Cancer Signalling NetworkINPP5D
Wikipedia pathwaysINPP5D
Orthology - Evolution
OrthoDB3635
GeneTree (enSembl)ENSG00000168918
Phylogenetic Trees/Animal Genes : TreeFamINPP5D
HOGENOMQ92835
Homologs : HomoloGeneINPP5D
Homology/Alignments : Family Browser (UCSC)INPP5D
Gene fusions - Rearrangements
Fusion : MitelmanINPP5D/ABL1 [2q37.1/9q34.12]  
Fusion : MitelmanTUBD1/INPP5D [17q23.1/2q37.1]  
Fusion PortalTUBD1 17q23.1 INPP5D 2q37.1 HNSC
Fusion : QuiverINPP5D
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINPP5D [hg38]
dbVarINPP5D
ClinVarINPP5D
MonarchINPP5D
1000_GenomesINPP5D 
Exome Variant ServerINPP5D
GNOMAD BrowserENSG00000168918
Varsome BrowserINPP5D
Genomic Variants (DGV)INPP5D [DGVbeta]
DECIPHERINPP5D [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINPP5D 
Mutations
ICGC Data PortalINPP5D 
TCGA Data PortalINPP5D 
Broad Tumor PortalINPP5D
OASIS PortalINPP5D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINPP5D  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DINPP5D
Mutations and Diseases : HGMDINPP5D
BioMutasearch INPP5D
DgiDB (Drug Gene Interaction Database)INPP5D
DoCM (Curated mutations)INPP5D (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INPP5D (select a term)
intoGenINPP5D
Cancer3DINPP5D(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601582   
Orphanet
DisGeNETINPP5D
MedgenINPP5D
Genetic Testing Registry INPP5D
NextProtQ92835 [Medical]
GENETestsINPP5D
Target ValidationINPP5D
Huge Navigator INPP5D [HugePedia]
ClinGenINPP5D
Clinical trials, drugs, therapy
MyCancerGenomeINPP5D
Protein Interactions : CTD
Pharm GKB GenePA29887
PharosQ92835
Clinical trialINPP5D
Miscellaneous
canSAR (ICR)INPP5D (select the gene name)
HarmonizomeINPP5D
DataMed IndexINPP5D
Probes
Litterature
PubMed148 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXINPP5D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:26:48 CET 2021

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