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INPP5F (inositol polyphosphate-5-phosphatase F)

Identity

Alias_symbol (synonym)SAC2
KIAA0966
hSac2
Other aliasMSTP007
MSTPO47
hSAC2
HGNC (Hugo) INPP5F
LocusID (NCBI) 22876
Atlas_Id 43324
Location 10q26.11  [Link to chromosome band 10q26]
Location_base_pair Starts at 121578769 and ends at 121588662 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
INPP5F (10q26.11) / INPP5F (10q26.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)INPP5F   17054
LRG (Locus Reference Genomic)LRG_1061
Cards
Entrez_Gene (NCBI)INPP5F  22876  inositol polyphosphate-5-phosphatase F
AliasesMSTP007; MSTPO47; SAC2; hSAC2
GeneCards (Weizmann)INPP5F
Ensembl hg19 (Hinxton)ENSG00000198825 [Gene_View]  chr10:121578769-121588662 [Contig_View]  INPP5F [Vega]
Ensembl hg38 (Hinxton)ENSG00000198825 [Gene_View]  chr10:121578769-121588662 [Contig_View]  INPP5F [Vega]
ICGC DataPortalENSG00000198825
TCGA cBioPortalINPP5F
AceView (NCBI)INPP5F
Genatlas (Paris)INPP5F
WikiGenes22876
SOURCE (Princeton)INPP5F
Genetics Home Reference (NIH)INPP5F
Genomic and cartography
GoldenPath hg19 (UCSC)INPP5F  -     chr10:121578769-121588662 +  10q26.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)INPP5F  -     10q26.11   [Description]    (hg38-Dec_2013)
EnsemblINPP5F - 10q26.11 [CytoView hg19]  INPP5F - 10q26.11 [CytoView hg38]
Mapping of homologs : NCBIINPP5F [Mapview hg19]  INPP5F [Mapview hg38]
OMIM609389   
Gene and transcription
Genbank (Entrez)AB023183 AF109361 AF113227 AI492073 AI783668
RefSeq transcript (Entrez)NM_001243194 NM_001243195 NM_014937
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_044999 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)INPP5F
Cluster EST : UnigeneHs.369755 [ NCBI ]
CGAP (NCI)Hs.369755
Alternative Splicing GalleryENSG00000198825
Gene ExpressionINPP5F [ NCBI-GEO ]   INPP5F [ EBI - ARRAY_EXPRESS ]   INPP5F [ SEEK ]   INPP5F [ MEM ]
Gene Expression Viewer (FireBrowse)INPP5F [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22876
GTEX Portal (Tissue expression)INPP5F
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2H2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2H2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2H2
Splice isoforms : SwissVarQ9Y2H2
Catalytic activity : Enzyme3.1.3.- [ Enzyme-Expasy ]   3.1.3.-3.1.3.- [ IntEnz-EBI ]   3.1.3.- [ BRENDA ]   3.1.3.- [ KEGG ]   
PhosPhoSitePlusQ9Y2H2
Domaine pattern : Prosite (Expaxy)SAC (PS50275)   
Domains : Interpro (EBI)Inositol_phosphatase    SAC_dom   
Domain families : Pfam (Sanger)hSac2 (PF12456)    Syja_N (PF02383)   
Domain families : Pfam (NCBI)pfam12456    pfam02383   
Conserved Domain (NCBI)INPP5F
DMDM Disease mutations22876
Blocks (Seattle)INPP5F
PDB (SRS)4XUU   
PDB (PDBSum)4XUU   
PDB (IMB)4XUU   
PDB (RSDB)4XUU   
Structural Biology KnowledgeBase4XUU   
SCOP (Structural Classification of Proteins)4XUU   
CATH (Classification of proteins structures)4XUU   
SuperfamilyQ9Y2H2
Human Protein AtlasENSG00000198825
Peptide AtlasQ9Y2H2
HPRD11048
IPIIPI00480159   IPI00890685   IPI00890735   IPI00383580   IPI00384184   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2H2
IntAct (EBI)Q9Y2H2
FunCoupENSG00000198825
BioGRIDINPP5F
STRING (EMBL)INPP5F
ZODIACINPP5F
Ontologies - Pathways
QuickGOQ9Y2H2
Ontology : AmiGOpositive regulation of receptor recycling  protein binding  early endosome  coated pit  phosphatidylinositol biosynthetic process  inositol monophosphate 1-phosphatase activity  cardiac muscle hypertrophy in response to stress  dephosphorylation  inositol-4,5-bisphosphate 5-phosphatase activity  phosphatidylinositol catabolic process  early endosome membrane  phosphatidylinositol phosphate 5-phosphatase activity  phosphatidylinositol phosphate 5-phosphatase activity  phosphatidylinositol phosphate 4-phosphatase activity  phosphatidylinositol phosphate 4-phosphatase activity  negative regulation of tyrosine phosphorylation of Stat3 protein  protein homodimerization activity  protein homodimerization activity  clathrin-coated endocytic vesicle  phosphatidylinositol dephosphorylation  phosphatidylinositol-mediated signaling  negative regulation of axon regeneration  regulation of protein kinase B signaling  inositol monophosphate 3-phosphatase activity  inositol monophosphate 4-phosphatase activity  recycling endosome  recycling endosome  clathrin-mediated endocytosis  regulation of cell motility  regulation of endocytic recycling  regulation of endocytic recycling  
Ontology : EGO-EBIpositive regulation of receptor recycling  protein binding  early endosome  coated pit  phosphatidylinositol biosynthetic process  inositol monophosphate 1-phosphatase activity  cardiac muscle hypertrophy in response to stress  dephosphorylation  inositol-4,5-bisphosphate 5-phosphatase activity  phosphatidylinositol catabolic process  early endosome membrane  phosphatidylinositol phosphate 5-phosphatase activity  phosphatidylinositol phosphate 5-phosphatase activity  phosphatidylinositol phosphate 4-phosphatase activity  phosphatidylinositol phosphate 4-phosphatase activity  negative regulation of tyrosine phosphorylation of Stat3 protein  protein homodimerization activity  protein homodimerization activity  clathrin-coated endocytic vesicle  phosphatidylinositol dephosphorylation  phosphatidylinositol-mediated signaling  negative regulation of axon regeneration  regulation of protein kinase B signaling  inositol monophosphate 3-phosphatase activity  inositol monophosphate 4-phosphatase activity  recycling endosome  recycling endosome  clathrin-mediated endocytosis  regulation of cell motility  regulation of endocytic recycling  regulation of endocytic recycling  
NDEx NetworkINPP5F
Atlas of Cancer Signalling NetworkINPP5F
Wikipedia pathwaysINPP5F
Orthology - Evolution
OrthoDB22876
GeneTree (enSembl)ENSG00000198825
Phylogenetic Trees/Animal Genes : TreeFamINPP5F
HOVERGENQ9Y2H2
HOGENOMQ9Y2H2
Homologs : HomoloGeneINPP5F
Homology/Alignments : Family Browser (UCSC)INPP5F
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINPP5F [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INPP5F
dbVarINPP5F
ClinVarINPP5F
1000_GenomesINPP5F 
Exome Variant ServerINPP5F
ExAC (Exome Aggregation Consortium)INPP5F (select the gene name)
Genetic variants : HAPMAP22876
Genomic Variants (DGV)INPP5F [DGVbeta]
DECIPHER (Syndromes)10:121578769-121588662  ENSG00000198825
CONAN: Copy Number AnalysisINPP5F 
Mutations
ICGC Data PortalINPP5F 
TCGA Data PortalINPP5F 
Broad Tumor PortalINPP5F
OASIS PortalINPP5F [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINPP5F  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINPP5F
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INPP5F
DgiDB (Drug Gene Interaction Database)INPP5F
DoCM (Curated mutations)INPP5F (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INPP5F (select a term)
intoGenINPP5F
Cancer3DINPP5F(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609389   
Orphanet
MedgenINPP5F
Genetic Testing Registry INPP5F
NextProtQ9Y2H2 [Medical]
TSGene22876
GENETestsINPP5F
Huge Navigator INPP5F [HugePedia]
snp3D : Map Gene to Disease22876
BioCentury BCIQINPP5F
ClinGenINPP5F
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22876
Chemical/Pharm GKB GenePA134927878
Clinical trialINPP5F
Miscellaneous
canSAR (ICR)INPP5F (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINPP5F
EVEXINPP5F
GoPubMedINPP5F
iHOPINPP5F
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:05:19 CEST 2017

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