INS (insulin)

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INS (insulin)

Identity

Other names	IDDM2
	ILPR
	IRDN
	MODY10
HGNC (Hugo)	INS
LocusID (NCBI)	3630
Location	11p15.5
Location_base_pair	Starts at 2181009 and ends at 2182439 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	INS 6081
Entrez_Gene (NCBI)	INS 3630 insulin
	Cards
GeneCards (Weizmann)	INS
Ensembl (Hinxton)	ENSG00000254647 [Gene_View] chr11:2181009-2182439 [Contig_View] INS [Vega]
AceView (NCBI)	INS
Genatlas (Paris)	INS
SOURCE (Stanford)	NM_000207 NM_001185097 NM_001185098
	Genomic and cartography
GoldenPath (UCSC)	INS - 11p15.5 chr11:2181009-2182439 - 11p15.5 [Description] (hg19-Feb_2009)
Ensembl	INS - 11p15.5 [CytoView]
Mapping of homologs : NCBI	INS [Mapview]
OMIM	125850 125852 147510 176730 606176 613370
	Gene and transcription
Genbank (Entrez)	AY899304 BC005255 BM510347 BM510748 BP322143
RefSeq transcript (SRS)	NM_000207 NM_001185097 NM_001185098
RefSeq transcript (Entrez)	NM_000207 NM_001185097 NM_001185098
RefSeq genomic (SRS)	AC_000143 NC_000011 NC_018922 NG_007114 NT_009237 NW_001838018 NW_004078070
RefSeq genomic (Entrez)	AC_000143 NC_000011 NC_018922 NG_007114 NT_009237 NW_001838018 NW_004078070
Consensus coding sequences : CCDS (NCBI)	INS
Cluster EST : Unigene	Hs.272259 [ SRS ] Hs.272259 [ NCBI ]
CGAP (NCI)	Hs.272259
Alternative Splicing : Fast-db (Paris)	GSHG0005467
Alternative Splicing Gallery	ENSG00000254647
Gene Expression	INS [ NCBI-GEO ] INS [ EBI - ARRAY_EXPRESS ]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P01308 (SRS) P01308 (Uniprot)
NextProt	P01308
With graphics : InterPro	P01308
Splice isoforms : SwissVar	P01308(Swissvar)
Domaine pattern : Prosite (SRS)	INSULIN (PS00262)
Domaine pattern : Prosite (Expaxy)	INSULIN (PS00262)
Domains : Interpro (SRS)	Insulin Insulin-like Insulin_CS Insulin_family
Domains : Interpro (EBI)	Insulin Insulin-like Insulin_CS Insulin_family
Related proteins : CluSTr	P01308
Domain families : Pfam (SRS)	Insulin (PF00049)
Domain families : Pfam (Sanger)	Insulin (PF00049)
Domain families : Pfam (NCBI)	pfam00049
Domain families : Smart (EMBL)	IlGF (SM00078)
DMDM	3630
Blocks (Seattle)	P01308
PDB (SRS)	1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G54 2G56 2H67 2HH4 2HHO 2HIU 2JMN 2JUM 2JUU 2JUV 2JV1 2JZQ 2K91 2K9R 2KJJ 2KJU 2KQP 2KQQ 2KXK 2L1Y 2L1Z 2LGB 2OLY 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI 2QIU 2R34 2R35 2R36 2RN5 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3BRR 3BXQ 3E7Y 3E7Z 3EXX 3FQ9 3HYD 3I3Z 3I40 3ILG 3INC 3IR0 3JSD 3KQ6 3P2X 3P33 3Q6E 3ROV 3TT8 3U4N 3UTQ 3UTS 3UTT 3ZQR 3ZS2 3ZU1 4AIY 5AIY
PDB (PDBSum)	1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G54 2G56 2H67 2HH4 2HHO 2HIU 2JMN 2JUM 2JUU 2JUV 2JV1 2JZQ 2K91 2K9R 2KJJ 2KJU 2KQP 2KQQ 2KXK 2L1Y 2L1Z 2LGB 2OLY 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI 2QIU 2R34 2R35 2R36 2RN5 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3BRR 3BXQ 3E7Y 3E7Z 3EXX 3FQ9 3HYD 3I3Z 3I40 3ILG 3INC 3IR0 3JSD 3KQ6 3P2X 3P33 3Q6E 3ROV 3TT8 3U4N 3UTQ 3UTS 3UTT 3ZQR 3ZS2 3ZU1 4AIY 5AIY
PDB (IMB)	1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G54 2G56 2H67 2HH4 2HHO 2HIU 2JMN 2JUM 2JUU 2JUV 2JV1 2JZQ 2K91 2K9R 2KJJ 2KJU 2KQP 2KQQ 2KXK 2L1Y 2L1Z 2LGB 2OLY 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI 2QIU 2R34 2R35 2R36 2RN5 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3BRR 3BXQ 3E7Y 3E7Z 3EXX 3FQ9 3HYD 3I3Z 3I40 3ILG 3INC 3IR0 3JSD 3KQ6 3P2X 3P33 3Q6E 3ROV 3TT8 3U4N 3UTQ 3UTS 3UTT 3ZQR 3ZS2 3ZU1 4AIY 5AIY
PDB (RSDB)	1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G54 2G56 2H67 2HH4 2HHO 2HIU 2JMN 2JUM 2JUU 2JUV 2JV1 2JZQ 2K91 2K9R 2KJJ 2KJU 2KQP 2KQQ 2KXK 2L1Y 2L1Z 2LGB 2OLY 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI 2QIU 2R34 2R35 2R36 2RN5 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3BRR 3BXQ 3E7Y 3E7Z 3EXX 3FQ9 3HYD 3I3Z 3I40 3ILG 3INC 3IR0 3JSD 3KQ6 3P2X 3P33 3Q6E 3ROV 3TT8 3U4N 3UTQ 3UTS 3UTT 3ZQR 3ZS2 3ZU1 4AIY 5AIY
Human Protein Atlas	ENSG00000254647
HPRD	01455
	Protein Interaction databases
DIP (DOE-UCLA)	P01308
IntAct (EBI)	P01308
FunCoup	ENSG00000254647
REACTOME	INS
Protein Interaction Database	3630
BioGRID	INS
InParanoid	P01308
Interologous Interaction database	P01308
IntegromeDB	INS
	Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)	INS
SNP (GeneSNP Utah)	INS
SNP : HGBase	INS
Genetic variants : HAPMAP	INS
Somatic Mutations in Cancer : COSMIC	INS
CONAN: Copy Number Analysis	INS
Mutations and Diseases : HGMD	INS
OMIM	125850 125852 147510 176730 606176 613370
GENETests	125850 125852 147510 176730 606176 613370
Disease Genetic Association	INS
Huge Navigator	INS [HugePedia] INS [HugeCancerGEM]
Genomic Variants	INS INS [DGVbeta]
snp3D : Map Gene to Disease	3630
	General knowledge
Homologs : HomoloGene	INS
Homology/Alignments : Family Browser (UCSC)	INS
Phylogenetic Trees/Animal Genes : TreeFam	INS
Chemical/Protein Interactions : CTD	3630
Chemical/Pharm GKB Gene	PA201
Clinical trial	INS
Cancer Resource (Charite)	ENSG00000254647
Ontology : AmiGO	MAPK cascade protease binding negative regulation of acute inflammatory response insulin receptor binding insulin receptor binding insulin-like growth factor receptor binding hormone activity hormone activity hormone activity protein binding extracellular region extracellular region extracellular space endoplasmic reticulum lumen Golgi lumen glucose metabolic process energy reserve metabolic process regulation of transcription, DNA-dependent regulation of cellular amino acid metabolic process acute-phase response G-protein coupled receptor signaling pathway cell-cell signaling positive regulation of cell proliferation insulin receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase cascade glucose transport regulation of transmembrane transporter activity secretory granule positive regulation of cell growth positive regulation of cell migration endocrine pancreas development endosome lumen positive regulation of protein autophosphorylation activation of protein kinase B activity positive regulation of cellular protein metabolic process negative regulation of protein oligomerization regulation of protein localization negative regulation of NAD(P)H oxidase activity wound healing negative regulation of protein catabolic process glucose homeostasis negative regulation of apoptotic process positive regulation of MAPK cascade small molecule metabolic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation negative regulation of gluconeogenesis positive regulation of glycogen biosynthetic process positive regulation of DNA replication negative regulation of glycogen catabolic process positive regulation of glycolysis positive regulation of glycolysis positive regulation of mitosis negative regulation of proteolysis negative regulation of vasodilation positive regulation of vasodilation negative regulation of fatty acid metabolic process positive regulation of glucose import positive regulation of insulin receptor signaling pathway alpha-beta T cell activation positive regulation of lipid biosynthetic process regulation of protein secretion negative regulation of protein secretion positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation regulation of insulin secretion negative regulation of lipid catabolic process positive regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity positive regulation of protein kinase B signaling cascade fatty acid homeostasis negative regulation of respiratory burst involved in inflammatory response positive regulation of respiratory burst positive regulation of peptide hormone secretion positive regulation of brown fat cell differentiation negative regulation of feeding behavior
Ontology : EGO-EBI	MAPK cascade protease binding negative regulation of acute inflammatory response insulin receptor binding insulin receptor binding insulin-like growth factor receptor binding hormone activity hormone activity hormone activity protein binding extracellular region extracellular region extracellular space endoplasmic reticulum lumen Golgi lumen glucose metabolic process energy reserve metabolic process regulation of transcription, DNA-dependent regulation of cellular amino acid metabolic process acute-phase response G-protein coupled receptor signaling pathway cell-cell signaling positive regulation of cell proliferation insulin receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase cascade glucose transport regulation of transmembrane transporter activity secretory granule positive regulation of cell growth positive regulation of cell migration endocrine pancreas development endosome lumen positive regulation of protein autophosphorylation activation of protein kinase B activity positive regulation of cellular protein metabolic process negative regulation of protein oligomerization regulation of protein localization negative regulation of NAD(P)H oxidase activity wound healing negative regulation of protein catabolic process glucose homeostasis negative regulation of apoptotic process positive regulation of MAPK cascade small molecule metabolic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation negative regulation of gluconeogenesis positive regulation of glycogen biosynthetic process positive regulation of DNA replication negative regulation of glycogen catabolic process positive regulation of glycolysis positive regulation of glycolysis positive regulation of mitosis negative regulation of proteolysis negative regulation of vasodilation positive regulation of vasodilation negative regulation of fatty acid metabolic process positive regulation of glucose import positive regulation of insulin receptor signaling pathway alpha-beta T cell activation positive regulation of lipid biosynthetic process regulation of protein secretion negative regulation of protein secretion positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation regulation of insulin secretion negative regulation of lipid catabolic process positive regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity positive regulation of protein kinase B signaling cascade fatty acid homeostasis negative regulation of respiratory burst involved in inflammatory response positive regulation of respiratory burst positive regulation of peptide hormone secretion positive regulation of brown fat cell differentiation negative regulation of feeding behavior
	Other databases
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
PubGene	INS
iHOP	INS

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	01-2013	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:33:14 CEST 2013

Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

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jlhuret@AtlasGeneticsOncology.org.

Atlas of Genetics and Cytogenetics in Oncology and Haematology

INS (insulin)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute