Atlas of Genetics and Cytogenetics in Oncology and Haematology


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INS (insulin)

Identity

Other namesIDDM1
IDDM2
ILPR
IRDN
MODY10
HGNC (Hugo) INS
LocusID (NCBI) 3630
Location 11p15.5
Location_base_pair Starts at 2181009 and ends at 2182439 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias t0817q24q22ID1494

External links

Nomenclature
HGNC (Hugo)INS   6081
Cards
Entrez_Gene (NCBI)INS  3630  insulin
GeneCards (Weizmann)INS
Ensembl (Hinxton)ENSG00000254647 [Gene_View]  chr11:2181009-2182439 [Contig_View]  INS [Vega]
ICGC DataPortalENSG00000254647
cBioPortalINS
AceView (NCBI)INS
Genatlas (Paris)INS
WikiGenes3630
SOURCE (Princeton)NM_000207 NM_001185097 NM_001185098 NM_001291897
Genomic and cartography
GoldenPath (UCSC)INS  -  11p15.5   chr11:2181009-2182439 -  11p15.5   [Description]    (hg19-Feb_2009)
EnsemblINS - 11p15.5 [CytoView]
Mapping of homologs : NCBIINS [Mapview]
OMIM125852   176730   606176   613370   
Gene and transcription
Genbank (Entrez)AY899304 BC005255 BM510347 BM510748 BP322143
RefSeq transcript (Entrez)NM_000207 NM_001185097 NM_001185098 NM_001291897
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_007114 NT_009237 NW_001838018 NW_004929378
Consensus coding sequences : CCDS (NCBI)INS
Cluster EST : UnigeneHs.272259 [ NCBI ]
CGAP (NCI)Hs.272259
Alternative Splicing : Fast-db (Paris)GSHG0005467
Alternative Splicing GalleryENSG00000254647
Gene ExpressionINS [ NCBI-GEO ]     INS [ SEEK ]   INS [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01308 (Uniprot)
NextProtP01308  [Medical]
With graphics : InterProP01308
Splice isoforms : SwissVarP01308 (Swissvar)
Domaine pattern : Prosite (Expaxy)INSULIN (PS00262)   
Domains : Interpro (EBI)Insulin [organisation]   Insulin-like [organisation]   Insulin_CS [organisation]   Insulin_family [organisation]  
Related proteins : CluSTrP01308
Domain families : Pfam (Sanger)Insulin (PF00049)   
Domain families : Pfam (NCBI)pfam00049   
Domain families : Smart (EMBL)IlGF (SM00078)  
DMDM Disease mutations3630
Blocks (Seattle)P01308
PDB (SRS)1A7F    1AI0    1AIY    1B9E    1BEN    1EFE    1EV3    1EV6    1EVR    1FU2    1FUB    1G7A    1G7B    1GUJ    1HIQ    1HIS    1HIT    1HLS    1HTV    1HUI    1IOG    1IOH    1J73    1JCA    1JCO    1JK8    1K3M    1KMF    1LKQ    1LPH    1MHI    1MHJ    1MSO    1OS3    1OS4    1Q4V    1QIY    1QIZ    1QJ0    1RWE    1SF1    1SJT    1SJU    1T0C    1T1K    1T1P    1T1Q    1TRZ    1TYL    1TYM    1UZ9    1VKT    1W8P    1XDA    1XGL    1XW7    1ZEG    1ZEH    1ZNJ    2AIY    2C8Q    2C8R    2CEU    2G54    2G56    2H67    2HH4    2HHO    2HIU    2JMN    2JUM    2JUU    2JUV    2JV1    2JZQ    2K91    2K9R    2KJJ    2KJU    2KQP    2KQQ    2KXK    2L1Y    2L1Z    2LGB    2LWZ    2M1D    2M1E    2M2M    2M2N    2M2O    2M2P    2OLY    2OLZ    2OM0    2OM1    2OMG    2OMH    2OMI    2QIU    2R34    2R35    2R36    2RN5    2VJZ    2VK0    2W44    2WBY    2WC0    2WRU    2WRV    2WRW    2WRX    2WS0    2WS1    2WS4    2WS6    2WS7    3AIY    3BRR    3BXQ    3E7Y    3E7Z    3EXX    3FQ9    3HYD    3I3Z    3I40    3ILG    3INC    3IR0    3JSD    3KQ6    3P2X    3P33    3Q6E    3ROV    3TT8    3U4N    3UTQ    3UTS    3UTT    3V19    3V1G    3W11    3W12    3W13    3W7Y    3W7Z    3W80    3ZI3    3ZQR    3ZS2    3ZU1    4AIY    4AJX    4AJZ    4AK0    4AKJ    4EFX    4EWW    4EWX    4EWZ    4EX0    4EX1    4EXX    4EY1    4EY9    4EYD    4EYN    4EYP    4F0N    4F0O    4F1A    4F1B    4F1C    4F1D    4F1F    4F1G    4F4T    4F4V    4F51    4F8F    4FG3    4FKA    4GBC    4GBI    4GBK    4GBL    4GBN    4IUZ    4IYD    4IYF    5AIY   
PDB (PDBSum)1A7F    1AI0    1AIY    1B9E    1BEN    1EFE    1EV3    1EV6    1EVR    1FU2    1FUB    1G7A    1G7B    1GUJ    1HIQ    1HIS    1HIT    1HLS    1HTV    1HUI    1IOG    1IOH    1J73    1JCA    1JCO    1JK8    1K3M    1KMF    1LKQ    1LPH    1MHI    1MHJ    1MSO    1OS3    1OS4    1Q4V    1QIY    1QIZ    1QJ0    1RWE    1SF1    1SJT    1SJU    1T0C    1T1K    1T1P    1T1Q    1TRZ    1TYL    1TYM    1UZ9    1VKT    1W8P    1XDA    1XGL    1XW7    1ZEG    1ZEH    1ZNJ    2AIY    2C8Q    2C8R    2CEU    2G54    2G56    2H67    2HH4    2HHO    2HIU    2JMN    2JUM    2JUU    2JUV    2JV1    2JZQ    2K91    2K9R    2KJJ    2KJU    2KQP    2KQQ    2KXK    2L1Y    2L1Z    2LGB    2LWZ    2M1D    2M1E    2M2M    2M2N    2M2O    2M2P    2OLY    2OLZ    2OM0    2OM1    2OMG    2OMH    2OMI    2QIU    2R34    2R35    2R36    2RN5    2VJZ    2VK0    2W44    2WBY    2WC0    2WRU    2WRV    2WRW    2WRX    2WS0    2WS1    2WS4    2WS6    2WS7    3AIY    3BRR    3BXQ    3E7Y    3E7Z    3EXX    3FQ9    3HYD    3I3Z    3I40    3ILG    3INC    3IR0    3JSD    3KQ6    3P2X    3P33    3Q6E    3ROV    3TT8    3U4N    3UTQ    3UTS    3UTT    3V19    3V1G    3W11    3W12    3W13    3W7Y    3W7Z    3W80    3ZI3    3ZQR    3ZS2    3ZU1    4AIY    4AJX    4AJZ    4AK0    4AKJ    4EFX    4EWW    4EWX    4EWZ    4EX0    4EX1    4EXX    4EY1    4EY9    4EYD    4EYN    4EYP    4F0N    4F0O    4F1A    4F1B    4F1C    4F1D    4F1F    4F1G    4F4T    4F4V    4F51    4F8F    4FG3    4FKA    4GBC    4GBI    4GBK    4GBL    4GBN    4IUZ    4IYD    4IYF    5AIY   
PDB (IMB)1A7F    1AI0    1AIY    1B9E    1BEN    1EFE    1EV3    1EV6    1EVR    1FU2    1FUB    1G7A    1G7B    1GUJ    1HIQ    1HIS    1HIT    1HLS    1HTV    1HUI    1IOG    1IOH    1J73    1JCA    1JCO    1JK8    1K3M    1KMF    1LKQ    1LPH    1MHI    1MHJ    1MSO    1OS3    1OS4    1Q4V    1QIY    1QIZ    1QJ0    1RWE    1SF1    1SJT    1SJU    1T0C    1T1K    1T1P    1T1Q    1TRZ    1TYL    1TYM    1UZ9    1VKT    1W8P    1XDA    1XGL    1XW7    1ZEG    1ZEH    1ZNJ    2AIY    2C8Q    2C8R    2CEU    2G54    2G56    2H67    2HH4    2HHO    2HIU    2JMN    2JUM    2JUU    2JUV    2JV1    2JZQ    2K91    2K9R    2KJJ    2KJU    2KQP    2KQQ    2KXK    2L1Y    2L1Z    2LGB    2LWZ    2M1D    2M1E    2M2M    2M2N    2M2O    2M2P    2OLY    2OLZ    2OM0    2OM1    2OMG    2OMH    2OMI    2QIU    2R34    2R35    2R36    2RN5    2VJZ    2VK0    2W44    2WBY    2WC0    2WRU    2WRV    2WRW    2WRX    2WS0    2WS1    2WS4    2WS6    2WS7    3AIY    3BRR    3BXQ    3E7Y    3E7Z    3EXX    3FQ9    3HYD    3I3Z    3I40    3ILG    3INC    3IR0    3JSD    3KQ6    3P2X    3P33    3Q6E    3ROV    3TT8    3U4N    3UTQ    3UTS    3UTT    3V19    3V1G    3W11    3W12    3W13    3W7Y    3W7Z    3W80    3ZI3    3ZQR    3ZS2    3ZU1    4AIY    4AJX    4AJZ    4AK0    4AKJ    4EFX    4EWW    4EWX    4EWZ    4EX0    4EX1    4EXX    4EY1    4EY9    4EYD    4EYN    4EYP    4F0N    4F0O    4F1A    4F1B    4F1C    4F1D    4F1F    4F1G    4F4T    4F4V    4F51    4F8F    4FG3    4FKA    4GBC    4GBI    4GBK    4GBL    4GBN    4IUZ    4IYD    4IYF    5AIY   
PDB (RSDB)1A7F    1AI0    1AIY    1B9E    1BEN    1EFE    1EV3    1EV6    1EVR    1FU2    1FUB    1G7A    1G7B    1GUJ    1HIQ    1HIS    1HIT    1HLS    1HTV    1HUI    1IOG    1IOH    1J73    1JCA    1JCO    1JK8    1K3M    1KMF    1LKQ    1LPH    1MHI    1MHJ    1MSO    1OS3    1OS4    1Q4V    1QIY    1QIZ    1QJ0    1RWE    1SF1    1SJT    1SJU    1T0C    1T1K    1T1P    1T1Q    1TRZ    1TYL    1TYM    1UZ9    1VKT    1W8P    1XDA    1XGL    1XW7    1ZEG    1ZEH    1ZNJ    2AIY    2C8Q    2C8R    2CEU    2G54    2G56    2H67    2HH4    2HHO    2HIU    2JMN    2JUM    2JUU    2JUV    2JV1    2JZQ    2K91    2K9R    2KJJ    2KJU    2KQP    2KQQ    2KXK    2L1Y    2L1Z    2LGB    2LWZ    2M1D    2M1E    2M2M    2M2N    2M2O    2M2P    2OLY    2OLZ    2OM0    2OM1    2OMG    2OMH    2OMI    2QIU    2R34    2R35    2R36    2RN5    2VJZ    2VK0    2W44    2WBY    2WC0    2WRU    2WRV    2WRW    2WRX    2WS0    2WS1    2WS4    2WS6    2WS7    3AIY    3BRR    3BXQ    3E7Y    3E7Z    3EXX    3FQ9    3HYD    3I3Z    3I40    3ILG    3INC    3IR0    3JSD    3KQ6    3P2X    3P33    3Q6E    3ROV    3TT8    3U4N    3UTQ    3UTS    3UTT    3V19    3V1G    3W11    3W12    3W13    3W7Y    3W7Z    3W80    3ZI3    3ZQR    3ZS2    3ZU1    4AIY    4AJX    4AJZ    4AK0    4AKJ    4EFX    4EWW    4EWX    4EWZ    4EX0    4EX1    4EXX    4EY1    4EY9    4EYD    4EYN    4EYP    4F0N    4F0O    4F1A    4F1B    4F1C    4F1D    4F1F    4F1G    4F4T    4F4V    4F51    4F8F    4FG3    4FKA    4GBC    4GBI    4GBK    4GBL    4GBN    4IUZ    4IYD    4IYF    5AIY   
Human Protein AtlasENSG00000254647 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP01308
HPRD01455
Protein Interaction databases
DIP (DOE-UCLA)P01308
IntAct (EBI)P01308
FunCoupENSG00000254647
BioGRIDINS
InParanoidP01308
Interologous Interaction database P01308
IntegromeDBINS
STRING (EMBL)INS
Ontologies - Pathways
Ontology : AmiGOMAPK cascade  protease binding  negative regulation of acute inflammatory response  insulin receptor binding  insulin receptor binding  insulin-like growth factor receptor binding  hormone activity  hormone activity  hormone activity  protein binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum lumen  Golgi lumen  glucose metabolic process  energy reserve metabolic process  regulation of transcription, DNA-templated  regulation of cellular amino acid metabolic process  acute-phase response  G-protein coupled receptor signaling pathway  cell-cell signaling  positive regulation of cell proliferation  insulin receptor signaling pathway  positive regulation of phosphatidylinositol 3-kinase signaling  glucose transport  regulation of transmembrane transporter activity  positive regulation of cell growth  positive regulation of cell migration  endocrine pancreas development  endosome lumen  positive regulation of protein autophosphorylation  activation of protein kinase B activity  positive regulation of cellular protein metabolic process  negative regulation of protein oligomerization  regulation of protein localization  negative regulation of NAD(P)H oxidase activity  secretory granule lumen  wound healing  negative regulation of protein catabolic process  glucose homeostasis  identical protein binding  positive regulation of MAPK cascade  cellular protein metabolic process  small molecule metabolic process  positive regulation of nitric oxide biosynthetic process  positive regulation of cell differentiation  negative regulation of gluconeogenesis  positive regulation of glycogen biosynthetic process  positive regulation of DNA replication  negative regulation of glycogen catabolic process  positive regulation of glycolytic process  positive regulation of glycolytic process  positive regulation of mitosis  negative regulation of proteolysis  negative regulation of vasodilation  positive regulation of vasodilation  negative regulation of fatty acid metabolic process  positive regulation of glucose import  positive regulation of insulin receptor signaling pathway  alpha-beta T cell activation  positive regulation of lipid biosynthetic process  regulation of protein secretion  negative regulation of protein secretion  positive regulation of cytokine secretion  positive regulation of peptidyl-tyrosine phosphorylation  regulation of insulin secretion  negative regulation of lipid catabolic process  positive regulation of nitric-oxide synthase activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of protein kinase B signaling  fatty acid homeostasis  negative regulation of respiratory burst involved in inflammatory response  positive regulation of respiratory burst  positive regulation of peptide hormone secretion  positive regulation of brown fat cell differentiation  negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  negative regulation of feeding behavior  
Ontology : EGO-EBIMAPK cascade  protease binding  negative regulation of acute inflammatory response  insulin receptor binding  insulin receptor binding  insulin-like growth factor receptor binding  hormone activity  hormone activity  hormone activity  protein binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum lumen  Golgi lumen  glucose metabolic process  energy reserve metabolic process  regulation of transcription, DNA-templated  regulation of cellular amino acid metabolic process  acute-phase response  G-protein coupled receptor signaling pathway  cell-cell signaling  positive regulation of cell proliferation  insulin receptor signaling pathway  positive regulation of phosphatidylinositol 3-kinase signaling  glucose transport  regulation of transmembrane transporter activity  positive regulation of cell growth  positive regulation of cell migration  endocrine pancreas development  endosome lumen  positive regulation of protein autophosphorylation  activation of protein kinase B activity  positive regulation of cellular protein metabolic process  negative regulation of protein oligomerization  regulation of protein localization  negative regulation of NAD(P)H oxidase activity  secretory granule lumen  wound healing  negative regulation of protein catabolic process  glucose homeostasis  identical protein binding  positive regulation of MAPK cascade  cellular protein metabolic process  small molecule metabolic process  positive regulation of nitric oxide biosynthetic process  positive regulation of cell differentiation  negative regulation of gluconeogenesis  positive regulation of glycogen biosynthetic process  positive regulation of DNA replication  negative regulation of glycogen catabolic process  positive regulation of glycolytic process  positive regulation of glycolytic process  positive regulation of mitosis  negative regulation of proteolysis  negative regulation of vasodilation  positive regulation of vasodilation  negative regulation of fatty acid metabolic process  positive regulation of glucose import  positive regulation of insulin receptor signaling pathway  alpha-beta T cell activation  positive regulation of lipid biosynthetic process  regulation of protein secretion  negative regulation of protein secretion  positive regulation of cytokine secretion  positive regulation of peptidyl-tyrosine phosphorylation  regulation of insulin secretion  negative regulation of lipid catabolic process  positive regulation of nitric-oxide synthase activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of protein kinase B signaling  fatty acid homeostasis  negative regulation of respiratory burst involved in inflammatory response  positive regulation of respiratory burst  positive regulation of peptide hormone secretion  positive regulation of brown fat cell differentiation  negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  negative regulation of feeding behavior  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    HIF-1 signaling pathway    FoxO signaling pathway    Oocyte meiosis    Regulation of autophagy    mTOR signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Insulin signaling pathway    Insulin secretion    Ovarian steroidogenesis    Progesterone-mediated oocyte maturation    Prolactin signaling pathway    Type II diabetes mellitus    Non-alcoholic fatty liver disease (NAFLD)    Type I diabetes mellitus    Maturity onset diabetes of the young    Aldosterone-regulated sodium reabsorption    Prostate cancer   
Protein Interaction DatabaseINS
Wikipedia pathwaysINS
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)INS
snp3D : Map Gene to Disease3630
SNP (GeneSNP Utah)INS
SNP : HGBaseINS
Genetic variants : HAPMAPINS
Exome VariantINS
1000_GenomesINS 
ICGC programENSG00000254647 
Somatic Mutations in Cancer : COSMICINS 
CONAN: Copy Number AnalysisINS 
Mutations and Diseases : HGMDINS
Genomic VariantsINS  INS [DGVbeta]
dbVarINS
ClinVarINS
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM125852    176730    606176    613370   
MedgenINS
GENETestsINS
Disease Genetic AssociationINS
Huge Navigator INS [HugePedia]  INS [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneINS
Homology/Alignments : Family Browser (UCSC)INS
Phylogenetic Trees/Animal Genes : TreeFamINS
Chemical/Protein Interactions : CTD3630
Chemical/Pharm GKB GenePA201
Clinical trialINS
Cancer Resource (Charite)ENSG00000254647
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineINS
iHOPINS
OncoSearchINS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:59:53 CEST 2014

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