INS (insulin)

Identity

Other names	-
HGNC	INS
Location	11p15.5
Location_base_pair	Starts at 2137585 and ends at 2139015 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	INS   6081
Entrez_Gene	INS  3630  insulin
	Cards
GeneCards	INS
Ensembl	INS [Search_View]   ENSG00000129965 [Gene_View]
Genatlas	INS
GeneLynx	INS
eGenome	INS
euGene	3630
	Genomic and cartography
GoldenPath	INS  -  11p15.5   chr11:2137585-2139015 -  11p15.5   [Description]    (hg18-March_2006)
Ensembl	INS - 11p15.5 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	INS
	Gene and transcription
Genbank	AY899304 [ ENTREZ ]
Genbank	BC005255 [ ENTREZ ]
Genbank	BM510748 [ ENTREZ ]
Genbank	BT006808 [ ENTREZ ]
Genbank	DQ893040 [ ENTREZ ]
RefSeq	NM_000207 [ SRS ]    NM_000207 [ ENTREZ ]
RefSeq	AC_000054 [ SRS ]    AC_000054 [ ENTREZ ]
RefSeq	AC_000143 [ SRS ]    AC_000143 [ ENTREZ ]
RefSeq	NC_000011 [ SRS ]    NC_000011 [ ENTREZ ]
RefSeq	NG_007114 [ SRS ]    NG_007114 [ ENTREZ ]
RefSeq	NT_009237 [ SRS ]    NT_009237 [ ENTREZ ]
RefSeq	NW_001838018 [ SRS ]    NW_001838018 [ ENTREZ ]
RefSeq	NW_924962 [ SRS ]    NW_924962 [ ENTREZ ]
AceView	INS AceView - NCBI
Unigene	Hs.523414 [ SRS ]    Hs.523414 [ NCBI ]     HS523414 [ spliceNest ]
Fast-db	846 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P01308 [ SRS]    P01308 [ EXPASY ]     P01308 [ INTERPRO ]     P01308 [ UNIPROT ]
Prosite	PS00262 INSULIN [ SRS ]    PS00262 INSULIN [ Expasy ]
Interpro	IPR004825 Ins/IGF/relaxin [ SRS ]    IPR004825 Ins/IGF/relaxin [ EBI ]
CluSTr	P01308
Pfam	PF00049 Insulin [ SRS ]    PF00049 Insulin [ Sanger ]    pfam00049 [ NCBI-CDD ]
Smart	SM00078 IlGF [EMBL]
Prodom	PD015667 Mollusc_ins[INRA-Toulouse]
Prodom	P01308 INS_HUMAN [ Domain structure ]   P01308 INS_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P01308
PDB	1A7F [ SRS ]    1A7F [ PdbSum ],   1A7F [ IMB ]   1A7F [ RSDB ]
PDB	1AI0 [ SRS ]    1AI0 [ PdbSum ],   1AI0 [ IMB ]   1AI0 [ RSDB ]
PDB	1AIY [ SRS ]    1AIY [ PdbSum ],   1AIY [ IMB ]   1AIY [ RSDB ]
PDB	1B9E [ SRS ]    1B9E [ PdbSum ],   1B9E [ IMB ]   1B9E [ RSDB ]
PDB	1BEN [ SRS ]    1BEN [ PdbSum ],   1BEN [ IMB ]   1BEN [ RSDB ]
PDB	1EFE [ SRS ]    1EFE [ PdbSum ],   1EFE [ IMB ]   1EFE [ RSDB ]
PDB	1EV3 [ SRS ]    1EV3 [ PdbSum ],   1EV3 [ IMB ]   1EV3 [ RSDB ]
PDB	1EV6 [ SRS ]    1EV6 [ PdbSum ],   1EV6 [ IMB ]   1EV6 [ RSDB ]
PDB	1EVR [ SRS ]    1EVR [ PdbSum ],   1EVR [ IMB ]   1EVR [ RSDB ]
PDB	1FU2 [ SRS ]    1FU2 [ PdbSum ],   1FU2 [ IMB ]   1FU2 [ RSDB ]
PDB	1FUB [ SRS ]    1FUB [ PdbSum ],   1FUB [ IMB ]   1FUB [ RSDB ]
PDB	1G7A [ SRS ]    1G7A [ PdbSum ],   1G7A [ IMB ]   1G7A [ RSDB ]
PDB	1G7B [ SRS ]    1G7B [ PdbSum ],   1G7B [ IMB ]   1G7B [ RSDB ]
PDB	1GUJ [ SRS ]    1GUJ [ PdbSum ],   1GUJ [ IMB ]   1GUJ [ RSDB ]
PDB	1HIQ [ SRS ]    1HIQ [ PdbSum ],   1HIQ [ IMB ]   1HIQ [ RSDB ]
PDB	1HIS [ SRS ]    1HIS [ PdbSum ],   1HIS [ IMB ]   1HIS [ RSDB ]
PDB	1HIT [ SRS ]    1HIT [ PdbSum ],   1HIT [ IMB ]   1HIT [ RSDB ]
PDB	1HLS [ SRS ]    1HLS [ PdbSum ],   1HLS [ IMB ]   1HLS [ RSDB ]
PDB	1HTV [ SRS ]    1HTV [ PdbSum ],   1HTV [ IMB ]   1HTV [ RSDB ]
PDB	1HUI [ SRS ]    1HUI [ PdbSum ],   1HUI [ IMB ]   1HUI [ RSDB ]
PDB	1IOG [ SRS ]    1IOG [ PdbSum ],   1IOG [ IMB ]   1IOG [ RSDB ]
PDB	1IOH [ SRS ]    1IOH [ PdbSum ],   1IOH [ IMB ]   1IOH [ RSDB ]
PDB	1J73 [ SRS ]    1J73 [ PdbSum ],   1J73 [ IMB ]   1J73 [ RSDB ]
PDB	1JCA [ SRS ]    1JCA [ PdbSum ],   1JCA [ IMB ]   1JCA [ RSDB ]
PDB	1JCO [ SRS ]    1JCO [ PdbSum ],   1JCO [ IMB ]   1JCO [ RSDB ]
PDB	1K3M [ SRS ]    1K3M [ PdbSum ],   1K3M [ IMB ]   1K3M [ RSDB ]
PDB	1KMF [ SRS ]    1KMF [ PdbSum ],   1KMF [ IMB ]   1KMF [ RSDB ]
PDB	1LKQ [ SRS ]    1LKQ [ PdbSum ],   1LKQ [ IMB ]   1LKQ [ RSDB ]
PDB	1LPH [ SRS ]    1LPH [ PdbSum ],   1LPH [ IMB ]   1LPH [ RSDB ]
PDB	1MHI [ SRS ]    1MHI [ PdbSum ],   1MHI [ IMB ]   1MHI [ RSDB ]
PDB	1MHJ [ SRS ]    1MHJ [ PdbSum ],   1MHJ [ IMB ]   1MHJ [ RSDB ]
PDB	1MSO [ SRS ]    1MSO [ PdbSum ],   1MSO [ IMB ]   1MSO [ RSDB ]
PDB	1OS3 [ SRS ]    1OS3 [ PdbSum ],   1OS3 [ IMB ]   1OS3 [ RSDB ]
PDB	1OS4 [ SRS ]    1OS4 [ PdbSum ],   1OS4 [ IMB ]   1OS4 [ RSDB ]
PDB	1QIY [ SRS ]    1QIY [ PdbSum ],   1QIY [ IMB ]   1QIY [ RSDB ]
PDB	1QIZ [ SRS ]    1QIZ [ PdbSum ],   1QIZ [ IMB ]   1QIZ [ RSDB ]
PDB	1QJ0 [ SRS ]    1QJ0 [ PdbSum ],   1QJ0 [ IMB ]   1QJ0 [ RSDB ]
PDB	1RWE [ SRS ]    1RWE [ PdbSum ],   1RWE [ IMB ]   1RWE [ RSDB ]
PDB	1SF1 [ SRS ]    1SF1 [ PdbSum ],   1SF1 [ IMB ]   1SF1 [ RSDB ]
PDB	1SJT [ SRS ]    1SJT [ PdbSum ],   1SJT [ IMB ]   1SJT [ RSDB ]
PDB	1SJU [ SRS ]    1SJU [ PdbSum ],   1SJU [ IMB ]   1SJU [ RSDB ]
PDB	1T0C [ SRS ]    1T0C [ PdbSum ],   1T0C [ IMB ]   1T0C [ RSDB ]
PDB	1T1K [ SRS ]    1T1K [ PdbSum ],   1T1K [ IMB ]   1T1K [ RSDB ]
PDB	1T1P [ SRS ]    1T1P [ PdbSum ],   1T1P [ IMB ]   1T1P [ RSDB ]
PDB	1T1Q [ SRS ]    1T1Q [ PdbSum ],   1T1Q [ IMB ]   1T1Q [ RSDB ]
PDB	1TRZ [ SRS ]    1TRZ [ PdbSum ],   1TRZ [ IMB ]   1TRZ [ RSDB ]
PDB	1TYL [ SRS ]    1TYL [ PdbSum ],   1TYL [ IMB ]   1TYL [ RSDB ]
PDB	1TYM [ SRS ]    1TYM [ PdbSum ],   1TYM [ IMB ]   1TYM [ RSDB ]
PDB	1UZ9 [ SRS ]    1UZ9 [ PdbSum ],   1UZ9 [ IMB ]   1UZ9 [ RSDB ]
PDB	1VKT [ SRS ]    1VKT [ PdbSum ],   1VKT [ IMB ]   1VKT [ RSDB ]
PDB	1W8P [ SRS ]    1W8P [ PdbSum ],   1W8P [ IMB ]   1W8P [ RSDB ]
PDB	1XDA [ SRS ]    1XDA [ PdbSum ],   1XDA [ IMB ]   1XDA [ RSDB ]
PDB	1XGL [ SRS ]    1XGL [ PdbSum ],   1XGL [ IMB ]   1XGL [ RSDB ]
PDB	1XW7 [ SRS ]    1XW7 [ PdbSum ],   1XW7 [ IMB ]   1XW7 [ RSDB ]
PDB	1ZEG [ SRS ]    1ZEG [ PdbSum ],   1ZEG [ IMB ]   1ZEG [ RSDB ]
PDB	1ZEH [ SRS ]    1ZEH [ PdbSum ],   1ZEH [ IMB ]   1ZEH [ RSDB ]
PDB	1ZNJ [ SRS ]    1ZNJ [ PdbSum ],   1ZNJ [ IMB ]   1ZNJ [ RSDB ]
PDB	2AIY [ SRS ]    2AIY [ PdbSum ],   2AIY [ IMB ]   2AIY [ RSDB ]
PDB	2C8Q [ SRS ]    2C8Q [ PdbSum ],   2C8Q [ IMB ]   2C8Q [ RSDB ]
PDB	2C8R [ SRS ]    2C8R [ PdbSum ],   2C8R [ IMB ]   2C8R [ RSDB ]
PDB	2CEU [ SRS ]    2CEU [ PdbSum ],   2CEU [ IMB ]   2CEU [ RSDB ]
PDB	2H67 [ SRS ]    2H67 [ PdbSum ],   2H67 [ IMB ]   2H67 [ RSDB ]
PDB	2HH4 [ SRS ]    2HH4 [ PdbSum ],   2HH4 [ IMB ]   2HH4 [ RSDB ]
PDB	2HHO [ SRS ]    2HHO [ PdbSum ],   2HHO [ IMB ]   2HHO [ RSDB ]
PDB	2HIU [ SRS ]    2HIU [ PdbSum ],   2HIU [ IMB ]   2HIU [ RSDB ]
PDB	2JMN [ SRS ]    2JMN [ PdbSum ],   2JMN [ IMB ]   2JMN [ RSDB ]
PDB	2JV1 [ SRS ]    2JV1 [ PdbSum ],   2JV1 [ IMB ]   2JV1 [ RSDB ]
PDB	2JZQ [ SRS ]    2JZQ [ PdbSum ],   2JZQ [ IMB ]   2JZQ [ RSDB ]
PDB	2OLY [ SRS ]    2OLY [ PdbSum ],   2OLY [ IMB ]   2OLY [ RSDB ]
PDB	2OLZ [ SRS ]    2OLZ [ PdbSum ],   2OLZ [ IMB ]   2OLZ [ RSDB ]
PDB	2OM0 [ SRS ]    2OM0 [ PdbSum ],   2OM0 [ IMB ]   2OM0 [ RSDB ]
PDB	2OM1 [ SRS ]    2OM1 [ PdbSum ],   2OM1 [ IMB ]   2OM1 [ RSDB ]
PDB	2OMG [ SRS ]    2OMG [ PdbSum ],   2OMG [ IMB ]   2OMG [ RSDB ]
PDB	2OMH [ SRS ]    2OMH [ PdbSum ],   2OMH [ IMB ]   2OMH [ RSDB ]
PDB	2OMI [ SRS ]    2OMI [ PdbSum ],   2OMI [ IMB ]   2OMI [ RSDB ]
PDB	2QIU [ SRS ]    2QIU [ PdbSum ],   2QIU [ IMB ]   2QIU [ RSDB ]
PDB	3AIY [ SRS ]    3AIY [ PdbSum ],   3AIY [ IMB ]   3AIY [ RSDB ]
PDB	4AIY [ SRS ]    4AIY [ PdbSum ],   4AIY [ IMB ]   4AIY [ RSDB ]
PDB	5AIY [ SRS ]    5AIY [ PdbSum ],   5AIY [ IMB ]   5AIY [ RSDB ]
HPRD	01455
	Protein Interaction databases
DIP	P01308
IntAct	P01308
	Polymorphism : SNP, mutations, diseases
OMIM	125850;176730    [ map ]
GENECLINICS	125850;176730
SNP	INS [dbSNP-NCBI]
SNP	NM_000207 [SNP-NCI]
SNP	INS [GeneSNPs - Utah]  INS] [HGBASE - SRS]
HAPMAP	INS [HAPMAP]
HGMD	INS
	General knowledge
Family Browser	INS [UCSC Family Browser]
SOURCE	NM_000207
SMD	Hs.523414
SAGE	Hs.523414
GO	negative regulation of acute inflammatory response [Amigo]  negative regulation of acute inflammatory response
GO	insulin receptor binding [Amigo]  insulin receptor binding
GO	insulin-like growth factor receptor binding [Amigo]  insulin-like growth factor receptor binding
GO	hormone activity [Amigo]  hormone activity
GO	protein binding [Amigo]  protein binding
GO	insulin-like growth factor binding [Amigo]  insulin-like growth factor binding
GO	extracellular region [Amigo]  extracellular region
GO	extracellular space [Amigo]  extracellular space
GO	carbohydrate metabolic process [Amigo]  carbohydrate metabolic process
GO	glucose metabolic process [Amigo]  glucose metabolic process
GO	regulation of amino acid metabolic process [Amigo]  regulation of amino acid metabolic process
GO	acute-phase response [Amigo]  acute-phase response
GO	G-protein coupled receptor protein signaling pathway [Amigo]  G-protein coupled receptor protein signaling pathway
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	cell death [Amigo]  cell death
GO	negative regulation of metabolic process [Amigo]  negative regulation of metabolic process
GO	positive regulation of metabolic process [Amigo]  positive regulation of metabolic process
GO	phosphoinositide 3-kinase cascade [Amigo]  phosphoinositide 3-kinase cascade
GO	glucose transport [Amigo]  glucose transport
GO	regulation of transmembrane transporter activity [Amigo]  regulation of transmembrane transporter activity
GO	positive regulation of cellular protein metabolic process [Amigo]  positive regulation of cellular protein metabolic process
GO	regulation of gene-specific transcription [Amigo]  regulation of gene-specific transcription
GO	regulation of protein localization [Amigo]  regulation of protein localization
GO	negative regulation of NAD(P)H oxidase activity [Amigo]  negative regulation of NAD(P)H oxidase activity
GO	wound healing [Amigo]  wound healing
GO	negative regulation of protein catabolic process [Amigo]  negative regulation of protein catabolic process
GO	glucose homeostasis [Amigo]  glucose homeostasis
GO	positive regulation of nitric oxide biosynthetic process [Amigo]  positive regulation of nitric oxide biosynthetic process
GO	respiratory burst [Amigo]  respiratory burst
GO	positive regulation of DNA replication [Amigo]  positive regulation of DNA replication
GO	negative regulation of glycogen catabolic process [Amigo]  negative regulation of glycogen catabolic process
GO	positive regulation of glycolysis [Amigo]  positive regulation of glycolysis
GO	positive regulation of glycolysis [Amigo]  positive regulation of glycolysis
GO	negative regulation of proteolysis [Amigo]  negative regulation of proteolysis
GO	negative regulation of vasodilation [Amigo]  negative regulation of vasodilation
GO	positive regulation of vasodilation [Amigo]  positive regulation of vasodilation
GO	negative regulation of fatty acid metabolic process [Amigo]  negative regulation of fatty acid metabolic process
GO	positive regulation of glucose import [Amigo]  positive regulation of glucose import
GO	positive regulation of insulin receptor signaling pathway [Amigo]  positive regulation of insulin receptor signaling pathway
GO	alpha-beta T cell activation [Amigo]  alpha-beta T cell activation
GO	negative regulation of protein secretion [Amigo]  negative regulation of protein secretion
GO	positive regulation of cytokine secretion [Amigo]  positive regulation of cytokine secretion
GO	positive regulation of nitric-oxide synthase activity [Amigo]  positive regulation of nitric-oxide synthase activity
GO	fatty acid homeostasis [Amigo]  fatty acid homeostasis
BIOCARTA	Growth Hormone Signaling Pathway    [Genes]
BIOCARTA	Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)    [Genes]
BIOCARTA	Insulin Signaling Pathway    [Genes]
BIOCARTA	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)    [Genes]
KEGG	Regulation of autophagy
KEGG	mTOR signaling pathway
KEGG	Regulation of actin cytoskeleton
KEGG	Insulin signaling pathway
KEGG	Type II diabetes mellitus
KEGG	Type I diabetes mellitus
KEGG	Maturity onset diabetes of the young
KEGG	Dentatorubropallidoluysian atrophy (DRPLA)
PubGene	INS
TreeFam	INS
CTD	3630 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	INS Related clones (RZPD - Berlin)
	PubMed
PubMed	335 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:46:46 2008