Atlas of Genetics and Cytogenetics in Oncology and Haematology


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INS (insulin)

Identity

Alias_namesIDDM2
IDDM1
insulin-dependent diabetes mellitus 2
Other aliasIDDM
ILPR
IRDN
MODY10
HGNC (Hugo) INS
LocusID (NCBI) 3630
Atlas_Id 46120
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 2159779 and ends at 2161209 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IGF2 (11p15.5) / INS (11p15.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;7)(q22;q34) IRS4/TRB


External links

Nomenclature
HGNC (Hugo)INS   6081
Cards
Entrez_Gene (NCBI)INS  3630  insulin
AliasesIDDM; IDDM1; IDDM2; ILPR; 
IRDN; MODY10
GeneCards (Weizmann)INS
Ensembl hg19 (Hinxton)ENSG00000254647 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000254647 [Gene_View]  chr11:2159779-2161209 [Contig_View]  INS [Vega]
ICGC DataPortalENSG00000254647
TCGA cBioPortalINS
AceView (NCBI)INS
Genatlas (Paris)INS
WikiGenes3630
SOURCE (Princeton)INS
Genetics Home Reference (NIH)INS
Genomic and cartography
GoldenPath hg38 (UCSC)INS  -     chr11:2159779-2161209 -  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INS  -     11p15.5   [Description]    (hg19-Feb_2009)
EnsemblINS - 11p15.5 [CytoView hg19]  INS - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBIINS [Mapview hg19]  INS [Mapview hg38]
OMIM125852   176730   606176   613370   616214   
Gene and transcription
Genbank (Entrez)AY899304 BC005255 BM510347 BM510748 BP322143
RefSeq transcript (Entrez)NM_000207 NM_001185097 NM_001185098 NM_001291897
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)INS
Cluster EST : UnigeneHs.272259 [ NCBI ]
CGAP (NCI)Hs.272259
Alternative Splicing GalleryENSG00000254647
Gene ExpressionINS [ NCBI-GEO ]   INS [ EBI - ARRAY_EXPRESS ]   INS [ SEEK ]   INS [ MEM ]
Gene Expression Viewer (FireBrowse)INS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3630
GTEX Portal (Tissue expression)INS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01308   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01308  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01308
Splice isoforms : SwissVarP01308
PhosPhoSitePlusP01308
Domaine pattern : Prosite (Expaxy)INSULIN (PS00262)   
Domains : Interpro (EBI)Insulin    Insulin-like    Insulin_CS    Insulin_family   
Domain families : Pfam (Sanger)Insulin (PF00049)   
Domain families : Pfam (NCBI)pfam00049   
Domain families : Smart (EMBL)IlGF (SM00078)  
Conserved Domain (NCBI)INS
DMDM Disease mutations3630
Blocks (Seattle)INS
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP01308
Human Protein AtlasENSG00000254647
Peptide AtlasP01308
HPRD01455
Protein Interaction databases
DIP (DOE-UCLA)P01308
IntAct (EBI)P01308
FunCoupENSG00000254647
BioGRIDINS
STRING (EMBL)INS
ZODIACINS
Ontologies - Pathways
QuickGOP01308
Ontology : AmiGOGolgi membrane  MAPK cascade  protease binding  negative regulation of acute inflammatory response  insulin receptor binding  insulin receptor binding  insulin-like growth factor receptor binding  hormone activity  hormone activity  hormone activity  protein binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum lumen  Golgi lumen  glucose metabolic process  regulation of transcription, DNA-templated  regulation of cellular amino acid metabolic process  ER to Golgi vesicle-mediated transport  acute-phase response  G-protein coupled receptor signaling pathway  cell-cell signaling  positive regulation of cell proliferation  insulin receptor signaling pathway  insulin receptor signaling pathway  positive regulation of gene expression  positive regulation of phosphatidylinositol 3-kinase signaling  glucose transport  regulation of transmembrane transporter activity  transport vesicle  positive regulation of cell growth  positive regulation of cell migration  endosome lumen  positive regulation of protein autophosphorylation  activation of protein kinase B activity  positive regulation of cellular protein metabolic process  negative regulation of protein oligomerization  regulation of protein localization  endoplasmic reticulum-Golgi intermediate compartment membrane  negative regulation of NAD(P)H oxidase activity  secretory granule lumen  wound healing  negative regulation of protein catabolic process  glucose homeostasis  identical protein binding  positive regulation of MAPK cascade  cellular protein metabolic process  positive regulation of nitric oxide biosynthetic process  positive regulation of cell differentiation  negative regulation of gluconeogenesis  positive regulation of glycogen biosynthetic process  positive regulation of DNA replication  negative regulation of glycogen catabolic process  positive regulation of glycolytic process  positive regulation of glycolytic process  positive regulation of mitotic nuclear division  negative regulation of proteolysis  negative regulation of fatty acid metabolic process  positive regulation of glucose import  positive regulation of insulin receptor signaling pathway  alpha-beta T cell activation  positive regulation of lipid biosynthetic process  regulation of protein secretion  negative regulation of protein secretion  positive regulation of cytokine secretion  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of lipid catabolic process  negative regulation of lipid catabolic process  positive regulation of nitric-oxide synthase activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of protein kinase B signaling  fatty acid homeostasis  negative regulation of respiratory burst involved in inflammatory response  positive regulation of respiratory burst  positive regulation of peptide hormone secretion  positive regulation of brown fat cell differentiation  positive regulation of blood vessel diameter  negative regulation of blood vessel diameter  positive regulation of protein localization to nucleus  negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  negative regulation of feeding behavior  
Ontology : EGO-EBIGolgi membrane  MAPK cascade  protease binding  negative regulation of acute inflammatory response  insulin receptor binding  insulin receptor binding  insulin-like growth factor receptor binding  hormone activity  hormone activity  hormone activity  protein binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum lumen  Golgi lumen  glucose metabolic process  regulation of transcription, DNA-templated  regulation of cellular amino acid metabolic process  ER to Golgi vesicle-mediated transport  acute-phase response  G-protein coupled receptor signaling pathway  cell-cell signaling  positive regulation of cell proliferation  insulin receptor signaling pathway  insulin receptor signaling pathway  positive regulation of gene expression  positive regulation of phosphatidylinositol 3-kinase signaling  glucose transport  regulation of transmembrane transporter activity  transport vesicle  positive regulation of cell growth  positive regulation of cell migration  endosome lumen  positive regulation of protein autophosphorylation  activation of protein kinase B activity  positive regulation of cellular protein metabolic process  negative regulation of protein oligomerization  regulation of protein localization  endoplasmic reticulum-Golgi intermediate compartment membrane  negative regulation of NAD(P)H oxidase activity  secretory granule lumen  wound healing  negative regulation of protein catabolic process  glucose homeostasis  identical protein binding  positive regulation of MAPK cascade  cellular protein metabolic process  positive regulation of nitric oxide biosynthetic process  positive regulation of cell differentiation  negative regulation of gluconeogenesis  positive regulation of glycogen biosynthetic process  positive regulation of DNA replication  negative regulation of glycogen catabolic process  positive regulation of glycolytic process  positive regulation of glycolytic process  positive regulation of mitotic nuclear division  negative regulation of proteolysis  negative regulation of fatty acid metabolic process  positive regulation of glucose import  positive regulation of insulin receptor signaling pathway  alpha-beta T cell activation  positive regulation of lipid biosynthetic process  regulation of protein secretion  negative regulation of protein secretion  positive regulation of cytokine secretion  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of lipid catabolic process  negative regulation of lipid catabolic process  positive regulation of nitric-oxide synthase activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of protein kinase B signaling  fatty acid homeostasis  negative regulation of respiratory burst involved in inflammatory response  positive regulation of respiratory burst  positive regulation of peptide hormone secretion  positive regulation of brown fat cell differentiation  positive regulation of blood vessel diameter  negative regulation of blood vessel diameter  positive regulation of protein localization to nucleus  negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  negative regulation of feeding behavior  
Pathways : KEGG   
NDEx NetworkINS
Atlas of Cancer Signalling NetworkINS
Wikipedia pathwaysINS
Orthology - Evolution
OrthoDB3630
GeneTree (enSembl)ENSG00000254647
Phylogenetic Trees/Animal Genes : TreeFamINS
HOVERGENP01308
HOGENOMP01308
Homologs : HomoloGeneINS
Homology/Alignments : Family Browser (UCSC)INS
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INS
dbVarINS
ClinVarINS
1000_GenomesINS 
Exome Variant ServerINS
ExAC (Exome Aggregation Consortium)INS (select the gene name)
Genetic variants : HAPMAP3630
Genomic Variants (DGV)INS [DGVbeta]
DECIPHERINS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINS 
Mutations
ICGC Data PortalINS 
TCGA Data PortalINS 
Broad Tumor PortalINS
OASIS PortalINS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch INS
DgiDB (Drug Gene Interaction Database)INS
DoCM (Curated mutations)INS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INS (select a term)
intoGenINS
Cancer3DINS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM125852    176730    606176    613370    616214   
Orphanet8028    14458   
MedgenINS
Genetic Testing Registry INS
NextProtP01308 [Medical]
TSGene3630
GENETestsINS
Target ValidationINS
Huge Navigator INS [HugePedia]
snp3D : Map Gene to Disease3630
BioCentury BCIQINS
ClinGenINS (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3630
Chemical/Pharm GKB GenePA201
Clinical trialINS
Miscellaneous
canSAR (ICR)INS (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINS
EVEXINS
GoPubMedINS
iHOPINS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:38:37 CEST 2017

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