INSIG1 (insulin induced gene 1)

2007-02-01 Affiliation

Identity

HGNC

INSIG1

LOCATION

7q36.3

LOCUSID

3638

ALIAS

CL6

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3638
MIM: 602055
HGNC: 6083
Ensembl: ENSG00000186480

Variants:

dbSNP: 3638
ClinVar: 3638
TCGA: ENSG00000186480
COSMIC: INSIG1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000186480	ENST00000340368	O15503
ENSG00000186480	ENST00000340368	A0A024RD68
ENSG00000186480	ENST00000342407	O15503
ENSG00000186480	ENST00000344756	F5H6P3
ENSG00000186480	ENST00000425172	C9JSG8
ENSG00000186480	ENST00000476756	H7C5L3

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Regulation of cholesterol biosynthesis by SREBP (SREBF)	REACTOME	R-HSA-1655829

References

Pubmed ID	Year	Title	Citations
16168377	2005	Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.	133
12535518	2003	Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.	111
15085196	2004	Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.	93
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15899885	2005	Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.	81
16399501	2006	Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.	76
15304479	2004	Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1.	63
17043353	2006	Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78.	56
18187584	2008	Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.	51
18835813	2008	Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.	40

Citation

Dessen P

INSIG1 (insulin induced gene 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43700/insig1