Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3638
MIM: 602055
HGNC: 6083
Ensembl: ENSG00000186480
Variants:
dbSNP: 3638
ClinVar: 3638
TCGA: ENSG00000186480
COSMIC: INSIG1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Metabolism of lipids and lipoproteins | REACTOME | R-HSA-556833 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | REACTOME | R-HSA-1655829 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37087475 | 2023 | A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer. | 9 |
| 37087475 | 2023 | A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer. | 9 |
| 33722690 | 2021 | Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. | 13 |
| 34198853 | 2021 | The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity. | 4 |
| 34298014 | 2021 | Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis. | 2 |
| 33722690 | 2021 | Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. | 13 |
| 34198853 | 2021 | The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity. | 4 |
| 34298014 | 2021 | Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis. | 2 |
| 32322062 | 2020 | The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. | 126 |
| 32322062 | 2020 | The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. | 126 |
| 30563842 | 2019 | Insulin-induced gene 1 (INSIG1) inhibits HIV-1 production by degrading Gag via activity of the ubiquitin ligase TRC8. | 3 |
| 31658356 | 2019 | Investigation of the association between obesity and insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China. | 1 |
| 30563842 | 2019 | Insulin-induced gene 1 (INSIG1) inhibits HIV-1 production by degrading Gag via activity of the ubiquitin ligase TRC8. | 3 |
| 31658356 | 2019 | Investigation of the association between obesity and insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China. | 1 |
| 30118702 | 2018 | HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages. | 6 |
Citation
Dessen P
INSIG1 (insulin induced gene 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43700/insig1
