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INSIG1 (insulin induced gene 1)

Identity

Alias_symbol (synonym)CL-6
MGC1405
Other aliasCL6
HGNC (Hugo) INSIG1
LocusID (NCBI) 3638
Atlas_Id 43700
Location 7q36.3  [Link to chromosome band 7q36]
Location_base_pair Starts at 155297772 and ends at 155310235 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
INSIG1 (7q36.2) / C3orf17 (3q13.2)INSIG1 (7q36.2) / DPP6 (7q36.2)INSIG1 7q36.2 / DPP6 7q36.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)INSIG1   6083
Cards
Entrez_Gene (NCBI)INSIG1  3638  insulin induced gene 1
AliasesCL6
GeneCards (Weizmann)INSIG1
Ensembl hg19 (Hinxton)ENSG00000186480 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186480 [Gene_View]  chr7:155297772-155310235 [Contig_View]  INSIG1 [Vega]
ICGC DataPortalENSG00000186480
TCGA cBioPortalINSIG1
AceView (NCBI)INSIG1
Genatlas (Paris)INSIG1
WikiGenes3638
SOURCE (Princeton)INSIG1
Genetics Home Reference (NIH)INSIG1
Genomic and cartography
GoldenPath hg38 (UCSC)INSIG1  -     chr7:155297772-155310235 +  7q36.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INSIG1  -     7q36.3   [Description]    (hg19-Feb_2009)
EnsemblINSIG1 - 7q36.3 [CytoView hg19]  INSIG1 - 7q36.3 [CytoView hg38]
Mapping of homologs : NCBIINSIG1 [Mapview hg19]  INSIG1 [Mapview hg38]
OMIM602055   
Gene and transcription
Genbank (Entrez)AA565248 AF086365 AK095977 AK291675 AL541939
RefSeq transcript (Entrez)NM_001346590 NM_001346591 NM_001346592 NM_001346593 NM_001346594 NM_005542 NM_198336 NM_198337
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)INSIG1
Cluster EST : UnigeneHs.520819 [ NCBI ]
CGAP (NCI)Hs.520819
Alternative Splicing GalleryENSG00000186480
Gene ExpressionINSIG1 [ NCBI-GEO ]   INSIG1 [ EBI - ARRAY_EXPRESS ]   INSIG1 [ SEEK ]   INSIG1 [ MEM ]
Gene Expression Viewer (FireBrowse)INSIG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3638
GTEX Portal (Tissue expression)INSIG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15503   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15503  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15503
Splice isoforms : SwissVarO15503
PhosPhoSitePlusO15503
Domains : Interpro (EBI)INSIG-1    INSIG_fam   
Domain families : Pfam (Sanger)INSIG (PF07281)   
Domain families : Pfam (NCBI)pfam07281   
Conserved Domain (NCBI)INSIG1
DMDM Disease mutations3638
Blocks (Seattle)INSIG1
PDB (SRS)4J81   
PDB (PDBSum)4J81   
PDB (IMB)4J81   
PDB (RSDB)4J81   
Structural Biology KnowledgeBase4J81   
SCOP (Structural Classification of Proteins)4J81   
CATH (Classification of proteins structures)4J81   
SuperfamilyO15503
Human Protein AtlasENSG00000186480
Peptide AtlasO15503
HPRD03633
IPIIPI00290111   IPI00936137   IPI00383583   IPI00383584   IPI01015945   
Protein Interaction databases
DIP (DOE-UCLA)O15503
IntAct (EBI)O15503
FunCoupENSG00000186480
BioGRIDINSIG1
STRING (EMBL)INSIG1
ZODIACINSIG1
Ontologies - Pathways
QuickGOO15503
Ontology : AmiGOprotein binding  endoplasmic reticulum  endoplasmic reticulum membrane  triglyceride metabolic process  cholesterol biosynthetic process  metabolic process  cell proliferation  negative regulation of steroid biosynthetic process  SREBP signaling pathway  SREBP-SCAP-Insig complex  inner ear morphogenesis  middle ear morphogenesis  negative regulation of fat cell differentiation  negative regulation of fatty acid biosynthetic process  palate development  cranial suture morphogenesis  negative regulation of cargo loading into COPII-coated vesicle  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum  endoplasmic reticulum membrane  triglyceride metabolic process  cholesterol biosynthetic process  metabolic process  cell proliferation  negative regulation of steroid biosynthetic process  SREBP signaling pathway  SREBP-SCAP-Insig complex  inner ear morphogenesis  middle ear morphogenesis  negative regulation of fat cell differentiation  negative regulation of fatty acid biosynthetic process  palate development  cranial suture morphogenesis  negative regulation of cargo loading into COPII-coated vesicle  
NDEx NetworkINSIG1
Atlas of Cancer Signalling NetworkINSIG1
Wikipedia pathwaysINSIG1
Orthology - Evolution
OrthoDB3638
GeneTree (enSembl)ENSG00000186480
Phylogenetic Trees/Animal Genes : TreeFamINSIG1
HOVERGENO15503
HOGENOMO15503
Homologs : HomoloGeneINSIG1
Homology/Alignments : Family Browser (UCSC)INSIG1
Gene fusions - Rearrangements
Fusion : MitelmanINSIG1/DPP6 [7q36.2/7q36.2]  
Fusion: TCGAINSIG1 7q36.2 DPP6 7q36.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINSIG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INSIG1
dbVarINSIG1
ClinVarINSIG1
1000_GenomesINSIG1 
Exome Variant ServerINSIG1
ExAC (Exome Aggregation Consortium)INSIG1 (select the gene name)
Genetic variants : HAPMAP3638
Genomic Variants (DGV)INSIG1 [DGVbeta]
DECIPHERINSIG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINSIG1 
Mutations
ICGC Data PortalINSIG1 
TCGA Data PortalINSIG1 
Broad Tumor PortalINSIG1
OASIS PortalINSIG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINSIG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINSIG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INSIG1
DgiDB (Drug Gene Interaction Database)INSIG1
DoCM (Curated mutations)INSIG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INSIG1 (select a term)
intoGenINSIG1
Cancer3DINSIG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602055   
Orphanet
MedgenINSIG1
Genetic Testing Registry INSIG1
NextProtO15503 [Medical]
TSGene3638
GENETestsINSIG1
Huge Navigator INSIG1 [HugePedia]
snp3D : Map Gene to Disease3638
BioCentury BCIQINSIG1
ClinGenINSIG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3638
Chemical/Pharm GKB GenePA29890
Clinical trialINSIG1
Miscellaneous
canSAR (ICR)INSIG1 (select the gene name)
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINSIG1
EVEXINSIG1
GoPubMedINSIG1
iHOPINSIG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:20:36 CEST 2017

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