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INSIG2 (insulin induced gene 2)

Identity

Other aliasINSIG-2
HGNC (Hugo) INSIG2
LocusID (NCBI) 51141
Atlas_Id 50205
Location 2q14.1  [Link to chromosome band 2q14]
Location_base_pair Starts at 118088418 and ends at 118110031 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
VPS52 (6p21.32) / INSIG2 (2q14.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)INSIG2   20452
Cards
Entrez_Gene (NCBI)INSIG2  51141  insulin induced gene 2
AliasesINSIG-2
GeneCards (Weizmann)INSIG2
Ensembl hg19 (Hinxton)ENSG00000125629 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125629 [Gene_View]  ENSG00000125629 [Sequence]  chr2:118088418-118110031 [Contig_View]  INSIG2 [Vega]
ICGC DataPortalENSG00000125629
TCGA cBioPortalINSIG2
AceView (NCBI)INSIG2
Genatlas (Paris)INSIG2
WikiGenes51141
SOURCE (Princeton)INSIG2
Genetics Home Reference (NIH)INSIG2
Genomic and cartography
GoldenPath hg38 (UCSC)INSIG2  -     chr2:118088418-118110031 +  2q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INSIG2  -     2q14.1   [Description]    (hg19-Feb_2009)
GoldenPathINSIG2 - 2q14.1 [CytoView hg19]  INSIG2 - 2q14.1 [CytoView hg38]
ImmunoBaseENSG00000125629
Mapping of homologs : NCBIINSIG2 [Mapview hg19]  INSIG2 [Mapview hg38]
OMIM608660   
Gene and transcription
Genbank (Entrez)AF125392 AF527632 AK021692 AK291433 AK298599
RefSeq transcript (Entrez)NM_001321329 NM_001321330 NM_001321331 NM_001321332 NM_001321333 NM_016133
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)INSIG2
Cluster EST : UnigeneHs.7089 [ NCBI ]
CGAP (NCI)Hs.7089
Alternative Splicing GalleryENSG00000125629
Gene ExpressionINSIG2 [ NCBI-GEO ]   INSIG2 [ EBI - ARRAY_EXPRESS ]   INSIG2 [ SEEK ]   INSIG2 [ MEM ]
Gene Expression Viewer (FireBrowse)INSIG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51141
GTEX Portal (Tissue expression)INSIG2
Human Protein AtlasENSG00000125629-INSIG2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5U4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5U4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5U4
Splice isoforms : SwissVarQ9Y5U4
PhosPhoSitePlusQ9Y5U4
Domains : Interpro (EBI)INSIG_fam   
Domain families : Pfam (Sanger)INSIG (PF07281)   
Domain families : Pfam (NCBI)pfam07281   
Conserved Domain (NCBI)INSIG2
DMDM Disease mutations51141
Blocks (Seattle)INSIG2
PDB (RSDB)4J82   
PDB Europe4J82   
PDB (PDBSum)4J82   
PDB (IMB)4J82   
Structural Biology KnowledgeBase4J82   
SCOP (Structural Classification of Proteins)4J82   
CATH (Classification of proteins structures)4J82   
SuperfamilyQ9Y5U4
Human Protein Atlas [tissue]ENSG00000125629-INSIG2 [tissue]
Peptide AtlasQ9Y5U4
HPRD16361
IPIIPI00413159   IPI00917261   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5U4
IntAct (EBI)Q9Y5U4
FunCoupENSG00000125629
BioGRIDINSIG2
STRING (EMBL)INSIG2
ZODIACINSIG2
Ontologies - Pathways
QuickGOQ9Y5U4
Ontology : AmiGOprotein binding  endoplasmic reticulum membrane  triglyceride metabolic process  cholesterol biosynthetic process  transcription factor binding  negative regulation of steroid biosynthetic process  response to insulin  SREBP signaling pathway  SREBP-SCAP-Insig complex  inner ear morphogenesis  middle ear morphogenesis  negative regulation of fatty acid biosynthetic process  roof of mouth development  cranial suture morphogenesis  response to fatty acid  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum membrane  triglyceride metabolic process  cholesterol biosynthetic process  transcription factor binding  negative regulation of steroid biosynthetic process  response to insulin  SREBP signaling pathway  SREBP-SCAP-Insig complex  inner ear morphogenesis  middle ear morphogenesis  negative regulation of fatty acid biosynthetic process  roof of mouth development  cranial suture morphogenesis  response to fatty acid  
NDEx NetworkINSIG2
Atlas of Cancer Signalling NetworkINSIG2
Wikipedia pathwaysINSIG2
Orthology - Evolution
OrthoDB51141
GeneTree (enSembl)ENSG00000125629
Phylogenetic Trees/Animal Genes : TreeFamINSIG2
HOGENOMQ9Y5U4
Homologs : HomoloGeneINSIG2
Homology/Alignments : Family Browser (UCSC)INSIG2
Gene fusions - Rearrangements
Fusion : QuiverINSIG2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINSIG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INSIG2
dbVarINSIG2
ClinVarINSIG2
1000_GenomesINSIG2 
Exome Variant ServerINSIG2
ExAC (Exome Aggregation Consortium)ENSG00000125629
GNOMAD BrowserENSG00000125629
Varsome BrowserINSIG2
Genetic variants : HAPMAP51141
Genomic Variants (DGV)INSIG2 [DGVbeta]
DECIPHERINSIG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINSIG2 
Mutations
ICGC Data PortalINSIG2 
TCGA Data PortalINSIG2 
Broad Tumor PortalINSIG2
OASIS PortalINSIG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINSIG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINSIG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INSIG2
DgiDB (Drug Gene Interaction Database)INSIG2
DoCM (Curated mutations)INSIG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INSIG2 (select a term)
intoGenINSIG2
Cancer3DINSIG2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608660   
Orphanet
DisGeNETINSIG2
MedgenINSIG2
Genetic Testing Registry INSIG2
NextProtQ9Y5U4 [Medical]
TSGene51141
GENETestsINSIG2
Target ValidationINSIG2
Huge Navigator INSIG2 [HugePedia]
snp3D : Map Gene to Disease51141
BioCentury BCIQINSIG2
ClinGenINSIG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51141
Chemical/Pharm GKB GenePA134890284
Clinical trialINSIG2
Miscellaneous
canSAR (ICR)INSIG2 (select the gene name)
DataMed IndexINSIG2
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINSIG2
EVEXINSIG2
GoPubMedINSIG2
iHOPINSIG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 7 18:05:18 CEST 2019
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