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INSL3 (insulin like 3)

Identity

Alias_namesRLNL
relaxin-like factor
insulin-like 3 (Leydig cell)
Alias_symbol (synonym)RLF
MGC119818
MGC119819
Other aliasley-I-L
HGNC (Hugo) INSL3
LocusID (NCBI) 3640
Atlas_Id 45583
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 17927322 and ends at 17932383 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
JAK3 (19p13.11) / INSL3 (19p13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)INSL3   6086
Cards
Entrez_Gene (NCBI)INSL3  3640  insulin like 3
AliasesRLF; RLNL; ley-I-L
GeneCards (Weizmann)INSL3
Ensembl hg19 (Hinxton)ENSG00000248099 [Gene_View]  chr19:17927322-17932383 [Contig_View]  INSL3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000248099 [Gene_View]  chr19:17927322-17932383 [Contig_View]  INSL3 [Vega]
ICGC DataPortalENSG00000248099
TCGA cBioPortalINSL3
AceView (NCBI)INSL3
Genatlas (Paris)INSL3
WikiGenes3640
SOURCE (Princeton)INSL3
Genetics Home Reference (NIH)INSL3
Genomic and cartography
GoldenPath hg19 (UCSC)INSL3  -     chr19:17927322-17932383 -  19p13.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)INSL3  -     19p13.11   [Description]    (hg38-Dec_2013)
EnsemblINSL3 - 19p13.11 [CytoView hg19]  INSL3 - 19p13.11 [CytoView hg38]
Mapping of homologs : NCBIINSL3 [Mapview hg19]  INSL3 [Mapview hg38]
OMIM146738   219050   
Gene and transcription
Genbank (Entrez)AK302780 AY082014 BC032810 BC040435 BC053345
RefSeq transcript (Entrez)NM_001265587 NM_005543
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_012092 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)INSL3
Cluster EST : UnigeneHs.37062 [ NCBI ]
CGAP (NCI)Hs.37062
Alternative Splicing GalleryENSG00000248099
Gene ExpressionINSL3 [ NCBI-GEO ]   INSL3 [ EBI - ARRAY_EXPRESS ]   INSL3 [ SEEK ]   INSL3 [ MEM ]
Gene Expression Viewer (FireBrowse)INSL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3640
GTEX Portal (Tissue expression)INSL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51460   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51460  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51460
Splice isoforms : SwissVarP51460
PhosPhoSitePlusP51460
Domaine pattern : Prosite (Expaxy)INSULIN (PS00262)   
Domains : Interpro (EBI)Insulin-like    Insulin_CS   
Domain families : Pfam (Sanger)Insulin (PF00049)   
Domain families : Pfam (NCBI)pfam00049   
Domain families : Smart (EMBL)IlGF (SM00078)  
Conserved Domain (NCBI)INSL3
DMDM Disease mutations3640
Blocks (Seattle)INSL3
PDB (SRS)2H8B    2K6T    2K6U   
PDB (PDBSum)2H8B    2K6T    2K6U   
PDB (IMB)2H8B    2K6T    2K6U   
PDB (RSDB)2H8B    2K6T    2K6U   
Structural Biology KnowledgeBase2H8B    2K6T    2K6U   
SCOP (Structural Classification of Proteins)2H8B    2K6T    2K6U   
CATH (Classification of proteins structures)2H8B    2K6T    2K6U   
SuperfamilyP51460
Human Protein AtlasENSG00000248099
Peptide AtlasP51460
HPRD08854
IPIIPI00018695   IPI00815936   
Protein Interaction databases
DIP (DOE-UCLA)P51460
IntAct (EBI)P51460
FunCoupENSG00000248099
BioGRIDINSL3
STRING (EMBL)INSL3
ZODIACINSL3
Ontologies - Pathways
QuickGOP51460
Ontology : AmiGOoocyte maturation  G-protein coupled receptor binding  protease binding  receptor binding  insulin receptor binding  hormone activity  extracellular region  extracellular space  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  cell-cell signaling  spermatogenesis  positive regulation of cell proliferation  negative regulation of cell proliferation  male gonad development  positive regulation of epithelial cell migration  positive regulation of cAMP biosynthetic process  negative regulation of apoptotic process  perinuclear region of cytoplasm  positive regulation of wound healing  
Ontology : EGO-EBIoocyte maturation  G-protein coupled receptor binding  protease binding  receptor binding  insulin receptor binding  hormone activity  extracellular region  extracellular space  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  cell-cell signaling  spermatogenesis  positive regulation of cell proliferation  negative regulation of cell proliferation  male gonad development  positive regulation of epithelial cell migration  positive regulation of cAMP biosynthetic process  negative regulation of apoptotic process  perinuclear region of cytoplasm  positive regulation of wound healing  
NDEx NetworkINSL3
Atlas of Cancer Signalling NetworkINSL3
Wikipedia pathwaysINSL3
Orthology - Evolution
OrthoDB3640
GeneTree (enSembl)ENSG00000248099
Phylogenetic Trees/Animal Genes : TreeFamINSL3
HOVERGENP51460
HOGENOMP51460
Homologs : HomoloGeneINSL3
Homology/Alignments : Family Browser (UCSC)INSL3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINSL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INSL3
dbVarINSL3
ClinVarINSL3
1000_GenomesINSL3 
Exome Variant ServerINSL3
ExAC (Exome Aggregation Consortium)INSL3 (select the gene name)
Genetic variants : HAPMAP3640
Genomic Variants (DGV)INSL3 [DGVbeta]
DECIPHER (Syndromes)19:17927322-17932383  ENSG00000248099
CONAN: Copy Number AnalysisINSL3 
Mutations
ICGC Data PortalINSL3 
TCGA Data PortalINSL3 
Broad Tumor PortalINSL3
OASIS PortalINSL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINSL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINSL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INSL3
DgiDB (Drug Gene Interaction Database)INSL3
DoCM (Curated mutations)INSL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INSL3 (select a term)
intoGenINSL3
Cancer3DINSL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146738    219050   
Orphanet
MedgenINSL3
Genetic Testing Registry INSL3
NextProtP51460 [Medical]
TSGene3640
GENETestsINSL3
Huge Navigator INSL3 [HugePedia]
snp3D : Map Gene to Disease3640
BioCentury BCIQINSL3
ClinGenINSL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3640
Chemical/Pharm GKB GenePA29893
Clinical trialINSL3
Miscellaneous
canSAR (ICR)INSL3 (select the gene name)
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINSL3
EVEXINSL3
GoPubMedINSL3
iHOPINSL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:05:20 CEST 2017

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