Atlas of Genetics and Cytogenetics in Oncology and Haematology

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INSR (insulin receptor)

Identity

Other namesCD220
HHF5
HGNC (Hugo) INSR
LocusID (NCBI) 3643
Location 19p13.2
Location_base_pair Starts at 7112266 and ends at 7294011 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)INSR   6091
Entrez_Gene (NCBI)INSR  3643  insulin receptor
Cards
GeneCards (Weizmann)INSR
Ensembl (Hinxton)ENSG00000171105 [Gene_View]  chr19:7112266-7294011 [Contig_View]  INSR [Vega]
AceView (NCBI)INSR
Genatlas (Paris)INSR
SOURCE (Stanford)NM_000208 NM_001079817
Genomic and cartography
GoldenPath (UCSC)INSR  -  19p13.2   chr19:7112266-7294011 -  19p13.2   [Description]    (hg19-Feb_2009)
EnsemblINSR - 19p13.2 [CytoView]
Mapping of homologs : NCBIINSR [Mapview]
OMIM147670   246200   262190   609968   610549   
Gene and transcription
Genbank (Entrez)AB208861 AK025527 AL365454 BC047591 BC117172
RefSeq transcript (SRS)NM_000208 NM_001079817
RefSeq transcript (Entrez)NM_000208 NM_001079817
RefSeq genomic (SRS)AC_000151 NC_000019 NC_018930 NG_008852 NT_011255 NW_001838478 NW_004078096
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_008852 NT_011255 NW_001838478 NW_004078096
Consensus coding sequences : CCDS (NCBI)INSR
Cluster EST : UnigeneHs.465744 [ SRS ] Hs.465744 [ NCBI ]
CGAP (NCI)Hs.465744
Alternative Splicing : Fast-db (Paris)GSHG0033920
Alternative Splicing GalleryENSG00000171105
Gene ExpressionINSR [ NCBI-GEO ]   INSR [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06213 (SRS) P06213 (Uniprot)
NextProtP06213
With graphics : InterProP06213
Splice isoforms : SwissVarP06213(Swissvar)
Domaine pattern : Prosite (SRS)FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domains : Interpro (SRS)EGF_rcpt_L    Fibronectin_type3    Furin-like_Cys-rich_dom    Furin_repeat    Growth_fac_rcpt    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_insulin-like_rcpt    Tyr_kinase_rcpt_2_CS   
Domains : Interpro (EBI)EGF_rcpt_L    Fibronectin_type3    Furin-like_Cys-rich_dom    Furin_repeat    Growth_fac_rcpt    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_insulin-like_rcpt    Tyr_kinase_rcpt_2_CS   
Related proteins : CluSTrP06213
Domain families : Pfam (SRS)fn3 (PF00041)    Furin-like (PF00757)    Pkinase_Tyr (PF07714)    Recep_L_domain (PF01030)   
Domain families : Pfam (Sanger)fn3 (PF00041)    Furin-like (PF00757)    Pkinase_Tyr (PF07714)    Recep_L_domain (PF01030)   
Domain families : Pfam (NCBI)pfam00041    pfam00757    pfam07714    pfam01030   
Domain families : Smart (EMBL)FN3 (SM00060)  FU (SM00261)  TyrKc (SM00219)  
DMDM3643
Blocks (Seattle)P06213
PDB (SRS)1GAG    1I44    1IR3    1IRK    1P14    1RQQ    2AUH    2B4S    2DTG    2HR7    2Z8C    3BU3    3BU5    3BU6    3EKK    3EKN    3ETA    3LOH   
PDB (PDBSum)1GAG    1I44    1IR3    1IRK    1P14    1RQQ    2AUH    2B4S    2DTG    2HR7    2Z8C    3BU3    3BU5    3BU6    3EKK    3EKN    3ETA    3LOH   
PDB (IMB)1GAG    1I44    1IR3    1IRK    1P14    1RQQ    2AUH    2B4S    2DTG    2HR7    2Z8C    3BU3    3BU5    3BU6    3EKK    3EKN    3ETA    3LOH   
PDB (RSDB)1GAG    1I44    1IR3    1IRK    1P14    1RQQ    2AUH    2B4S    2DTG    2HR7    2Z8C    3BU3    3BU5    3BU6    3EKK    3EKN    3ETA    3LOH   
Human Protein AtlasENSG00000171105
HPRD00975
IPIIPI00220325   IPI00930161   IPI01010929   IPI00930138   IPI00025803   
Protein Interaction databases
DIP (DOE-UCLA)P06213
IntAct (EBI)P06213
FunCoupENSG00000171105
REACTOMEINSR
Protein Interaction Database3643
BioGRIDINSR
InParanoidP06213
Interologous Interaction database P06213
IntegromeDBINSR
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)INSR
SNP (GeneSNP Utah)INSR
SNP : HGBaseINSR
Genetic variants : HAPMAPINSR
Somatic Mutations in Cancer : COSMICINSR 
CONAN: Copy Number AnalysisINSR 
Mutations and Diseases : HGMDINSR
OMIM147670    246200    262190    609968    610549   
GENETests147670    246200    262190    609968    610549   
Disease Genetic AssociationINSR
Huge Navigator INSR [HugePedia]  INSR [HugeCancerGEM]
Genomic VariantsINSR  INSR [DGVbeta]
snp3D : Map Gene to Disease3643
General knowledge
Homologs : HomoloGeneINSR
Homology/Alignments : Family Browser (UCSC)INSR
Phylogenetic Trees/Animal Genes : TreeFamINSR
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Chemical/Protein Interactions : CTD3643
Chemical/Pharm GKB GenePA202
Clinical trialINSR
Cancer Resource (Charite)ENSG00000171105
Ontology : AmiGOactivation of MAPK activity  negative regulation of protein phosphorylation  positive regulation of protein phosphorylation  heart morphogenesis  protein tyrosine kinase activity  protein tyrosine kinase activity  receptor signaling protein tyrosine kinase activity  insulin-activated receptor activity  insulin-like growth factor receptor binding  protein binding  ATP binding  GTP binding  nucleus  cytosol  plasma membrane  plasma membrane  integral to plasma membrane  insulin receptor complex  caveola  carbohydrate metabolic process  regulation of transcription, DNA-dependent  G-protein coupled receptor signaling pathway  positive regulation of cell proliferation  positive regulation of cell proliferation  insulin receptor signaling pathway  insulin receptor signaling pathway  response to glucose stimulus  endosome membrane  response to manganese ion  regulation of hydrogen peroxide metabolic process  positive regulation of glycoprotein biosynthetic process  negative regulation of gene expression  response to activity  membrane  peptidyl-tyrosine phosphorylation  transformation of host cell by virus  protein phosphatase binding  signal transduction by phosphorylation  male sex determination  positive regulation of cell migration  exocrine pancreas development  lipoic acid binding  insulin-like growth factor I binding  insulin-like growth factor II binding  activation of protein kinase activity  activation of protein kinase B activity  response to estradiol stimulus  protein complex binding  negative regulation of transporter activity  cellular response to insulin stimulus  response to vitamin D  response to testosterone stimulus  response to tumor necrosis factor  SH2 domain binding  glucose homeostasis  positive regulation of MAPK cascade  3-phosphoinositide-dependent protein kinase binding  phosphatidylinositol 3-kinase binding  insulin binding  insulin binding  insulin receptor substrate binding  synapse  positive regulation of nitric oxide biosynthetic process  fat cell differentiation  response to ethanol  positive regulation of glycogen biosynthetic process  positive regulation of DNA replication  positive regulation of glycolysis  positive regulation of mitosis  regulation of embryonic development  positive regulation of glucose import  positive regulation of glucose import  protein autophosphorylation  protein autophosphorylation  positive regulation of developmental growth  protein heterotetramerization  response to glucocorticoid stimulus  PTB domain binding  positive regulation of protein kinase B signaling cascade  positive regulation of respiratory burst  cellular response to growth factor stimulus  
Ontology : EGO-EBIactivation of MAPK activity  negative regulation of protein phosphorylation  positive regulation of protein phosphorylation  heart morphogenesis  protein tyrosine kinase activity  protein tyrosine kinase activity  receptor signaling protein tyrosine kinase activity  insulin-activated receptor activity  insulin-like growth factor receptor binding  protein binding  ATP binding  GTP binding  nucleus  cytosol  plasma membrane  plasma membrane  integral to plasma membrane  insulin receptor complex  caveola  carbohydrate metabolic process  regulation of transcription, DNA-dependent  G-protein coupled receptor signaling pathway  positive regulation of cell proliferation  positive regulation of cell proliferation  insulin receptor signaling pathway  insulin receptor signaling pathway  response to glucose stimulus  endosome membrane  response to manganese ion  regulation of hydrogen peroxide metabolic process  positive regulation of glycoprotein biosynthetic process  negative regulation of gene expression  response to activity  membrane  peptidyl-tyrosine phosphorylation  transformation of host cell by virus  protein phosphatase binding  signal transduction by phosphorylation  male sex determination  positive regulation of cell migration  exocrine pancreas development  lipoic acid binding  insulin-like growth factor I binding  insulin-like growth factor II binding  activation of protein kinase activity  activation of protein kinase B activity  response to estradiol stimulus  protein complex binding  negative regulation of transporter activity  cellular response to insulin stimulus  response to vitamin D  response to testosterone stimulus  response to tumor necrosis factor  SH2 domain binding  glucose homeostasis  positive regulation of MAPK cascade  3-phosphoinositide-dependent protein kinase binding  phosphatidylinositol 3-kinase binding  insulin binding  insulin binding  insulin receptor substrate binding  synapse  positive regulation of nitric oxide biosynthetic process  fat cell differentiation  response to ethanol  positive regulation of glycogen biosynthetic process  positive regulation of DNA replication  positive regulation of glycolysis  positive regulation of mitosis  regulation of embryonic development  positive regulation of glucose import  positive regulation of glucose import  protein autophosphorylation  protein autophosphorylation  positive regulation of developmental growth  protein heterotetramerization  response to glucocorticoid stimulus  PTB domain binding  positive regulation of protein kinase B signaling cascade  positive regulation of respiratory burst  cellular response to growth factor stimulus  
Pathways : BIOCARTAInsulin Signaling Pathway [Genes]    Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) [Genes]    Growth Hormone Signaling Pathway [Genes]   
Pathways : KEGGDentatorubropallidoluysian atrophy (DRPLA)Type II diabetes mellitusAdherens junctionInsulin signaling pathway
Other databases
Probes
Litterature
PubMed459 Pubmed reference(s) in Entrez
PubGeneINSR
iHOPINSR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:44:42 CEST 2013
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