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INSR (insulin receptor)

Identity

Other namesCD220
HHF5
HGNC (Hugo) INSR
LocusID (NCBI) 3643
Location 19p13.2
Location_base_pair Starts at 7112266 and ends at 7294011 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)INSR   6091
Cards
Entrez_Gene (NCBI)INSR  3643  insulin receptor
GeneCards (Weizmann)INSR
Ensembl (Hinxton)ENSG00000171105 [Gene_View]  chr19:7112266-7294011 [Contig_View]  INSR [Vega]
ICGC DataPortalENSG00000171105
AceView (NCBI)INSR
Genatlas (Paris)INSR
WikiGenes3643
SOURCE (Princeton)NM_000208 NM_001079817
Genomic and cartography
GoldenPath (UCSC)INSR  -  19p13.2   chr19:7112266-7294011 -  19p13.2   [Description]    (hg19-Feb_2009)
EnsemblINSR - 19p13.2 [CytoView]
Mapping of homologs : NCBIINSR [Mapview]
OMIM147670   246200   262190   609968   610549   
Gene and transcription
Genbank (Entrez)AB208861 AK025527 AL365454 BC047591 BC117172
RefSeq transcript (Entrez)NM_000208 NM_001079817
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_008852 NT_011295 NW_001838478 NW_004929412
Consensus coding sequences : CCDS (NCBI)INSR
Cluster EST : UnigeneHs.465744 [ NCBI ]
CGAP (NCI)Hs.465744
Alternative Splicing : Fast-db (Paris)GSHG0033920
Alternative Splicing GalleryENSG00000171105
Gene ExpressionINSR [ NCBI-GEO ]     INSR [ SEEK ]   INSR [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06213 (Uniprot)
NextProtP06213  [Medical]
With graphics : InterProP06213
Splice isoforms : SwissVarP06213 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domains : Interpro (EBI)EGF_rcpt_L    Fibronectin_type3    Furin-like_Cys-rich_dom    Furin_repeat    Growth_fac_rcpt_N_dom    Ig-like_fold    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_insulin-like_rcpt    Tyr_kinase_rcpt_2_CS   
Related proteins : CluSTrP06213
Domain families : Pfam (Sanger)fn3 (PF00041)    Furin-like (PF00757)    Pkinase_Tyr (PF07714)    Recep_L_domain (PF01030)   
Domain families : Pfam (NCBI)pfam00041    pfam00757    pfam07714    pfam01030   
Domain families : Smart (EMBL)FN3 (SM00060)  FU (SM00261)  TyrKc (SM00219)  
DMDM Disease mutations3643
Blocks (Seattle)P06213
PDB (SRS)1GAG    1I44    1IR3    1IRK    1P14    1RQQ    2AUH    2B4S    2DTG    2HR7    2MFR    2Z8C    3BU3    3BU5    3BU6    3EKK    3EKN    3ETA    3LOH    3W11    3W12    3W13    3W14    4IBM   
PDB (PDBSum)1GAG    1I44    1IR3    1IRK    1P14    1RQQ    2AUH    2B4S    2DTG    2HR7    2MFR    2Z8C    3BU3    3BU5    3BU6    3EKK    3EKN    3ETA    3LOH    3W11    3W12    3W13    3W14    4IBM   
PDB (IMB)1GAG    1I44    1IR3    1IRK    1P14    1RQQ    2AUH    2B4S    2DTG    2HR7    2MFR    2Z8C    3BU3    3BU5    3BU6    3EKK    3EKN    3ETA    3LOH    3W11    3W12    3W13    3W14    4IBM   
PDB (RSDB)1GAG    1I44    1IR3    1IRK    1P14    1RQQ    2AUH    2B4S    2DTG    2HR7    2MFR    2Z8C    3BU3    3BU5    3BU6    3EKK    3EKN    3ETA    3LOH    3W11    3W12    3W13    3W14    4IBM   
Human Protein AtlasENSG00000171105
Peptide AtlasP06213
HPRD00975
IPIIPI00220325   IPI00930161   IPI01010929   IPI00930138   IPI00025803   
Protein Interaction databases
DIP (DOE-UCLA)P06213
IntAct (EBI)P06213
FunCoupENSG00000171105
BioGRIDINSR
InParanoidP06213
Interologous Interaction database P06213
IntegromeDBINSR
STRING (EMBL)INSR
Ontologies - Pathways
Ontology : AmiGOactivation of MAPK activity  positive regulation of protein phosphorylation  heart morphogenesis  protein tyrosine kinase activity  protein tyrosine kinase activity  receptor signaling protein tyrosine kinase activity  insulin-activated receptor activity  insulin-like growth factor receptor binding  protein binding  ATP binding  GTP binding  plasma membrane  plasma membrane  integral component of plasma membrane  insulin receptor complex  caveola  carbohydrate metabolic process  regulation of transcription, DNA-templated  G-protein coupled receptor signaling pathway  positive regulation of cell proliferation  positive regulation of cell proliferation  insulin receptor signaling pathway  insulin receptor signaling pathway  endosome membrane  membrane  peptidyl-tyrosine phosphorylation  transformation of host cell by virus  signal transduction by phosphorylation  male sex determination  positive regulation of cell migration  exocrine pancreas development  insulin-like growth factor I binding  insulin-like growth factor II binding  activation of protein kinase activity  activation of protein kinase B activity  cellular response to insulin stimulus  glucose homeostasis  receptor complex  positive regulation of MAPK cascade  phosphatidylinositol 3-kinase binding  insulin binding  insulin binding  insulin receptor substrate binding  positive regulation of nitric oxide biosynthetic process  positive regulation of glycogen biosynthetic process  positive regulation of DNA replication  positive regulation of glycolytic process  positive regulation of mitosis  regulation of embryonic development  positive regulation of glucose import  positive regulation of glucose import  protein autophosphorylation  protein autophosphorylation  positive regulation of developmental growth  protein heterotetramerization  PTB domain binding  positive regulation of protein kinase B signaling  positive regulation of respiratory burst  extracellular vesicular exosome  cellular response to growth factor stimulus  
Ontology : EGO-EBIactivation of MAPK activity  positive regulation of protein phosphorylation  heart morphogenesis  protein tyrosine kinase activity  protein tyrosine kinase activity  receptor signaling protein tyrosine kinase activity  insulin-activated receptor activity  insulin-like growth factor receptor binding  protein binding  ATP binding  GTP binding  plasma membrane  plasma membrane  integral component of plasma membrane  insulin receptor complex  caveola  carbohydrate metabolic process  regulation of transcription, DNA-templated  G-protein coupled receptor signaling pathway  positive regulation of cell proliferation  positive regulation of cell proliferation  insulin receptor signaling pathway  insulin receptor signaling pathway  endosome membrane  membrane  peptidyl-tyrosine phosphorylation  transformation of host cell by virus  signal transduction by phosphorylation  male sex determination  positive regulation of cell migration  exocrine pancreas development  insulin-like growth factor I binding  insulin-like growth factor II binding  activation of protein kinase activity  activation of protein kinase B activity  cellular response to insulin stimulus  glucose homeostasis  receptor complex  positive regulation of MAPK cascade  phosphatidylinositol 3-kinase binding  insulin binding  insulin binding  insulin receptor substrate binding  positive regulation of nitric oxide biosynthetic process  positive regulation of glycogen biosynthetic process  positive regulation of DNA replication  positive regulation of glycolytic process  positive regulation of mitosis  regulation of embryonic development  positive regulation of glucose import  positive regulation of glucose import  protein autophosphorylation  protein autophosphorylation  positive regulation of developmental growth  protein heterotetramerization  PTB domain binding  positive regulation of protein kinase B signaling  positive regulation of respiratory burst  extracellular vesicular exosome  cellular response to growth factor stimulus  
Pathways : BIOCARTAInsulin Signaling Pathway [Genes]    Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) [Genes]    Growth Hormone Signaling Pathway [Genes]   
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    HIF-1 signaling pathway    FoxO signaling pathway    PI3K-Akt signaling pathway    Adherens junction    Insulin signaling pathway    Ovarian steroidogenesis    Type II diabetes mellitus    Non-alcoholic fatty liver disease (NAFLD)    Aldosterone-regulated sodium reabsorption   
Protein Interaction DatabaseINSR
Wikipedia pathwaysINSR
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)INSR
SNP (GeneSNP Utah)INSR
SNP : HGBaseINSR
Genetic variants : HAPMAPINSR
1000_GenomesINSR 
ICGC programENSG00000171105 
CONAN: Copy Number AnalysisINSR 
Somatic Mutations in Cancer : COSMICINSR 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Mutations and Diseases : HGMDINSR
OMIM147670    246200    262190    609968    610549   
MedgenINSR
GENETestsINSR
Disease Genetic AssociationINSR
Huge Navigator INSR [HugePedia]  INSR [HugeCancerGEM]
Genomic VariantsINSR  INSR [DGVbeta]
Exome VariantINSR
dbVarINSR
ClinVarINSR
snp3D : Map Gene to Disease3643
General knowledge
Homologs : HomoloGeneINSR
Homology/Alignments : Family Browser (UCSC)INSR
Phylogenetic Trees/Animal Genes : TreeFamINSR
Chemical/Protein Interactions : CTD3643
Chemical/Pharm GKB GenePA202
Clinical trialINSR
Cancer Resource (Charite)ENSG00000171105
Other databases
Probes
Litterature
PubMed490 Pubmed reference(s) in Entrez
CoreMineINSR
iHOPINSR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:53:18 CEST 2014

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