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INSRR (insulin receptor related receptor)

Identity

Alias (NCBI)IRR
HGNC (Hugo) INSRR
HGNC Alias symbIRR
LocusID (NCBI) 3645
Atlas_Id 43325
Location 1q23.1  [Link to chromosome band 1q23]
Location_base_pair Starts at 156840063 and ends at 156859117 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASH1L (1q22) / INSRR (1q23.1)ASH1L 1q22 / INSRR 1q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)INSRR   6093
Cards
Entrez_Gene (NCBI)INSRR    insulin receptor related receptor
AliasesIRR
GeneCards (Weizmann)INSRR
Ensembl hg19 (Hinxton)ENSG00000027644 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000027644 [Gene_View]  ENSG00000027644 [Sequence]  chr1:156840063-156859117 [Contig_View]  INSRR [Vega]
ICGC DataPortalENSG00000027644
TCGA cBioPortalINSRR
AceView (NCBI)INSRR
Genatlas (Paris)INSRR
SOURCE (Princeton)INSRR
Genetics Home Reference (NIH)INSRR
Genomic and cartography
GoldenPath hg38 (UCSC)INSRR  -     chr1:156840063-156859117 -  1q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INSRR  -     1q23.1   [Description]    (hg19-Feb_2009)
GoldenPathINSRR - 1q23.1 [CytoView hg19]  INSRR - 1q23.1 [CytoView hg38]
ImmunoBaseENSG00000027644
Genome Data Viewer NCBIINSRR [Mapview hg19]  
OMIM147671   
Gene and transcription
Genbank (Entrez)AF064078 AK310760 J05046 JQ991924
RefSeq transcript (Entrez)NM_014215
Consensus coding sequences : CCDS (NCBI)INSRR
Gene ExpressionINSRR [ NCBI-GEO ]   INSRR [ EBI - ARRAY_EXPRESS ]   INSRR [ SEEK ]   INSRR [ MEM ]
Gene Expression Viewer (FireBrowse)INSRR [ Firebrowse - Broad ]
GenevisibleExpression of INSRR in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3645
GTEX Portal (Tissue expression)INSRR
Human Protein AtlasENSG00000027644-INSRR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14616   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14616  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14616
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP14616
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Furin-like_Cys-rich_dom    Furin_repeat    Growth_fac_rcpt_cys_sf    Ig-like_fold    INSRR    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Rcpt_L-dom    Rcpt_L-dom_sf    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_insulin-like_rcpt    Tyr_kinase_rcpt_2_CS   
Domain families : Pfam (Sanger)Furin-like (PF00757)    PK_Tyr_Ser-Thr (PF07714)    Recep_L_domain (PF01030)   
Domain families : Pfam (NCBI)pfam00757    pfam07714    pfam01030   
Domain families : Smart (EMBL)FN3 (SM00060)  FU (SM00261)  TyrKc (SM00219)  
Conserved Domain (NCBI)INSRR
SuperfamilyP14616
AlphaFold pdb e-kbP14616   
Human Protein Atlas [tissue]ENSG00000027644-INSRR [tissue]
HPRD00976
Protein Interaction databases
DIP (DOE-UCLA)P14616
IntAct (EBI)P14616
BioGRIDINSRR
STRING (EMBL)INSRR
ZODIACINSRR
Ontologies - Pathways
QuickGOP14616
Ontology : AmiGOtransmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  insulin-activated receptor activity  protein binding  ATP binding  integral component of plasma membrane  integral component of plasma membrane  insulin receptor complex  transmembrane receptor protein tyrosine kinase signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  insulin receptor signaling pathway  peptidyl-tyrosine phosphorylation  male sex determination  axon  actin cytoskeleton reorganization  positive regulation of kinase activity  receptor complex  receptor complex  phosphatidylinositol 3-kinase binding  insulin receptor substrate binding  protein autophosphorylation  cellular response to alkaline pH  
Ontology : EGO-EBItransmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  insulin-activated receptor activity  protein binding  ATP binding  integral component of plasma membrane  integral component of plasma membrane  insulin receptor complex  transmembrane receptor protein tyrosine kinase signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  insulin receptor signaling pathway  peptidyl-tyrosine phosphorylation  male sex determination  axon  actin cytoskeleton reorganization  positive regulation of kinase activity  receptor complex  receptor complex  phosphatidylinositol 3-kinase binding  insulin receptor substrate binding  protein autophosphorylation  cellular response to alkaline pH  
Pathways : KEGGRegulation of actin cytoskeleton    Prostate cancer   
NDEx NetworkINSRR
Atlas of Cancer Signalling NetworkINSRR
Wikipedia pathwaysINSRR
Orthology - Evolution
OrthoDB3645
GeneTree (enSembl)ENSG00000027644
Phylogenetic Trees/Animal Genes : TreeFamINSRR
Homologs : HomoloGeneINSRR
Homology/Alignments : Family Browser (UCSC)INSRR
Gene fusions - Rearrangements
Fusion : MitelmanASH1L/INSRR [1q22/1q23.1]  
Fusion : QuiverINSRR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINSRR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INSRR
dbVarINSRR
ClinVarINSRR
MonarchINSRR
1000_GenomesINSRR 
Exome Variant ServerINSRR
GNOMAD BrowserENSG00000027644
Varsome BrowserINSRR
ACMGINSRR variants
VarityP14616
Genomic Variants (DGV)INSRR [DGVbeta]
DECIPHERINSRR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINSRR 
Mutations
ICGC Data PortalINSRR 
TCGA Data PortalINSRR 
Broad Tumor PortalINSRR
OASIS PortalINSRR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINSRR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DINSRR
Mutations and Diseases : HGMDINSRR
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaINSRR
DgiDB (Drug Gene Interaction Database)INSRR
DoCM (Curated mutations)INSRR
CIViC (Clinical Interpretations of Variants in Cancer)INSRR
Cancer3DINSRR
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147671   
Orphanet
DisGeNETINSRR
MedgenINSRR
Genetic Testing Registry INSRR
NextProtP14616 [Medical]
GENETestsINSRR
Target ValidationINSRR
Huge Navigator INSRR [HugePedia]
ClinGenINSRR
Clinical trials, drugs, therapy
MyCancerGenomeINSRR
Protein Interactions : CTDINSRR
Pharm GKB GenePA29899
PharosP14616
Clinical trialINSRR
Miscellaneous
canSAR (ICR)INSRR
HarmonizomeINSRR
DataMed IndexINSRR
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXINSRR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:14:04 CEST 2021

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