Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

INSRR (insulin receptor related receptor)

Identity

Alias_symbol (synonym)IRR
Other alias
HGNC (Hugo) INSRR
LocusID (NCBI) 3645
Atlas_Id 43325
Location 1q23.1  [Link to chromosome band 1q23]
Location_base_pair Starts at 156840873 and ends at 156858920 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASH1L (1q22) / INSRR (1q23.1)ASH1L 1q22 / INSRR 1q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)INSRR   6093
Cards
Entrez_Gene (NCBI)INSRR  3645  insulin receptor related receptor
AliasesIRR
GeneCards (Weizmann)INSRR
Ensembl hg19 (Hinxton)ENSG00000027644 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000027644 [Gene_View]  chr1:156840873-156858920 [Contig_View]  INSRR [Vega]
ICGC DataPortalENSG00000027644
TCGA cBioPortalINSRR
AceView (NCBI)INSRR
Genatlas (Paris)INSRR
WikiGenes3645
SOURCE (Princeton)INSRR
Genetics Home Reference (NIH)INSRR
Genomic and cartography
GoldenPath hg38 (UCSC)INSRR  -     chr1:156840873-156858920 -  1q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INSRR  -     1q23.1   [Description]    (hg19-Feb_2009)
EnsemblINSRR - 1q23.1 [CytoView hg19]  INSRR - 1q23.1 [CytoView hg38]
Mapping of homologs : NCBIINSRR [Mapview hg19]  INSRR [Mapview hg38]
OMIM147671   
Gene and transcription
Genbank (Entrez)AF064078 AK310760 BC156081 BC157044 J05046
RefSeq transcript (Entrez)NM_014215
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)INSRR
Cluster EST : UnigeneHs.248138 [ NCBI ]
CGAP (NCI)Hs.248138
Alternative Splicing GalleryENSG00000027644
Gene ExpressionINSRR [ NCBI-GEO ]   INSRR [ EBI - ARRAY_EXPRESS ]   INSRR [ SEEK ]   INSRR [ MEM ]
Gene Expression Viewer (FireBrowse)INSRR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3645
GTEX Portal (Tissue expression)INSRR
Human Protein AtlasENSG00000027644-INSRR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14616   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14616  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14616
Splice isoforms : SwissVarP14616
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusP14616
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domains : Interpro (EBI)###############################################################################################################################################################################################################################################################                                                               
Domain families : Pfam (Sanger)Furin-like (PF00757)    Pkinase_Tyr (PF07714)    Recep_L_domain (PF01030)   
Domain families : Pfam (NCBI)pfam00757    pfam07714    pfam01030   
Domain families : Smart (EMBL)FN3 (SM00060)  FU (SM00261)  TyrKc (SM00219)  
Conserved Domain (NCBI)INSRR
DMDM Disease mutations3645
Blocks (Seattle)INSRR
SuperfamilyP14616
Human Protein Atlas [tissue]ENSG00000027644-INSRR [tissue]
Peptide AtlasP14616
HPRD00976
IPIIPI00027212   
Protein Interaction databases
DIP (DOE-UCLA)P14616
IntAct (EBI)P14616
FunCoupENSG00000027644
BioGRIDINSRR
STRING (EMBL)INSRR
ZODIACINSRR
Ontologies - Pathways
QuickGOP14616
Ontology : AmiGOtransmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  ATP binding  integral component of plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  peptidyl-tyrosine phosphorylation  male sex determination  actin cytoskeleton reorganization  receptor complex  phosphatidylinositol 3-kinase binding  insulin receptor substrate binding  protein autophosphorylation  cellular response to alkaline pH  
Ontology : EGO-EBItransmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  ATP binding  integral component of plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  peptidyl-tyrosine phosphorylation  male sex determination  actin cytoskeleton reorganization  receptor complex  phosphatidylinositol 3-kinase binding  insulin receptor substrate binding  protein autophosphorylation  cellular response to alkaline pH  
Pathways : KEGGRegulation of actin cytoskeleton    Prostate cancer   
NDEx NetworkINSRR
Atlas of Cancer Signalling NetworkINSRR
Wikipedia pathwaysINSRR
Orthology - Evolution
OrthoDB3645
GeneTree (enSembl)ENSG00000027644
Phylogenetic Trees/Animal Genes : TreeFamINSRR
HOVERGENP14616
HOGENOMP14616
Homologs : HomoloGeneINSRR
Homology/Alignments : Family Browser (UCSC)INSRR
Gene fusions - Rearrangements
Fusion : MitelmanASH1L/INSRR [1q22/1q23.1]  [t(1;1)(q22;q23)]  
Fusion: TCGAASH1L 1q22 INSRR 1q23.1 LUAD
Fusion: Tumor Portal INSRR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINSRR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INSRR
dbVarINSRR
ClinVarINSRR
1000_GenomesINSRR 
Exome Variant ServerINSRR
ExAC (Exome Aggregation Consortium)ENSG00000027644
GNOMAD BrowserENSG00000027644
Genetic variants : HAPMAP3645
Genomic Variants (DGV)INSRR [DGVbeta]
DECIPHERINSRR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINSRR 
Mutations
ICGC Data PortalINSRR 
TCGA Data PortalINSRR 
Broad Tumor PortalINSRR
OASIS PortalINSRR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINSRR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINSRR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INSRR
DgiDB (Drug Gene Interaction Database)INSRR
DoCM (Curated mutations)INSRR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INSRR (select a term)
intoGenINSRR
Cancer3DINSRR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147671   
Orphanet
MedgenINSRR
Genetic Testing Registry INSRR
NextProtP14616 [Medical]
TSGene3645
GENETestsINSRR
Target ValidationINSRR
Huge Navigator INSRR [HugePedia]
snp3D : Map Gene to Disease3645
BioCentury BCIQINSRR
ClinGenINSRR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3645
Chemical/Pharm GKB GenePA29899
Clinical trialINSRR
Miscellaneous
canSAR (ICR)INSRR (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINSRR
EVEXINSRR
GoPubMedINSRR
iHOPINSRR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:54:33 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.