Atlas of Genetics and Cytogenetics in Oncology and Haematology

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INTS4 (integrator complex subunit 4)

Identity

Alias_symbol (synonym)INT4
MGC16733
MST093
Other alias
HGNC (Hugo) INTS4
LocusID (NCBI) 92105
Atlas_Id 54012
Location 11q14.1  [Link to chromosome band 11q14]
Location_base_pair Starts at 77878720 and ends at 77994671 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
INTS4 (11q14.1) / EMSY (11q13.5)INTS4 (11q14.1) / GAB2 (11q14.1)INTS4 (11q14.1) / KCTD14 (11q14.1)
INTS4 (11q14.1) / NARS2 (11q14.1)INTS4 (11q14.1) / POLD3 (11q13.4)INTS4 (11q14.1) / PPFIA1 (11q13.3)
INTS4 (11q14.1) / TXLNG (Xp22.2)PRCP (11q14.1) / INTS4 (11q14.1)RSF1 (11q14.1) / INTS4 (11q14.1)
TENM4 (11q14.1) / INTS4 (11q14.1)UVRAG (11q13.5) / INTS4 (11q14.1)INTS4 11q14.1 / GAB2 11q14.1
INTS4 11q14.1 / C11orf30 11q13.5INTS4 11q14.1 / GAB2 11q14.1INTS4 11q14.1 / KCTD14 11q14.1
INTS4 11q14.1 / NARS2 11q14.1INTS4 11q14.1 / POLD3 11q13.4INTS4 11q14.1 / PPFIA1 11q13.3
ODZ4 INTS4 11q14.1RSF1 11q14.1 / INTS4 11q14.1UVRAG 11q13.5 / INTS4 11q14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q13;q14) PPP6R3/INTS4

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  t(11;11)(q13;q14) INTS4/POLD3
t(11;11)(q13;q14) INTS4/PPFIA1
t(11;11)(q13;q14) UVRAG/INTS4
INTS4/GAB2 (11q14)
INTS4/KCTD14 (11q14)
INTS4/NARS2 (11q14)
RSF1/INTS4 (11q14)
TENM4/INTS4 (11q14)

External links

Nomenclature
HGNC (Hugo)INTS4   25048
Cards
Entrez_Gene (NCBI)INTS4  92105  integrator complex subunit 4
AliasesINT4; MST093
GeneCards (Weizmann)INTS4
Ensembl hg19 (Hinxton)ENSG00000149262 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149262 [Gene_View]  ENSG00000149262 [Sequence]  chr11:77878720-77994671 [Contig_View]  INTS4 [Vega]
ICGC DataPortalENSG00000149262
TCGA cBioPortalINTS4
AceView (NCBI)INTS4
Genatlas (Paris)INTS4
WikiGenes92105
SOURCE (Princeton)INTS4
Genetics Home Reference (NIH)INTS4
Genomic and cartography
GoldenPath hg38 (UCSC)INTS4  -     chr11:77878720-77994671 -  11q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)INTS4  -     11q14.1   [Description]    (hg19-Feb_2009)
INTS4 - 11q14.1 [CytoView hg19]  INTS4 - 11q14.1 [CytoView hg38]
Mapping of homologs : NCBIINTS4 [Mapview hg19]  INTS4 [Mapview hg38]
OMIM611348   
Gene and transcription
Genbank (Entrez)AF172822 AK000455 AK290866 AL834171 BC006369
RefSeq transcript (Entrez)NM_033547
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)INTS4
Cluster EST : UnigeneHs.533723 [ NCBI ]
CGAP (NCI)Hs.533723
Alternative Splicing GalleryENSG00000149262
Gene ExpressionINTS4 [ NCBI-GEO ]   INTS4 [ EBI - ARRAY_EXPRESS ]   INTS4 [ SEEK ]   INTS4 [ MEM ]
Gene Expression Viewer (FireBrowse)INTS4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)92105
GTEX Portal (Tissue expression)INTS4
Human Protein AtlasENSG00000149262-INTS4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96HW7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96HW7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96HW7
Splice isoforms : SwissVarQ96HW7
PhosPhoSitePlusQ96HW7
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Cohesin_HEAT   
Domain families : Pfam (Sanger)Cohesin_HEAT (PF12765)   
Domain families : Pfam (NCBI)pfam12765   
Conserved Domain (NCBI)INTS4
DMDM Disease mutations92105
Blocks (Seattle)INTS4
SuperfamilyQ96HW7
Human Protein Atlas [tissue]ENSG00000149262-INTS4 [tissue]
Peptide AtlasQ96HW7
HPRD12386
IPIIPI00446765   IPI00795935   IPI00748403   IPI00419468   IPI00973732   IPI00981039   
Protein Interaction databases
DIP (DOE-UCLA)Q96HW7
IntAct (EBI)Q96HW7
FunCoupENSG00000149262
BioGRIDINTS4
STRING (EMBL)INTS4
ZODIACINTS4
Ontologies - Pathways
QuickGOQ96HW7
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  snRNA processing  snRNA processing  integrator complex  integrator complex  snRNA transcription by RNA polymerase II  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  snRNA processing  snRNA processing  integrator complex  integrator complex  snRNA transcription by RNA polymerase II  
NDEx NetworkINTS4
Atlas of Cancer Signalling NetworkINTS4
Wikipedia pathwaysINTS4
Orthology - Evolution
OrthoDB92105
GeneTree (enSembl)ENSG00000149262
Phylogenetic Trees/Animal Genes : TreeFamINTS4
HOGENOMQ96HW7
Homologs : HomoloGeneINTS4
Homology/Alignments : Family Browser (UCSC)INTS4
Gene fusions - Rearrangements
Fusion : MitelmanINTS4/C11orf30 [11q14.1/11q13.5]  
Fusion : MitelmanINTS4/GAB2 [11q14.1/11q14.1]  [del(11)(q14)]  [del(11)(q14q14)]  
[t(11;11)(q14;q14)]  
Fusion : MitelmanINTS4/KCTD14 [11q14.1/11q14.1]  [t(11;11)(q14;q14)]  
Fusion : MitelmanINTS4/NARS2 [11q14.1/11q14.1]  [t(11;11)(q14;q14)]  
Fusion : MitelmanINTS4/POLD3 [11q14.1/11q13.4]  [t(11;11)(q13;q14)]  
Fusion : MitelmanINTS4/PPFIA1 [11q14.1/11q13.3]  [t(11;11)(q13;q14)]  
Fusion : MitelmanRSF1/INTS4 [11q14.1/11q14.1]  [t(11;11)(q14;q14)]  
Fusion : MitelmanTENM4/INTS4 [11q14.1/11q14.1]  [t(11;11)(q14;q14)]  
Fusion : MitelmanUVRAG/INTS4 [11q13.5/11q14.1]  [t(11;11)(q13;q14)]  
Fusion PortalINTS4 11q14.1 C11orf30 11q13.5 BRCA
Fusion PortalINTS4 11q14.1 GAB2 11q14.1 BRCA
Fusion PortalINTS4 11q14.1 KCTD14 11q14.1 BRCA
Fusion PortalINTS4 11q14.1 NARS2 11q14.1 OV
Fusion PortalINTS4 11q14.1 POLD3 11q13.4 BRCA
Fusion PortalINTS4 11q14.1 PPFIA1 11q13.3 BRCA
Fusion PortalODZ4 INTS4 11q14.1 BRCA
Fusion PortalRSF1 11q14.1 INTS4 11q14.1 LUSC SKCM
Fusion PortalUVRAG 11q13.5 INTS4 11q14.1 BRCA
Fusion : QuiverINTS4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerINTS4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INTS4
dbVarINTS4
ClinVarINTS4
1000_GenomesINTS4 
Exome Variant ServerINTS4
ExAC (Exome Aggregation Consortium)ENSG00000149262
GNOMAD BrowserENSG00000149262
Varsome BrowserINTS4
Genetic variants : HAPMAP92105
Genomic Variants (DGV)INTS4 [DGVbeta]
DECIPHERINTS4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisINTS4 
Mutations
ICGC Data PortalINTS4 
TCGA Data PortalINTS4 
Broad Tumor PortalINTS4
OASIS PortalINTS4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICINTS4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDINTS4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch INTS4
DgiDB (Drug Gene Interaction Database)INTS4
DoCM (Curated mutations)INTS4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)INTS4 (select a term)
intoGenINTS4
Cancer3DINTS4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611348   
Orphanet
DisGeNETINTS4
MedgenINTS4
Genetic Testing Registry INTS4
NextProtQ96HW7 [Medical]
TSGene92105
GENETestsINTS4
Target ValidationINTS4
Huge Navigator INTS4 [HugePedia]
snp3D : Map Gene to Disease92105
BioCentury BCIQINTS4
ClinGenINTS4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD92105
Chemical/Pharm GKB GenePA144596421
Clinical trialINTS4
Miscellaneous
canSAR (ICR)INTS4 (select the gene name)
DataMed IndexINTS4
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINTS4
EVEXINTS4
GoPubMedINTS4
iHOPINTS4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 21 15:51:18 CET 2019
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