IP6K1 (inositol hexakisphosphate kinase 1)

2007-04-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
IHPK1,PiUS
FUSION GENES

Other Information

Locus ID:

NCBI: 9807
MIM: 606991
HGNC: 18360
Ensembl: ENSG00000176095

Variants:

dbSNP: 9807
ClinVar: 9807
TCGA: ENSG00000176095
COSMIC: IP6K1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176095ENST00000321599Q92551
ENSG00000176095ENST00000321599A0A024R2X2
ENSG00000176095ENST00000395238Q92551
ENSG00000176095ENST00000460540Q92551
ENSG00000176095ENST00000468463C9JNA8
ENSG00000176095ENST00000613416Q92551
ENSG00000176095ENST00000613416A0A024R2X2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Phosphatidylinositol signaling systemKEGGko04070
Phosphatidylinositol signaling systemKEGGhsa04070
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IPs in the nucleusREACTOMER-HSA-1855191
Synthesis of pyrophosphates in the cytosolREACTOMER-HSA-1855167

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
342290602021miR-125a-5p impairs the metastatic potential in breast cancer via IP(6)K1 targeting.5
347570462021Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis.8
348414282021IP6K1 upregulates the formation of processing bodies by influencing protein-protein interactions on the mRNA cap.4
342290602021miR-125a-5p impairs the metastatic potential in breast cancer via IP(6)K1 targeting.5
347570462021Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis.8
348414282021IP6K1 upregulates the formation of processing bodies by influencing protein-protein interactions on the mRNA cap.4
311863492019The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export.46
311863492019The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export.46
295228192018Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.12
295228192018Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.12
281541322017Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.26
281541322017Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.26
271406812016Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.26
274744092016Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport.33
271406812016Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.26

Citation

Dessen P

IP6K1 (inositol hexakisphosphate kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47330/ip6k1