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IP6K2 (inositol hexakisphosphate kinase 2)

Identity

Alias_namesIHPK2
inositol hexaphosphate kinase 2
Other aliasPIUS
HGNC (Hugo) IP6K2
LocusID (NCBI) 51447
Atlas_Id 42934
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 48688003 and ends at 48717278 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IP6K2 (3p21.31) / IP6K2 (3p21.31)IP6K2 (3p21.31) / PRKAR2A (3p21.31)IP6K2 3p21.31 / PRKAR2A 3p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IP6K2   17313
Cards
Entrez_Gene (NCBI)IP6K2  51447  inositol hexakisphosphate kinase 2
AliasesIHPK2; PIUS
GeneCards (Weizmann)IP6K2
Ensembl hg19 (Hinxton)ENSG00000068745 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000068745 [Gene_View]  chr3:48688003-48717278 [Contig_View]  IP6K2 [Vega]
ICGC DataPortalENSG00000068745
TCGA cBioPortalIP6K2
AceView (NCBI)IP6K2
Genatlas (Paris)IP6K2
WikiGenes51447
SOURCE (Princeton)IP6K2
Genetics Home Reference (NIH)IP6K2
Genomic and cartography
GoldenPath hg38 (UCSC)IP6K2  -     chr3:48688003-48717278 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IP6K2  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblIP6K2 - 3p21.31 [CytoView hg19]  IP6K2 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIIP6K2 [Mapview hg19]  IP6K2 [Mapview hg38]
OMIM606992   
Gene and transcription
Genbank (Entrez)AF177145 AK024045 AK097016 AK290526 AK291501
RefSeq transcript (Entrez)NM_001005909 NM_001005910 NM_001005911 NM_001005912 NM_001005913 NM_001146178 NM_001146179 NM_001190316 NM_001190317 NM_016291
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IP6K2
Cluster EST : UnigeneHs.595983 [ NCBI ]
CGAP (NCI)Hs.595983
Alternative Splicing GalleryENSG00000068745
Gene ExpressionIP6K2 [ NCBI-GEO ]   IP6K2 [ EBI - ARRAY_EXPRESS ]   IP6K2 [ SEEK ]   IP6K2 [ MEM ]
Gene Expression Viewer (FireBrowse)IP6K2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51447
GTEX Portal (Tissue expression)IP6K2
Human Protein AtlasENSG00000068745-IP6K2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHH9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHH9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHH9
Splice isoforms : SwissVarQ9UHH9
Catalytic activity : Enzyme2.7.4.21 [ Enzyme-Expasy ]   2.7.4.212.7.4.21 [ IntEnz-EBI ]   2.7.4.21 [ BRENDA ]   2.7.4.21 [ KEGG ]   
PhosPhoSitePlusQ9UHH9
Domains : Interpro (EBI)IPK   
Domain families : Pfam (Sanger)IPK (PF03770)   
Domain families : Pfam (NCBI)pfam03770   
Conserved Domain (NCBI)IP6K2
DMDM Disease mutations51447
Blocks (Seattle)IP6K2
SuperfamilyQ9UHH9
Human Protein Atlas [tissue]ENSG00000068745-IP6K2 [tissue]
Peptide AtlasQ9UHH9
HPRD07380
IPIIPI00426289   IPI00385653   IPI00426291   IPI00789139   IPI00925324   IPI00876908   IPI00924428   IPI00910441   IPI00925695   IPI00925932   IPI00927342   IPI00927554   IPI00926931   IPI00924741   IPI00924880   IPI00927782   IPI00925557   IPI00926807   IPI00926957   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHH9
IntAct (EBI)Q9UHH9
FunCoupENSG00000068745
BioGRIDIP6K2
STRING (EMBL)IP6K2
ZODIACIP6K2
Ontologies - Pathways
QuickGOQ9UHH9
Ontology : AmiGOinositol-1,3,4,5,6-pentakisphosphate kinase activity  inositol hexakisphosphate kinase activity  inositol hexakisphosphate kinase activity  inositol heptakisphosphate kinase activity  inositol hexakisphosphate 5-kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  phosphate ion transport  inositol-1,4,5-trisphosphate 3-kinase activity  negative regulation of cell growth  positive regulation of apoptotic process  inositol phosphate metabolic process  intermediate filament cytoskeleton  phosphatidylinositol phosphorylation  inositol hexakisphosphate 1-kinase activity  inositol hexakisphosphate 3-kinase activity  inositol 5-diphosphate pentakisphosphate 5-kinase activity  inositol diphosphate tetrakisphosphate kinase activity  type I interferon signaling pathway  
Ontology : EGO-EBIinositol-1,3,4,5,6-pentakisphosphate kinase activity  inositol hexakisphosphate kinase activity  inositol hexakisphosphate kinase activity  inositol heptakisphosphate kinase activity  inositol hexakisphosphate 5-kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  phosphate ion transport  inositol-1,4,5-trisphosphate 3-kinase activity  negative regulation of cell growth  positive regulation of apoptotic process  inositol phosphate metabolic process  intermediate filament cytoskeleton  phosphatidylinositol phosphorylation  inositol hexakisphosphate 1-kinase activity  inositol hexakisphosphate 3-kinase activity  inositol 5-diphosphate pentakisphosphate 5-kinase activity  inositol diphosphate tetrakisphosphate kinase activity  type I interferon signaling pathway  
NDEx NetworkIP6K2
Atlas of Cancer Signalling NetworkIP6K2
Wikipedia pathwaysIP6K2
Orthology - Evolution
OrthoDB51447
GeneTree (enSembl)ENSG00000068745
Phylogenetic Trees/Animal Genes : TreeFamIP6K2
HOVERGENQ9UHH9
HOGENOMQ9UHH9
Homologs : HomoloGeneIP6K2
Homology/Alignments : Family Browser (UCSC)IP6K2
Gene fusions - Rearrangements
Fusion : MitelmanIP6K2/PRKAR2A [3p21.31/3p21.31]  
Fusion: TCGA_MDACCIP6K2 3p21.31 PRKAR2A 3p21.31 BRCA
Tumor Fusion PortalIP6K2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIP6K2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IP6K2
dbVarIP6K2
ClinVarIP6K2
1000_GenomesIP6K2 
Exome Variant ServerIP6K2
ExAC (Exome Aggregation Consortium)ENSG00000068745
GNOMAD BrowserENSG00000068745
Genetic variants : HAPMAP51447
Genomic Variants (DGV)IP6K2 [DGVbeta]
DECIPHERIP6K2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIP6K2 
Mutations
ICGC Data PortalIP6K2 
TCGA Data PortalIP6K2 
Broad Tumor PortalIP6K2
OASIS PortalIP6K2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIP6K2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIP6K2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IP6K2
DgiDB (Drug Gene Interaction Database)IP6K2
DoCM (Curated mutations)IP6K2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IP6K2 (select a term)
intoGenIP6K2
Cancer3DIP6K2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606992   
Orphanet
DisGeNETIP6K2
MedgenIP6K2
Genetic Testing Registry IP6K2
NextProtQ9UHH9 [Medical]
TSGene51447
GENETestsIP6K2
Target ValidationIP6K2
Huge Navigator IP6K2 [HugePedia]
snp3D : Map Gene to Disease51447
BioCentury BCIQIP6K2
ClinGenIP6K2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51447
Chemical/Pharm GKB GenePA164720999
Clinical trialIP6K2
Miscellaneous
canSAR (ICR)IP6K2 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIP6K2
EVEXIP6K2
GoPubMedIP6K2
iHOPIP6K2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:18:00 CET 2017

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