Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IPO5 (importin 5)

Identity

Alias_namesKPNB3
RANBP5
karyopherin (importin) beta 3
RAN binding protein 5
Alias_symbol (synonym)IMB3
MGC2068
Pse1
Other aliasimp5
HGNC (Hugo) IPO5
LocusID (NCBI) 3843
Atlas_Id 41102
Location 13q32.2  [Link to chromosome band 13q32]
Location_base_pair Starts at 97953675 and ends at 98024296 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BTBD10 (11p15.2) / IPO5 (13q32.2)EP300 (22q13.2) / IPO5 (13q32.2)IPO5 (13q32.2) / IPO5 (13q32.2)
JA040725 () / IPO5 (13q32.2)PDE8A (15q25.3) / IPO5 (13q32.2)EP300 22q13.2 / IPO5 13q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IPO5   6402
Cards
Entrez_Gene (NCBI)IPO5  3843  importin 5
AliasesIMB3; KPNB3; Pse1; RANBP5; 
imp5
GeneCards (Weizmann)IPO5
Ensembl hg19 (Hinxton)ENSG00000065150 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065150 [Gene_View]  chr13:97953675-98024296 [Contig_View]  IPO5 [Vega]
ICGC DataPortalENSG00000065150
TCGA cBioPortalIPO5
AceView (NCBI)IPO5
Genatlas (Paris)IPO5
WikiGenes3843
SOURCE (Princeton)IPO5
Genetics Home Reference (NIH)IPO5
Genomic and cartography
GoldenPath hg38 (UCSC)IPO5  -     chr13:97953675-98024296 +  13q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IPO5  -     13q32.2   [Description]    (hg19-Feb_2009)
EnsemblIPO5 - 13q32.2 [CytoView hg19]  IPO5 - 13q32.2 [CytoView hg38]
Mapping of homologs : NCBIIPO5 [Mapview hg19]  IPO5 [Mapview hg38]
OMIM602008   
Gene and transcription
Genbank (Entrez)AB074173 AF339834 AK125031 AK225286 AK302812
RefSeq transcript (Entrez)NM_002271
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IPO5
Cluster EST : UnigeneHs.712598 [ NCBI ]
CGAP (NCI)Hs.712598
Alternative Splicing GalleryENSG00000065150
Gene ExpressionIPO5 [ NCBI-GEO ]   IPO5 [ EBI - ARRAY_EXPRESS ]   IPO5 [ SEEK ]   IPO5 [ MEM ]
Gene Expression Viewer (FireBrowse)IPO5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3843
GTEX Portal (Tissue expression)IPO5
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00410   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00410  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00410
Splice isoforms : SwissVarO00410
PhosPhoSitePlusO00410
Domaine pattern : Prosite (Expaxy)IMPORTIN_B_NT (PS50166)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    HEAT    Importin-beta_N    TOG   
Domain families : Pfam (Sanger)HEAT (PF02985)   
Domain families : Pfam (NCBI)pfam02985   
Domain families : Smart (EMBL)TOG (SM01349)  
Conserved Domain (NCBI)IPO5
DMDM Disease mutations3843
Blocks (Seattle)IPO5
SuperfamilyO00410
Human Protein AtlasENSG00000065150
Peptide AtlasO00410
HPRD03597
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)O00410
IntAct (EBI)O00410
FunCoupENSG00000065150
BioGRIDIPO5
STRING (EMBL)IPO5
ZODIACIPO5
Ontologies - Pathways
QuickGOO00410
Ontology : AmiGOprotein import into nucleus, translocation  RNA binding  GTPase inhibitor activity  protein binding  nucleus  nuclear pore  nucleolus  cytoplasm  cytoplasm  NLS-bearing protein import into nucleus  NLS-bearing protein import into nucleus  ribosomal protein import into nucleus  nuclear localization sequence binding  Ran GTPase binding  protein transporter activity  protein transporter activity  membrane  viral process  nuclear membrane  negative regulation of GTPase activity  nuclear periphery  positive regulation of protein import into nucleus  cellular response to amino acid stimulus  
Ontology : EGO-EBIprotein import into nucleus, translocation  RNA binding  GTPase inhibitor activity  protein binding  nucleus  nuclear pore  nucleolus  cytoplasm  cytoplasm  NLS-bearing protein import into nucleus  NLS-bearing protein import into nucleus  ribosomal protein import into nucleus  nuclear localization sequence binding  Ran GTPase binding  protein transporter activity  protein transporter activity  membrane  viral process  nuclear membrane  negative regulation of GTPase activity  nuclear periphery  positive regulation of protein import into nucleus  cellular response to amino acid stimulus  
NDEx NetworkIPO5
Atlas of Cancer Signalling NetworkIPO5
Wikipedia pathwaysIPO5
Orthology - Evolution
OrthoDB3843
GeneTree (enSembl)ENSG00000065150
Phylogenetic Trees/Animal Genes : TreeFamIPO5
HOVERGENO00410
HOGENOMO00410
Homologs : HomoloGeneIPO5
Homology/Alignments : Family Browser (UCSC)IPO5
Gene fusions - Rearrangements
Fusion : MitelmanEP300/IPO5 [22q13.2/13q32.2]  [t(13;22)(q32;q13)]  
Fusion: TCGAEP300 22q13.2 IPO5 13q32.2 BRCA
Fusion Cancer (Beijing)JA040725 [IPO5]  -  13q32.2 [FUSC001188]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIPO5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IPO5
dbVarIPO5
ClinVarIPO5
1000_GenomesIPO5 
Exome Variant ServerIPO5
ExAC (Exome Aggregation Consortium)IPO5 (select the gene name)
Genetic variants : HAPMAP3843
Genomic Variants (DGV)IPO5 [DGVbeta]
DECIPHERIPO5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIPO5 
Mutations
ICGC Data PortalIPO5 
TCGA Data PortalIPO5 
Broad Tumor PortalIPO5
OASIS PortalIPO5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIPO5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIPO5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IPO5
DgiDB (Drug Gene Interaction Database)IPO5
DoCM (Curated mutations)IPO5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IPO5 (select a term)
intoGenIPO5
Cancer3DIPO5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602008   
Orphanet
MedgenIPO5
Genetic Testing Registry IPO5
NextProtO00410 [Medical]
TSGene3843
GENETestsIPO5
Target ValidationIPO5
Huge Navigator IPO5 [HugePedia]
snp3D : Map Gene to Disease3843
BioCentury BCIQIPO5
ClinGenIPO5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3843
Chemical/Pharm GKB GenePA30193
Clinical trialIPO5
Miscellaneous
canSAR (ICR)IPO5 (select the gene name)
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIPO5
EVEXIPO5
GoPubMedIPO5
iHOPIPO5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:04:09 CEST 2017

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