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IPO8 (importin 8)

Identity

Alias_namesRANBP8
RAN binding protein 8
Alias_symbol (synonym)IMP8
Other alias
HGNC (Hugo) IPO8
LocusID (NCBI) 10526
Atlas_Id 47460
Location 12p11.21  [Link to chromosome band 12p11]
Location_base_pair Starts at 30781915 and ends at 30830178 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IPO8 (12p11.21) / CDH13 (16q23.3)IPO8 (12p11.21) / KRT86 (12q13.13)IPO8 12p11.21 / CDH13 16q23.3
IPO8 12p11.21 / KRT86 12q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IPO8   9853
Cards
Entrez_Gene (NCBI)IPO8  10526  importin 8
AliasesRANBP8
GeneCards (Weizmann)IPO8
Ensembl hg19 (Hinxton)ENSG00000133704 [Gene_View]  chr12:30781915-30830178 [Contig_View]  IPO8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000133704 [Gene_View]  chr12:30781915-30830178 [Contig_View]  IPO8 [Vega]
ICGC DataPortalENSG00000133704
TCGA cBioPortalIPO8
AceView (NCBI)IPO8
Genatlas (Paris)IPO8
WikiGenes10526
SOURCE (Princeton)IPO8
Genetics Home Reference (NIH)IPO8
Genomic and cartography
GoldenPath hg19 (UCSC)IPO8  -     chr12:30781915-30830178 -  12p11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IPO8  -     12p11.21   [Description]    (hg38-Dec_2013)
EnsemblIPO8 - 12p11.21 [CytoView hg19]  IPO8 - 12p11.21 [CytoView hg38]
Mapping of homologs : NCBIIPO8 [Mapview hg19]  IPO8 [Mapview hg38]
OMIM605600   
Gene and transcription
Genbank (Entrez)AA620453 AB209602 AK000201 AK025607 AK130090
RefSeq transcript (Entrez)NM_001190995 NM_006390
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_009714 NW_004929383
Consensus coding sequences : CCDS (NCBI)IPO8
Cluster EST : UnigeneHs.505136 [ NCBI ]
CGAP (NCI)Hs.505136
Alternative Splicing GalleryENSG00000133704
Gene ExpressionIPO8 [ NCBI-GEO ]   IPO8 [ EBI - ARRAY_EXPRESS ]   IPO8 [ SEEK ]   IPO8 [ MEM ]
Gene Expression Viewer (FireBrowse)IPO8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10526
GTEX Portal (Tissue expression)IPO8
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15397   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15397  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15397
Splice isoforms : SwissVarO15397
PhosPhoSitePlusO15397
Domaine pattern : Prosite (Expaxy)IMPORTIN_B_NT (PS50166)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Cse1    Importin-beta_N   
Domain families : Pfam (Sanger)Cse1 (PF08506)    IBN_N (PF03810)   
Domain families : Pfam (NCBI)pfam08506    pfam03810   
Domain families : Smart (EMBL)IBN_N (SM00913)  
Conserved Domain (NCBI)IPO8
DMDM Disease mutations10526
Blocks (Seattle)IPO8
SuperfamilyO15397
Human Protein AtlasENSG00000133704
Peptide AtlasO15397
HPRD09282
IPIIPI00007401   IPI01011377   IPI00793997   IPI01012782   IPI01013245   IPI01011829   IPI01012349   IPI01011835   IPI01010872   
Protein Interaction databases
DIP (DOE-UCLA)O15397
IntAct (EBI)O15397
FunCoupENSG00000133704
BioGRIDIPO8
STRING (EMBL)IPO8
ZODIACIPO8
Ontologies - Pathways
QuickGOO15397
Ontology : AmiGOprotein binding  nuclear envelope  nucleoplasm  cytosol  cytosol  protein import into nucleus  signal transduction  Ran GTPase binding  protein transporter activity  gene silencing by RNA  
Ontology : EGO-EBIprotein binding  nuclear envelope  nucleoplasm  cytosol  cytosol  protein import into nucleus  signal transduction  Ran GTPase binding  protein transporter activity  gene silencing by RNA  
NDEx NetworkIPO8
Atlas of Cancer Signalling NetworkIPO8
Wikipedia pathwaysIPO8
Orthology - Evolution
OrthoDB10526
GeneTree (enSembl)ENSG00000133704
Phylogenetic Trees/Animal Genes : TreeFamIPO8
HOVERGENO15397
HOGENOMO15397
Homologs : HomoloGeneIPO8
Homology/Alignments : Family Browser (UCSC)IPO8
Gene fusions - Rearrangements
Fusion : MitelmanIPO8/CDH13 [12p11.21/16q23.3]  
Fusion : MitelmanIPO8/KRT86 [12p11.21/12q13.13]  [t(12;12)(p11;q13)]  
Fusion: TCGAIPO8 12p11.21 CDH13 16q23.3 BRCA
Fusion: TCGAIPO8 12p11.21 KRT86 12q13.13 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIPO8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IPO8
dbVarIPO8
ClinVarIPO8
1000_GenomesIPO8 
Exome Variant ServerIPO8
ExAC (Exome Aggregation Consortium)IPO8 (select the gene name)
Genetic variants : HAPMAP10526
Genomic Variants (DGV)IPO8 [DGVbeta]
DECIPHER (Syndromes)12:30781915-30830178  ENSG00000133704
CONAN: Copy Number AnalysisIPO8 
Mutations
ICGC Data PortalIPO8 
TCGA Data PortalIPO8 
Broad Tumor PortalIPO8
OASIS PortalIPO8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIPO8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIPO8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IPO8
DgiDB (Drug Gene Interaction Database)IPO8
DoCM (Curated mutations)IPO8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IPO8 (select a term)
intoGenIPO8
Cancer3DIPO8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605600   
Orphanet
MedgenIPO8
Genetic Testing Registry IPO8
NextProtO15397 [Medical]
TSGene10526
GENETestsIPO8
Huge Navigator IPO8 [HugePedia]
snp3D : Map Gene to Disease10526
BioCentury BCIQIPO8
ClinGenIPO8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10526
Chemical/Pharm GKB GenePA34214
Clinical trialIPO8
Miscellaneous
canSAR (ICR)IPO8 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIPO8
EVEXIPO8
GoPubMedIPO8
iHOPIPO8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:05:24 CEST 2017

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