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IQGAP1 (IQ motif containing GTPase activating protein 1)

Identity

Alias_symbol (synonym)p195
KIAA0051
SAR1
HUMORFA01
Other alias
HGNC (Hugo) IQGAP1
LocusID (NCBI) 8826
Atlas_Id 45512
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 90388241 and ends at 90502243 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADRBK1 (11q13.2) / IQGAP1 (15q26.1)CAMK2D (4q26) / IQGAP1 (15q26.1)EFNA5 (5q21.3) / IQGAP1 (15q26.1)
IQGAP1 (15q26.1) / AKAP13 (15q25.3)IQGAP1 (15q26.1) / MESP2 (15q26.1)IQGAP1 (15q26.1) / PRC1 (15q26.1)
IQGAP1 (15q26.1) / PSMD4 (1q21.3)IQGAP1 (15q26.1) / TTLL13P (15q26.1)IQGAP1 (15q26.1) / ZNF774 (15q26.1)
SCGB1D2 (11q12.3) / IQGAP1 (15q26.1)SH3BGRL3 (1p36.11) / IQGAP1 (15q26.1)TRPM3 (9q21.12) / IQGAP1 (15q26.1)
UNC45A (15q26.1) / IQGAP1 (15q26.1)ADRBK1 11q13.2 / IQGAP1 15q26.1IQGAP1 15q26.1 / MESP2 15q26.1
IQGAP1 15q26.1 TTLL13IQGAP1 15q26.1 / ZNF774 15q26.1SCGB1D2 11q12.3 / IQGAP1 15q26.1
UNC45A 15q26.1 / IQGAP1 15q26.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IQGAP1   6110
Cards
Entrez_Gene (NCBI)IQGAP1  8826  IQ motif containing GTPase activating protein 1
AliasesHUMORFA01; SAR1; p195
GeneCards (Weizmann)IQGAP1
Ensembl hg19 (Hinxton)ENSG00000140575 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140575 [Gene_View]  chr15:90388241-90502243 [Contig_View]  IQGAP1 [Vega]
ICGC DataPortalENSG00000140575
TCGA cBioPortalIQGAP1
AceView (NCBI)IQGAP1
Genatlas (Paris)IQGAP1
WikiGenes8826
SOURCE (Princeton)IQGAP1
Genetics Home Reference (NIH)IQGAP1
Genomic and cartography
GoldenPath hg38 (UCSC)IQGAP1  -     chr15:90388241-90502243 +  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IQGAP1  -     15q26.1   [Description]    (hg19-Feb_2009)
EnsemblIQGAP1 - 15q26.1 [CytoView hg19]  IQGAP1 - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIIQGAP1 [Mapview hg19]  IQGAP1 [Mapview hg38]
OMIM603379   
Gene and transcription
Genbank (Entrez)AF401205 AI924000 AK055054 AK125643 AK298000
RefSeq transcript (Entrez)NM_003870
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IQGAP1
Cluster EST : UnigeneHs.430551 [ NCBI ]
CGAP (NCI)Hs.430551
Alternative Splicing GalleryENSG00000140575
Gene ExpressionIQGAP1 [ NCBI-GEO ]   IQGAP1 [ EBI - ARRAY_EXPRESS ]   IQGAP1 [ SEEK ]   IQGAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)IQGAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8826
GTEX Portal (Tissue expression)IQGAP1
Human Protein AtlasENSG00000140575-IQGAP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46940   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46940  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46940
Splice isoforms : SwissVarP46940
PhosPhoSitePlusP46940
Domaine pattern : Prosite (Expaxy)CH (PS50021)    IQ (PS50096)    RAS_GTPASE_ACTIV_1 (PS00509)    RAS_GTPASE_ACTIV_2 (PS50018)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)CH-domain    IQ_motif_EF-hand-BS    Myosin-like_IQ_dom    P-loop_NTPase    RasGAP_C    RasGAP_CS    RasGAP_dom    Rho_GTPase_activation_prot    WW_dom   
Domain families : Pfam (Sanger)CH (PF00307)    IQ (PF00612)    RasGAP (PF00616)    RasGAP_C (PF03836)   
Domain families : Pfam (NCBI)pfam00307    pfam00612    pfam00616    pfam03836   
Domain families : Smart (EMBL)CH (SM00033)  IQ (SM00015)  RasGAP (SM00323)  WW (SM00456)  
Conserved Domain (NCBI)IQGAP1
DMDM Disease mutations8826
Blocks (Seattle)IQGAP1
PDB (SRS)1X0H    2RR8    3FAY    3I6X    5L0O   
PDB (PDBSum)1X0H    2RR8    3FAY    3I6X    5L0O   
PDB (IMB)1X0H    2RR8    3FAY    3I6X    5L0O   
PDB (RSDB)1X0H    2RR8    3FAY    3I6X    5L0O   
Structural Biology KnowledgeBase1X0H    2RR8    3FAY    3I6X    5L0O   
SCOP (Structural Classification of Proteins)1X0H    2RR8    3FAY    3I6X    5L0O   
CATH (Classification of proteins structures)1X0H    2RR8    3FAY    3I6X    5L0O   
SuperfamilyP46940
Human Protein Atlas [tissue]ENSG00000140575-IQGAP1 [tissue]
Peptide AtlasP46940
HPRD04541
IPIIPI00009342   IPI00979837   
Protein Interaction databases
DIP (DOE-UCLA)P46940
IntAct (EBI)P46940
FunCoupENSG00000140575
BioGRIDIQGAP1
STRING (EMBL)IQGAP1
ZODIACIQGAP1
Ontologies - Pathways
QuickGOP46940
Ontology : AmiGOruffle  regulation of cytokine production  GTPase inhibitor activity  GTPase activator activity  calcium ion binding  protein binding  calmodulin binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  cytoplasm  cytosol  microtubule  actin filament  plasma membrane  focal adhesion  signal transduction  epidermal growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  actin cytoskeleton  microtubule cytoskeleton  lateral plasma membrane  protein kinase binding  protein phosphatase binding  protein domain specific binding  axon  growth cone  midbody  secretory granule membrane  extrinsic component of cytoplasmic side of plasma membrane  protein complex binding  negative regulation of GTPase activity  negative regulation of dephosphorylation  slit diaphragm  cellular response to platelet-derived growth factor stimulus  cytoplasmic ribonucleoprotein granule  neuron projection  protein complex  neutrophil degranulation  positive regulation of MAP kinase activity  protein serine/threonine kinase activator activity  positive regulation of GTPase activity  S100 protein binding  membrane raft  cadherin binding  positive regulation of protein kinase activity  platelet-derived growth factor receptor signaling pathway  Rac GTPase binding  mitogen-activated protein kinase binding  positive regulation of focal adhesion assembly  extracellular exosome  cellular response to calcium ion  cellular response to epidermal growth factor stimulus  glomerular visceral epithelial cell development  positive regulation of dendrite development  positive regulation of peptidyl-tyrosine autophosphorylation  positive regulation of cellular protein localization  positive regulation of vascular associated smooth muscle cell migration  neuron projection extension  response to angiotensin  
Ontology : EGO-EBIruffle  regulation of cytokine production  GTPase inhibitor activity  GTPase activator activity  calcium ion binding  protein binding  calmodulin binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  cytoplasm  cytosol  microtubule  actin filament  plasma membrane  focal adhesion  signal transduction  epidermal growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  actin cytoskeleton  microtubule cytoskeleton  lateral plasma membrane  protein kinase binding  protein phosphatase binding  protein domain specific binding  axon  growth cone  midbody  secretory granule membrane  extrinsic component of cytoplasmic side of plasma membrane  protein complex binding  negative regulation of GTPase activity  negative regulation of dephosphorylation  slit diaphragm  cellular response to platelet-derived growth factor stimulus  cytoplasmic ribonucleoprotein granule  neuron projection  protein complex  neutrophil degranulation  positive regulation of MAP kinase activity  protein serine/threonine kinase activator activity  positive regulation of GTPase activity  S100 protein binding  membrane raft  cadherin binding  positive regulation of protein kinase activity  platelet-derived growth factor receptor signaling pathway  Rac GTPase binding  mitogen-activated protein kinase binding  positive regulation of focal adhesion assembly  extracellular exosome  cellular response to calcium ion  cellular response to epidermal growth factor stimulus  glomerular visceral epithelial cell development  positive regulation of dendrite development  positive regulation of peptidyl-tyrosine autophosphorylation  positive regulation of cellular protein localization  positive regulation of vascular associated smooth muscle cell migration  neuron projection extension  response to angiotensin  
Pathways : KEGGAdherens junction    Regulation of actin cytoskeleton    Proteoglycans in cancer   
NDEx NetworkIQGAP1
Atlas of Cancer Signalling NetworkIQGAP1
Wikipedia pathwaysIQGAP1
Orthology - Evolution
OrthoDB8826
GeneTree (enSembl)ENSG00000140575
Phylogenetic Trees/Animal Genes : TreeFamIQGAP1
HOVERGENP46940
HOGENOMP46940
Homologs : HomoloGeneIQGAP1
Homology/Alignments : Family Browser (UCSC)IQGAP1
Gene fusions - Rearrangements
Fusion : MitelmanADRBK1/IQGAP1 [11q13.2/15q26.1]  [t(11;15)(q13;q26)]  
Fusion : MitelmanIQGAP1/AKAP13 [15q26.1/15q25.3]  [t(15;15)(q25;q26)]  
Fusion : MitelmanIQGAP1/MESP2 [15q26.1/15q26.1]  [t(15;15)(q26;q26)]  
Fusion : MitelmanIQGAP1/TTLL13P [15q26.1/15q26.1]  [t(15;15)(q26;q26)]  
Fusion : MitelmanIQGAP1/ZNF774 [15q26.1/15q26.1]  [t(15;15)(q26;q26)]  
Fusion : MitelmanSCGB1D2/IQGAP1 [11q12.3/15q26.1]  [t(11;15)(q12;q26)]  
Fusion : MitelmanUNC45A/IQGAP1 [15q26.1/15q26.1]  [t(15;15)(q26;q26)]  
Fusion: TCGA_MDACCADRBK1 11q13.2 IQGAP1 15q26.1 BRCA
Fusion: TCGA_MDACCIQGAP1 15q26.1 MESP2 15q26.1 BRCA
Fusion: TCGA_MDACCIQGAP1 15q26.1 TTLL13 BRCA
Fusion: TCGA_MDACCIQGAP1 15q26.1 ZNF774 15q26.1 THCA
Fusion: TCGA_MDACCSCGB1D2 11q12.3 IQGAP1 15q26.1 BRCA
Fusion: TCGA_MDACCUNC45A 15q26.1 IQGAP1 15q26.1 OV
Tumor Fusion PortalIQGAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIQGAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IQGAP1
dbVarIQGAP1
ClinVarIQGAP1
1000_GenomesIQGAP1 
Exome Variant ServerIQGAP1
ExAC (Exome Aggregation Consortium)ENSG00000140575
GNOMAD BrowserENSG00000140575
Genetic variants : HAPMAP8826
Genomic Variants (DGV)IQGAP1 [DGVbeta]
DECIPHERIQGAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIQGAP1 
Mutations
ICGC Data PortalIQGAP1 
TCGA Data PortalIQGAP1 
Broad Tumor PortalIQGAP1
OASIS PortalIQGAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIQGAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIQGAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IQGAP1
DgiDB (Drug Gene Interaction Database)IQGAP1
DoCM (Curated mutations)IQGAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IQGAP1 (select a term)
intoGenIQGAP1
Cancer3DIQGAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603379   
Orphanet
DisGeNETIQGAP1
MedgenIQGAP1
Genetic Testing Registry IQGAP1
NextProtP46940 [Medical]
TSGene8826
GENETestsIQGAP1
Target ValidationIQGAP1
Huge Navigator IQGAP1 [HugePedia]
snp3D : Map Gene to Disease8826
BioCentury BCIQIQGAP1
ClinGenIQGAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8826
Chemical/Pharm GKB GenePA29910
Clinical trialIQGAP1
Miscellaneous
canSAR (ICR)IQGAP1 (select the gene name)
Probes
Litterature
PubMed222 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIQGAP1
EVEXIQGAP1
GoPubMedIQGAP1
iHOPIQGAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:18:03 CET 2017

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