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IQGAP1 (IQ motif containing GTPase activating protein 1)

Identity

Alias (NCBI)HUMORFA01
SAR1
p195
HGNC (Hugo) IQGAP1
HGNC Alias symbp195
KIAA0051
SAR1
HUMORFA01
HGNC Alias nameRasGAP-like with IQ motifs
LocusID (NCBI) 8826
Atlas_Id 45512
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 90388242 and ends at 90502239 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADRBK1 (11q13.2) / IQGAP1 (15q26.1)CAMK2D (4q26) / IQGAP1 (15q26.1)EFNA5 (5q21.3) / IQGAP1 (15q26.1)
IQGAP1 (15q26.1) / AKAP13 (15q25.3)IQGAP1 (15q26.1) / MESP2 (15q26.1)IQGAP1 (15q26.1) / PRC1 (15q26.1)
IQGAP1 (15q26.1) / PSMD4 (1q21.3)IQGAP1 (15q26.1) / TTLL13P (15q26.1)IQGAP1 (15q26.1) / ZNF774 (15q26.1)
SCGB1D2 (11q12.3) / IQGAP1 (15q26.1)SH3BGRL3 (1p36.11) / IQGAP1 (15q26.1)TRPM3 (9q21.12) / IQGAP1 (15q26.1)
UNC45A (15q26.1) / IQGAP1 (15q26.1)ADRBK1 11q13.2 / IQGAP1 15q26.1IQGAP1 15q26.1 / MESP2 15q26.1
IQGAP1 15q26.1 TTLL13IQGAP1 15q26.1 / ZNF774 15q26.1SCGB1D2 11q12.3 / IQGAP1 15q26.1
UNC45A 15q26.1 / IQGAP1 15q26.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IQGAP1   6110
Cards
Entrez_Gene (NCBI)IQGAP1    IQ motif containing GTPase activating protein 1
AliasesHUMORFA01; SAR1; p195
GeneCards (Weizmann)IQGAP1
Ensembl hg19 (Hinxton)ENSG00000140575 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140575 [Gene_View]  ENSG00000140575 [Sequence]  chr15:90388242-90502239 [Contig_View]  IQGAP1 [Vega]
ICGC DataPortalENSG00000140575
TCGA cBioPortalIQGAP1
AceView (NCBI)IQGAP1
Genatlas (Paris)IQGAP1
SOURCE (Princeton)IQGAP1
Genetics Home Reference (NIH)IQGAP1
Genomic and cartography
GoldenPath hg38 (UCSC)IQGAP1  -     chr15:90388242-90502239 +  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IQGAP1  -     15q26.1   [Description]    (hg19-Feb_2009)
GoldenPathIQGAP1 - 15q26.1 [CytoView hg19]  IQGAP1 - 15q26.1 [CytoView hg38]
ImmunoBaseENSG00000140575
Genome Data Viewer NCBIIQGAP1 [Mapview hg19]  
OMIM603379   
Gene and transcription
Genbank (Entrez)AF401205 AI924000 AK055054 AK125643 AK298000
RefSeq transcript (Entrez)NM_003870
Consensus coding sequences : CCDS (NCBI)IQGAP1
Gene ExpressionIQGAP1 [ NCBI-GEO ]   IQGAP1 [ EBI - ARRAY_EXPRESS ]   IQGAP1 [ SEEK ]   IQGAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)IQGAP1 [ Firebrowse - Broad ]
GenevisibleExpression of IQGAP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8826
GTEX Portal (Tissue expression)IQGAP1
Human Protein AtlasENSG00000140575-IQGAP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46940   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46940  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46940
PhosPhoSitePlusP46940
Domaine pattern : Prosite (Expaxy)CH (PS50021)    IQ (PS50096)    RAS_GTPASE_ACTIV_1 (PS00509)    RAS_GTPASE_ACTIV_2 (PS50018)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)CH-domain    CH_dom_sf    IQ_motif_EF-hand-BS    P-loop_NTPase    RasGAP_C    RasGAP_CS    RasGAP_dom    Rho_GTPase_activation_prot    WW_dom   
Domain families : Pfam (Sanger)CH (PF00307)    IQ (PF00612)    RasGAP (PF00616)    RasGAP_C (PF03836)   
Domain families : Pfam (NCBI)pfam00307    pfam00612    pfam00616    pfam03836   
Domain families : Smart (EMBL)CH (SM00033)  IQ (SM00015)  RasGAP (SM00323)  WW (SM00456)  
Conserved Domain (NCBI)IQGAP1
PDB (RSDB)1X0H    2RR8    3FAY    3I6X    5L0O   
PDB Europe1X0H    2RR8    3FAY    3I6X    5L0O   
PDB (PDBSum)1X0H    2RR8    3FAY    3I6X    5L0O   
PDB (IMB)1X0H    2RR8    3FAY    3I6X    5L0O   
Structural Biology KnowledgeBase1X0H    2RR8    3FAY    3I6X    5L0O   
SCOP (Structural Classification of Proteins)1X0H    2RR8    3FAY    3I6X    5L0O   
CATH (Classification of proteins structures)1X0H    2RR8    3FAY    3I6X    5L0O   
SuperfamilyP46940
AlphaFold pdb e-kbP46940   
Human Protein Atlas [tissue]ENSG00000140575-IQGAP1 [tissue]
HPRD04541
Protein Interaction databases
DIP (DOE-UCLA)P46940
IntAct (EBI)P46940
BioGRIDIQGAP1
STRING (EMBL)IQGAP1
ZODIACIQGAP1
Ontologies - Pathways
QuickGOP46940
Ontology : AmiGOruffle  MAP-kinase scaffold activity  GTPase inhibitor activity  GTPase activator activity  calcium ion binding  protein binding  calmodulin binding  calmodulin binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleus  cytoplasm  cytoplasm  cytosol  microtubule  actin filament  plasma membrane  plasma membrane  focal adhesion  signal transduction  epidermal growth factor receptor signaling pathway  regulation of mitotic cell cycle  actin cytoskeleton  microtubule cytoskeleton  cell migration  protein kinase binding  protein phosphatase binding  protein domain specific binding  axon  growth cone  midbody  secretory granule membrane  extrinsic component of cytoplasmic side of plasma membrane  small GTPase binding  regulation of actin cytoskeleton organization  protein-containing complex  slit diaphragm  cytoplasmic ribonucleoprotein granule  neuron projection  regulation of GTPase activity  neutrophil degranulation  positive regulation of MAP kinase activity  positive regulation of MAPK cascade  protein serine/threonine kinase activator activity  S100 protein binding  membrane raft  cadherin binding  positive regulation of protein kinase activity  actin filament binding  mitogen-activated protein kinase binding  positive regulation of focal adhesion assembly  molecular adaptor activity  extracellular exosome  cellular response to calcium ion  cellular response to epidermal growth factor stimulus  glomerular visceral epithelial cell development  positive regulation of dendrite development  positive regulation of peptidyl-tyrosine autophosphorylation  positive regulation of cellular protein localization  positive regulation of vascular associated smooth muscle cell migration  neuron projection extension  response to angiotensin  
Ontology : EGO-EBIruffle  MAP-kinase scaffold activity  GTPase inhibitor activity  GTPase activator activity  calcium ion binding  protein binding  calmodulin binding  calmodulin binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleus  cytoplasm  cytoplasm  cytosol  microtubule  actin filament  plasma membrane  plasma membrane  focal adhesion  signal transduction  epidermal growth factor receptor signaling pathway  regulation of mitotic cell cycle  actin cytoskeleton  microtubule cytoskeleton  cell migration  protein kinase binding  protein phosphatase binding  protein domain specific binding  axon  growth cone  midbody  secretory granule membrane  extrinsic component of cytoplasmic side of plasma membrane  small GTPase binding  regulation of actin cytoskeleton organization  protein-containing complex  slit diaphragm  cytoplasmic ribonucleoprotein granule  neuron projection  regulation of GTPase activity  neutrophil degranulation  positive regulation of MAP kinase activity  positive regulation of MAPK cascade  protein serine/threonine kinase activator activity  S100 protein binding  membrane raft  cadherin binding  positive regulation of protein kinase activity  actin filament binding  mitogen-activated protein kinase binding  positive regulation of focal adhesion assembly  molecular adaptor activity  extracellular exosome  cellular response to calcium ion  cellular response to epidermal growth factor stimulus  glomerular visceral epithelial cell development  positive regulation of dendrite development  positive regulation of peptidyl-tyrosine autophosphorylation  positive regulation of cellular protein localization  positive regulation of vascular associated smooth muscle cell migration  neuron projection extension  response to angiotensin  
Pathways : KEGGAdherens junction    Regulation of actin cytoskeleton    Proteoglycans in cancer   
NDEx NetworkIQGAP1
Atlas of Cancer Signalling NetworkIQGAP1
Wikipedia pathwaysIQGAP1
Orthology - Evolution
OrthoDB8826
GeneTree (enSembl)ENSG00000140575
Phylogenetic Trees/Animal Genes : TreeFamIQGAP1
Homologs : HomoloGeneIQGAP1
Homology/Alignments : Family Browser (UCSC)IQGAP1
Gene fusions - Rearrangements
Fusion : MitelmanADRBK1/IQGAP1 [11q13.2/15q26.1]  
Fusion : MitelmanIQGAP1/AKAP13 [15q26.1/15q25.3]  
Fusion : MitelmanIQGAP1/MESP2 [15q26.1/15q26.1]  
Fusion : MitelmanIQGAP1/TTLL13P [15q26.1/15q26.1]  
Fusion : MitelmanIQGAP1/ZNF774 [15q26.1/15q26.1]  
Fusion : MitelmanSCGB1D2/IQGAP1 [11q12.3/15q26.1]  
Fusion : MitelmanUNC45A/IQGAP1 [15q26.1/15q26.1]  
Fusion : QuiverIQGAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIQGAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IQGAP1
dbVarIQGAP1
ClinVarIQGAP1
MonarchIQGAP1
1000_GenomesIQGAP1 
Exome Variant ServerIQGAP1
GNOMAD BrowserENSG00000140575
Varsome BrowserIQGAP1
ACMGIQGAP1 variants
VarityP46940
Genomic Variants (DGV)IQGAP1 [DGVbeta]
DECIPHERIQGAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIQGAP1 
Mutations
ICGC Data PortalIQGAP1 
TCGA Data PortalIQGAP1 
Broad Tumor PortalIQGAP1
OASIS PortalIQGAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIQGAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIQGAP1
Mutations and Diseases : HGMDIQGAP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIQGAP1
DgiDB (Drug Gene Interaction Database)IQGAP1
DoCM (Curated mutations)IQGAP1
CIViC (Clinical Interpretations of Variants in Cancer)IQGAP1
Cancer3DIQGAP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603379   
Orphanet
DisGeNETIQGAP1
MedgenIQGAP1
Genetic Testing Registry IQGAP1
NextProtP46940 [Medical]
GENETestsIQGAP1
Target ValidationIQGAP1
Huge Navigator IQGAP1 [HugePedia]
ClinGenIQGAP1
Clinical trials, drugs, therapy
MyCancerGenomeIQGAP1
Protein Interactions : CTDIQGAP1
Pharm GKB GenePA29910
PharosP46940
Clinical trialIQGAP1
Miscellaneous
canSAR (ICR)IQGAP1
HarmonizomeIQGAP1
DataMed IndexIQGAP1
Probes
Litterature
PubMed342 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIQGAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:09 CEST 2021

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