Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IQGAP3 (IQ motif containing GTPase activating protein 3)

Identity

Alias (NCBI)-
HGNC (Hugo) IQGAP3
LocusID (NCBI) 128239
Atlas_Id 54383
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 156525405 and ends at 156572565 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FCRL4 (1q23.1) / IQGAP3 (1q22)GON4L (1q22) / IQGAP3 (1q22)IQGAP3 (1q22) / ETV3 (1q23.1)
IQGAP3 (1q22) / SH2D2A (1q23.1)LOC401320 (7p14.3) / IQGAP3 (1q22)RP4-788L13.1 () / IQGAP3 (1q22)
GON4L 1q22 / IQGAP3 1q22IQGAP3 1q22 / ETV3 1q23.1IQGAP3 1q22 / SH2D2A 1q23.1
RP4-788L13.1 IQGAP3 1q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IQGAP3   20669
Cards
Entrez_Gene (NCBI)IQGAP3    IQ motif containing GTPase activating protein 3
Aliases
GeneCards (Weizmann)IQGAP3
Ensembl hg19 (Hinxton)ENSG00000183856 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183856 [Gene_View]  ENSG00000183856 [Sequence]  chr1:156525405-156572565 [Contig_View]  IQGAP3 [Vega]
ICGC DataPortalENSG00000183856
TCGA cBioPortalIQGAP3
AceView (NCBI)IQGAP3
Genatlas (Paris)IQGAP3
SOURCE (Princeton)IQGAP3
Genetics Home Reference (NIH)IQGAP3
Genomic and cartography
GoldenPath hg38 (UCSC)IQGAP3  -     chr1:156525405-156572565 -  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IQGAP3  -     1q22   [Description]    (hg19-Feb_2009)
GoldenPathIQGAP3 - 1q22 [CytoView hg19]  IQGAP3 - 1q22 [CytoView hg38]
ImmunoBaseENSG00000183856
Genome Data Viewer NCBIIQGAP3 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB105103 AK122653 AY253300 BC033549 BC131536
RefSeq transcript (Entrez)NM_178229
Consensus coding sequences : CCDS (NCBI)IQGAP3
Gene ExpressionIQGAP3 [ NCBI-GEO ]   IQGAP3 [ EBI - ARRAY_EXPRESS ]   IQGAP3 [ SEEK ]   IQGAP3 [ MEM ]
Gene Expression Viewer (FireBrowse)IQGAP3 [ Firebrowse - Broad ]
GenevisibleExpression of IQGAP3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)128239
GTEX Portal (Tissue expression)IQGAP3
Human Protein AtlasENSG00000183856-IQGAP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86VI3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86VI3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86VI3
PhosPhoSitePlusQ86VI3
Domaine pattern : Prosite (Expaxy)CH (PS50021)    IQ (PS50096)    RAS_GTPASE_ACTIV_1 (PS00509)    RAS_GTPASE_ACTIV_2 (PS50018)   
Domains : Interpro (EBI)CH-domain    CH_dom_sf    IQ_motif_EF-hand-BS    RasGAP_C    RasGAP_CS    RasGAP_dom    Rho_GTPase_activation_prot   
Domain families : Pfam (Sanger)CH (PF00307)    IQ (PF00612)    RasGAP (PF00616)    RasGAP_C (PF03836)   
Domain families : Pfam (NCBI)pfam00307    pfam00612    pfam00616    pfam03836   
Domain families : Smart (EMBL)CH (SM00033)  IQ (SM00015)  RasGAP (SM00323)  
Conserved Domain (NCBI)IQGAP3
PDB (RSDB)3ISU   
PDB Europe3ISU   
PDB (PDBSum)3ISU   
PDB (IMB)3ISU   
Structural Biology KnowledgeBase3ISU   
SCOP (Structural Classification of Proteins)3ISU   
CATH (Classification of proteins structures)3ISU   
SuperfamilyQ86VI3
AlphaFold pdb e-kbQ86VI3   
Human Protein Atlas [tissue]ENSG00000183856-IQGAP3 [tissue]
HPRD11051
Protein Interaction databases
DIP (DOE-UCLA)Q86VI3
IntAct (EBI)Q86VI3
BioGRIDIQGAP3
STRING (EMBL)IQGAP3
ZODIACIQGAP3
Ontologies - Pathways
QuickGOQ86VI3
Ontology : AmiGOG1/S transition of mitotic cell cycle  activation of MAPK activity  GTPase activator activity  protein binding  calmodulin binding  calmodulin binding  cytoplasm  cytosol  cell-cell junction  Ras protein signal transduction  regulation of cell size  positive regulation of gene expression  negative regulation of gene expression  lateral plasma membrane  small GTPase binding  regulation of actin cytoskeleton organization  positive regulation of mammary gland epithelial cell proliferation  regulation of GTPase activity  actin filament binding  ERK1 and ERK2 cascade  myosin VI light chain binding  cellular response to organic substance  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  activation of MAPK activity  GTPase activator activity  protein binding  calmodulin binding  calmodulin binding  cytoplasm  cytosol  cell-cell junction  Ras protein signal transduction  regulation of cell size  positive regulation of gene expression  negative regulation of gene expression  lateral plasma membrane  small GTPase binding  regulation of actin cytoskeleton organization  positive regulation of mammary gland epithelial cell proliferation  regulation of GTPase activity  actin filament binding  ERK1 and ERK2 cascade  myosin VI light chain binding  cellular response to organic substance  
Pathways : KEGGRegulation of actin cytoskeleton   
NDEx NetworkIQGAP3
Atlas of Cancer Signalling NetworkIQGAP3
Wikipedia pathwaysIQGAP3
Orthology - Evolution
OrthoDB128239
GeneTree (enSembl)ENSG00000183856
Phylogenetic Trees/Animal Genes : TreeFamIQGAP3
Homologs : HomoloGeneIQGAP3
Homology/Alignments : Family Browser (UCSC)IQGAP3
Gene fusions - Rearrangements
Fusion : MitelmanFCRL4/IQGAP3 [1q23.1/1q22]  
Fusion : MitelmanIQGAP3/ETV3 [1q22/1q23.1]  
Fusion : MitelmanIQGAP3/SH2D2A [1q22/1q23.1]  
Fusion : QuiverIQGAP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIQGAP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IQGAP3
dbVarIQGAP3
ClinVarIQGAP3
MonarchIQGAP3
1000_GenomesIQGAP3 
Exome Variant ServerIQGAP3
GNOMAD BrowserENSG00000183856
Varsome BrowserIQGAP3
ACMGIQGAP3 variants
VarityQ86VI3
Genomic Variants (DGV)IQGAP3 [DGVbeta]
DECIPHERIQGAP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIQGAP3 
Mutations
ICGC Data PortalIQGAP3 
TCGA Data PortalIQGAP3 
Broad Tumor PortalIQGAP3
OASIS PortalIQGAP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIQGAP3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIQGAP3
Mutations and Diseases : HGMDIQGAP3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIQGAP3
DgiDB (Drug Gene Interaction Database)IQGAP3
DoCM (Curated mutations)IQGAP3
CIViC (Clinical Interpretations of Variants in Cancer)IQGAP3
Cancer3DIQGAP3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETIQGAP3
MedgenIQGAP3
Genetic Testing Registry IQGAP3
NextProtQ86VI3 [Medical]
GENETestsIQGAP3
Target ValidationIQGAP3
Huge Navigator IQGAP3 [HugePedia]
ClinGenIQGAP3
Clinical trials, drugs, therapy
MyCancerGenomeIQGAP3
Protein Interactions : CTDIQGAP3
Pharm GKB GenePA134954177
PharosQ86VI3
Clinical trialIQGAP3
Miscellaneous
canSAR (ICR)IQGAP3
HarmonizomeIQGAP3
DataMed IndexIQGAP3
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIQGAP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:14:09 CEST 2021

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