Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IQGAP3 (IQ motif containing GTPase activating protein 3)

Identity

Other alias-
HGNC (Hugo) IQGAP3
LocusID (NCBI) 128239
Atlas_Id 54383
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 156525405 and ends at 156572604 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FCRL4 (1q23.1) / IQGAP3 (1q22)GON4L (1q22) / IQGAP3 (1q22)IQGAP3 (1q22) / ETV3 (1q23.1)
IQGAP3 (1q22) / SH2D2A (1q23.1)LOC401320 (7p14.3) / IQGAP3 (1q22)RP4-788L13.1 () / IQGAP3 (1q22)
GON4L 1q22 / IQGAP3 1q22IQGAP3 1q22 / ETV3 1q23.1IQGAP3 1q22 / SH2D2A 1q23.1
RP4-788L13.1 IQGAP3 1q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IQGAP3   20669
Cards
Entrez_Gene (NCBI)IQGAP3  128239  IQ motif containing GTPase activating protein 3
Aliases
GeneCards (Weizmann)IQGAP3
Ensembl hg19 (Hinxton)ENSG00000183856 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183856 [Gene_View]  chr1:156525405-156572604 [Contig_View]  IQGAP3 [Vega]
ICGC DataPortalENSG00000183856
TCGA cBioPortalIQGAP3
AceView (NCBI)IQGAP3
Genatlas (Paris)IQGAP3
WikiGenes128239
SOURCE (Princeton)IQGAP3
Genetics Home Reference (NIH)IQGAP3
Genomic and cartography
GoldenPath hg38 (UCSC)IQGAP3  -     chr1:156525405-156572604 -  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IQGAP3  -     1q22   [Description]    (hg19-Feb_2009)
EnsemblIQGAP3 - 1q22 [CytoView hg19]  IQGAP3 - 1q22 [CytoView hg38]
Mapping of homologs : NCBIIQGAP3 [Mapview hg19]  IQGAP3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB105103 AK122653 AY253300 BC033549 BC131536
RefSeq transcript (Entrez)NM_178229
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IQGAP3
Cluster EST : UnigeneHs.591495 [ NCBI ]
CGAP (NCI)Hs.591495
Alternative Splicing GalleryENSG00000183856
Gene ExpressionIQGAP3 [ NCBI-GEO ]   IQGAP3 [ EBI - ARRAY_EXPRESS ]   IQGAP3 [ SEEK ]   IQGAP3 [ MEM ]
Gene Expression Viewer (FireBrowse)IQGAP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)128239
GTEX Portal (Tissue expression)IQGAP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86VI3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86VI3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86VI3
Splice isoforms : SwissVarQ86VI3
PhosPhoSitePlusQ86VI3
Domaine pattern : Prosite (Expaxy)CH (PS50021)    IQ (PS50096)    RAS_GTPASE_ACTIV_1 (PS00509)    RAS_GTPASE_ACTIV_2 (PS50018)   
Domains : Interpro (EBI)CH-domain    IQ_motif_EF-hand-BS    RasGAP_C    RasGAP_CS    RasGAP_dom    Rho_GTPase_activation_prot   
Domain families : Pfam (Sanger)CH (PF00307)    IQ (PF00612)    RasGAP (PF00616)    RasGAP_C (PF03836)   
Domain families : Pfam (NCBI)pfam00307    pfam00612    pfam00616    pfam03836   
Domain families : Smart (EMBL)CH (SM00033)  IQ (SM00015)  RasGAP (SM00323)  
Conserved Domain (NCBI)IQGAP3
DMDM Disease mutations128239
Blocks (Seattle)IQGAP3
PDB (SRS)3ISU   
PDB (PDBSum)3ISU   
PDB (IMB)3ISU   
PDB (RSDB)3ISU   
Structural Biology KnowledgeBase3ISU   
SCOP (Structural Classification of Proteins)3ISU   
CATH (Classification of proteins structures)3ISU   
SuperfamilyQ86VI3
Human Protein AtlasENSG00000183856
Peptide AtlasQ86VI3
HPRD11051
IPIIPI00328905   IPI00981831   
Protein Interaction databases
DIP (DOE-UCLA)Q86VI3
IntAct (EBI)Q86VI3
FunCoupENSG00000183856
BioGRIDIQGAP3
STRING (EMBL)IQGAP3
ZODIACIQGAP3
Ontologies - Pathways
QuickGOQ86VI3
Ontology : AmiGOG1/S transition of mitotic cell cycle  activation of MAPK activity  calmodulin binding  cytosol  cell-cell junction  Ras protein signal transduction  regulation of cell size  positive regulation of gene expression  negative regulation of gene expression  lateral plasma membrane  Rho GTPase binding  positive regulation of mammary gland epithelial cell proliferation  regulation of GTPase activity  ERK1 and ERK2 cascade  myosin VI light chain binding  cellular response to organic substance  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  activation of MAPK activity  calmodulin binding  cytosol  cell-cell junction  Ras protein signal transduction  regulation of cell size  positive regulation of gene expression  negative regulation of gene expression  lateral plasma membrane  Rho GTPase binding  positive regulation of mammary gland epithelial cell proliferation  regulation of GTPase activity  ERK1 and ERK2 cascade  myosin VI light chain binding  cellular response to organic substance  
Pathways : KEGGRegulation of actin cytoskeleton   
NDEx NetworkIQGAP3
Atlas of Cancer Signalling NetworkIQGAP3
Wikipedia pathwaysIQGAP3
Orthology - Evolution
OrthoDB128239
GeneTree (enSembl)ENSG00000183856
Phylogenetic Trees/Animal Genes : TreeFamIQGAP3
HOVERGENQ86VI3
HOGENOMQ86VI3
Homologs : HomoloGeneIQGAP3
Homology/Alignments : Family Browser (UCSC)IQGAP3
Gene fusions - Rearrangements
Fusion : MitelmanFCRL4/IQGAP3 [1q23.1/1q22]  [t(1;1)(q23;q23)]  
Fusion : MitelmanIQGAP3/ETV3 [1q22/1q23.1]  [t(1;1)(q23;q23)]  
Fusion : MitelmanIQGAP3/SH2D2A [1q22/1q23.1]  [t(1;1)(q23;q23)]  
Fusion: TCGAGON4L 1q22 IQGAP3 1q22 BRCA
Fusion: TCGAIQGAP3 1q22 ETV3 1q23.1 BRCA
Fusion: TCGAIQGAP3 1q22 SH2D2A 1q23.1 BRCA
Fusion: TCGARP4-788L13.1 IQGAP3 1q22 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIQGAP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IQGAP3
dbVarIQGAP3
ClinVarIQGAP3
1000_GenomesIQGAP3 
Exome Variant ServerIQGAP3
ExAC (Exome Aggregation Consortium)IQGAP3 (select the gene name)
Genetic variants : HAPMAP128239
Genomic Variants (DGV)IQGAP3 [DGVbeta]
DECIPHERIQGAP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIQGAP3 
Mutations
ICGC Data PortalIQGAP3 
TCGA Data PortalIQGAP3 
Broad Tumor PortalIQGAP3
OASIS PortalIQGAP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIQGAP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIQGAP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IQGAP3
DgiDB (Drug Gene Interaction Database)IQGAP3
DoCM (Curated mutations)IQGAP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IQGAP3 (select a term)
intoGenIQGAP3
Cancer3DIQGAP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenIQGAP3
Genetic Testing Registry IQGAP3
NextProtQ86VI3 [Medical]
TSGene128239
GENETestsIQGAP3
Huge Navigator IQGAP3 [HugePedia]
snp3D : Map Gene to Disease128239
BioCentury BCIQIQGAP3
ClinGenIQGAP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD128239
Chemical/Pharm GKB GenePA134954177
Clinical trialIQGAP3
Miscellaneous
canSAR (ICR)IQGAP3 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIQGAP3
EVEXIQGAP3
GoPubMedIQGAP3
iHOPIQGAP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:20:42 CEST 2017

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