Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IRAK1 (interleukin 1 receptor associated kinase 1)

Identity

Alias_symbol (synonym)IRAK
pelle
Other alias
HGNC (Hugo) IRAK1
LocusID (NCBI) 3654
Atlas_Id 43326
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 154010506 and ends at 154019891 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNAH14 (1q42.12) / IRAK1 (Xq28)IRAK1 (Xq28) / MECP2 (Xq28)IRAK1 Xq28 / MECP2 Xq28

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IRAK1   6112
Cards
Entrez_Gene (NCBI)IRAK1  3654  interleukin 1 receptor associated kinase 1
AliasesIRAK; pelle
GeneCards (Weizmann)IRAK1
Ensembl hg19 (Hinxton)ENSG00000184216 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184216 [Gene_View]  chrX:154010506-154019891 [Contig_View]  IRAK1 [Vega]
ICGC DataPortalENSG00000184216
TCGA cBioPortalIRAK1
AceView (NCBI)IRAK1
Genatlas (Paris)IRAK1
WikiGenes3654
SOURCE (Princeton)IRAK1
Genetics Home Reference (NIH)IRAK1
Genomic and cartography
GoldenPath hg38 (UCSC)IRAK1  -     chrX:154010506-154019891 -  Xq28   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRAK1  -     Xq28   [Description]    (hg19-Feb_2009)
EnsemblIRAK1 - Xq28 [CytoView hg19]  IRAK1 - Xq28 [CytoView hg38]
Mapping of homologs : NCBIIRAK1 [Mapview hg19]  IRAK1 [Mapview hg38]
OMIM300283   
Gene and transcription
Genbank (Entrez)AF346607 AM392624 AM393211 BC014963 BC054000
RefSeq transcript (Entrez)NM_001025242 NM_001025243 NM_001569
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IRAK1
Cluster EST : UnigeneHs.522819 [ NCBI ]
CGAP (NCI)Hs.522819
Alternative Splicing GalleryENSG00000184216
Gene ExpressionIRAK1 [ NCBI-GEO ]   IRAK1 [ EBI - ARRAY_EXPRESS ]   IRAK1 [ SEEK ]   IRAK1 [ MEM ]
Gene Expression Viewer (FireBrowse)IRAK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3654
GTEX Portal (Tissue expression)IRAK1
Human Protein AtlasENSG00000184216-IRAK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51617   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51617  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51617
Splice isoforms : SwissVarP51617
PhosPhoSitePlusP51617
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)DEATH-like_dom    Death_domain    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Death (PF00531)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00531    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)IRAK1
DMDM Disease mutations3654
Blocks (Seattle)IRAK1
SuperfamilyP51617
Human Protein Atlas [tissue]ENSG00000184216-IRAK1 [tissue]
Peptide AtlasP51617
HPRD02235
IPIIPI00293652   IPI00472717   IPI00060149   IPI00640278   IPI00647563   IPI00646527   IPI00646038   IPI00385328   IPI00879385   IPI00894401   
Protein Interaction databases
DIP (DOE-UCLA)P51617
IntAct (EBI)P51617
FunCoupENSG00000184216
BioGRIDIRAK1
STRING (EMBL)IRAK1
ZODIACIRAK1
Ontologies - Pathways
QuickGOP51617
Ontology : AmiGOactivation of MAPK activity  regulation of cytokine-mediated signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  NF-kappaB-inducing kinase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  lipid particle  cytosol  cytosol  plasma membrane  protein phosphorylation  signal transduction  transmembrane receptor protein serine/threonine kinase signaling pathway  activation of NF-kappaB-inducing kinase activity  JNK cascade  aging  endosome membrane  kinase activity  heat shock protein binding  lipopolysaccharide-mediated signaling pathway  negative regulation of NF-kappaB transcription factor activity  positive regulation of type I interferon production  response to lipopolysaccharide  toll-like receptor 2 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 9 signaling pathway  cellular response to heat  protein homodimerization activity  protein homodimerization activity  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of MAP kinase activity  interleukin-1 receptor complex  positive regulation of transcription, DNA-templated  protein autophosphorylation  protein autophosphorylation  protein heterodimerization activity  positive regulation of smooth muscle cell proliferation  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein oligomerization  type I interferon signaling pathway  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  response to interleukin-1  cellular response to hypoxia  
Ontology : EGO-EBIactivation of MAPK activity  regulation of cytokine-mediated signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  NF-kappaB-inducing kinase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  lipid particle  cytosol  cytosol  plasma membrane  protein phosphorylation  signal transduction  transmembrane receptor protein serine/threonine kinase signaling pathway  activation of NF-kappaB-inducing kinase activity  JNK cascade  aging  endosome membrane  kinase activity  heat shock protein binding  lipopolysaccharide-mediated signaling pathway  negative regulation of NF-kappaB transcription factor activity  positive regulation of type I interferon production  response to lipopolysaccharide  toll-like receptor 2 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 9 signaling pathway  cellular response to heat  protein homodimerization activity  protein homodimerization activity  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of MAP kinase activity  interleukin-1 receptor complex  positive regulation of transcription, DNA-templated  protein autophosphorylation  protein autophosphorylation  protein heterodimerization activity  positive regulation of smooth muscle cell proliferation  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein oligomerization  type I interferon signaling pathway  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  response to interleukin-1  cellular response to hypoxia  
Pathways : BIOCARTASignal transduction through IL1R [Genes]   
Pathways : KEGG   
NDEx NetworkIRAK1
Atlas of Cancer Signalling NetworkIRAK1
Wikipedia pathwaysIRAK1
Orthology - Evolution
OrthoDB3654
GeneTree (enSembl)ENSG00000184216
Phylogenetic Trees/Animal Genes : TreeFamIRAK1
HOVERGENP51617
HOGENOMP51617
Homologs : HomoloGeneIRAK1
Homology/Alignments : Family Browser (UCSC)IRAK1
Gene fusions - Rearrangements
Fusion: TCGA_MDACCIRAK1 Xq28 MECP2 Xq28 BLCA
Tumor Fusion PortalIRAK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRAK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRAK1
dbVarIRAK1
ClinVarIRAK1
1000_GenomesIRAK1 
Exome Variant ServerIRAK1
ExAC (Exome Aggregation Consortium)ENSG00000184216
GNOMAD BrowserENSG00000184216
Genetic variants : HAPMAP3654
Genomic Variants (DGV)IRAK1 [DGVbeta]
DECIPHERIRAK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRAK1 
Mutations
ICGC Data PortalIRAK1 
TCGA Data PortalIRAK1 
Broad Tumor PortalIRAK1
OASIS PortalIRAK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRAK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIRAK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch IRAK1
DgiDB (Drug Gene Interaction Database)IRAK1
DoCM (Curated mutations)IRAK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRAK1 (select a term)
intoGenIRAK1
Cancer3DIRAK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300283   
Orphanet12394   
DisGeNETIRAK1
MedgenIRAK1
Genetic Testing Registry IRAK1
NextProtP51617 [Medical]
TSGene3654
GENETestsIRAK1
Target ValidationIRAK1
Huge Navigator IRAK1 [HugePedia]
snp3D : Map Gene to Disease3654
BioCentury BCIQIRAK1
ClinGenIRAK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3654
Chemical/Pharm GKB GenePA29912
Clinical trialIRAK1
Miscellaneous
canSAR (ICR)IRAK1 (select the gene name)
Probes
Litterature
PubMed234 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIRAK1
EVEXIRAK1
GoPubMedIRAK1
iHOPIRAK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Nov 20 20:41:34 CET 2017

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