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IRAK3 (interleukin 1 receptor associated kinase 3)

Identity

Alias_namesinterleukin-1 receptor-associated kinase 3
Alias_symbol (synonym)IRAK-M
Other aliasASRT5
IRAKM
HGNC (Hugo) IRAK3
LocusID (NCBI) 11213
Atlas_Id 43328
Location 12q14.3  [Link to chromosome band 12q14]
Location_base_pair Starts at 66189198 and ends at 66254614 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ABI1 (10p12.1) / IRAK3 (12q14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IRAK3   17020
Cards
Entrez_Gene (NCBI)IRAK3  11213  interleukin 1 receptor associated kinase 3
AliasesASRT5; IRAKM
GeneCards (Weizmann)IRAK3
Ensembl hg19 (Hinxton)ENSG00000090376 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000090376 [Gene_View]  chr12:66189198-66254614 [Contig_View]  IRAK3 [Vega]
ICGC DataPortalENSG00000090376
TCGA cBioPortalIRAK3
AceView (NCBI)IRAK3
Genatlas (Paris)IRAK3
WikiGenes11213
SOURCE (Princeton)IRAK3
Genetics Home Reference (NIH)IRAK3
Genomic and cartography
GoldenPath hg38 (UCSC)IRAK3  -     chr12:66189198-66254614 +  12q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRAK3  -     12q14.3   [Description]    (hg19-Feb_2009)
EnsemblIRAK3 - 12q14.3 [CytoView hg19]  IRAK3 - 12q14.3 [CytoView hg38]
Mapping of homologs : NCBIIRAK3 [Mapview hg19]  IRAK3 [Mapview hg38]
OMIM604459   611064   
Gene and transcription
Genbank (Entrez)AF113136 AK023663 AK298645 AK314040 AL049435
RefSeq transcript (Entrez)NM_001142523 NM_007199
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IRAK3
Cluster EST : UnigeneHs.369265 [ NCBI ]
CGAP (NCI)Hs.369265
Alternative Splicing GalleryENSG00000090376
Gene ExpressionIRAK3 [ NCBI-GEO ]   IRAK3 [ EBI - ARRAY_EXPRESS ]   IRAK3 [ SEEK ]   IRAK3 [ MEM ]
Gene Expression Viewer (FireBrowse)IRAK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11213
GTEX Portal (Tissue expression)IRAK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y616   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y616  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y616
Splice isoforms : SwissVarQ9Y616
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9Y616
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)DEATH-like_dom    Death_domain    IRAK3    Kinase-like_dom    Prot_kinase_dom   
Domain families : Pfam (Sanger)Death (PF00531)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00531    pfam00069   
Domain families : Smart (EMBL)DEATH (SM00005)  
Conserved Domain (NCBI)IRAK3
DMDM Disease mutations11213
Blocks (Seattle)IRAK3
SuperfamilyQ9Y616
Human Protein AtlasENSG00000090376
Peptide AtlasQ9Y616
HPRD05123
IPIIPI00026984   IPI00909153   IPI00796604   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y616
IntAct (EBI)Q9Y616
FunCoupENSG00000090376
BioGRIDIRAK3
STRING (EMBL)IRAK3
ZODIACIRAK3
Ontologies - Pathways
QuickGOQ9Y616
Ontology : AmiGOmagnesium ion binding  negative regulation of cytokine-mediated signaling pathway  MyD88-dependent toll-like receptor signaling pathway  protein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  protein phosphorylation  response to virus  positive regulation of macrophage tolerance induction  negative regulation of macrophage cytokine production  cytokine-mediated signaling pathway  negative regulation of NF-kappaB transcription factor activity  response to peptidoglycan  response to lipopolysaccharide  negative regulation of interleukin-12 production  negative regulation of interleukin-12 production  negative regulation of interleukin-6 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  negative regulation of toll-like receptor signaling pathway  negative regulation of protein catabolic process  protein homodimerization activity  negative regulation of protein complex disassembly  regulation of protein complex disassembly  response to exogenous dsRNA  negative regulation of MAP kinase activity  negative regulation of innate immune response  protein autophosphorylation  protein heterodimerization activity  positive regulation of NF-kappaB transcription factor activity  interleukin-1-mediated signaling pathway  response to interleukin-1  
Ontology : EGO-EBImagnesium ion binding  negative regulation of cytokine-mediated signaling pathway  MyD88-dependent toll-like receptor signaling pathway  protein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  protein phosphorylation  response to virus  positive regulation of macrophage tolerance induction  negative regulation of macrophage cytokine production  cytokine-mediated signaling pathway  negative regulation of NF-kappaB transcription factor activity  response to peptidoglycan  response to lipopolysaccharide  negative regulation of interleukin-12 production  negative regulation of interleukin-12 production  negative regulation of interleukin-6 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  negative regulation of toll-like receptor signaling pathway  negative regulation of protein catabolic process  protein homodimerization activity  negative regulation of protein complex disassembly  regulation of protein complex disassembly  response to exogenous dsRNA  negative regulation of MAP kinase activity  negative regulation of innate immune response  protein autophosphorylation  protein heterodimerization activity  positive regulation of NF-kappaB transcription factor activity  interleukin-1-mediated signaling pathway  response to interleukin-1  
Pathways : BIOCARTASignal transduction through IL1R [Genes]   
Pathways : KEGGApoptosis    Neurotrophin signaling pathway   
NDEx NetworkIRAK3
Atlas of Cancer Signalling NetworkIRAK3
Wikipedia pathwaysIRAK3
Orthology - Evolution
OrthoDB11213
GeneTree (enSembl)ENSG00000090376
Phylogenetic Trees/Animal Genes : TreeFamIRAK3
HOVERGENQ9Y616
HOGENOMQ9Y616
Homologs : HomoloGeneIRAK3
Homology/Alignments : Family Browser (UCSC)IRAK3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRAK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRAK3
dbVarIRAK3
ClinVarIRAK3
1000_GenomesIRAK3 
Exome Variant ServerIRAK3
ExAC (Exome Aggregation Consortium)IRAK3 (select the gene name)
Genetic variants : HAPMAP11213
Genomic Variants (DGV)IRAK3 [DGVbeta]
DECIPHERIRAK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRAK3 
Mutations
ICGC Data PortalIRAK3 
TCGA Data PortalIRAK3 
Broad Tumor PortalIRAK3
OASIS PortalIRAK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRAK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIRAK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IRAK3
DgiDB (Drug Gene Interaction Database)IRAK3
DoCM (Curated mutations)IRAK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRAK3 (select a term)
intoGenIRAK3
Cancer3DIRAK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604459    611064   
Orphanet
MedgenIRAK3
Genetic Testing Registry IRAK3
NextProtQ9Y616 [Medical]
TSGene11213
GENETestsIRAK3
Target ValidationIRAK3
Huge Navigator IRAK3 [HugePedia]
snp3D : Map Gene to Disease11213
BioCentury BCIQIRAK3
ClinGenIRAK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11213
Chemical/Pharm GKB GenePA38431
Clinical trialIRAK3
Miscellaneous
canSAR (ICR)IRAK3 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIRAK3
EVEXIRAK3
GoPubMedIRAK3
iHOPIRAK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Jun 7 12:38:46 CEST 2017

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