Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IRAK4 (interleukin 1 receptor associated kinase 4)

Identity

Alias (NCBI)IMD67
IPD1
IRAK-4
NY-REN-64
REN64
HGNC (Hugo) IRAK4
HGNC Alias symbNY-REN-64
LocusID (NCBI) 51135
Atlas_Id 40989
Location 12q12  [Link to chromosome band 12q12]
Location_base_pair Starts at 43758951 and ends at 43789541 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C12orf29 (12q21.32) / IRAK4 (12q12)GPATCH8 (17q21.31) / IRAK4 (12q12)HDAC7 (12q13.11) / IRAK4 (12q12)
C12orf29 12q21.32 / IRAK4 12q12HDAC7 12q13.11 / IRAK4 12q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(12;12)(q12;q13) HDAC7/IRAK4
t(12;12)(q12;q21) C12orf29/IRAK4

External links

Nomenclature
HGNC (Hugo)IRAK4   17967
LRG (Locus Reference Genomic)LRG_75
Cards
Entrez_Gene (NCBI)IRAK4    interleukin 1 receptor associated kinase 4
AliasesIMD67; IPD1; IRAK-4; NY-REN-64; 
REN64
GeneCards (Weizmann)IRAK4
Ensembl hg19 (Hinxton)ENSG00000198001 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198001 [Gene_View]  ENSG00000198001 [Sequence]  chr12:43758951-43789541 [Contig_View]  IRAK4 [Vega]
ICGC DataPortalENSG00000198001
TCGA cBioPortalIRAK4
AceView (NCBI)IRAK4
Genatlas (Paris)IRAK4
SOURCE (Princeton)IRAK4
Genetics Home Reference (NIH)IRAK4
Genomic and cartography
GoldenPath hg38 (UCSC)IRAK4  -     chr12:43758951-43789541 +  12q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRAK4  -     12q12   [Description]    (hg19-Feb_2009)
GoldenPathIRAK4 - 12q12 [CytoView hg19]  IRAK4 - 12q12 [CytoView hg38]
ImmunoBaseENSG00000198001
genome Data Viewer NCBIIRAK4 [Mapview hg19]  
OMIM606883   607676   
Gene and transcription
Genbank (Entrez)AF155118 AF445802 AI126481 AK000528 AK027301
RefSeq transcript (Entrez)NM_001114182 NM_001145256 NM_001145257 NM_001145258 NM_001351338 NM_001351339 NM_001351340 NM_001351341 NM_001351342 NM_001351343 NM_001351344 NM_001351345 NM_016123
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IRAK4
Alternative Splicing GalleryENSG00000198001
Gene ExpressionIRAK4 [ NCBI-GEO ]   IRAK4 [ EBI - ARRAY_EXPRESS ]   IRAK4 [ SEEK ]   IRAK4 [ MEM ]
Gene Expression Viewer (FireBrowse)IRAK4 [ Firebrowse - Broad ]
GenevisibleExpression of IRAK4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51135
GTEX Portal (Tissue expression)IRAK4
Human Protein AtlasENSG00000198001-IRAK4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NWZ3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NWZ3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NWZ3
Splice isoforms : SwissVarQ9NWZ3
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9NWZ3
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)DEATH-like_dom_sf    IRAK4    IRAK4_Death    Kinase-like_dom_sf    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)IRAK4
Blocks (Seattle)IRAK4
PDB (RSDB)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN    5K72    5K75    5K76    5K7G    5K7I    5KX7    5KX8    5T1S    5T1T    5UIQ    5UIR    5UIS    5UIT    5UIU    5W84    5W85    6EG9    6EGA    6EGD    6EGE    6EGF    6F3D    6F3E    6F3G    6F3I    6MOM    6N8G    6O8U    6O94    6O95    6O9D    6RFI    6RFJ    6UYA   
PDB Europe2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN    5K72    5K75    5K76    5K7G    5K7I    5KX7    5KX8    5T1S    5T1T    5UIQ    5UIR    5UIS    5UIT    5UIU    5W84    5W85    6EG9    6EGA    6EGD    6EGE    6EGF    6F3D    6F3E    6F3G    6F3I    6MOM    6N8G    6O8U    6O94    6O95    6O9D    6RFI    6RFJ    6UYA   
PDB (PDBSum)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN    5K72    5K75    5K76    5K7G    5K7I    5KX7    5KX8    5T1S    5T1T    5UIQ    5UIR    5UIS    5UIT    5UIU    5W84    5W85    6EG9    6EGA    6EGD    6EGE    6EGF    6F3D    6F3E    6F3G    6F3I    6MOM    6N8G    6O8U    6O94    6O95    6O9D    6RFI    6RFJ    6UYA   
PDB (IMB)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN    5K72    5K75    5K76    5K7G    5K7I    5KX7    5KX8    5T1S    5T1T    5UIQ    5UIR    5UIS    5UIT    5UIU    5W84    5W85    6EG9    6EGA    6EGD    6EGE    6EGF    6F3D    6F3E    6F3G    6F3I    6MOM    6N8G    6O8U    6O94    6O95    6O9D    6RFI    6RFJ    6UYA   
Structural Biology KnowledgeBase2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN    5K72    5K75    5K76    5K7G    5K7I    5KX7    5KX8    5T1S    5T1T    5UIQ    5UIR    5UIS    5UIT    5UIU    5W84    5W85    6EG9    6EGA    6EGD    6EGE    6EGF    6F3D    6F3E    6F3G    6F3I    6MOM    6N8G    6O8U    6O94    6O95    6O9D    6RFI    6RFJ    6UYA   
SCOP (Structural Classification of Proteins)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN    5K72    5K75    5K76    5K7G    5K7I    5KX7    5KX8    5T1S    5T1T    5UIQ    5UIR    5UIS    5UIT    5UIU    5W84    5W85    6EG9    6EGA    6EGD    6EGE    6EGF    6F3D    6F3E    6F3G    6F3I    6MOM    6N8G    6O8U    6O94    6O95    6O9D    6RFI    6RFJ    6UYA   
CATH (Classification of proteins structures)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN    5K72    5K75    5K76    5K7G    5K7I    5KX7    5KX8    5T1S    5T1T    5UIQ    5UIR    5UIS    5UIT    5UIU    5W84    5W85    6EG9    6EGA    6EGD    6EGE    6EGF    6F3D    6F3E    6F3G    6F3I    6MOM    6N8G    6O8U    6O94    6O95    6O9D    6RFI    6RFJ    6UYA   
SuperfamilyQ9NWZ3
Human Protein Atlas [tissue]ENSG00000198001-IRAK4 [tissue]
Peptide AtlasQ9NWZ3
HPRD06051
IPIIPI00007641   IPI00798404   IPI00385374   IPI01021863   IPI01021300   IPI01021420   
Protein Interaction databases
DIP (DOE-UCLA)Q9NWZ3
IntAct (EBI)Q9NWZ3
BioGRIDIRAK4
STRING (EMBL)IRAK4
ZODIACIRAK4
Ontologies - Pathways
QuickGOQ9NWZ3
Ontology : AmiGOmagnesium ion binding  cytokine production  toll-like receptor signaling pathway  neutrophil mediated immunity  MyD88-dependent toll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  interleukin-1 receptor binding  protein binding  ATP binding  extracellular space  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  JNK cascade  endosome membrane  cytokine-mediated signaling pathway  toll-like receptor 9 signaling pathway  intracellular signal transduction  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  positive regulation of smooth muscle cell proliferation  interleukin-1-mediated signaling pathway  neutrophil migration  
Ontology : EGO-EBImagnesium ion binding  cytokine production  toll-like receptor signaling pathway  neutrophil mediated immunity  MyD88-dependent toll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  interleukin-1 receptor binding  protein binding  ATP binding  extracellular space  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  JNK cascade  endosome membrane  cytokine-mediated signaling pathway  toll-like receptor 9 signaling pathway  intracellular signal transduction  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  positive regulation of smooth muscle cell proliferation  interleukin-1-mediated signaling pathway  neutrophil migration  
Pathways : KEGGNF-kappa B signaling pathway    Apoptosis    Toll-like receptor signaling pathway    Neurotrophin signaling pathway    Pertussis    Leishmaniasis    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Tuberculosis    Measles    Influenza A   
NDEx NetworkIRAK4
Atlas of Cancer Signalling NetworkIRAK4
Wikipedia pathwaysIRAK4
Orthology - Evolution
OrthoDB51135
GeneTree (enSembl)ENSG00000198001
Phylogenetic Trees/Animal Genes : TreeFamIRAK4
HOGENOMQ9NWZ3
Homologs : HomoloGeneIRAK4
Homology/Alignments : Family Browser (UCSC)IRAK4
Gene fusions - Rearrangements
Fusion : MitelmanC12orf29/IRAK4 [12q21.32/12q12]  
Fusion : MitelmanHDAC7/IRAK4 [12q13.11/12q12]  
Fusion PortalC12orf29 12q21.32 IRAK4 12q12 PRAD
Fusion PortalHDAC7 12q13.11 IRAK4 12q12 BRCA
Fusion : QuiverIRAK4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRAK4 [hg38]
dbVarIRAK4
ClinVarIRAK4
MonarchIRAK4
1000_GenomesIRAK4 
Exome Variant ServerIRAK4
GNOMAD BrowserENSG00000198001
Varsome BrowserIRAK4
Genomic Variants (DGV)IRAK4 [DGVbeta]
DECIPHERIRAK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRAK4 
Mutations
ICGC Data PortalIRAK4 
TCGA Data PortalIRAK4 
Broad Tumor PortalIRAK4
OASIS PortalIRAK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRAK4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIRAK4
Mutations and Diseases : HGMDIRAK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch IRAK4
DgiDB (Drug Gene Interaction Database)IRAK4
DoCM (Curated mutations)IRAK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRAK4 (select a term)
intoGenIRAK4
Cancer3DIRAK4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606883    607676   
Orphanet10963   
DisGeNETIRAK4
MedgenIRAK4
Genetic Testing Registry IRAK4
NextProtQ9NWZ3 [Medical]
GENETestsIRAK4
Target ValidationIRAK4
Huge Navigator IRAK4 [HugePedia]
ClinGenIRAK4
Clinical trials, drugs, therapy
MyCancerGenomeIRAK4
Protein Interactions : CTD
Pharm GKB GenePA134914577
PharosQ9NWZ3
Clinical trialIRAK4
Miscellaneous
canSAR (ICR)IRAK4 (select the gene name)
HarmonizomeIRAK4
DataMed IndexIRAK4
Probes
Litterature
PubMed154 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIRAK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:20:33 CET 2021
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