Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IRAK4 (interleukin-1 receptor-associated kinase 4)

Identity

Other namesIPD1
IRAK-4
NY-REN-64
REN64
HGNC (Hugo) IRAK4
LocusID (NCBI) 51135
Location 12q12
Location_base_pair Starts at 44152747 and ends at 44183346 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IRAK4   17967
Cards
Entrez_Gene (NCBI)IRAK4  51135  interleukin-1 receptor-associated kinase 4
GeneCards (Weizmann)IRAK4
Ensembl (Hinxton)ENSG00000198001 [Gene_View]  chr12:44152747-44183346 [Contig_View]  IRAK4 [Vega]
ICGC DataPortalENSG00000198001
cBioPortalIRAK4
AceView (NCBI)IRAK4
Genatlas (Paris)IRAK4
WikiGenes51135
SOURCE (Princeton)NM_001114182 NM_001145256 NM_001145257 NM_001145258 NM_016123
Genomic and cartography
GoldenPath (UCSC)IRAK4  -  12q12   chr12:44152747-44183346 +  12q12   [Description]    (hg19-Feb_2009)
EnsemblIRAK4 - 12q12 [CytoView]
Mapping of homologs : NCBIIRAK4 [Mapview]
OMIM606883   607676   610799   
Gene and transcription
Genbank (Entrez)AF155118 AF445802 AI126481 AK000528 AK027301
RefSeq transcript (Entrez)NM_001114182 NM_001145256 NM_001145257 NM_001145258 NM_016123
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_009892 NT_029419 NW_001838057 NW_004929384
Consensus coding sequences : CCDS (NCBI)IRAK4
Cluster EST : UnigeneHs.138499 [ NCBI ]
CGAP (NCI)Hs.138499
Alternative Splicing : Fast-db (Paris)GSHG0006596
Alternative Splicing GalleryENSG00000198001
Gene ExpressionIRAK4 [ NCBI-GEO ]     IRAK4 [ SEEK ]   IRAK4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NWZ3 (Uniprot)
NextProtQ9NWZ3  [Medical]
With graphics : InterProQ9NWZ3
Splice isoforms : SwissVarQ9NWZ3 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)DEATH-like_dom [organisation]   IL-1_rcpt-assoc_kin4 [organisation]   Kinase-like_dom [organisation]   Prot_kinase_dom [organisation]  
Related proteins : CluSTrQ9NWZ3
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
DMDM Disease mutations51135
Blocks (Seattle)Q9NWZ3
PDB (SRS)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP   
PDB (PDBSum)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP   
PDB (IMB)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP   
PDB (RSDB)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP   
Human Protein AtlasENSG00000198001 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9NWZ3
HPRD06051
IPIIPI00007641   IPI00798404   IPI00385374   IPI01021863   IPI01021300   IPI01021420   
Protein Interaction databases
DIP (DOE-UCLA)Q9NWZ3
IntAct (EBI)Q9NWZ3
FunCoupENSG00000198001
BioGRIDIRAK4
InParanoidQ9NWZ3
Interologous Interaction database Q9NWZ3
IntegromeDBIRAK4
STRING (EMBL)IRAK4
Ontologies - Pathways
Ontology : AmiGOmagnesium ion binding  cytokine production  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  interleukin-1 receptor binding  protein binding  ATP binding  cytosol  plasma membrane  protein phosphorylation  JNK cascade  endosome membrane  cytokine-mediated signaling pathway  toll-like receptor 2 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  positive regulation of transcription from RNA polymerase II promoter  positive regulation of smooth muscle cell proliferation  
Ontology : EGO-EBImagnesium ion binding  cytokine production  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  interleukin-1 receptor binding  protein binding  ATP binding  cytosol  plasma membrane  protein phosphorylation  JNK cascade  endosome membrane  cytokine-mediated signaling pathway  toll-like receptor 2 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  positive regulation of transcription from RNA polymerase II promoter  positive regulation of smooth muscle cell proliferation  
Pathways : KEGGNF-kappa B signaling pathway    Apoptosis    Toll-like receptor signaling pathway    Neurotrophin signaling pathway    Pertussis    Leishmaniasis    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Tuberculosis    Measles    Influenza A   
Protein Interaction DatabaseIRAK4
Wikipedia pathwaysIRAK4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IRAK4
snp3D : Map Gene to Disease51135
SNP (GeneSNP Utah)IRAK4
SNP : HGBaseIRAK4
Genetic variants : HAPMAPIRAK4
Exome VariantIRAK4
1000_GenomesIRAK4 
ICGC programENSG00000198001 
Somatic Mutations in Cancer : COSMICIRAK4 
CONAN: Copy Number AnalysisIRAK4 
Mutations and Diseases : HGMDIRAK4
Mutations and Diseases : intOGenIRAK4
Genomic VariantsIRAK4  IRAK4 [DGVbeta]
dbVarIRAK4
ClinVarIRAK4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM606883    607676    610799   
MedgenIRAK4
GENETestsIRAK4
Disease Genetic AssociationIRAK4
Huge Navigator IRAK4 [HugePedia]  IRAK4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneIRAK4
Homology/Alignments : Family Browser (UCSC)IRAK4
Phylogenetic Trees/Animal Genes : TreeFamIRAK4
Chemical/Protein Interactions : CTD51135
Chemical/Pharm GKB GenePA134914577
Clinical trialIRAK4
Cancer Resource (Charite)ENSG00000198001
Other databases
Probes
Litterature
PubMed110 Pubmed reference(s) in Entrez
CoreMineIRAK4
iHOPIRAK4
OncoSearchIRAK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:51:10 CEST 2014

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