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IRAK4 (interleukin 1 receptor associated kinase 4)

Identity

Other namesIPD1
IRAK-4
NY-REN-64
REN64
HGNC (Hugo) IRAK4
LocusID (NCBI) 51135
Atlas_Id 40989
Location 12q12  [Link to chromosome band 12q12]
Location_base_pair Starts at 44152747 and ends at 44183346 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C12orf29 (12q21.32) / IRAK4 (12q12)GPATCH8 (17q21.31) / IRAK4 (12q12)HDAC7 (12q13.11) / IRAK4 (12q12)
C12orf29 12q21.32 / IRAK4 12q12HDAC7 12q13.11 / IRAK4 12q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IRAK4   17967
Cards
Entrez_Gene (NCBI)IRAK4  51135  interleukin 1 receptor associated kinase 4
AliasesIPD1; IRAK-4; NY-REN-64; REN64
GeneCards (Weizmann)IRAK4
Ensembl hg19 (Hinxton)ENSG00000198001 [Gene_View]  chr12:44152747-44183346 [Contig_View]  IRAK4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000198001 [Gene_View]  chr12:44152747-44183346 [Contig_View]  IRAK4 [Vega]
ICGC DataPortalENSG00000198001
TCGA cBioPortalIRAK4
AceView (NCBI)IRAK4
Genatlas (Paris)IRAK4
WikiGenes51135
SOURCE (Princeton)IRAK4
Genomic and cartography
GoldenPath hg19 (UCSC)IRAK4  -     chr12:44152747-44183346 +  12q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IRAK4  -     12q12   [Description]    (hg38-Dec_2013)
EnsemblIRAK4 - 12q12 [CytoView hg19]  IRAK4 - 12q12 [CytoView hg38]
Mapping of homologs : NCBIIRAK4 [Mapview hg19]  IRAK4 [Mapview hg38]
OMIM606883   607676   610799   
Gene and transcription
Genbank (Entrez)AF155118 AF445802 AI126481 AK000528 AK027301
RefSeq transcript (Entrez)NM_001114182 NM_001145256 NM_001145257 NM_001145258 NM_016123
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_009892 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)IRAK4
Cluster EST : UnigeneHs.138499 [ NCBI ]
CGAP (NCI)Hs.138499
Alternative Splicing GalleryENSG00000198001
Gene ExpressionIRAK4 [ NCBI-GEO ]   IRAK4 [ EBI - ARRAY_EXPRESS ]   IRAK4 [ SEEK ]   IRAK4 [ MEM ]
Gene Expression Viewer (FireBrowse)IRAK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51135
GTEX Portal (Tissue expression)IRAK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NWZ3 (Uniprot)
NextProtQ9NWZ3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NWZ3
Splice isoforms : SwissVarQ9NWZ3 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9NWZ3
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)DEATH-like_dom    IL-1_rcpt-assoc_kin4    Kinase-like_dom    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
DMDM Disease mutations51135
Blocks (Seattle)IRAK4
PDB (SRS)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN   
PDB (PDBSum)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN   
PDB (IMB)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN   
PDB (RSDB)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN   
Structural Biology KnowledgeBase2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN   
SCOP (Structural Classification of Proteins)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN   
CATH (Classification of proteins structures)2NRU    2NRY    2O8Y    2OIB    2OIC    2OID    3MOP    4RMZ    4U97    4U9A    4XS2    4Y73    4YO6    4YP8    4ZTL    4ZTM    4ZTN   
SuperfamilyQ9NWZ3
Human Protein AtlasENSG00000198001
Peptide AtlasQ9NWZ3
HPRD06051
IPIIPI00007641   IPI00798404   IPI00385374   IPI01021863   IPI01021300   IPI01021420   
Protein Interaction databases
DIP (DOE-UCLA)Q9NWZ3
IntAct (EBI)Q9NWZ3
FunCoupENSG00000198001
BioGRIDIRAK4
STRING (EMBL)IRAK4
ZODIACIRAK4
Ontologies - Pathways
QuickGOQ9NWZ3
Ontology : AmiGOmagnesium ion binding  cytokine production  toll-like receptor signaling pathway  neutrophil mediated immunity  MyD88-dependent toll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  interleukin-1 receptor binding  protein binding  ATP binding  extracellular space  nucleus  cytoplasm  cytosol  plasma membrane  JNK cascade  endosome membrane  cytokine-mediated signaling pathway  toll-like receptor 9 signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  positive regulation of smooth muscle cell proliferation  neutrophil migration  
Ontology : EGO-EBImagnesium ion binding  cytokine production  toll-like receptor signaling pathway  neutrophil mediated immunity  MyD88-dependent toll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  interleukin-1 receptor binding  protein binding  ATP binding  extracellular space  nucleus  cytoplasm  cytosol  plasma membrane  JNK cascade  endosome membrane  cytokine-mediated signaling pathway  toll-like receptor 9 signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  positive regulation of smooth muscle cell proliferation  neutrophil migration  
Pathways : KEGGNF-kappa B signaling pathway    Apoptosis    Toll-like receptor signaling pathway    Neurotrophin signaling pathway    Pertussis    Leishmaniasis    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Tuberculosis    Measles    Influenza A   
NDEx NetworkIRAK4
Atlas of Cancer Signalling NetworkIRAK4
Wikipedia pathwaysIRAK4
Orthology - Evolution
OrthoDB51135
GeneTree (enSembl)ENSG00000198001
Phylogenetic Trees/Animal Genes : TreeFamIRAK4
Homologs : HomoloGeneIRAK4
Homology/Alignments : Family Browser (UCSC)IRAK4
Gene fusions - Rearrangements
Fusion: TCGAC12orf29 12q21.32 IRAK4 12q12 PRAD
Fusion: TCGAHDAC7 12q13.11 IRAK4 12q12 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerIRAK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRAK4
dbVarIRAK4
ClinVarIRAK4
1000_GenomesIRAK4 
Exome Variant ServerIRAK4
ExAC (Exome Aggregation Consortium)IRAK4 (select the gene name)
Genetic variants : HAPMAP51135
Genomic Variants (DGV)IRAK4 [DGVbeta]
Mutations
ICGC Data PortalIRAK4 
TCGA Data PortalIRAK4 
Broad Tumor PortalIRAK4
OASIS PortalIRAK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRAK4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch IRAK4
DgiDB (Drug Gene Interaction Database)IRAK4
DoCM (Curated mutations)IRAK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRAK4 (select a term)
intoGenIRAK4
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:44152747-44183346  ENSG00000198001
CONAN: Copy Number AnalysisIRAK4 
Mutations and Diseases : HGMDIRAK4
OMIM606883    607676    610799   
MedgenIRAK4
Genetic Testing Registry IRAK4
NextProtQ9NWZ3 [Medical]
TSGene51135
GENETestsIRAK4
Huge Navigator IRAK4 [HugePedia]
snp3D : Map Gene to Disease51135
BioCentury BCIQIRAK4
ClinGenIRAK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51135
Chemical/Pharm GKB GenePA134914577
Clinical trialIRAK4
Miscellaneous
canSAR (ICR)IRAK4 (select the gene name)
Probes
Litterature
PubMed123 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIRAK4
EVEXIRAK4
GoPubMedIRAK4
iHOPIRAK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 18:55:22 CEST 2016

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