IREB2 (iron responsive element binding protein 2)

2011-06-01  

Identity

HGNC
LOCATION
15q25.1
LOCUSID
ALIAS
ACO3,IRE-BP
FUSION GENES

Other Information

Locus ID:

NCBI: 3658
MIM: 147582
HGNC: 6115
Ensembl: ENSG00000136381

Variants:

dbSNP: 3658
ClinVar: 3658
TCGA: ENSG00000136381
COSMIC: IREB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136381ENST00000258886P48200
ENSG00000136381ENST00000558525H0YL48
ENSG00000136381ENST00000558570H0YNL8
ENSG00000136381ENST00000559091H0YN46
ENSG00000136381ENST00000559215H0YMA8
ENSG00000136381ENST00000560440P48200
ENSG00000136381ENST00000560840H0YLE0

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198000472009Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene.69
267525192016Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.65
206569432010Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease.55
128885682003Oxygen and iron regulation of iron regulatory protein 2.42
250067442014Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.41
242857262014IRP2 regulates breast tumor growth.38
224614312012CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland.37
204050062010Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert.31
122004532002Multiple, conserved iron-responsive elements in the 3'-untranslated region of transferrin receptor mRNA enhance binding of iron regulatory protein 2.30
176042812007Excess capacity of the iron regulatory protein system.29

Citation

Dessen P

IREB2 (iron responsive element binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52239/ireb2