IRF2 (interferon regulatory factor 2)

2003-05-01  

Identity

HGNC
LOCATION
4q35.1
LOCUSID
ALIAS
IRF-2
FUSION GENES

Other Information

Locus ID:

NCBI: 3660
MIM: 147576
HGNC: 6117
Ensembl: ENSG00000168310

Variants:

dbSNP: 3660
ClinVar: 3660
TCGA: ENSG00000168310
COSMIC: IRF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168310ENST00000393593P14316
ENSG00000168310ENST00000502750H0Y956
ENSG00000168310ENST00000505067K4DIA4
ENSG00000168310ENST00000506230D6R9N5
ENSG00000168310ENST00000507523K4DIA5
ENSG00000168310ENST00000509274D6RED1
ENSG00000168310ENST00000510814D6RB08

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Interferon gamma signalingREACTOMER-HSA-877300
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
246078432014Survival in patients with high-risk prostate cancer is predicted by miR-221, which regulates proliferation, apoptosis, and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3.41
124798172002IFN-gamma represses IL-4 expression via IRF-1 and IRF-2.40
192476922009Analyses of associations with asthma in four asthma population samples from Canada and Australia.39
152264322004Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.35
172001202007PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cells.25
284714472017MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer.20
261735862016MicroRNA-18a modulates P53 expression by targeting IRF2 in gastric cancer patients.14
183950092008IRF-2 regulates NF-kappaB activity by modulating the subcellular localization of NF-kappaB.12
221134742012Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum.12

Citation

Dessen P

IRF2 (interferon regulatory factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40991/irf2