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IRF2 (interferon regulatory factor 2)

Identity

Alias (NCBI)IRF-2
HGNC (Hugo) IRF2
LocusID (NCBI) 3660
Atlas_Id 40991
Location 4q35.1  [Link to chromosome band 4q35]
Location_base_pair Starts at 184387730 and ends at 184474550 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IRF2 (4q35.1) / EMP1 (12p13.1)ZNF804A (2q32.1) / IRF2 (4q35.1)ZNF804A 2q32.1 / IRF2 4q35.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;17)(q42;q21) IRF2BP2/RARA


External links

 

Nomenclature
HGNC (Hugo)IRF2   6117
Cards
Entrez_Gene (NCBI)IRF2    interferon regulatory factor 2
AliasesIRF-2
GeneCards (Weizmann)IRF2
Ensembl hg19 (Hinxton)ENSG00000168310 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168310 [Gene_View]  ENSG00000168310 [Sequence]  chr4:184387730-184474550 [Contig_View]  IRF2 [Vega]
ICGC DataPortalENSG00000168310
TCGA cBioPortalIRF2
AceView (NCBI)IRF2
Genatlas (Paris)IRF2
SOURCE (Princeton)IRF2
Genetics Home Reference (NIH)IRF2
Genomic and cartography
GoldenPath hg38 (UCSC)IRF2  -     chr4:184387730-184474550 -  4q35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRF2  -     4q35.1   [Description]    (hg19-Feb_2009)
GoldenPathIRF2 - 4q35.1 [CytoView hg19]  IRF2 - 4q35.1 [CytoView hg38]
ImmunoBaseENSG00000168310
Genome Data Viewer NCBIIRF2 [Mapview hg19]  
OMIM147576   
Gene and transcription
Genbank (Entrez)AA361545 AK312953 BC015803 BP200998 BQ017798
RefSeq transcript (Entrez)NM_002199
Consensus coding sequences : CCDS (NCBI)IRF2
Gene ExpressionIRF2 [ NCBI-GEO ]   IRF2 [ EBI - ARRAY_EXPRESS ]   IRF2 [ SEEK ]   IRF2 [ MEM ]
Gene Expression Viewer (FireBrowse)IRF2 [ Firebrowse - Broad ]
GenevisibleExpression of IRF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3660
GTEX Portal (Tissue expression)IRF2
Human Protein AtlasENSG00000168310-IRF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14316   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14316  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14316
PhosPhoSitePlusP14316
Domaine pattern : Prosite (Expaxy)IRF_1 (PS00601)    IRF_2 (PS51507)   
Domains : Interpro (EBI)Interferon_reg_fac_CS    Interferon_reg_fact_DNA-bd_dom    IRF1/IRF2    IRF2    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)IRF (PF00605)   
Domain families : Pfam (NCBI)pfam00605   
Domain families : Smart (EMBL)IRF (SM00348)  
Conserved Domain (NCBI)IRF2
SuperfamilyP14316
AlphaFold pdb e-kbP14316   
Human Protein Atlas [tissue]ENSG00000168310-IRF2 [tissue]
HPRD00962
Protein Interaction databases
DIP (DOE-UCLA)P14316
IntAct (EBI)P14316
BioGRIDIRF2
STRING (EMBL)IRF2
ZODIACIRF2
Ontologies - Pathways
QuickGOP14316
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  immune system process  DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  cytosol  focal adhesion  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  blood coagulation  cell population proliferation  positive regulation of transcription by RNA polymerase II  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  immune system process  DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  cytosol  focal adhesion  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  blood coagulation  cell population proliferation  positive regulation of transcription by RNA polymerase II  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  sequence-specific double-stranded DNA binding  
Pathways : BIOCARTAThe information-processing pathway at the IFN-beta enhancer [Genes]   
NDEx NetworkIRF2
Atlas of Cancer Signalling NetworkIRF2
Wikipedia pathwaysIRF2
Orthology - Evolution
OrthoDB3660
GeneTree (enSembl)ENSG00000168310
Phylogenetic Trees/Animal Genes : TreeFamIRF2
Homologs : HomoloGeneIRF2
Homology/Alignments : Family Browser (UCSC)IRF2
Gene fusions - Rearrangements
Fusion : MitelmanZNF804A/IRF2 [2q32.1/4q35.1]  
Fusion : QuiverIRF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRF2
dbVarIRF2
ClinVarIRF2
MonarchIRF2
1000_GenomesIRF2 
Exome Variant ServerIRF2
GNOMAD BrowserENSG00000168310
Varsome BrowserIRF2
ACMGIRF2 variants
VarityP14316
Genomic Variants (DGV)IRF2 [DGVbeta]
DECIPHERIRF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRF2 
Mutations
ICGC Data PortalIRF2 
TCGA Data PortalIRF2 
Broad Tumor PortalIRF2
OASIS PortalIRF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIRF2
Mutations and Diseases : HGMDIRF2
intOGen PortalIRF2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIRF2
DgiDB (Drug Gene Interaction Database)IRF2
DoCM (Curated mutations)IRF2
CIViC (Clinical Interpretations of Variants in Cancer)IRF2
Cancer3DIRF2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147576   
Orphanet
DisGeNETIRF2
MedgenIRF2
Genetic Testing Registry IRF2
NextProtP14316 [Medical]
GENETestsIRF2
Target ValidationIRF2
Huge Navigator IRF2 [HugePedia]
ClinGenIRF2
Clinical trials, drugs, therapy
MyCancerGenomeIRF2
Protein Interactions : CTDIRF2
Pharm GKB GenePA29916
PharosP14316
Clinical trialIRF2
Miscellaneous
canSAR (ICR)IRF2
HarmonizomeIRF2
DataMed IndexIRF2
Probes
Litterature
PubMed94 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIRF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:12 CEST 2021

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