Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

IRF2 (interferon regulatory factor 2)

Identity

Other aliasIRF-2
HGNC (Hugo) IRF2
LocusID (NCBI) 3660
Atlas_Id 40991
Location 4q35.1  [Link to chromosome band 4q35]
Location_base_pair Starts at 184387722 and ends at 184474572 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IRF2 (4q35.1) / EMP1 (12p13.1)ZNF804A (2q32.1) / IRF2 (4q35.1)ZNF804A 2q32.1 / IRF2 4q35.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;17)(p34;q21) IRF2BP2/RARA


External links

Nomenclature
HGNC (Hugo)IRF2   6117
Cards
Entrez_Gene (NCBI)IRF2  3660  interferon regulatory factor 2
AliasesIRF-2
GeneCards (Weizmann)IRF2
Ensembl hg19 (Hinxton)ENSG00000168310 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168310 [Gene_View]  chr4:184387722-184474572 [Contig_View]  IRF2 [Vega]
ICGC DataPortalENSG00000168310
TCGA cBioPortalIRF2
AceView (NCBI)IRF2
Genatlas (Paris)IRF2
WikiGenes3660
SOURCE (Princeton)IRF2
Genetics Home Reference (NIH)IRF2
Genomic and cartography
GoldenPath hg38 (UCSC)IRF2  -     chr4:184387722-184474572 -  4q35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRF2  -     4q35.1   [Description]    (hg19-Feb_2009)
EnsemblIRF2 - 4q35.1 [CytoView hg19]  IRF2 - 4q35.1 [CytoView hg38]
Mapping of homologs : NCBIIRF2 [Mapview hg19]  IRF2 [Mapview hg38]
OMIM147576   
Gene and transcription
Genbank (Entrez)AA361545 AK312953 BC015803 BP200998 BQ017798
RefSeq transcript (Entrez)NM_002199
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IRF2
Cluster EST : UnigeneHs.654566 [ NCBI ]
CGAP (NCI)Hs.654566
Alternative Splicing GalleryENSG00000168310
Gene ExpressionIRF2 [ NCBI-GEO ]   IRF2 [ EBI - ARRAY_EXPRESS ]   IRF2 [ SEEK ]   IRF2 [ MEM ]
Gene Expression Viewer (FireBrowse)IRF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3660
GTEX Portal (Tissue expression)IRF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14316   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14316  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14316
Splice isoforms : SwissVarP14316
PhosPhoSitePlusP14316
Domaine pattern : Prosite (Expaxy)IRF_1 (PS00601)    IRF_2 (PS51507)   
Domains : Interpro (EBI)Interferon_reg_fac_CS    Interferon_reg_fact_DNA-bd_dom    IRF1/IRF2    IRF2    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)IRF (PF00605)   
Domain families : Pfam (NCBI)pfam00605   
Domain families : Smart (EMBL)IRF (SM00348)  
Conserved Domain (NCBI)IRF2
DMDM Disease mutations3660
Blocks (Seattle)IRF2
SuperfamilyP14316
Human Protein AtlasENSG00000168310
Peptide AtlasP14316
HPRD00962
IPIIPI00293657   IPI00967033   IPI00965244   IPI00964826   IPI00966668   IPI00966424   IPI00966777   IPI00966037   
Protein Interaction databases
DIP (DOE-UCLA)P14316
IntAct (EBI)P14316
FunCoupENSG00000168310
BioGRIDIRF2
STRING (EMBL)IRF2
ZODIACIRF2
Ontologies - Pathways
QuickGOP14316
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleoplasm  nucleoplasm  cytosol  cytosol  focal adhesion  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  blood coagulation  cell proliferation  positive regulation of transcription from RNA polymerase II promoter  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleoplasm  nucleoplasm  cytosol  cytosol  focal adhesion  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  blood coagulation  cell proliferation  positive regulation of transcription from RNA polymerase II promoter  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  
Pathways : BIOCARTAThe information-processing pathway at the IFN-beta enhancer [Genes]   
NDEx NetworkIRF2
Atlas of Cancer Signalling NetworkIRF2
Wikipedia pathwaysIRF2
Orthology - Evolution
OrthoDB3660
GeneTree (enSembl)ENSG00000168310
Phylogenetic Trees/Animal Genes : TreeFamIRF2
HOVERGENP14316
HOGENOMP14316
Homologs : HomoloGeneIRF2
Homology/Alignments : Family Browser (UCSC)IRF2
Gene fusions - Rearrangements
Fusion : MitelmanZNF804A/IRF2 [2q32.1/4q35.1]  [t(2;4)(q32;q35)]  
Fusion: TCGAZNF804A 2q32.1 IRF2 4q35.1 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRF2
dbVarIRF2
ClinVarIRF2
1000_GenomesIRF2 
Exome Variant ServerIRF2
ExAC (Exome Aggregation Consortium)IRF2 (select the gene name)
Genetic variants : HAPMAP3660
Genomic Variants (DGV)IRF2 [DGVbeta]
DECIPHERIRF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRF2 
Mutations
ICGC Data PortalIRF2 
TCGA Data PortalIRF2 
Broad Tumor PortalIRF2
OASIS PortalIRF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIRF2
intOGen PortalIRF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IRF2
DgiDB (Drug Gene Interaction Database)IRF2
DoCM (Curated mutations)IRF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRF2 (select a term)
intoGenIRF2
Cancer3DIRF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147576   
Orphanet
MedgenIRF2
Genetic Testing Registry IRF2
NextProtP14316 [Medical]
TSGene3660
GENETestsIRF2
Target ValidationIRF2
Huge Navigator IRF2 [HugePedia]
snp3D : Map Gene to Disease3660
BioCentury BCIQIRF2
ClinGenIRF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3660
Chemical/Pharm GKB GenePA29916
Clinical trialIRF2
Miscellaneous
canSAR (ICR)IRF2 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIRF2
EVEXIRF2
GoPubMedIRF2
iHOPIRF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:13:36 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.