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IRF5 (interferon regulatory factor 5)

Identity

Other namesSLEB10
HGNC (Hugo) IRF5
LocusID (NCBI) 3663
Location 7q32.1
Location_base_pair Starts at 128580724 and ends at 128590096 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IRF5   6120
Cards
Entrez_Gene (NCBI)IRF5  3663  interferon regulatory factor 5
GeneCards (Weizmann)IRF5
Ensembl hg19 (Hinxton)ENSG00000128604 [Gene_View]  chr7:128580724-128590096 [Contig_View]  IRF5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000128604 [Gene_View]  chr7:128580724-128590096 [Contig_View]  IRF5 [Vega]
ICGC DataPortalENSG00000128604
cBioPortalIRF5
AceView (NCBI)IRF5
Genatlas (Paris)IRF5
WikiGenes3663
SOURCE (Princeton)IRF5
Genomic and cartography
GoldenPath hg19 (UCSC)IRF5  -     chr7:128580724-128590096 +  7q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IRF5  -     7q32.1   [Description]    (hg38-Dec_2013)
EnsemblIRF5 - 7q32.1 [CytoView hg19]  IRF5 - 7q32.1 [CytoView hg38]
Mapping of homologs : NCBIIRF5 [Mapview hg19]  IRF5 [Mapview hg38]
OMIM607218   612245   612251   
Gene and transcription
Genbank (Entrez)AK293654 AK297083 AL713733 AY504946 AY504947
RefSeq transcript (Entrez)NM_001098627 NM_001098629 NM_001098630 NM_001242452 NM_032643
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NG_012306 NT_007933 NW_001839071 NW_004929332
Consensus coding sequences : CCDS (NCBI)IRF5
Cluster EST : UnigeneHs.521181 [ NCBI ]
CGAP (NCI)Hs.521181
Alternative Splicing : Fast-db (Paris)GSHG0027708
Alternative Splicing GalleryENSG00000128604
Gene ExpressionIRF5 [ NCBI-GEO ]     IRF5 [ SEEK ]   IRF5 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13568 (Uniprot)
NextProtQ13568  [Medical]
With graphics : InterProQ13568
Splice isoforms : SwissVarQ13568 (Swissvar)
Domaine pattern : Prosite (Expaxy)IRF_1 (PS00601)    IRF_2 (PS51507)   
Domains : Interpro (EBI)Interferon_reg_fac_CS    Interferon_reg_fact_DNA-bd_dom    Interferon_reg_factor-3    SMAD_dom-like    SMAD_FHA_domain    WHTH_DNA-bd_dom   
Related proteins : CluSTrQ13568
Domain families : Pfam (Sanger)IRF (PF00605)    IRF-3 (PF10401)   
Domain families : Pfam (NCBI)pfam00605    pfam10401   
Domain families : Smart (EMBL)IRF (SM00348)  
DMDM Disease mutations3663
Blocks (Seattle)Q13568
PDB (SRS)3DSH   
PDB (PDBSum)3DSH   
PDB (IMB)3DSH   
PDB (RSDB)3DSH   
Human Protein AtlasENSG00000128604
Peptide AtlasQ13568
HPRD06240
IPIIPI00396061   IPI00220220   IPI00746140   IPI01017875   IPI00884156   IPI00947025   IPI00940314   IPI00760667   IPI00946330   IPI00946869   IPI00945580   
Protein Interaction databases
DIP (DOE-UCLA)Q13568
IntAct (EBI)Q13568
FunCoupENSG00000128604
BioGRIDIRF5
IntegromeDBIRF5
STRING (EMBL)IRF5
Ontologies - Pathways
QuickGOQ13568
Ontology : AmiGOregulatory region DNA binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  cytoplasm  cytosol  transcription, DNA-templated  cytokine-mediated signaling pathway  response to peptidoglycan  response to muramyl dipeptide  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interleukin-12 production  positive regulation of apoptotic process  positive regulation of transcription from RNA polymerase II promoter  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  
Ontology : EGO-EBIregulatory region DNA binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  cytoplasm  cytosol  transcription, DNA-templated  cytokine-mediated signaling pathway  response to peptidoglycan  response to muramyl dipeptide  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interleukin-12 production  positive regulation of apoptotic process  positive regulation of transcription from RNA polymerase II promoter  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  
Pathways : BIOCARTAThe information-processing pathway at the IFN-beta enhancer [Genes]   
Pathways : KEGGToll-like receptor signaling pathway   
Protein Interaction DatabaseIRF5
DoCM (Curated mutations)IRF5
Wikipedia pathwaysIRF5
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIRF5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRF5
dbVarIRF5
ClinVarIRF5
1000_GenomesIRF5 
Exome Variant ServerIRF5
SNP (GeneSNP Utah)IRF5
SNP : HGBaseIRF5
Genetic variants : HAPMAPIRF5
Genomic VariantsIRF5  IRF5 [DGVbeta]
Mutations
ICGC Data PortalENSG00000128604 
Somatic Mutations in Cancer : COSMICIRF5 
CONAN: Copy Number AnalysisIRF5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:128580724-128590096
Mutations and Diseases : HGMDIRF5
OMIM607218    612245    612251   
MedgenIRF5
NextProtQ13568 [Medical]
GENETestsIRF5
Disease Genetic AssociationIRF5
Huge Navigator IRF5 [HugePedia]  IRF5 [HugeCancerGEM]
snp3D : Map Gene to Disease3663
DGIdb (Drug Gene Interaction db)IRF5
General knowledge
Homologs : HomoloGeneIRF5
Homology/Alignments : Family Browser (UCSC)IRF5
Phylogenetic Trees/Animal Genes : TreeFamIRF5
Chemical/Protein Interactions : CTD3663
Chemical/Pharm GKB GenePA29919
Clinical trialIRF5
Cancer Resource (Charite)ENSG00000128604
Other databases
Probes
Litterature
PubMed165 Pubmed reference(s) in Entrez
CoreMineIRF5
GoPubMedIRF5
iHOPIRF5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:11:57 CET 2014

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