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IRF5 (interferon regulatory factor 5)

Identity

Other namesSLEB10
HGNC (Hugo) IRF5
LocusID (NCBI) 3663
Atlas_Id 40992
Location 7q32.1
Location_base_pair Starts at 128580724 and ends at 128590096 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IRF5   6120
Cards
Entrez_Gene (NCBI)IRF5  3663  interferon regulatory factor 5
AliasesSLEB10
GeneCards (Weizmann)IRF5
Ensembl hg19 (Hinxton)ENSG00000128604 [Gene_View]  chr7:128580724-128590096 [Contig_View]  IRF5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000128604 [Gene_View]  chr7:128580724-128590096 [Contig_View]  IRF5 [Vega]
ICGC DataPortalENSG00000128604
TCGA cBioPortalIRF5
AceView (NCBI)IRF5
Genatlas (Paris)IRF5
WikiGenes3663
SOURCE (Princeton)IRF5
Genomic and cartography
GoldenPath hg19 (UCSC)IRF5  -     chr7:128580724-128590096 +  7q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IRF5  -     7q32.1   [Description]    (hg38-Dec_2013)
EnsemblIRF5 - 7q32.1 [CytoView hg19]  IRF5 - 7q32.1 [CytoView hg38]
Mapping of homologs : NCBIIRF5 [Mapview hg19]  IRF5 [Mapview hg38]
OMIM607218   612245   612251   
Gene and transcription
Genbank (Entrez)AK293654 AK297083 AL713733 AY504946 AY504947
RefSeq transcript (Entrez)NM_001098627 NM_001098629 NM_001098630 NM_001242452 NM_032643
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_012306 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)IRF5
Cluster EST : UnigeneHs.521181 [ NCBI ]
CGAP (NCI)Hs.521181
Alternative Splicing GalleryENSG00000128604
Gene ExpressionIRF5 [ NCBI-GEO ]   IRF5 [ EBI - ARRAY_EXPRESS ]   IRF5 [ SEEK ]   IRF5 [ MEM ]
Gene Expression Viewer (FireBrowse)IRF5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3663
GTEX Portal (Tissue expression)IRF5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13568 (Uniprot)
NextProtQ13568  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13568
Splice isoforms : SwissVarQ13568 (Swissvar)
PhosPhoSitePlusQ13568
Domaine pattern : Prosite (Expaxy)IRF_1 (PS00601)    IRF_2 (PS51507)   
Domains : Interpro (EBI)Interferon_reg_fac_CS    Interferon_reg_fact_DNA-bd_dom    Interferon_reg_factor-3    IRF5    SMAD_dom-like    SMAD_FHA_domain    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)IRF (PF00605)    IRF-3 (PF10401)   
Domain families : Pfam (NCBI)pfam00605    pfam10401   
Domain families : Smart (EMBL)IRF (SM00348)  
DMDM Disease mutations3663
Blocks (Seattle)IRF5
PDB (SRS)3DSH   
PDB (PDBSum)3DSH   
PDB (IMB)3DSH   
PDB (RSDB)3DSH   
Structural Biology KnowledgeBase3DSH   
SCOP (Structural Classification of Proteins)3DSH   
CATH (Classification of proteins structures)3DSH   
SuperfamilyQ13568
Human Protein AtlasENSG00000128604
Peptide AtlasQ13568
HPRD06240
IPIIPI00396061   IPI00220220   IPI00746140   IPI01017875   IPI00884156   IPI00947025   IPI00940314   IPI00760667   IPI00946330   IPI00946869   IPI00945580   
Protein Interaction databases
DIP (DOE-UCLA)Q13568
IntAct (EBI)Q13568
FunCoupENSG00000128604
BioGRIDIRF5
STRING (EMBL)IRF5
ZODIACIRF5
Ontologies - Pathways
QuickGOQ13568
Ontology : AmiGOregulatory region DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  cytoplasm  cytosol  transcription, DNA-templated  response to peptidoglycan  response to muramyl dipeptide  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interleukin-12 production  positive regulation of apoptotic process  positive regulation of transcription from RNA polymerase II promoter  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  
Ontology : EGO-EBIregulatory region DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  cytoplasm  cytosol  transcription, DNA-templated  response to peptidoglycan  response to muramyl dipeptide  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interleukin-12 production  positive regulation of apoptotic process  positive regulation of transcription from RNA polymerase II promoter  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  
Pathways : BIOCARTAThe information-processing pathway at the IFN-beta enhancer [Genes]   
Pathways : KEGGToll-like receptor signaling pathway   
NDEx Network
Atlas of Cancer Signalling NetworkIRF5
Wikipedia pathwaysIRF5
Orthology - Evolution
OrthoDB3663
GeneTree (enSembl)ENSG00000128604
Phylogenetic Trees/Animal Genes : TreeFamIRF5
Homologs : HomoloGeneIRF5
Homology/Alignments : Family Browser (UCSC)IRF5
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIRF5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRF5
dbVarIRF5
ClinVarIRF5
1000_GenomesIRF5 
Exome Variant ServerIRF5
ExAC (Exome Aggregation Consortium)IRF5 (select the gene name)
Genetic variants : HAPMAP3663
Genomic Variants (DGV)IRF5 [DGVbeta]
Mutations
ICGC Data PortalIRF5 
TCGA Data PortalIRF5 
Broad Tumor PortalIRF5
OASIS PortalIRF5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRF5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IRF5
DgiDB (Drug Gene Interaction Database)IRF5
DoCM (Curated mutations)IRF5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRF5 (select a term)
intoGenIRF5
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:128580724-128590096  ENSG00000128604
CONAN: Copy Number AnalysisIRF5 
Mutations and Diseases : HGMDIRF5
OMIM607218    612245    612251   
MedgenIRF5
Genetic Testing Registry IRF5
NextProtQ13568 [Medical]
TSGene3663
GENETestsIRF5
Huge Navigator IRF5 [HugePedia]
snp3D : Map Gene to Disease3663
BioCentury BCIQIRF5
ClinGenIRF5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3663
Chemical/Pharm GKB GenePA29919
Clinical trialIRF5
Miscellaneous
canSAR (ICR)IRF5 (select the gene name)
Probes
Litterature
PubMed196 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIRF5
EVEXIRF5
GoPubMedIRF5
iHOPIRF5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:07:10 CEST 2016

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