| Nomenclature |
|---|
| HGNC (Hugo) | IRF6 6121 |
| Cards |
|---|
| Entrez_Gene (NCBI) | IRF6 interferon regulatory factor 6 |
| Aliases | LPS; OFC6; PIT; PPS; |
| PPS1; VWS; VWS1 |
| GeneCards (Weizmann) | IRF6 |
| Ensembl hg19 (Hinxton) | ENSG00000117595 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000117595 [Gene_View] ENSG00000117595 [Sequence] chr1:209785618-209806142 [Contig_View] IRF6 [Vega] |
| ICGC DataPortal | ENSG00000117595 |
| TCGA cBioPortal | IRF6 |
| AceView (NCBI) | IRF6 |
| Genatlas (Paris) | IRF6 |
| SOURCE (Princeton) | IRF6 |
| Genetics Home Reference (NIH) | IRF6 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | IRF6 - chr1:209785618-209806142 - 1q32.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | IRF6 - 1q32.2 [Description] (hg19-Feb_2009) |
| GoldenPath | IRF6 - 1q32.2 [CytoView hg19] IRF6 - 1q32.2 [CytoView hg38] |
| ImmunoBase | ENSG00000117595 |
| genome Data Viewer NCBI | IRF6 [Mapview hg19] |
| OMIM | 119300 119500 607199 608864 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF027292 AK296960 AK312857 BC014852 BI770148 |
| RefSeq transcript (Entrez) | NM_001206696 NM_006147 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | IRF6 |
| Alternative Splicing Gallery | ENSG00000117595 |
| Gene Expression | IRF6 [ NCBI-GEO ] IRF6 [ EBI - ARRAY_EXPRESS ]
IRF6 [ SEEK ] IRF6 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | IRF6 [ Firebrowse - Broad ] |
| Genevisible | Expression of IRF6 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 3664 |
| GTEX Portal (Tissue expression) | IRF6 |
| Human Protein Atlas | ENSG00000117595-IRF6 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O14896 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O14896 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O14896 |
| Splice isoforms : SwissVar | O14896 |
| PhosPhoSitePlus | O14896 |
| Domaine pattern : Prosite (Expaxy) | IRF_1 (PS00601) IRF_2 (PS51507) |
| Domains : Interpro (EBI) | Interferon_reg_fac_CS Interferon_reg_fact_DNA-bd_dom Interferon_reg_factor-3 SMAD-like_dom_sf SMAD_FHA_dom_sf WH-like_DNA-bd_sf WH_DNA-bd_sf |
| Domain families : Pfam (Sanger) | IRF (PF00605) IRF-3 (PF10401) |
| Domain families : Pfam (NCBI) | pfam00605 pfam10401 |
| Domain families : Smart (EMBL) | IRF (SM00348) IRF-3 (SM01243) |
| Conserved Domain (NCBI) | IRF6 |
| Blocks (Seattle) | IRF6 |
| Superfamily | O14896 |
| Human Protein Atlas [tissue] | ENSG00000117595-IRF6 [tissue] |
| Peptide Atlas | O14896 |
| HPRD | 06227 |
| IPI | IPI00024290 IPI01012366 IPI00645422 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O14896 |
| IntAct (EBI) | O14896 |
| BioGRID | IRF6 |
| STRING (EMBL) | IRF6 |
| ZODIAC | IRF6 |
| Ontologies - Pathways |
|---|
| QuickGO | O14896 |
| Ontology : AmiGO | nuclear chromatin transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific immune system process DNA binding DNA-binding transcription factor activity protein binding nucleus nucleoplasm cytoplasm cytosol cytosol cell cycle arrest negative regulation of cell proliferation cell junction keratinocyte differentiation sequence-specific DNA binding keratinocyte proliferation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II cell development roof of mouth development interferon-gamma-mediated signaling pathway type I interferon signaling pathway mammary gland epithelial cell differentiation extracellular exosome |
| Ontology : EGO-EBI | nuclear chromatin transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific immune system process DNA binding DNA-binding transcription factor activity protein binding nucleus nucleoplasm cytoplasm cytosol cytosol cell cycle arrest negative regulation of cell proliferation cell junction keratinocyte differentiation sequence-specific DNA binding keratinocyte proliferation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II cell development roof of mouth development interferon-gamma-mediated signaling pathway type I interferon signaling pathway mammary gland epithelial cell differentiation extracellular exosome |
| NDEx Network | IRF6 |
| Atlas of Cancer Signalling Network | IRF6 |
| Wikipedia pathways | IRF6 |
| Orthology - Evolution |
|---|
| OrthoDB | 3664 |
| GeneTree (enSembl) | ENSG00000117595 |
| Phylogenetic Trees/Animal Genes : TreeFam | IRF6 |
| HOGENOM | O14896 |
| Homologs : HomoloGene | IRF6 |
| Homology/Alignments : Family Browser (UCSC) | IRF6 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | IRF6 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | IRF6 [hg38] |
| dbVar | IRF6 |
| ClinVar | IRF6 |
| Monarch | IRF6 |
| 1000_Genomes | IRF6 |
| Exome Variant Server | IRF6 |
| GNOMAD Browser | ENSG00000117595 |
| Varsome Browser | IRF6 |
| Genomic Variants (DGV) | IRF6 [DGVbeta] |
| DECIPHER | IRF6 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | IRF6 |
| Mutations |
|---|
| ICGC Data Portal | IRF6 |
| TCGA Data Portal | IRF6 |
| Broad Tumor Portal | IRF6 |
| OASIS Portal | IRF6 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | IRF6 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | IRF6 |
| Mutations and Diseases : HGMD | IRF6 |
| intOGen Portal | IRF6 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search IRF6 |
| DgiDB (Drug Gene Interaction Database) | IRF6 |
| DoCM (Curated mutations) | IRF6 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | IRF6 (select a term) |
| intoGen | IRF6 |
| Cancer3D | IRF6(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 119300 119500 607199 608864 |
| Orphanet | 967 1534 14371 |
| DisGeNET | IRF6 |
| Medgen | IRF6 |
| Genetic Testing Registry | IRF6
|
| NextProt | O14896 [Medical] |
| GENETests | IRF6 |
| Target Validation | IRF6 |
| Huge Navigator |
IRF6 [HugePedia] |
| ClinGen | IRF6 (curated) |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | IRF6 |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA29920 |
| Pharos | O14896 |
| Clinical trial | IRF6 |
| Miscellaneous |
|---|
| canSAR (ICR) | IRF6 (select the gene name) |
| Harmonizome | IRF6 |
| DataMed Index | IRF6 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 165 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | IRF6 |
